McCarley, Robin L. BIOGRAPHICAL SKETCH Robin L. McCarley ...

Principal Investigator/Program Director (Last, First, Middle): McCarley, Robin L.
BIOGRAPHICAL SKETCH
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NAME
Robin L. McCarley
eRA COMMONS USER NAME
tunnellsu
POSITION TITLE
Professor of Chemistry
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s) FIELD OF STUDY
Lake Forest College, IL BA 1986 Chemistry
University of North Carolina PhD 1990 Analytical Chemistry
University of Texas, NSF Postdoctoral Fellow 1990-1992 Analytical Chemistry
A. Positions and Honors. List in chronological order previous positions, concluding with your present
position. List any honors. Include present membership on any Federal Government public advisory
committee.
Positions and Employment
January 2007–present LSU Alumni Professor LOUISIANA STATE UNIVERSITY
August 2002–present Professor of Chemistry LOUISIANA STATE UNIVERSITY
August 1998–August 2002 Assoc. Professor of Chemistry LOUISIANA STATE UNIVERSITY
July 1992–August 1998 Assist. Professor of Chemistry LOUISIANA STATE UNIVERSITY
Honors
2007 Barbara Womack Alumni Professorship,
2003 LSU Distinguished Faculty Award
2002 LSU College of Basic Sciences Award of Excellence in Undergraduate Teaching
1998 LSU College of Basic Sciences Faculty Research Award
1993 Society for Analytical Chemists of Pittsburgh Award
1991-1992 National Science Foundation Postdoctoral Fellow in Chemistry
1990 The American Chemical Society Analytical Division Summer Fellowship
1989 The Electrochemical Society Summer Energy Fellowship
1989 Department of Education Fellowship, University of North Carolina
1989 The North Carolina-American Chemical Society Centennial Scholarship
1987 The Charles N. Reilley-Upjohn Award in Analytical Chemistry
1986 Phi Beta Kappa, Sigma Xi
1985 Phi Sigma Iota
B. Selected peer-reviewed publications (in chronological order).
(Publications selected from 80 peer-reviewed publications)
1. S.A. Soper, A.C. Henry, B. Vaidya, M. Galloway, M. Wabuyele, and R.L. McCarley, Surface
Modification of Polymer-Based Microfluidic Devices, Anal. Chim. Acta. 2002, 470, 87-99.
2. Vaidya, S.A. Soper, and R.L. McCarley, Surface Modification and Characterization of Microfabricated
Poly(carbonate) Devices: Manipulation of Electroosmotic Flow, The Analyst 2002, 127, 1289-1292.
3. S.L. Caston and R.L. McCarley, Characteristics of Nanoscopic Band Electrodes, J. Electroanal. Chem.
2002, 529, 124-134.
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4. M. Galloway, W. Stryjewski, A. Henry, S.M. Ford, S. Llopis, R.L. McCarley, S.A. Soper, Contact
Conductivity Detection in Poly(methyl methacylate)-Based Microfluidic Devices for Analysis of Monoand
Polyanionic Molecules, Anal. Chem. 2002, 74, 2407-2415.
5. E.E. Doomes, R.W. Zurales, R.L. McCarley, and E.D. Poliakoff, Correlations Between Heterocycle
Ring Size and X-ray Spectra, J. Chem. Phys. 2003, 119, 4399-4404.
6. E.E. Doomes, P.N. Floriano, R.W. Tittsworth, R.L. McCarley, and E.D. Poliakoff, Anomalous XANES
Spectra of Octadecanethiol Adsorbed on Ag(111), J. Phys. Chem. B 2003, 107, 10193-10197.
7. Y. C. Xu, B. Vaidya, A. B. Patel, S. M. Ford, R. L. McCarley, and S. A. Soper Solid-phase reversible
immobilization in microfluidic chips for the purification of dye-labeled DNA sequencing fragments, Anal.
Chem. 2003, 75, 2975-2984.
8. Y. Wang, B. Vaidya, H. D. Farquar, W. Stryjewski, R. P. Hammer, R. L. McCarley, S. A. Soper, Y. W.
Cheng and F. Barany, Microarrays assembled in microfluidic chips fabricated from poly(methyl
methacrylate) for the detection of low-abundant DNA mutations, Anal. Chem. 2003, 75, 1130-1140.
9. M.A. Witek, S.Wei, B. Vaidya, A.A. Adams, L. Zhu, W. Stryjewski, R.L. McCarley and S.A. Soper Cell
Transport via Electromigration in Polymer-based Microfluidic Devices, Lab on a Chip 2004, 4, 464-472.
10. R.L. McCarley, B. Vaidya, S. Wei, A.F. Smith, A.B. Patel, J. Feng, M.C. Murphy and S.A. Soper,
Resist-free Patterning of Surface Architectures in Polymer-based Microanalytical Devices, J. Am.
Chem. Soc. 2005, 127, 842-843.
11. S.S. Balamurugan, G.B. Bantchev, Y. Yang, and R.L. McCarley, Highly Water-Soluble Thermally
Responsive Poly(thiophene)-based Brushes, Angewandte Chemie 2005, 44, 4872-4876.
12. W. Ong and R.L. McCarley, Positive Dendritic Effects on the Electron-Donating Potencies of
Poly(propylene imine) Dendrimers,Organic Letters 2005, 7(7), 1287-1290.
13. Situma, Y. Wang, M. Hupert, F. Barany, R.L. McCarley and S.A. Soper, Fabrication of DNA
microarrays onto poly(methyl methacrylate) with ultraviolet patterning and microfluidics for the
detection of low-abundant point mutations,Anal. Biochem. 2005, 340(1),123-135.
14. Surface-Induced Aggregation of Beta Amyloid Peptide by ω-Substituted Alkanethiol Monolayers
Supported on Gold,Langmuir 2005, 21(10), 4464-4470.
15. S. Wei, B. Vaidya, A.B. Patel, S.A. Soper, and R.L. McCarley, Photochemically Patterned Poly(methyl
methacrylate) Microanalytical Devices J. Phys. Chem. B. 2005, 109(35), 16988-16996.
16. W. Ong and R.L. McCarley, Redox-driven Shaving of Dendrimers Chem. Comm. 2005, (37), 4699-
4701.
17. S.A. Soper, M. Hashimoto, C. Situma, M.C. Murphy, and R.L. McCarley, Fabrication of DNA
Microarrays onto Polymer Substrates Using UV Modification Protocols with Integration into Microfluidic
Platforms for the Sensing of Low-Abundant DNA Point Mutations,Methods 2005, 37, 103-113.
18. R.P. Hammer, M.A. Etienne, Jed P. Aucoin, and R.L. McCarley, Stoichiometric Inhibition of Amyloid -
Protein Aggregation with Peptides Containing Alternating α,α-Disubstituted Amino Acids, J. Am.
Chem. Soc. 2006, 128, 3522-3523.
19. E.J. Pacsial-Ong, R.L. McCarley, W. Wang, and R.M. Strongin, Electrochemical Detection of
Glutathione Using Redox Indicators,Analytical Chemistry 2006, 78(21), 7577-7581.
W. Ong and R.L. McCarley, Chemically- and Electrochemically-Mediated Release of Dendrimer End
Groups, Macromolecules, 2006, 39(21); 7295-7301.
20. M.A. Witek, S.D. Llopis, A. Wheatley, R.L. McCarley, and S.A. Soper Purification and preconcentration
of genomic DNA from whole cell lysates using photoactivated polycarbonate (PPC) microfluidic chips,
Nucl. Acids Res. 2006, 34(10), e74.
21. S. Balamurugan, A. Obubuafo, S.A. Soper, R.L. McCarley, and D.A. Spivak, Designing Highly Specific
Biosensing Surfaces Using Aptamer Monolayers on Gold, Langmuir 2006; 22(14), 6446-6453.
22. A.D. Morara and R.L. McCarley, TEO-Pyrrole-Terminated Dendrimer Hosts – Synthesis and
Characterization, Org. Lett. 2006, 8(10), 1999-2002.
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23. G.B. Bantchev, P.S. Russo, R.L. McCarley, and R.P. Hammer, A Simple, Multi-angle, Multi-correlator
Depolarized Dynamic Light Scattering Apparatus, Rev. Sci. Inst. 2006, 77(4), 043902/1-043902/6.
24. X. S. Wu, P. W. Adams, Y. Yang, and R. L. McCarley, Interface Spin-Orbit Coupling in a Noncentrosymmetric
Thin-Film Superconductor, Phys. Rev. Lett. 2006, 96(12), 127002/1-127002/4.
25. G. Chen, S. A. Soper, and R. L. McCarley,
Integration of large-area polymer nanopillar arrays into microfluidic devices using in situ polymerization
cast molding, Lab on a Chip 2007, 7(11), 1424-1427.
26. F. Xu, P. Datta, H. Wang, S. Gurung, M. Hashimoto, S. Wei, J. Goettert, R.L. McCarley, and S.A.
Soper, Polymer Microfluidic Chips with Integrated Waveguides for Reading Microarrays, Anal. Chem.
2007, 79(23), 9007-9013.
27. G. Chen, S.A. Soper, and R.L. McCarley, Free-Standing, Erect Ultrahigh-Aspect-Ratio Polymer
Nanopillar and Nanotube Ensembles, Langmuir 2007, 23(23), 11777-11781.
28. G. Chen, R.L. McCarley, C. Situma, S. A. Soper, and J. G. Bolivar, Functional Template-Derived
Poly(methyl methacrylate) Nanopillars for Solid-Phase Biological Reactions, Chem. Mater. 2007,
19(16), 3855-3857.
29. S. Balamurugan, A. Obubuafo, S. A. Soper, R. L. McCarley, and D. A. Spivak
Effect of Linker Structure on Surface Density of Aptamer Monolayers and their Corresponding Protein
Binding Efficiency, Anal. Chem. 2008, 80(24), 9630–9634
30. J.G. Bolivar, S.A. Soper and R.L. McCarley, Nitroavidin as a Ligand for the Surface Capture and
Release of Biotinylated Proteins, Anal. Chem., 2008, 80(23), 9336-9342
31. W. Ong, Y. Yang, A. Cruciano, and R. L. McCarley, Redox-Triggered Release of a Liposomal Payload,
J. Am. Chem. Soc. 2008, 130(44), 14739 – 14744.
32. A. Obubuafo, S. Balamurugan, H. Shadpour, D. Spivak, R. L. McCarley, and S. A. Soper,
Poly(methyl methacrylate) microchip affinity capillary gel electrophoresis of aptamer-protein complexes
for the analysis of thrombin in plasma, Electrophoresis 2008, 29(16), 3436-3445.
33. S. A. Soper, A. A. Adams, P. Okagbare, J. Feng, M. Hupert, D. Patterson, J. Goettert, R. L. McCarley,
M. Murphy, and D. Nikitopoulos, Highly Efficient Circulating Tumor Cell Isolation from Whole Blood
and Label-free Enumeration Using Polymer-Based Microfluidics with an Integrated Conductivity
Sensor, J. Am. Chem. Soc. 2008, 130(27), 8633-8641.
C. Research Support.
Ongoing Research Support
1R21CA135585 (McCarley) 07/01/2009–05/31/2012
National Institutes of Health/National Cancer Institute
Reductase Enzyme-responsive, Self-immolative Nanovehicles
A new family of redox-responsive liposomes that deliver their contents upon application of a reductive
stimulus are being developed and evaluated.
Role: Investigator
CHE-0910845 (McCarley) 07/01/2009–06/30/2012
National Science Foundation
Responsive Molecular Assemblies
The major goals of this project are to explore the physical properties of responsive molecular assemblies
made in the PI’s laboratory using light scattering, NMR, fluorescence spectroscopy, and stopped-flow
spectrometry.
Role: Investigator
EPS-0701491 (Co-PI) PI: Steven Soper 2007-2011
National Science Foundation-EPSCoR
Center for BioModular Microsystems
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This project is a State-wide effort targeting the fabrication of genetic-based analysis systems using
microfabrication methods that lead to modular, polymer-based devices.
Role: Co-Investigator
CTS-0404314 (Co PI) PI: Barry Dellinger 2004-2009
National Science Foundation-Chemical and Transport Systems
NIRT: Combustion-Generated Nanoparticles: The Role of Transition Metals in Nanoparticle and Pollutant
Formation
The project revolves around the synthesis and subsequent characterization of template-synthesized metal
oxide nanoparticles and their role in the production of dioxins and PAH materials.
Role: Co-Investigator
5R01EB006639-02 (Co-PI) PI: Steven Soper 2007–2011
National Institutes of Health/National Human Genome Research Institute
High Throughput Modular Microfluidic Systems for Drug Discovery/Development
This research focuses on developing new highly integrated polymer BioMEMS platforms to achieve
advantages in the screening of libraries of drug candidates using parallelized infrared fluorescence assays.
Role: Co-investigator
Completed Research Support
CHE-0108961 (PI) PI: McCarley 2001-2005
National Science Foundation-Chemistry
Stabilized Molecular Assemblies
The major goals of this project are to synthesize and characterize/evaluate a series of stimuli-responsive
dendrimeric hosts.
Role: Investigator
2R01 HG01499-07 (Co-PI) PI: Steven Soper 2003-2007
National Institutes of Health/National Human Genome Research Institute
Modular Microfluidic System for Automated DNA Sequence Analysis
Efforts on this project are directed at the specific application of microsystem technologies and near-infrared
spectroscopic methods to high-throughput, high-fidelity genetic screening assays.
Role: Co-investigator
EPS-0346411 (Co-PI) PI: Steven Soper 2004-2007
National Science Foundation-EPSCoR
Center for BioModular Microsystems
This project is a State-wide effort targeting the fabrication of genetic-based analysis systems using
microfabrication methods that lead to modular, polymer-based devices.
Role: Co-investigator
R24 CA84625-01 (Co-PI) PI: Steven Soper 2000-2005
National Institutes of Health/National Cancer Institute
The Design and Fabrication of Novel Micro-Instrument Platforms for Performing Genetic-Based Analyses
The thrust of this project is fabrication of miniaturized systems for genetic analysis, with a concentration on
fabrication of devices and their integration into functional systems instead of simple components.
Role: Co-investigator
DBI-0138048 (Co-PI) PI: Steven Soper 2001-2005
National Science Foundation-Biology
Single-Cell Proteomics
Miniaturized analytical instrumentation is being constructed for manipulating and evaluating single cells.
Role: Co-Investigator
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