Hemostatic therapy for treatment of oral anticoagulation-related ICH

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Expansion more common with longer time window • Hematoma expansion in 28% OAC-ICH patients admitted within 24 hours despite treatment Yasaka M, Thromb Haemost. 2003;89:278 –283 • Hematoma expansion up to day 7 Hematoma expansion No anticoagulants 16% On anticoagulants 54% Flibotte JJ, Neurology, 2004;63:1059
Goal: Rapid correction of warfarin induced coagulopathy
Page 1 and 2: Hemostatic therapy for treatment of
Page 3 and 4: The Controversy Should PCC or rFVII
Page 5: Larger size predicts worse outcome
Page 9 and 10: Vitamin K • Takes hours to days t
Page 11 and 12: Transfusion related acute lung inju
Page 13 and 14: Recombinant activated Factor VII
Page 15 and 16: FVIIa normalizes INR but not bleedi
Page 17 and 18: Literature review: PCC for warfarin
Page 19 and 20: FFP vs. PCC in OAC-related ICH •
Page 21 and 22: Survey of practice • Treat a hypo
Page 23: Conclusions • Give vitamin K •

Hemostatic therapy for treatment of oral anticoagulation-related ICH

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