Hemostatic therapy for treatment of oral anticoagulation-related ICH

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Choices<br />

• Vitamin K<br />

• Recombinant activated Factor VII (rFVIIa)<br />

• Fresh Frozen Plasma (FFP)<br />

• Prothrombin Complex Concentrate (PCC)

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Choices • Vitamin K • Recombinant activated Factor VII (rFVIIa) • Fresh Frozen Plasma (FFP) • Prothrombin Complex Concentrate (PCC)

Vitamin K • Takes hours to days to achieve an effective response • Still necessary when using rFVIIa, FFP or PCC • More rapid when given intravenously – Adverse events: 3 per 10,000

Page 1 and 2: Hemostatic therapy for treatment of
Page 3 and 4: The Controversy Should PCC or rFVII
Page 5 and 6: Larger size predicts worse outcome
Page 7: Goal: Rapid correction of warfarin
Page 11 and 12: Transfusion related acute lung inju
Page 13 and 14: Recombinant activated Factor VII
Page 15 and 16: FVIIa normalizes INR but not bleedi
Page 17 and 18: Literature review: PCC for warfarin
Page 19 and 20: FFP vs. PCC in OAC-related ICH •
Page 21 and 22: Survey of practice • Treat a hypo
Page 23: Conclusions • Give vitamin K •

Hemostatic therapy for treatment of oral anticoagulation-related ICH

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