Nutrient Metabolism—Research Communication

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rapidly in the intestine and essentially not recovered in plasma
at 24 h, suggesting an efficient elimination in urine. However,
it must be kept in mind that the dose of phloretin added to the
experimental meals was relatively high (22 mg). It is conceivable
that the bioavailability of phloretin could be modified by
lower doses and especially by consuming apples. It will be
interesting to evaluate the matrix effect of the fruit on phloretin
bioavailability.
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