TECHNICAL (RS)-METHOPRENE

WHO/IS/TC/414/2001 METHOPRENE
TECHNICAL
1.3 Packing and marking of packages
The technical (RS)-methoprene shall be packed in suitable clean containers as
specified in the order.
All packages shall bear, durably and legibly marked on the container the following:
Manufacturer’s name
Technical (RS)-methoprene (920 g/kg)
Batch or reference number and date of test
Net weight of contents
Date of manufacture
and the following minimum cautionary notice:
(RS)-methoprene is an insect growth regulator, a juvenile hormone analogue (juvenoid)
preventing insect metamorphosis to viable adults when applied to larval stages. Not known to
cause adverse effect by ingestion, inhalation and contact of skin but may irritate eyes.
Keep the material out of reach of children and away from foodstuffs and animal feed and their
containers.
First aid measures:
Ingestion: Do not induce vomiting, get medical attention.
Eye contact: Flush with large amounts of water.
Skin contact: Wash with soap and water.
2. Methods of determining chemical and physical properties
2.1 Methoprene content
2.1.1 Outline of method
The determination of the active ingredient content in (RS)-methoprene technical is
carried out by gas chromatography ( GC ), using the total area method.
The constituents are separated by GC on a methyl siloxane capillary column and
detected by flame ionization.
2.1.2 Apparatus
1. Gas-liquid chromatograph. Hewlett Packard 6890 GC with a HP 3398 GC
Chemstation software or equivalent
2. Chromatographic column. Capillary column 30 m long, 0.25 mm internal
diameter, 0.25 µm film thickness, filled with methyl siloxane (Type: HP-1) or
equivalent
Before use, condition a new column by purging with nitrogen overnight at about
280 °C. During this operation the column must not be connected to the detector
to avoid contamination by " initial bleed " of the stationary phase.
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