Gebruik van point-of care systemen bij patiënten met orale ... - KCE

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122 POC Anticoagulation KCE reports 117 9.1.2.2 MSAC 2005 This report is limited to the use of INR point-of-care testing in the general practice setting. Multiple electronic databases were searched: Medline, Embase, Cochrane Controlled Trials Register (now CENTRAL), Current Contents, Science Citation Index, Cochrane Database of Systematic Reviews, Evidence Based Reviews and CRD Database. In addition, other sources of information were consulted. A sensitive search string was used; search date October 2004. Outcomes considered were time in therapeutic range, major bleeding and thromboembolic events. Two studies were included in the report, of which one was a cross-over RCT and the other was a case series. The RCT is listed in table 9.1. 9.1.2.3 NIHR 2007 This report was identified in the search for systematic reviews, but was essentially a HTA report by the Health Technology Assessment Programme of the National Institute for Health Research (UK) 66 . Literature was searched in Medline, Embase, CENTRAL and CINAHL using a sensitive search string. In addition, reference lists were scanned and ongoing or unpublished studies were searched in trial registries. Search date was September 2005. The scope of the report included near patient testing in primary care, patient self-testing and patient self-management. The report included 16 RCTs, listed in table 9.1. 9.1.2.4 Christensen 2007 The databases Cochrane Controlled Trial Register and Medline were searched using a sensitive search string, supplemented by hand searching, reference tracking and personal files. Search date was December 2005. All RCTs including patient ≥ 18 years of age with an expected duration of oral anticoagulant treatment of ≥6 months and comparing POC self-management or self-testing with usual care were included. Outcomes were death, major complications including major thromboembolic events or major bleeding events, and minor complications. Ten studies were included in the systematic review, listed in table 9.1. 9.1.2.5 Heneghan 2006 The following databases were searched: Medline, Embase, CENTRAL, trials registries. In addition, references lists were checked, manufacturers approached and experts consulted. Search date was 2005. Studies were eligible if they were RCTs comparing patient self-testing or self-management to usual care, and reporting the clinical outcomes major bleeding and thromboembolic events. The review included 14 RCTs, listed in table 9.1. 9.1.2.6 Siebenhofer 2004 The authors searched Medline, Embase, the Cochrane Library and the Cochrane Controlled Trials Register, using a sensitive search string. Search date was January 2003. Studies were eligible in case they were randomised controlled trials, compared selfmanagement control versus routine care in oral anticoagulation patients. Outcomes included anticoagulation control, major bleeding, recurrent thromboembolism, all-cause mortality and treatment-related quality of life. Four studies were included, listed in table 9.1.
KCE Reports 117 POC Anticoagulation 123 9.1.2.7 Cochrane systematic review by Garcia-Alamino et al. Based on the information available, 18 studies were included (table 9.1), of which one unpublished (Kaatz). As additional information on the design and data of this unpublished study by Kaatz et al. was not yet available, it was not included in our review. Table 9.1: studies included in previous HTA reports and systematic reviews, and found in KCE update CADTH 2007 MSAC 2005 NIHR 2007 Christensen 2007 Heneghan 2006 Beyth 2000 x x x Siebenhofer 2004 Claes 2005 x Cromheecke 2000 x x x x x Fitzmaurice 2005 x x x Fitzmaurice 2002 x x x Fitzmaurice 2000 x Gadisseur 2003 x x x x Gardiner 2005 x x Gardiner 2006 x Horstkotte 1998 x x x Khan 2004 x x x Koertke 2000 x Koertke 2001 x x x x x Menendez-Jandula 2005 x x x x Sawicki 1999 x x x x x Shiach 2002 x x Sidhu 2001 x x x x Sunderji 2004 x x x x Voller 2005 x x x x Watzke 2000 x White 1989 Christensen 2006 Christensen 2007 Eitz 2008 Jackson 2004 Koertke 2007 Siebenhofer 2007 Siebenhofer 2008 Soliman Hamad 2009 Staresinic 2006 Kaatz (unpublished) x x Cochrane 2009 x x x x x x x x x x x x x x x KCE update 2009 x x x x x x x x x x x x
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