Nickel - The Risk Assessment Information System

Result #
Table 6.1 Mammalian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV)
Nickel
Page 2 of 3
Doses
Ref
Conc/ of
No. Test Organism #
Reference
Reproduction (REP)
59 Kakela et al, 1999 19293 Rat (Rattus norvegicus ) 4 U DR 28 d 3.5-9 mo SM M REP GIDX WO 1.10 3.31 80
60 Pandey and Srivastava, 2000 36722 Mouse (Mus musculus ) 4 U OR 35 d NR mo JV M REP SPCL SM 1.35 2.71 92
61 Pandey and Srivastava, 2000 36722 Mouse (Mus musculus ) 4 U OR 35 d NR NR JV M REP SPCL SM 1.70 3.40 92
62 Phatak and Patwardhan, 1950 14480 Rat (Rattus norvegicus ) 4 U FD 4 mo 4 w GE F REP PRWT WO 9.30 71
63 Chernoff and Kavlock, 1982 1260 Mouse (Mus musculus ) 2 U GV 5 d 60 d GE F REP PROG WO 45.3 86
64 Berman and Rehnberg, 1983 19064 Mouse (Mus musculus ) 3 U DR 15 d NR NR GE F REP PRFM WO 85.3 171 81
65 Seidenberg et al 1986 113 Mouse (Mus musculus ) 2 U GV 4 d NR NR GE F REP PRWT WO 90.6 82
66 Ambrose et al, 1976 14474 Dog (Canis familiaris ) 4 U FD 24 mo 6 mo JV B REP TEWT TE 112 74
67 Ambrose et al, 1976 14474 Rat (Rattus norvegicus ) 4 U FD 118 d 28 d GE F REP PRWT WO 164 327 84
68 Ambrose et al, 1976 14474 Rat (Rattus norvegicus ) 4 U FD 2 yr 28 d JV M REP TEWT TE 205 70
69 Schroeder and Mitchener, 1971 66 Rat (Rattus norvegicus ) 2 U DR 9 mo 21 d GE F REP DEYO WO 0.551 67
70 Pandey and Singh, 1999 19522 Mouse (Mus musculus ) 3 U GV 35 d NR NR JV M REP SPCV SM 0.797 81
71 Smith et al, 1993 62 Rat (Rattus norvegicus ) 4 M DR 23 w 62 d LC F REP DEYO WO 1.33 83
72 Pandey et al, 1999 19521 Mouse (Mus musculus ) 3 U GV 35 d NR NR JV M REP TEWT TE 1.35 86
73 Pandey et al, 1999 19520 Mouse (Mus musculus ) 2 U GV 35 d NR NR AD M REP RSUC WO 1.59 86
74 Obone et al, 1999 19507 Rat (Rattus norvegicus ) 4 U DR 13 w NR NR JV M REP TEWT TE 4.70 74
75 Waltschewa et al, 1972 19792 Rat (Rattus norvegicus ) 2 U GV 120 d 5 mo JV M REP SPCL SM 25.0 86
Growth (GRO)
76 Uthus and Poellot, 1997 19764 Rat (Rattus norvegicus ) 2 U FD 57 d NR NR JV M GRO BDWT WO 0.0844 77
77 Spears et al, 1986 19664 Cattle (Bos taurus ) 2 U FD 140 d 50 d JV M GRO BDWT WO 0.101 78
78 Chatterjee et al, 1979 19098 Rat (Rattus norvegicus ) 2 U FD 21 d NR NR JV M GRO BDWT WO 0.335 81
79 Spears et al, 1984 19671 Rat (Rattus norvegicus ) 3 U FD 49 d 1 d JV NR GRO BDWT WO 1.17 77
80 Smith et al, 1993 62 Rat (Rattus norvegicus ) 4 M DR 15 w 62 d LC F GRO BDWT WO 1.33 6.80 85
81 Szakmary et al, 1995 19729 Rat (Rattus norvegicus ) 2 U GV 8 d NR NR GE F GRO BDWT WO 1.36 84
82 Spears and Hatfield, 1985 19666 Rat (Rattus norvegicus ) 3 U FD 21 d NR NR JV M GRO BDWT WO 1.47 22.0 79
83 O'Dell et al, 1970 14477 Cattle (Bos taurus ) 4 U FD 8 w 14 w JV M GRO BDWT WO 1.64 6.55 82
84 Cikrt et al, 1992 19109 Rat (Rattus norvegicus ) 2 U DR 90 d NR NR JV F GRO BDWT WO 2.97 73
85 Nielsen et al, 1979 19461 Rat (Rattus norvegicus ) 3 U FD 9 w 21 d JV F GRO BDWT WO 4.56 67
86 Nielsen, 1980 19479 Rat (Rattus norvegicus ) 3 U FD 10 w NR NR JV F GRO BDWT WO 4.56 67
87 Schroeder et al, 1974 14484 Rat (Rattus norvegicus ) 2 M DR 1217 d 30 d JV B GRO BDWT WO 5.44 75
88 Gershbein et al 1983 136 Rat (Rattus norvegicus ) 2 U FD 80 d 44 d JV M GRO BDWT WO 5.89 68
89 ODell et al, 1970 14476 Cattle (Bos taurus ) 3 U FD 6 w NR NR LC F GRO BDWT WO 6.75 68
90 O'Dell et al, 1971 14479 Cattle (Bos taurus ) 4 UX FD 8 w 13-21 w JV M GRO BDWT WO 7.00 14.6 92
91 Oosting et al, 1991 19514 Rat (Rattus norvegicus ) 3 M FD 28 d 31 d JV M GRO BDWT WO 7.78 82
92 Ambrose et al, 1976 14474 Rat (Rattus norvegicus ) 4 U FD 6 w 28 d JV B GRO BDWT WO 9.11 91.1 81
93 Phatak and Patwardhan, 1950 14480 Rat (Rattus norvegicus ) 4 U FD 8 w 4 w JV B GRO BDWT WO 9.30 69
94 Whanger, 1973 63 Rat (Rattus norvegicus ) 4 U FD 6 w 35 d JV NR GRO BDWT WO 9.49 47.4 76
95 Kakela et al, 1999 19293 Rat (Rattus norvegicus ) 3 U DR 62 d 3.5-9 mo GE F GRO BDWT WO 11.4 70
96 Obone et al, 1999 19507 Rat (Rattus norvegicus ) 4 U DR 13 w NR NR JV M GRO BDWT WO 11.7 23.4 78
97 Alexander et al, 1978 36694 Meadow vole (Microtus pennsylvanicus ) 3 U FD 45 d 14 d JV NR GRO BDWT WO 12.5 68
98 Nation et al, 1985 19460 Rat (Rattus norvegicus ) 3 U FD 14 d 80 d JV M GRO BDWT WO 20.0 72
99 Alexander et al, 1978 36694 Meadow vole (Microtus pennsylvanicus ) 4 M FD 49 d 14 d JV NR GRO BDWT WO 29.4 309 85
101 Ambrose et al, 1976 14474 Dog (Canis familiaris ) 4 U FD 65 w 6 mo JV B GRO BDWT WO 45.0 112 82
100 Chernoff and Kavlock, 1982 1260 Mouse (Mus musculus ) 2 U GV 5 d 60 d GE F GRO BDWT WO 45.3 82
102 Berman and Rehnberg, 1983 19064 Mouse (Mus musculus ) 3 U DR 15 d NR NR GE F GRO BDWT WO 85.3 171 79
103 Dieter,et al, 1988 61 Mouse (Mus musculus ) 4 UX DR 180 d 6-8 w JV F GRO BDWT WO 107 148 84
104 Spears and Hatfield, 1985 19666 Rat (Rattus norvegicus ) 2 U FD 21 d NR NR JV M GRO BDWT WO 2.81 77
105 Oosting et al, 1991 19514 Rat (Rattus norvegicus ) 2 M FD 28 d 31 d JV M GRO BDWT WO 8.20 82
106 Clary, 1975 19111 Rat (Rattus norvegicus ) 2 U DR 4 mo NR NR JV M GRO BDWT WO 24.7 72
107 Weber and Reid, 1969 14485 Mouse (Mus musculus ) 3 U FD 4 w NR NR JV F GRO BDWT WO 208 73
Eco-SSL for Nickel March 2007
Method of Analyses
Route of Exposure
Exposure Duration
Duration Units
Age
Age Units
Lifestage
Sex
Effect Type
Effect Measure
Response Site
NOAEL Dose*
(mg/kg bw/day)
LOAEL Dose*
(mg/kg bw/day)
Total