Anastasia Detsi

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EDUCATION
CCUURRRRIICCUULLUUMM VVIITTAAEE
Dr ANASTASIA DETSI
11, Aghialou Str., Nea Smyrni, Athens GR-17124, Greece
Laboratory of Organic Chemistry,
School of Chemical Engineering,
National Technical University of Athens,
Heroon Poytechniou 9, Zografou Campus,
Athens GR-15773, Greece
+302107724126
+302107723072
adetsi@chemeng.ntua.gr
1998 Ph. D. Chemistry, Laboratory of Organic Chemistry, Department of Chemical
Engineering, National Technical University of Athens (NTUA), Athens, Greece.
Title of thesis: Development of new methodology for the synthesis of nitrogen
containing heterocyclic compounds, namely 3-substituted-4-hydroxy pyrrolin-
2-ones (tetramic acids) and 3-substituted-4-hydroxy-2-quinolinones.
1990 B. Sc. Chemistry, Chemistry Department, University of Athens, Athens,
Greece.
PROFESSIONAL EXPERIENCE
4/2007
to date Lecturer in Organic Chemistry, School of Chemical Engineering, National
Technical University of Athens, Greece
4/2004-
4/2005 Postdoctoral Research Associate, Institute of Organic and Pharmaceutical
Chemistry, National Hellenic Research Foundation (IOPC-NHRF), Athens,
Greece.
Design and synthesis of novel ether phospholipids possessing antileishmanial
activity.
Development of synthetic methodology for the synthesis of natural products
bearing an α,β-unsaturated ketone functionality.
11/2001-
3/2004 Postdoctoral Fellow, Laboratory of Organic Chemistry, Department of
Chemical Engineering, National Technical University of Athens (NTUA),
Athens, Greece.
Development of a new synthetic methodology for the synthesis of statine
analogues.
7-8/2001 Visiting postdoctoral researcher, Laboratory of Bioorganic Chemistry, Institute
of Molecular Chemistry, Department of Chemistry, University of Amsterdam,
The Netherlands. (STSM COST CHEMISTRY Action D13).
Solid phase synthesis of ether phospholipids.
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4/1998-
7/2001 Postdoctoral Research Associate, Institute of Organic and Pharmaceutical
Chemistry, National Hellenic Research Foundation, Athens, Greece.
Design and synthesis of novel compounds combining antioxidant and
antiarrhythmic activity.
Development of synthetic methodology for the stereoselective synthesis of
4-hydroxytamoxifen.
10/1992-
12/1992 Honorary Research Assistant, The Donnan and Robert Robinson Laboratories,
Department of Chemistry, University of Liverpool, Liverpool, UK.
Investigation of the mechanism of the Payne oxidation of aryl methyl
sulfides by hydrogen peroxide mediated by nitriles.
CURRENT RESEARCH INTERESTS
• Development of novel synthetic methodologies towards organic compounds
• Design and synthesis of bioactive compounds and natural product analogues
• Study of the biological activity of organic compounds
• Spectroscopic techniques for the structural characterization of organic molecules
(NMR, MS, FT-IR, UV-Vis).
PARTICIPATION IN RESEARCH PROGRAMMES
• NTUA Basic Research Committee Programme ‘ΠΕΒΕ 2008’
Title: New bioactive compounds as inhibitors of 5-lipoxygenase (5-LOX): design,
synthesis, characterization and structure-activity relationship studies’
Position: Principal Investigator (NTUA).
• European COST Action CM0801: ‘New drugs for neglected diseases’
Position: member of Working Group 3, ‘Structural Biology and Medicinal Chemistry’.
• Operational Programme "Competitiveness": ‘Coordinated Programme –
HEALTH-BIOMEDICINE, DIAGNOSTIC AND THERAPEUTIC METHODS’,
Activity 4.5.1-Action YB/39.
Title: ‘Therapeutic interventions for the combat of parasitic diseases’
Position: Postdoctoral Researcher (IOPC-NHRF).
• Postdoctoral Programme ‘ΠΕΝΕΔ 99ΕΔ 181’
Title: Development of novel biochemical methods for the evaluation of compounds with
antioxidant activity’.
Position: Postdoctoral Researcher (IOPC-NHRF).
• NTUA Research Programme
Title: ‘Foundation and Operation of Laboratory Unit of the School of Chemical
Engineering’
Position: Scientific Associate
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TEACHING EXPERIENCE
• School of Chemical Engineering, National Technical University of Athens (2007present)
Undergraduate: Organic Chemistry I, Organic Chemistry II, Laboratory of Organic
Chemistry, Instrumental Methods of Analysis (laboratory exercise for NMR spectroscopy).
• Mediterranean Agronomic Institute of Chania (MAICh), Department of Food Quality
and Natural Products, Chania, Crete, Greece (2001-present).
Postgraduate: Organic Chemistry, Laboratory Techniques
• Technological Institute of Athens, Department of Food Technology and Department
of Technological Applications (2002-2007)
Undergraduate: Laboratory of Organic Chemistry
• Hellenic Naval Academy (2000-2006)
Undergraduate: General Chemistry
SCHOLARSHIPS
• Greek State Scholarships’ Foundation (IKY), Scholarship for Postdoctoral Research
(2001-2002).
• European Union, Short Term Scientific Mission, COST Chemistry Action D13 "New
Molecules for Human Health Care" (2001).
• "Leonidas Zervas Foundation", Ph. D. Scholarship (1993-1994).
• Committee of Research, National Technical University of Athens, Ph.D. Scholarship
(1994-1997).
LIST OF PUBLICATIONS
1) Α. Detsi, J.Markopoulos and O.Igglessi-Markopoulou, "Reactions of N-hydroxysuccinimide
esters of N-alkoxycarbonyl-α-aminoacids with active methylene compounds.
Synthesis of 3-substituted tetramic acids", Chem. Comm., 1996, 1323.
2) A. Detsi, V.Bardakos, J.Markopoulos and O.Igglessi-Markopoulou, "Reactions of 2methyl-3,1-benzoxazin-4-one
with active methylene compounds. A new route to 3substituted-4-hydroxy-quinolin-2-ones",
J. Chem. Soc., Perkin Trans. 1, 1996, 2909.
3) V.Delieza, A.Detsi, V.Bardakos and O.Igglessi-Markopoulou, "Reactions of 2-methyl-
4H-pyrido-[2,3-d][3,1]-oxazin-4-one with active methylene compounds. A new efficient
route to 3-substituted-4-hydroxy-1,8-naphthyridin-2-ones", J. Chem. Soc., Perkin Trans.
1, 1997, 1487.
4) Α. Detsi, M.Micha-Screttas and O.Igglessi-Markopoulou, "Synthesis of N-alkoxycarbonyl-3-substituted
tetramic acids and functionalized enols via C-acylation reactions
of active methylene compounds with N-hydroxysuccinimide esters of N-alkoxycarbonylα-aminoacids",
J. Chem. Soc. Perkin Trans. 1, 1998, 2443.
5) Α. Detsi, E. Gavrielatos, M.-A. Adam, O. Igglessi-Markopoulou, J. Markopoulos, M.
Theologitis and M. Papadopoulos, "Synthesis and tautomeric studies of N-urethane
protected γ-amino functionalized butenoates using NMR, X-Ray crystallography and ab
initio calculations", Eur. J. Org. Chem., 2001, 4337.
6) M. Koufaki, T. Calogeropoulou, A. Detsi, A. Roditis, A. P. Kourounakis, P. Papazafiri, K.
Tsiakitzis, C. Gaitanaki, I. Beis and I. Kourounakis, "Novel potent inhibitors of lipid
peroxidation with protective effects against reperfusion arrhythmias", J. Med. Chem.,
2001, 44, 4300.
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7) Α. Detsi, M. Koufaki and T. Calogeropoulou, "Synthesis of (Z)-4-hydroxytamoxifen and
(Z)-2-{4-[1-(p-hydroxyphenyl)-2-phenyl]-1-butenyl} phenoxyacetic acid", J. Org. Chem.,
2002, 67, 4608-4611.
8) Markopoulos J., Detsi A., Gavrielatos E., Athanasellis G. and Igglessi-Markopoulou O.,
"Synthesis of chiral tetramic acids using activated derivatives of N-protected α-amino
acids as precursors. Structural characterization of tetramic acid complexes with metal
ions", Biomedical and Health Research, 2002, 55 (Drug Discovery and Design), p.25-32.
9) Avlonitis N., Lekka E., Detsi A., Koufaki M., Calogeropoulou T., Skoulika E., Siapi E.,
Kyrikou I., Mavromoustakos T., Tsotinis A and Makriyannis A. "Antileishmanial Ring-
Substituted Ether Phospholipids", J. Med. Chem., 2003, 46, 755-767.
10) Calogeropoulou T., Detsi A., Lekka E. and Koufaki M., "Strategies in the design of
prodrugs of anti-HIV agents", Current Topics in Medicinal Chemistry, 2003, 3 (13),
1467-1495.
11) C.-K. Skylaris, A. Detsi, J. Markopoulos, O. Igglessi-Markopoulou "Density functional
and ab initio study of the tautomeric forms of 3-acetyl tetronic and 3-acetyl tetramic
acids", Chem. Phys., 2003, 293 (3), 355-363.
12) G. Athanasellis, A. Detsi, K. Prousis, O. Igglessi-Markopoulou, J. Markopoulos "A novel
access to 2-aminofuranones via cyclisation of functionalized γ-hydroxy-α-butenoates
derived from N-hydroxybenzotriazole esters of α-hydroxy acids" Synthesis, 2003, 13,
2015-2022.
13) Α. Detsi, A. Afantitis, G. Athanasellis, J. Markopoulos, O. Igglessi-Markopoulou and C.-K.
Skylaris "Cyclisation of Novel Amino Oxo Esters to Tetramic Acids- Density Functional
Theory Study of the Reaction Mechanism" Eur. J. Org. Chem., 2003, 4593-4600.
14) Α. Detsi, P. Emirtzoglou, K. Proussis, A. Nikolopoulos, V. Skouridou and Olga Igglessi-
Markopoulou "Solid Phase Synthesis of Substituted 2-Amino-4-Pyrrolinones via
Spontaneous Postcleavage Cyclization" Synlett, 2004, 2, 353-355.
15) G. Athanasellis, G. Melagraki, H. Chatzidakis, A. Afantitis, A. Detsi, O. Igglessi-
Markopoulou, J. Markopoulos "Novel short step synthesis of functionalized γ-Phenyl-βhydroxybutenoates
and their cyclization to 4-hydroxy coumarins via the Nhydroxybenzotriazole
methology", Synthesis, 2004, 11, 1775-1782.
16) L. Zikou, G. Athanasellis, A. Detsi, A. Zografos, C. Mitsos, O. Igglessi-Markopoulou
"Novel Short-step Synthesis of Functionalized 4-Hydroxy-2-Quinolones Using 1-
Hydroxybenzotriazole Methodology" Bull. Chem.Soc.Japan, 2004, 77 , 1505-1508.
17) M. Koufaki, A. Detsi, E. Theodorou, C. Kiziridi, T. Calogeropoulou, A. Vassilopoulos , A.
P. Kourounakis, E. Rekka, P N. Kourounakis, C. Gaitanaki , P. Papazafiri "Synthesis of
Chroman Analogues of Lipoic Acid and Evaluation of their Activity against Reperfusion
Arrhythmias", Βioorg. Med. Chem., 2004, 12, 4835-4841.
18) K. C. Prousis, A. Detsi and O. Igglessi-Markopoulou “A Novel Traceless Solid Phase
Approach to Functionalized Tetramic Acids and 2-Amino-4-pyrrolinones“ Synlett, 2005,
2763-2767.
19) Α. Detsi, V. Roussis, A. Tsotinis, C. Roussakis, T. Calogeropoulou "A concise approach
to benzoic acid derivatives bearing an α,β-unsaturated ketone substituent: synthesis of
methyl taboganate” Synlett, 2005, 20, 3131-3135.
20) S. Kikionis, K. C. Prousis, A. Detsi, Ο. Igglessi-Markopoulou, ‘’A novel synthetic
approach to the thiotetronic ring system, the key intermediate for thiolactomycin
analogues’’ ARKIVOC, 2006, 12, 28-37.
21) Α. Detsi, D. Bouloumbasi, K. C. Prousis, M. Koufaki, G. Athanasellis, G. Melagraki, A.
Afantitis, O. Igglessi-Markopoulou, C. Kontogiorgis, D. J. Hadjipavlou-Litina, ’’Design and
Synthesis of Novel Quinolinone-3-aminoamides and Their α-Lipoic Acid Adducts as
Antioxidant and Anti-inflammatory Agents’’ J. Med. Chem. 2007, 50, 2450-2458.
22) T. Calogeropoulou; P. Angelou; A. Detsi; I. Fragiadaki; E. Scoulica, “Design and
Synthesis of Potent Antileishmanial Cycloalkylidene-Substituted Ether Phospholipid
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Derivatives” J. Med. Chem. 2008, 51, 897-908.
23) G. Melagraki , A. Afantitis , O. Igglessi-Markopoulou, A. Detsi, M. Koufaki, C.
Kontogiorgis, D. Hadjipavlou-Litina,” Synthesis and evaluation of the antioxidant and
anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid
adducts”, Eur. J. Med. Chem. 2009, 44, 3020-3026.
24) M. Koufaki, A. Detsi and C. Kiziridi, “Multifunctional Lipoic Acid Conjugates”, Curr. Med.
Chem. 2009, 16, 4728-4742.
25) A. Detsi, M. Majdalani, C. A. Kontogiorgis, D. Hadjipavlou-Litina, P. Kefalas, ‘Natural
and synthetic 2’-hydroxy-chalcones and aurones: Synthesis, characterization and
evaluation of the antioxidant and soybean lipoxygenase inhibitory activity’, Bioorg. Med.
Chem. 2009, 17, 8073-8085.
26) M. Roussaki, C. A. Kontogiorgis, D. Hadjipavlou-Litina, S. Hamilakis, A. Detsi, “A novel
synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase
inhibitory activity”, Bioorg. Med. Chem. Lett. 2010, 20, 3889–3892
27) S. Moussouni, A. Detsi, M. Majdalani, D. P. Makris, P. Kefalas “Crude peroxidase from
onion solid waste as a tool for organic synthesis. Part I: cyclisation of 2’,3,4,4’,6’pentahydroxy-chalcone
into aureusidin”, Tetrahedron Lett. 2010, 51, 4076–4078.
PRESENTATIONS IN CONFERENCES AND MEETINGS
65 presentations (oral and posters in International and Greek Conferences)
OTHER PROFESSIONAL ACTIVITIES
• Reviewer in the following research journals:
1) Journal of Medicinal Chemistry
2) Tetrahedron Letters
3) Letters in Organic Chemistry
4) Molecules
5) European Journal of Medicinal Chemistry
6) Bioorganic and Medicinal Chemistry
7) Molbank
• Member of the Association of Greek Chemists
• Member of the Organizing Committee of conferences and symposia (3 rd COST
B22 Annual Congress on “Drug Discovery and Development for Parasitic Diseases”,
Athens, Greece 2006; COST CHEMISTRY Action D13 Mid-Term Evaluation Workshop,
Athens, Greece 2001; 10 th -13 th Panhellenic Symposia of Medicinal Chemistry, 6 th 6th
International Conference "Instrumental Methods of Analysis - Modern Trends and
Applications" (IMA2009).
• International Chemistry Olympiads (IChO) for high school students: Head Mentor of
the Greek team at the 38 th IChO (Moscow, Russia, 2007); Scientific Observer at the
36 th IChO (Kiel, Germany, 2004); Mentor at the 35 th IChO (Athens, Greece, 2003)
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