Haluk Akademik Unvanı/Görevi: Prof.Dr. Mesleki ... - Fırat Üniversitesi

Kişisel Bilgiler
Soyadı: Keleştimur
Adı: Haluk
Akademik Unvanı/Görevi: Prof.Dr.
ÖZGEÇMĐŞ
Mesleki ve Profesyonel Anahtar Nitelik ve Becerileri: Laboratuar hayvanları üzerinde deneysel
çalışmalar, radioimmünoassay, hot plate, sterotaksik çalışmalar
Araştırma ilgi Alanı: Nöroendokrinoloji, üreme fizyolojisi, nörohipofiz, iştahın düzenlenmesi,
Uluslar arası Deneyim/Đşbirlikleri:
1987-1988 Londra Üniversitesi (1 yıl)
1990 Londra Üniversitesi (1 ay)
1992 New York Üniversitesi (2 ay)
1997 Londra Üniversitesi (1.5 ay)
2007 Pittsburgh Üniversitesi (2 ay)
Đletişim Bilgileri
Đş adresi:
Hastane Adı: Fırat Üniversitesi, Tıp Fakültesi, Fizyoloji AD
Cadde: -
Şehir: Elazığ
Ülke: Türkiye
Posta Kodu: 23119
Telefon / Faks: Tel: 424 2370000 / 4671 Faks: 424 2379138
E-posta: hkelestimur@firat.edu.tr
Doğum tarihi: 01.01.1959
Doğduğu Yer ve Ülke: Pötürge-Türkiye
Uyruğu: T.C.
Eğitim Gördüğü Ülke: Türkiye
Ana Dili: Türkçe
Bildiği Yabancı Dil: Đngilizce

Akademik Bilgiler
Fakülte/Üniversite (adı ve adresi): Fırat Üniversitesi, Veteriner Fakültesi, Elazığ
Mezuniyet tarihi: 1980
Mezuniyet Sonrası Eğitimi: (Kurumun Adı ve adresi, Mezuniyet Sonrası Eğitim Danışmanları)
Fırat Üniversitesi Sağlık Bilimleri Enstitüsü Fizyoloji Programı
Tez Danışmanları: Prof.Dr. Mehmet KOCABATMAZ
Başlama Bitirme
1980 1984
Tez başlığı:
Kastrasyonun ve testosteron hormonunun akkaraman ırkı erkek kuzularda büyüme performansı, bazı kan
metabolitlerinin düzeyleri ile karkas karekterleri üzerindeki fizyolojik etkileri.
Akreditasyon:
[Akreditasyon Kurumu (Üniversite, Tıbbi Dernek veya Resmi Kurum)]
Akademik Deneyim:
Profesör: Fırat Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı 1996-
Doçent: Fırat Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı 1990-1996
Yrd. Doç: Fırat Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı 1987-1990
Asistan: Fırat Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı 1981-1987
Üyesi Olduğu Meslek Kuruluşları: Türk Fizyolojik Bilimler Derneği, Türk Nöroendokrinoloji
Derneği, International Neuroendocrine Federation, European Biological Rhythms Society
Uluslar arası Yayınlar
1. Forsling ML, Kelestimur H, Windle R., The influence of reproductive status on vasopressin
release in the rat., J Endocrinol., 130(3), 387-93, 1991
2. Forsling ML, Stoughton RP, Zhou Y, Kelestimur H, Demaine C., The role of the pineal in
the control of the daily patterns of neurohypophysial hormone secretion., J Pineal Res.,
14(1), 45-51, 1993
3. Forsling ML, Stoughton R, Kelestimur H, Kostoglou-Athanassiou I, Demaine C., Release of
vasopressin in response to altered plasma volume and sodium concentrations following
pinealectomy in the rat., J Pineal Res., 20(4), 211-6, 1996
4. Kelestimur H, Leach RM, Ward JP, Forsling ML., Vasopressin and oxytocin release during
prolonged environmental hypoxia in the rat., Thorax., 52(1), 84-8, 1997
5. Semercioz A, Kelestimur H, Ustundag B, Baltaci AK, Yekeler H, Sarsilmaz M, Halifeoglu

I., Plasma renin activity and kidney damage in response to acute renal ischaemia and
ramipril treatment in ovariectomised and uninephrectomised rats, MEDICAL SCIENCE
RESEARCH, 25 (8), 533-536, 1997
6. Semercioz A, Ozercan IH, Baltaci AK, Mogulkoc R, Yilmaz B, Kelestimur H., Effectiveness
of hypothermia in preventing testicular injury following testicular torsion and detorsion,
MEDICAL SCIENCE RESEARCH, 26 (5), 327-330, 1998
7. Mogulkoc R, Canpolat L, Baltacı AK, Yilmaz B, Kelestimur H., Histological examination of
various tissues in rats with hypothyroidism induced by propylthiouracil or thyroidectomy.,
MEDICAL SCIENCE RESEARCH, 27 (12), 801-805, 1999
8. Kilic E, Ozdemir YG, Bolay H, Kelestimur H, Dalkara T., Pinealectomy aggravates and
melatonin administration attenuates brain damage in focal ischemia., J Cereb Blood Flow
Metab., 19(5), 511-6, 1999
9. Yilmaz B, Konar V, Kutlu S, Sandal S, Canpolat S, Gezen MR, Kelestimur H., Influence of
chronic morphine exposure on serum LH, FSH, testosterone levels, and body and testicular
weights in the developing male rat., Arch Androl., 43(3), 189-96, 1999
10. Mogulkoc R, Baltaci AK, Yilmaz B, Kelestimur H., Influence of hypovolemic and
hypertonic treatments on plasma vasopressin levels and fluid balance in the
propylthiouracil-induced hypothyroid rat., Neuro Endocrinol Lett., 20(5), 311-314, 1999
11. Yilmaz B, Kutlu S, Mogulkoc R, Canpolat S, Sandal S, Tarakci B, Kelestimur H.,
Melatonin inhibits testosterone secretion by acting at hypothalamo-pituitary-gonadal axis
in the rat., Neuro Endocrinol Lett., 21(4), 301-6, 2000
12. Mogulkoc R, Dogru O, Baltaci K, Yilmaz B, Kelestimur H., Influence of hypovolemic and
hypertonic treatments on plasma vasopressin levels and fluid balance in the thyroidectomyinduced
hypothyroid rats., Neuro Endocrinol Lett., 21(1), 35-38, 2000
13. Kus I, Sarsilmaz M, Ogeturk M, Yilmaz B, Kelestimur H, Oner H., Ultrastructural
interrelationship between the pineal gland and the testis in the male rat., Arch Androl.,
45(2), 119-24, 2000
14. Yilmaz B, Kutlu S, Canpolat S, Sandal S, Ayar A, Mogulkoc R, Kelestimur H., Effects of
paint thinner exposure on serum LH, FSH and testosterone levels and hypothalamic
catecholamine contents in the male rat., Biol Pharm Bull., 24(2), 163-6, 2001
15. Ayar A, Kutlu S, Yilmaz B, Kelestimur H., Melatonin inhibits spontaneous and oxytocininduced
contractions of rat myometrium in vitro., Neuro Endocrinol Lett., 22(3), 199-207,
2001
16. Ayar A, Martin DJ, Ozcan M, Kelestimur H., Melatonin inhibits high voltage activated
calcium currents in cultured rat dorsal root ganglion neurones., Neurosci Lett., 2;313(1-2),
73-7., 2001
17. Canpolat S, Sandal S, Yilmaz B, Yasar A, Kutlu S, Baydas G, Kelestimur H., Effects of
pinealectomy and exogenous melatonin on serum leptin levels in male rat., Eur J
Pharmacol., 28;428(1), 145-8, 2001
18. Baydas G, Gursu F, Canpolat S, Konar V, Yasar A, Canatan H, Kelestimur H., Effects of
pinealectomy on the circadian release pattern of leptin in male rat., Neuro Endocrinol Lett.,
22(6), 449-52, 2001
19. Kus I, Oner H, Ozogul C, Ayar A, Ozen OA, Sarsilmaz M, Kelestimur H., Effects of
estradiol benzoate on the ultrastructure of the pinealocyte in the ovariectomized rat., Neuro
Endocrinol Lett., 23(5-6), 405-10, 2002
20. Ayar A, Kelestimur H., The inhibitory effects of dantrolene on action potential-induced
calcium transients in cultured rat dorsal root ganglion neurons., Physiol Res., 51(4), 341-6,

2002
21. Baydas G, Gursu MF, Cikim G, Canpolat S, Yasar A, Canatan H, Kelestimur H., Effects of
pinealectomy on the levels and the circadian rhythm of plasma homocysteine in rats., J
Pineal Res., 33(3), 151-5, 2002
22. Kutlu S, Canpolat S, Sandal S, Ozcan M, Sarsilmaz M, Kelestimur H., Effects of central
and peripheral administration of leptin on pain threshold in rats and mice., Neuro
Endocrinol Lett., 24(3-4), 193-6, 2003
23. Ayar A, Celik H, Ozcelik O, Kelestimur H., Homocysteine-induced enhancement of
spontaneous contractions of myometrium isolated from pregnant women., Acta Obstet
Gynecol Scand., 82(9), 789-93., 2003
24. Baydas G, Kutlu S, Naziroglu M, Canpolat S, Sandal S, Ozcan M, Kelestimur H.,
Inhibitory effects of melatonin on neural lipid peroxidation induced by
intracerebroventricularly administered homocysteine., J Pineal Res., 34(1), 36-9, 2003
25. Ozcelik O, Kelestimur H., Effects of acute hypoxia on the determination of anaerobic
threshold using the heart rate-work rate relationships during incremental exercise tests.,
Physiol.Res., 53(1), 45-51, 2004
26. Ozcelik O, Aslan M, Ayar A, Kelestimur H., Effects of body mass index on maximal work
production capacity and aerobic fitness during incremental exercise., Physiol Res., 53(2),
165-70, 2004
27. Kutlu S, Yilmaz B, Canpolat S, Sandal S, Ozcan M, Kumru S, Kelestimur H., Mu opioid
modulation of oxytocin secretion in late pregnant and parturient rats. Involvement of
noradrenergic neurotransmission., Neuroendocrinology., 79(4), 197-203, 2004
28. Kus I, Sarsilmaz M, Colakoglu N, Kukne A, Ozen OA, Yilmaz B, Kelestimur H.,
Pinealectomy increases and exogenous melatonin decreases leptin production in rat
anterior pituitary cells: an immunohistochemical study., Physiol Res., 53(4), 403-8, 2004
29. Kus I, Sarsilmaz M, Ozen OA, Turkoglu AO, Pekmez H, Songur A, Kelestimur H., Light
and electron microscopic examination of pineal gland in rats exposed to constant light and
constant darkness., Neuro Endocrinol Lett., 25(1-2), 102-8, 2004
30. Ozcelik O, Celik H, Ayar A, Serhatlioglu S, Kelestimur H., Investigation of the influence of
training status on the relationship between the acute exercise and serum leptin levels in
obese females., Neuro Endocrinol Lett., 25(5), 381-5, 2004
31. Ozcelik O, Kelestimur H., Effects of acute hypoxia on the estimation of lactate threshold
from ventilatory gas exchange indices during an incremental exercise test., Physiol Res., 53
(6), 653-9, 2004
32. Ozcelik O, Ozkan Y, Karatas F, Kelestimur H. Exercise training as an adjunct to orlistat
therapy reduces oxidative stress in obese subjects. Tohoku J Exp Med. Aug;206(4):313-8,
2005.
33. Kus I, Sarsilmaz M, Canpolat S, Yilmaz B, Kelestimur H, Akpolat N, Ozogul C.
Immunohistochemical, histological and ultrastructural evaluation of the effects of leptin on
testes in mice. Arch Androl. ;51(5):395-405, 2005 Sep-Oct.
34. Ozcelik O, Dogan H, Celik H, Ayar A, Serhatlioglu S, Kelestimur H., Effects of different
weight loss protocols on serum leptin levels in obese females., Physiol Res., 54 (3), 271-7,
2005
35. Sandal S, Yilmaz B, Godekmerdan A, Kelestimur H, Carpenter DO. Effects of PCBs 52
and 77 on Th1/Th2 balance in mouse thymocyte cell cultures. Immunopharmacol

Immunotoxicol, 27(4), 601-13, 2005.
36. Ozcelik O, Dogan H, Kelestimur H. Effects of eight weeks of exercise training and orlistat
therapy on body composition and maximal exercise capacity in obese females. Public
Health, 120 (1), 76-82, 2006
37. Canpolat S, Aydın M, Yasar A, Colakoglu N, Yilmaz B, Kelestimur H. Effects of
pinealectomy and exogenous melatonin on immunohistochemical ghrelin staining of
arcuate nucleus and serum ghrelin levels in the rat., Neurosci Lett., 410(2), 132-36., 2006
38. Yilmaz B, Canpolat S, Sandal S, Akpolat N, Kutlu S, Ilhan N, Kelestimur H. Paint thinner
exposure inhibits testosterone synthesis and secretion in a reversible manner in the rat.
Reprod Toxicol., Nov;22(4):791-6. Epub 2006 Aug 18, 2006.
39. Aydin M, Canpolat S, Kuloglu T, Yasar A, Colakoglu N, Kelestimur H. Effects of
pinealectomy and exogenous melatonin on ghrelin and peptide YY in gastrointestinal
system and neuropeptide Y in hypothalamic arcuate nucleus: Immunohistochemical studies
in male rats., Regul Pept. 146(1-3), 197-203, 2008.
Uluslar arası Bilimsel toplantılarda Sunumlar
1. Demaine,C., Forsling,M.L., Keleştimur,H., Stoughton,R.P., Effects of Pinealectomy on
Daily Rhythms of Neurohypophysial Hormone Release in the Rat, Journal of Physiology,
423,12P,1990.
2. Keleştimur,H., Leach,R., Forsling,M.L., Chronic Hypoxia Raises Plasma Arginine
Vasopressin in Rats, Journal of Physiology, 426,90P,1990.
3. Demaine,C., Forsling,M.L., Keleştimur,H., Stoughton,R.P., Effect of Pinealectomy on the
Vasopressin Response to Altered Plasma Volume and Osmolality in the Rat, Journal of
Physiology, 427,19P,1990.
4. Forsling,M.L., Keleştimur,H., Kundi,S., Release of Vasopressin during Suppression of the
Oestrous Cycle in the Rat, Journal of Physiology, 422,59P,1990.
5. Keleştimur,H., Forsling,M.L., Demaine,C., The Effect of Daytime Exercise on Plasma
Neurohypophysial Hormone Concentrations in the Rat, Journal of Endocrinology, 132
(Suppl.), 196,1992.
6. Keleştimur,H., Selçuklu,A., Paşaoğlu,H., Keleştimur,F., Pineal Effects on Sodium
Homeostasis in the Rat, Melatonin and the Pineal Gland from Basic Science to Clinical
Application, Satellite Symposium of the IX th International Congress of
Endocrinology,Paris, France, ABSTRACTS, 144,1992.
7. Forsling,M.L., Demaine,C., Stoughton,R.P., Keleştimur,H., An Investigation of the Daily
Rhythms of Neurohypophysial Hormone Release in the Rat, 9TH International Congress of
Endocrinology,Nice, France, ABSTRACTS, 570,1992.
8. Keleştimur,H., Moğulkoç,R., Baltacı,A.K., Doğru,O., Kılıç,E., Kutlu,S., Sarsılmaz,M. The
effects of thyroidectomy dnd propylthiouracil-induced hypothyroidism on the vasopressin
response to hypovolemic and hypertonic stimuli in the rat. XXXIII. International Congress
of Physiological Sciences, St Petersburg, 1997.
9. Keleştimur H, Moğulkoç R, Baltacı AK, Doğru O, Kılıç E, Kutlu S, Sarsılmaz M, The
effects of thyroidectomy and propylthiouracil induced hypothyroidism on the vasopressin
response to hypovolemic and hypertonic stimuli in the rat, XXXIII Internatıonal Congress

of Physıologıcal Scıences, P058.03, St. Petersburg, RUSSIA, 1997
10. Canpolat L, Moğulkoç R, Baltacı AK, Keleştimur H, Kutlu S, Histological observation on
the various tissue at the hypothyroidism induced by ptu and thyroidectomy in the rat, P3-
173, Sevilla, SPAIN, 1998
11. Sarsılmaz,M., Kus,I., Yılmaz,B., Kukner,A., Kelestimur,H. Effects of melatonin on the
ultrastructure of Leydig cells in the pinealectomised rat. Journal of Reproduction and
Fertility, Abstracts Series, 21, 43-44, July 1998.
12. Kus,I., Sarsılmaz,M., Yılmaz,B., Öner H., Kelestimur,H. Effects of orchidectomy followed
by testosterone propionate administration on ultrastructure of rat pinealocytes. Journal of
Reproduction and Fertility, Abstracts Series, 21, 44, July 1998.
13. Canpolat,L., Moğulkoç,R., Baltacı,A.K., Keleştimur,H., Kutlu,S. Histological observation
on the various tissue at the hypothyroidism induced by PTU and the thyroidectomy in the
rat, Abstracts, IV. European Congress of Endocrinology, Sevilla, Spain, 9-13 May, 1998.
14. Ayar A, Kutlu S, Yilmaz B, Kelestimur H, The inhibitory actions of melatonin on oxytocininduced
contractions in the rat myometrium, British Physiological Society meeting, Journal
of Physiology. 497, 113P, Aberdeen, 2000
15. Yılmaz B., Kutlu S., Canpolat S., Sandal S. and Keleştimur H., Effect of paint thinner
exposure on serum LH, FSH and testosterone levels and hypothalamic noradrenergic
neurotransmission in the male rat., 19th Joint Meeting of the British Endocrine Societies,
with the European Federation of Endocrine societies, J Endocrinol suppl. Vol. 164, P188.,
Birmingham, U.K. 13-16, Mart, 2000.
16. Keleştimur H., Baydaş G., Canpolat S., Gürsu F., Yaşar A and Canatan H., Pinealectomy
increases serum leptin levels but does not change ıts circadian release pattern., 25th
Conference of the International Society for Chronobiology, P79, Antalya, Turkey 9-13,
Ekim, 2001
17. Keleştimur H., Canpolat S., Sandal S., Özcan M., Kutlu S. and Sarsılmaz M., Leptin
administiration may have an effect on pain threshold in mice., 3rd Forum of European
Neuroscience., P286., Paris, France 13-17 July, 2002
18. Colak R. Canpolat S, Ozcelik O, and Kelestimur H., Pinealectomy decreases food intake in
mice, 6th European Congress of Endocrinology, P0476, Lyon, France, Nisan,2003
19. Canpolat S., Sandal S., Kutlu S., Aydın M., Yılmaz B. and Keleştimur H., Effects of
melatonin on catecholaminergic neurotransmitters in brain areas regulating food intake in
the male rat, 23rd Joint Meeting of the British Endocrine Societies., P160, Brighton, UK,
Mart,2004
20. Yılmaz B., Akpolat N., Canpolat S., Sandal S., Kutlu S., Đlhan N. and Keleştimur H., Paint
thinner exposure inhibits testosterone synthesis and secretion in reversible manner in the
rat, 23rd Joint Meeting of the British Endocrine Societies, P182, Brighton, UK, Mart,2004
21. Kus I., Canpolat S., Akpolat N., Ozogul C., Yılmaz B., Sarsılmaz M., and Keleştimur H.,
Ultrastructural and immunohistochemical examination of effects of leptin on testis in mice.,
23rd Joint Meeting of the British Endocrine Societies., P183, Brighton, UK, Mart,2004
22. Keleştimur H., Baydaş G., Yılmaz B., Ayar A., Özçelik O., Kutlu S., Canpolat S., Sandal S.
and Yaşar A., Is there a functional interaction between melatonin and leptin., The 3rd
Regional Congress of ISPNE for Central & Eastern Europe., P.04., Nevşehir, Mayıs,2004

23. Özcan M., Kutlu S., Canpolat S., Sandal S., Aydın M. Keleştimur H., Ghrelin decreases
nociceptive threshold in mice., The 3rd Regional Congress of ISPNE for Central & Eastern
Europe., P.06., Nevşehir, Mayıs,2004
24. Karatepe M., Sandal S., Yılmaz B., Aydın M., Canpolat S., Kutlu S. and Keleştimur H.,
Determination of serum melatonin profiles in healthy male subjects by HPLC-UV method:
Comparison with conventional methods., The 3rd Regional Congress of ISPNE for Central
& Eastern Europe., P.13., Nevşehir, Mayıs,2004
25. Kutlu S., Yılmaz B., Canpolat S., Sandal S., Özcan M., Kumru S. and Keleştimur H., Βendorphin,
oxytocin and steroid hormone profiles in the late pregnant and parturient rats.,
The 3rd Regional Congress of ISPNE for Central & Eastern Europe., P.35., Nevşehir,
Mayıs,2004
26. Kavak B, Simsek M, Ozcan M, Kutlu S, Kumru S, Yilmaz B & Kelestimur H, Nebivolol
inhibits spontaneous and oxytocin induced contractions in the rat uterus, 24th Joint
Meeting of the British Endocrine Societies, P.50, Harrogate, UK, 2005
27. Yilmaz B, Aydin M, Kaya H, Kutlu S, Dorucu M, Cosan H, Kelestimur H, Enviromental
lead contamination and blood lead levels in children and adults in Keban district,
International Conference: Childre’s Enveromental Health in Central Asia, Abstract Book,
P217, Almaty, KAZAKHSTAN, 2005
28. Keleştimur H., Canpolat S, Colakoglu N, Aydin M and Yilmaz B. Pinealectomy abolishes
ghrelin staining in the hypothalamus of male rat: An immunohistochemical study,
Frontiers in Neuroendocrinology, 27, 1, 129P, 2006.
29. Kelestimur H., Sahin Z., Sandal S., Bulmus O., Ozdemir G. and Yilmaz B. Melatoninrelated
alterations in Th1/Th2 polarisation in primary thymocyte cultures of
pinealectomized rats, Frontiers in Neuroendocrinology, 27, 1, 103P, 2006.
30. Aydin M, Yilmaz B, Alcin E, Nedsvetsky VS, Kelestimur H. Effects of letrozole on ncam
expression, spatial learning and memmory and catecholaminergic neurotransmitter levels
in overictomized rats. Meeting of the European Neuroendocrine Association, October 17-
20, 2008 Antalya-Turkey.