is There Any Evidence-based Medicine for the Very Old?

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Drug ACEi Loop diuretics Beta-blockers Aldosterone antagonists ARBs Digoxin Treatment of HF in the Elderly: What Do the Guidelines Say Evidence (+) 0 + (+) + (+) Efficacy + + + + + + Side effects ↑ ↑ ↑ ↑↑ ↑ ↑ Tolerance ↓ ↓ ↓ ↓ ↓ ↓
% 40 30 20 10 Lack of effect of age on the effects on digoxin on outcome: Results from the DIG study HF hospitalizations P=0.0001 Digoxin Placebo 80 Age (years) % 40 30 20 10 HF mortality or HF hospitalizations P=0.0001 80 Age (years) Rich et al. J Am Coll Cardiol 2001; 38:806
Page 1 and 2: Heart Failure 2005 The octogenarian
Page 3 and 4: Mean Age of the Patients with Heart
Page 5 and 6: Factors Distinguishing HF in the El
Page 7 and 8: Baseline Characteristics of Patient
Page 9 and 10: % of patients 35 30 25 20 15 10 5 0
Page 11 and 12: Probability Non-cardiac Comorbidity
Page 13 and 14: Management of HF in the Elderly: Ge
Page 15 and 16: Pharmacological therapy of heart fa
Page 17 and 18: Drug ACEi Loop diuretics Beta-block
Page 19 and 20: Elderly Age is an Independent Predi
Page 21 and 22: Effects of ACE inhibitors on outcom
Page 25 and 26: BRING UP Reasons for Not Commencing
Page 27 and 28: % 100 75 50 25 0 84.3 70- 80 years
Page 29 and 30: % Effect of Bisoprolol on Mortality
Page 31 and 32: Beta-blockers Reduce Mortality also
Page 33 and 34: SENIORS: Baseline Characteristics A
Page 35 and 36: LVEF 35 % > 35 % Age 70-75 y > 75
Page 39 and 40: Drug ACEi Loop diuretics Beta-block
Page 41: 10 5 0 -5 -10 -15 -20 -25 -30 -35 L
Page 45 and 46: Randomised Controlled Trial of Card
Page 47 and 48: Randomized Controlled Trial of Spec
Page 49: Efficacy of Disease Management Prog

is There Any Evidence-based Medicine for the Very Old?

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