Market Capitalization – Big Pharma - Milken Institute

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Up to 6.5 years Up to 6 years Up to 4 years Total Drug Development Time From Laboratory to Patient Function US$, Billions Share Prehuman /Preclinical $11.0 31.9% Phase I $2.3 6.8% Phase ll $3.8 11.1% Phase Ill $8.0 23.3% Approval $4.1 12.0% Phase IV $3.7 10.7% Uncategorized $1.4 4.2% Total R&D $34.5 100%
Years 10 8 6 4 2 0 Total Development Time Drug and Biological Products 1985-1989 1990-1994 1995-1999 Biologicals Drugs 2000-2004
Page 2 and 3: Biopharmaceuticals: The Innovation
Page 4 and 5: Market Capitalization - Big Biotech
Page 6 and 7: Big Pharma vs. Big Biotech Market C
Page 8 and 9: U.S. Biotech Industry Summary Reven
Page 10 and 11: Nasdaq Biotech vs. Nasdaq Composite
Page 12 and 13: Mean Approval Time for New Biologic
Page 14 and 15: New Breast Cancer Drug Helps Women
Page 16 and 17: US$ Billions 35 30 25 20 15 10 5 0
Page 18 and 19: Industry R&D Predominately Higher t
Page 20 and 21: Biotech Deals and Amount Raised 199
Page 22 and 23: Total Alliance Numbers and Deal Val
Page 24 and 25: Alliance Deal Activity Top Transact
Page 26 and 27: US$ Billions 400 300 200 100 0 1994
Page 30 and 31: Biotech Products have Better U.S. A
Page 32 and 33: Clinical and Total Cost Reductions
Page 34 and 35: Years 20 15 10 5 0 Average Effectiv
Page 36 and 37: Generics’ Share of U.S Prescripti
Page 38 and 39: Medicines in Development For Heart
Page 40 and 41: Medicines in Development For Cancer
Page 43 and 44: Roadblocks in Early Stage Translati
Page 45 and 46: Product Roadblocks in Mid- Stage Tr
Page 47 and 48: Market Capitalization Investing in
Page 49 and 50: Year 2001 Private Financings 180 Ov
Page 51 and 52: $ What has Changed Since 2000 Biote
Page 53 and 54: Science Then Now Science all-import
Page 55 and 56: Exits Then Now Exit via IPO Acquisi
Page 57 and 58: New Paradigms 2000 2010 High severi
Page 59 and 60: Amgen IPO Prospectus Alpha Interfer
Page 61 and 62: Between 1900 and 2000, life expecta

Market Capitalization – Big Pharma - Milken Institute

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