Market Capitalization – Big Pharma - Milken Institute

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Funding Then Now Linear funding – Series A, Larger deals Series B, Series C Tranching Fund to next milestone Fund to profitability Big pharma validates Biotech company keeps technology by license more of the upside PSBF
Exits Then Now Exit via IPO Acquisition by other biotech or large pharma Reduce risk while Reduce risk maintaining “home run” potential 5 – 10 year holding periods 3 – 5 year holding periods PSBF
Page 2 and 3:
Biopharmaceuticals: The Innovation
Page 4 and 5: Market Capitalization - Big Biotech
Page 6 and 7: Big Pharma vs. Big Biotech Market C
Page 8 and 9: U.S. Biotech Industry Summary Reven
Page 10 and 11: Nasdaq Biotech vs. Nasdaq Composite
Page 12 and 13: Mean Approval Time for New Biologic
Page 14 and 15: New Breast Cancer Drug Helps Women
Page 16 and 17: US$ Billions 35 30 25 20 15 10 5 0
Page 18 and 19: Industry R&D Predominately Higher t
Page 20 and 21: Biotech Deals and Amount Raised 199
Page 22 and 23: Total Alliance Numbers and Deal Val
Page 24 and 25: Alliance Deal Activity Top Transact
Page 26 and 27: US$ Billions 400 300 200 100 0 1994
Page 28 and 29: Up to 6.5 years Up to 6 years Up to
Page 30 and 31: Biotech Products have Better U.S. A
Page 32 and 33: Clinical and Total Cost Reductions
Page 34 and 35: Years 20 15 10 5 0 Average Effectiv
Page 36 and 37: Generics’ Share of U.S Prescripti
Page 38 and 39: Medicines in Development For Heart
Page 40 and 41: Medicines in Development For Cancer
Page 43 and 44: Roadblocks in Early Stage Translati
Page 45 and 46: Product Roadblocks in Mid- Stage Tr
Page 47 and 48: Market Capitalization Investing in
Page 49 and 50: Year 2001 Private Financings 180 Ov
Page 51 and 52: $ What has Changed Since 2000 Biote
Page 53: Science Then Now Science all-import
Page 57 and 58: New Paradigms 2000 2010 High severi
Page 59 and 60: Amgen IPO Prospectus Alpha Interfer
Page 61 and 62: Between 1900 and 2000, life expecta
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Market Capitalization – Big Pharma - Milken Institute

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