Ilko K. Ilev, Ph.D. - Washington Academy of Sciences
Ilko K. Ilev, Ph.D. - Washington Academy of Sciences
Ilko K. Ilev, Ph.D. - Washington Academy of Sciences
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GRIN<br />
lens<br />
Input fiber<br />
Output fiber<br />
Single Cell/Intracellular Nanoprobing<br />
Input-output fiber<br />
Nano-tip<br />
• Fiber tapered nanoprobes with<br />
subwavelength nanoscale tips (< 100 nm)<br />
• Near-field microscopy combining with<br />
confocal microscopy<br />
• Direct chemical analysis and spectroscopy<br />
<strong>of</strong> single cell components using absorption,<br />
fluorescence and Raman spectroscopy<br />
•Optical stimulation <strong>of</strong> single neurons<br />
• Fiber-optic advantages<br />
– Nano-probe attached/fabricated on a single optical fiber<br />
– Confocal/multi-photon microscope using optical fiber(s)<br />
• Endoscopic advantages<br />
– Easier access to single cells<br />
– One device can be used for imaging, sensing and light delivery
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