Lakshminarayan V. Chinta - Fields Institute - University of Toronto

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The Brain 1μm capillary neuron astrocyte microglia 2% total body weight Consumes 20% O2 and 25% <strong>of</strong> glucose available to the body Neurovascular Coupling: Changes in neuronal activity are tightly coupled to changes in blood flow and oxygenation
Neurovascular coupling Brain Tissue increased neuronal activity Increased glial signaling Increased metabolism demand Mediators Cerebral Vasculature adaptation in flow, volume, and oxygenation <strong>of</strong> the vascular bed NO, GABA, 5HT, NE, DA, Ach, NPY, K+
Page 1: Quantitative Perfusion Estimates fr
Page 5 and 6: The Challenge How do you quantitati
Page 7 and 8: Resolution: ~ 1μm lateral (x, y) ~
Page 9 and 10: 2D bolus time series • Single 2D
Page 11 and 12: Transit time estimation from bolus
Page 13 and 14: Transit time estimation • The sig
Page 15 and 16: • Impulse response of the transfe
Page 17 and 18: Identification of closed paths and
Page 19 and 20: Registration of bolus plane to the
Page 21 and 22: Perfusion estimation - closed paths
Page 23 and 24: The problem in multiple paths • W
Page 25 and 26: TT estimation in individual segment
Page 27 and 28: CBF estimation in individual segmen
Page 29 and 30: Perfusion estimation mL/g/min 3.237
Page 31 and 32: Heterogeneity in perfusion across r
Page 33 and 34: Conclusion • Results show evidenc

Lakshminarayan V. Chinta - Fields Institute - University of Toronto

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