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UNIVERSITY OF NAPLES PhD Program “Human ... - FedOA

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In conclusion, we have underlined as the ontogenesis of gastrointestinal motor activity is<br />

influenced by several factors such as the smooth muscle activity, the CNS, the ENS and the<br />

neurohumoral system.<br />

We have also seen that early enteral feeding occupies a main role in the promotion of development<br />

of small intestinal functions and colonic motility.<br />

Further understanding about the timing of specific motor patterns in humans and their<br />

control mechanisms may allow neonatologists to rich the optimal feeding strategies to induce the<br />

better gastrointestinal function and to obtain the optimal feeding tolerance.<br />

REFERENCES<br />

1) Berseth CL. Assessment in intestinal motility as a guide in the feeding management of the<br />

newborn. Clin in Perinatol 1999; 26 (4): 1007-1015.<br />

2) Kedinger M, Simon-Assman P, Bouziges F et al. Smooth muscle actin expression during rat gut<br />

development and induction in fetal skin fibroblastic cells associated with intestinal embryonic<br />

epithelium. Differentiation 1990; 43:87-97.<br />

3) Milla PJ. Intestinal motility during ontogeny and intestinal pseudo-obstruction in children.<br />

Pediatric Clinics of north America 1996, 43(2) 511-532.<br />

4) Hasler WL. Is constipation caused by a loss of colonic interstitial cells of Cajal?<br />

Gastroenterology 2003; 125 (1): 264-5<br />

5) Hagger R, Gharaie S, Finlayson C and Kumar D. Regional and transmural density of interstitial<br />

cells of Cajal in human colon and rectum. Am J Physiol 1998; 275: G1309-G1316<br />

6) Der-Silaphet T, Malysz J, Hagel S et al . Interstitial cells of Cajal direct normal propulsive<br />

contractile activity in the mouse small intestine. Gastroenterology 1998; 114:724-736<br />

7) Kenny SE, Vanderwiden JM, Rintala RJ et al. Delayed maturation of the interstitial cells of<br />

Cajal: a new diagnosis for transient neonatal pseudoobstruction. Report of two cases. J pediatr<br />

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