UNIVERSITY OF NAPLES PhD Program “Human ... - FedOA

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many invasive batteries of tests - and to assist the researcher in order to use definitions which are as standardized as possible. Our objective was to perform a prospective survey in the general Italian pediatric population during the first two years of life in order to determine the prevalence and natural history of GER, as defined by the Rome II criteria. 48
METHODS In Italy all children from birth to 14 years of age are enrolled in the National Health Service (NHS). NHS pediatricians have under their care approximately 800 children each, who are distributed evenly throughout the country to cover the health needs of the entire Italian pediatric population. Initially seventy-five primary care pediatricians, from north-central and southern Italy, were selected. Those pediatricians were chosen from communities of all sizes, throughout the territory, by random selection of evenly numbered members provided from the membership list of the regional pediatric society. Subsequently, regional coordinators of the study within each territory presented the aim, outline and questionnaires of the study to the selected pediatricians. The survey was conducted by 59 pediatricians who agreed to participate in the study. From April 1 to June 30, 2004, each participating pediatrician was asked to record the number of infants examined per day in their office for acute, chronic care or routine follow-up evaluation, and to complete for each consecutive patient a detailed questionnaire to assess infant regurgitation according to the Rome II Criteria (6) (Table 1). Evidence of metabolic, gastrointestinal or central nervous system diseases, chronic debilitating diseases, neurological abnormalities, previous surgery of the gastrointestinal tract, use of acidsuppressive therapy (H2- antagonists, proton pump inhibitors) were considered exclusion criteria. In addition, infants with hematemesis, anemia, aspiration, apnea, failure to thrive, abnormal posturing and feeding or swallowing difficulties, were excluded from the study. Each child with a diagnosis of infant regurgitation according to the Rome II criteria was then reexamined by the same pediatrician with an interval of 2 months, until the age of 24 months, to determine whether there had been a resolution/worsening of symptoms or a change in the diagnosis (i.e. GERD, cow milk protein intolerance). After the diagnosis, additional investigation and treatment were left to the discretion of the primary care pediatrician. However, meetings were held 49
Page 1 and 2: “FEDERICO II” UNIVERSITY OF NAP
Page 3 and 4: -Boccia G, Manguso F, Miele E, Buon
Page 5 and 6: gastrointestinal tract are mediated
Page 7: trial has examined the relation amo
Page 11 and 12: Hernell O, Schmitz J (eds): Feeding
Page 13 and 14: Development of myogenic control The
Page 15 and 16: Extrinsic neural regulation refers
Page 17 and 18: gestation (17). Between 28 and 38 w
Page 19 and 20: since cluster rapresents 60-75% of
Page 21 and 22: in humans used amniography; aboral
Page 23 and 24: Surg 1998; 33:94-98 8) Sabri M, Bar
Page 43 and 44: CHAPTER 2 EPIDEMIOLOGY AND PHATOPHY
Page 45 and 46: ACKNOWLEDGMENTS : The authors would
Page 47: INTRODUCTION Gastroesophageal reflu
Page 51 and 52: RESULTS Fifty-nine out of 75 random
Page 53 and 54: DISCUSSION Regurgitation in infants
Page 55 and 56: eported to induce lower esophageal
Page 57 and 58: References 1) Nelson SP, Chen EH, S
Page 59 and 60: FIGURE LEGENDS Fig. 1: I-GERQ score
Page 61 and 62: Tab. 2 - Risk factors for GERD Risk
Page 63 and 64: I-GERQ Score Fig.2 16 14 12 10 8 6
Page 71 and 72: Dyspeptic symptoms in children: the
Page 73 and 74: INTRODUCTION Dyspeptic symptoms inc
Page 75 and 76: Dyspeptic symptoms and bowel habit
Page 77 and 78: RESULTS Eighty of 99 consecutively
Page 79 and 80: DISCUSSION Studies in children and
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Page 83 and 84: 8. Youle MS, Read NW. Effect of pai
Page 85 and 86: 29. Riezzo G, Chiloiro M, Guerra V,
Page 87 and 88: Table 1. Rome II functional dyspeps
Page 89 and 90: Table 3. Frequency of reported dysp
Page 91 and 92: Figure 2 91
Page 93: CHAPTER 3 DIAGNOSIS AND TREATMENT O
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ABSTRACT Objectives: To evaluate in
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elated to acid in children with chr
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A drop in pH below 4.0 lasting at l
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DISCUSSION Chronic unexplained coug
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andom symptom-reflux association. T
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REFERENCES 1. Morice AH. Epidemiolo
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21. Goldani HA, Silveira TR, Rocha
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Table 1 . Model of the contingency
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Table 3. Distribution of the 3 symp
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CONCLUSIONS WHAT THESE STUDIES ADD
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the appearance of peristalsis using
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REFERENCES 1) Jones MP, Dilley JB,
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31) Tache Y, Martinez V, Million M,
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UNIVERSITY OF NAPLES PhD Program “Human ... - FedOA

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