Verslag – Rapport – Bericht – Report - GSKE - FMRE

– Willenborg, S., Lucas, T., van Loo, G., Knipper, J., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A.,
Ferrara, N., Pasparakis, M. and Eming, S.A. (2012) CCR2 recruits an inflammatory macrophage subpopulation critical for
angiogenesis in tissue repair. Blood, 120(3), 613-25.
– Wolf, M.J., Hoos, A., Bauer, J., Boettcher, S., Knust, M., Weber, A., Simonavicius, N., Schneider, C., Lang, M., Moch,
Stürzl, M., Croner, R.S., Konrad, A., Manz, M.G., Moch, H., Aguzzi, A., van Loo, G., Pasparakis, M., Prinz, M., Borsig, L.
and Heikenwalder, M. (2012) Endothelial CCR2 signaling induced by colon carcinoma cells licenses extravasation via the
JAK2-Stat5 and p38MAPK pathway. Cancer Cell, 22, 91-105.
– Maelfait, J., Roose, K., Bogaert, P., Sze, M., Saelens, X., Pasparakis, M., Carpentier, I., van Loo, G.* and Beyaert, R.*
(2012) A20 (Tnfaip3) deficiency in myeloid cells protects against Influenza A virus infection. Plos. Pathog., 8 (3), e1002570.
(*equally contributed)
– Mc Guire, C., Beyaert, R. and van Loo, G. (2011) Death receptor signalling in central nervous system inflammation and
demyelination. Trends Neurosci., 34 (12), 619-628.
– Bonnet, M.C., Preukschat, D., Welz, P.S., van Loo, G., Ermolaeva, M.A., Bloch, W., Haase, H. and Pasparakis, M. (2011)
FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity, 35, 572-582.
– Welz, P.S., Wullaert, A., Vlantis, K., Kondylis, E., Fernandez-Majada, V., Ermolaeva, M., Kirsch, P., Sterner-Kock, A., van
Loo, G. and Pasparakis, M. (2011) FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.
Nature, 477, 330-334.
– Matmati, M., Jacques, P., Maelfait, J., Sze, M., Verheugen, E., Kool, M., Geboes, L., Mc Guire, C., Vereecke, L., Chu, Y.,
Staelens, S., Matthys, P., Lambrecht, B., Schmidt-Supprian, M., Pasparakis, M., Elewaut, D., Beyaert, R. and van Loo, G.
(2011) A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat. Genet.,
43 (9), 908-912.
– Vereecke, L., Beyaert, R. and van Loo, G. (2011) Genetic relationships between A20/TNFAIP3, chronic inflammation and
autoimmune disease. Biochem. Soc. Trans., 39 (4), 1086-1091.
– Kool, M., van Loo, G., Waelput, W., De Prijck, S., Muskens, F., Sze, M., van Praet, J., Branco-Madeira, F., Janssens, S.,
Reizis, B., Elewaut, D., Beyaert, R., Hammad, H. and Lambrecht, B.N. (2011) The ubiquitin-editing protein A20 prevents
dendritic cell activation, recognition of apoptotic cells and systemic autoimmunity. Immunity, 35 (1), 82-96.
– Vereecke, L., Beyaert, R. and van Loo, G. (2011) Enterocyte cell death and intestinal barrier maintenance in homeostasis
and disease. Trends Mol. Med., 17, 584-593.
– van Loo, G and Beyaert, R. (2011) Negative regulation of NF-kB and its involvement in rheumatoid arthritis. Arthritis Res.
& Ther., 13 (3), 221-231.
– Lippens, S., Lefebvre, S., Gilbert, B., Sze, M., Devos, M., Verhelst, K., Vereecke, L., Mc Guire, C., Guérin, C., Vandenabeele,
P., Pasparakis, M., Mikkola, M.L., Beyaert, R., Declercq, W. and van Loo G. (2011) The NF-kB regulatory protein A20
(TNFAIP3) controls epidermal homeostasis. Cell Death Differ., 18, 1845-1853.
– Chu, Y., J. Vahl, C., Kumar, D., Heger, K., Bertossi, A., Wójtowicz, E., Soberon, V., Schenten, D., Mack, B., Reutelshöfer,
M., Beyaert, R., Amann, K., van Loo, G. and Schmidt-Supprian, M. (2011) B cells lacking the tumor suppressor TNFAIP3/
A20 display impaired differentiation, hyperactivation and cause inflammation and autoimmunity in aged mice. Blood, 117
(7), 2227-2236..
– Raasch, J. * , Zeller, N*., van Loo, G. * , Merkler , D*., Mildner, A., Erny, D., Knobeloch, K.P., Bethea, J.R., Waisman, A., Knust,
M., Del Turco, D., Deller, T., Blank, T., Priller, J., Brück, W., Pasparakis, M. and Prinz, M. (2011) IkB kinase 2 determines
oligodendrocyte loss by non cell-autonomous activation of NF-kB in the CNS. Brain, 134 (4), 1184-1198. ( * equally contributed)
– Mc Guire, C., Volckaert, T., Sze, M., De Rycke, R., Waisman, A., Prinz, M., Beyaert, R., Pasparakis, M. and van Loo, G.
(2010) Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination. J. Immunol.,
185, 7646-7653.
– Verstrepen, L., Verhelst, K., van Loo, G., Carpentier, I., Ley S.C. and Beyaert, R. (2010) Expression, biological activities and
mechanisms of action of A20 (TNFAIP3). Biochem. Pharmacol., 80, 2009-2020.
– Vereecke, L., Sze, M., Mc Guire, C., Rogiers, B., Chu, Y., Schmidt-Supprian, M., Pasparakis, M., Beyaert, R. and van Loo,
G. (2010). Enterocyte specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis.
J. Exp. Med., 207 (7), 1513-1523.
– van Loo, G., Sze, M., Praet, J., McGuire, C., Bougarne, N., Ullrich, A., Haegeman, G., Prinz, M., Beyaert, R. and De
Bosscher, K. (2010). Anti-inflammatory properties of a plant-derived, nonsteroidal, dissociated glucocorticoid receptor
(GR) modulator in experimental autoimmune encephalomyelitis. Mol. Endocrinol., 24, 310-322.
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Verslag – Rapport – Report 2012