Geneeskundige Stichting Koningin Elisabeth ... - GSKE - FMRE

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134 developing hair cell (i.e. Jagged-2) showed that Hensen’s cells expressed this early marker when supernumerary hair cell production occurs. These results demonstrate that Hensen’s cells retain the capacity to differentiate either into tectal cells which themselves differentiate into HCs or into undertectal cells which are able to differentiate into Deiters’cells. Reference •Lee HR, Chang TH, Tebalt MJ, III, Senderowicz AM, Szabo E (1999) Induction of differentiation accompanies inhibition of Cdk2 in a non- small cell lung cancer cell line. Int J Oncol 15: 161-166.
Functional significance of neuroreceptors on neural stem cells Nguyen, L., Rocher, V., Belachew, S., Malgrange, B., Rogister, B., Moonen, G. and Rigo, J.M. Centre de Neurobiologie Cellulaire et Moléculaire, Université de Liège, Belgique During brain ontogenesis, the temporal and spatial generation of the different types of neuronal and glial cells from precursors occurs as a sequence of successive progenitor stages whose proliferation, survival and cell-fate choice are controlled by environmental and cellular regulatory molecules. Neurotransmitters belong to the chemical microenvironnement of neural cells, even at the earliest stages of brain development. It is now established that specific neurotransmitter receptors are present on progenitor cells of the developing central nervous system (CNS) and could play, during neural development, a role that has remained unsuspected until recently (for a review, see publication of Nguyen et al., 2000). In a recent study using immunocytochemistry and RT-PCR, which will be presented for publication in NeuroReport, we show that glycine ionotropic receptors (GlyRs) are expressed by postnatal rat striatum-derived nestin positive cells within neurospheres. By means of whole-cell patchclamp technique, we have moreover recorded strychnine-sensitive reversible inward currents triggered by glycine in these cells. Our results support therefore the functional expression of GlyRs in neurospheres by nestin positive neural progenitors likely including neural stem cells (NSCs). Furthermore, we have observed that NSCs also show modifications of their membrane conductance in response to the application of other transmitters (GABA, glutamate, acetylcholine and serotonin). In parallel, we have developed a new culture assay allowing both fast isolation and expansion of rat striatal multipotent progenitors that express PSA-NCAM, a marker which is a hallmark of cells close to NSCs but likely committed to the glial lineage. This defined model of an almost pure cell population will help us to better address the effects of neurotransmitters on neural progenitors proliferation, differentiation and migration capacities. Astroglial control of neuronal excitability and survival Rigo, J.M. 1 , Belachew, S. 1 , Hans, G., Malgrange, B. 1 , Rocher, V. 1 , Leprince, P. 1 , Kirchoff, F. 2 , Rogister, B. 1 and Moonen, G. 1 1 Centre de Neurobiologie Cellulaire et Moléculaire, Université de Liège, Belgique 2 Max Planck Institute for Experimental Medicine, Göttingen, Allemagne As a reminder, the INItoxins are inhibitors of inhibitory neurotransmission (such as NAF or β-carbolines) that are also neurotoxic (NAF is a neurotoxic astroglia-derived factor that also behaves as a negative allosteric modulator of ligand-gated chloride channels). Interactions of the INItoxins with ligand-gated chloride channels (the GABAAR and the GlyR) In a previous report, we showed that ∃β-carbolines (βCs), besides their well established negative allosteric modulation of GABA AR-mediated responses, also act on strychnine-sensitive 135
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Geneeskundige Stichting Koningin El
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Fondation Médicale Reine Elisabeth
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L’abondance et la qualité des pu
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Prof. Dr. A. Bossuyt Secrétaire du
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Prof. Dr. G. Orban Lab. voor Neuro-
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Reports of the University Research
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14 Members of the team: Christophe
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16 domains, most notably that of N-
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Report of the Research Group of Pro
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Part 1: Characterisation of noradre
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Part 2 : Chromogranins as neuro-imm
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Publications 2000 : • J. Depreite
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28 Collaborations with: A. Volny-Lu
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30 MATERIALS AND METHODS Surgery an
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32 RESULTS Recordings were obtained
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34 Responses to brush stimuli The s
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36 DISCUSSION This experimental stu
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PART 1: Molecular Pharmacology of A
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c) Most insurmountable AT 1 recepto
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dy tested biphenyl-tetrazole derive
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ii) More distant functional respons
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References •Aiyar N, Baker E, Vic
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•Olins GM, Chen ST, McMahon EG, P
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PART 2: The use of Endothelin 1 in
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vasoconstriction, peaked 20 minutes
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ACCEPTED • Vanderheyden P.M.L., F
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60 Prof. Dr. Christophe Erneux I.R.
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62 tion forming Ins(1,3,4,5)P 4 and
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64 Bibliography •Berridge, M.J. a
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68 University of Mons-Hainaut Labor
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70 Works carried out in 2000 1. We
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Genetic definition of brain tumours
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Analysing this way these 48 tumours
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Page 83 and 84: Genetic determinants of mouse brain
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Page 89 and 90: Report of the Research Group of Pro
Page 91 and 92: In vitro studies of the hypothalami
Page 93 and 94: vitro GnRH release by intact male g
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Page 101 and 102: Elucidation of the DAT primary sequ
Page 103 and 104: The role of presenilin-1 in the gam
Page 107 and 108: INTRODUCTION As usual, this activit
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Page 111 and 112: not lead to the integrative process
Page 113 and 114: REFERENCES Thesis •Steven Laureys
Page 115 and 116: • Positron emission tomography in
Page 117 and 118: Before scanning, subjects practised
Page 119 and 120: RESEARCH PROGRAM ON MEMORY FUNCTION
Page 121 and 122: Corticobasal degeneration, motor sl
Page 123 and 124: Figure 2. Brain Areas Disclosed Dur
Page 125 and 126: • Cognitive Neuropsychological an
Page 129 and 130: Neuregulin signaling regulates neur
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Page 133: Cell biology for prevention and tre
Page 137 and 138: Spinal Cord Traumatic Lesion Martin
Page 139 and 140: A.Schulman, and T.R.Van De Water, B
Page 141 and 142: •Identification of PSF, the PTB-a
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Page 147 and 148: Brain activations in a dot pattern
Page 149 and 150: References •R Vogels, G Sary, P D
Page 153 and 154: A Scientific activities 1. Overview
Page 155 and 156: 4. Purinergic receptors. Purinergic
Page 157 and 158: mals also scored higher in anxiety
Page 159 and 160: cell clones have been used in these
Page 161 and 162: •Ledent C, Valverde O, Cossu G, P
Page 163 and 164: • Snell BJ, Short JL, Drago J, Le
Page 167 and 168: I. Physiology and physiopathology o
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Page 171 and 172: Natl. Acad. Sci. USA, 96: 5257-5262
Page 173 and 174: in those who did not. In rats sacri
Page 175 and 176: (Poster). Abstract of the 4th EURON
Page 179 and 180: Positional cloning of the neuronal
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I. FMRI in Awake Behaving Macaques
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gressively higher levels of the cor
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MION was injected into the femoral
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Future Possibilities Future contras
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FIGURES Figure 1: FMRI responses in
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Figure 5: Average percent signal ch
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FUNCTIONAL MAGNETIC RESONANCE IMAGI
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explain these search processes. Par
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205
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Investigation of the molecular mech
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tral) cortex compared to non-depriv
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By comparing the percentual increas
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altered amino acid residue is equal
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BIBLIOGRAPHY - 2000 Publications in
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Soc. Neurosci. Abstr., 2000, vol. 2
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1. Coding of 3D-shape in macaque in
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3. Position sensitivity of macaque
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Publications: •JANSSEN P., VOGELS
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Geneeskundige Stichting Koningin Elisabeth ... - GSKE - FMRE

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