Geneeskundige Stichting Koningin Elisabeth ... - GSKE - FMRE
Geneeskundige Stichting Koningin Elisabeth ... - GSKE - FMRE
Geneeskundige Stichting Koningin Elisabeth ... - GSKE - FMRE
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78<br />
Using 178 tumours of this series for LOH analysis with Weber 8 and 9 set of markers, labelled<br />
radioactively or with fluorescence (LICOR DNA analyser), we have so far analysed chromosome<br />
22, as well as parts of two other chromosomes. Over 20 tumours showed large regions<br />
of homozygosity for chromosome 22 (Rousseau et al., unpublished). Numerous tumours showed<br />
LOH for the two other studied chromosomes (Rousseau et al., unpublished). Our ongoing efforts<br />
are aimed at identifying the smallest overlapping deleted regions using additional markers. This<br />
will allow the identification of the probable tumour suppresser gene(s) and to associate these<br />
deletions to the clinical characteristics.<br />
References:<br />
• Reifenberger et al. Molecular genetic analysis of oligodendroglial tumors shows preferential<br />
allelic deletions on 19q and 1p.Am J Pathol :145:1175-1190<br />
• Cairncross et al. Specific genetic predictors of chemotherapeutic response and survival in<br />
patients with anaplastic oligodendrogliomas. J Nat cancer Inst 90:1473-1479<br />
•P. Kleiheues & W.K. Cavenee. Pathology & Genetics. Tumours of the Nervous System IARC<br />
Press 2000.<br />
•C. Godfraind et al. 1p/19q deleted oligodendroglioma is a distinct histological tumour. In<br />
preparation.
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