Quantitative Methods in Renography - Nucleus

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More Practical Considerations • Correct start time • Problems if kidney activity appears later than heart • Need good statistics • Use higher administered activity • Must smooth curves But not too much • Identify plateau of retention function • Difficult if curves are too noisy • Height is used to measure relative function • Extrapolate to remove vascular background • Produce background subtracted renogram • By reconvolving subtracted retention function with blood input curve Richard Lawson Central Manchester Nuclear Medicine Centre
Summary - Deconvolution Deconvolution gives the renogram that would be obtained if an idealised bolus injection could be given straight into the renal artery with no recirculation Impulse Retention Function Uptake transit Vascular Background Mean Transit Time Eliminat ion Richard Lawson Time Central Manchester Nuclear Medicine Centre
Page 1 and 2:
Radionuclides in Nephrourology, Mik
Page 3 and 4:
Renography • Renography is a dyna
Page 5 and 6:
Background Subtraction
Page 7 and 8: Renogram Model Extravascular Tissue
Page 9 and 10: Background Subtraction Kidney ROI c
Page 11 and 12: Recognising Correct Subtraction Cur
Page 13 and 14: Recognising Correct Subtraction 0 1
Page 15 and 16: Three Phases of the Renogram Phase
Page 17 and 18: Background Subtraction Examples
Page 19 and 20: Example 1 - Background below kidney
Page 21 and 22: Example 1 - Rutland method L R Rela
Page 23 and 24: Example 2 • 50MBq 99m Tc MAG3 •
Page 25 and 26: Example 2 - Peri-renal background L
Page 27 and 28: Teaching Point • If using MAG3 an
Page 29 and 30: Example 3 - Background below kidney
Page 31 and 32: Example 3 - Rutland method L R Righ
Page 33 and 34: The Rutland Method
Page 35 and 36: Constant Infusion Model Extravascul
Page 37 and 38: Rutland Practice • Draw regions o
Page 39 and 40: Rutland Practice (continued) • Ca
Page 41 and 42: Deconvolution
Page 43 and 44: Mean Transit Time Impulse Retention
Page 45 and 46: But what about the real renogram ?
Page 47 and 48: Deconvolution 100 70 50 100 50 100
Page 49 and 50: Deconvolution Bolus R 4 R 3 I(t) R
Page 51 and 52: How to do it R ( t) = I( t) * H ( t
Page 53 and 54: Effect of Vascular Background Befor
Page 55 and 56: Renogram Example - Raw Curves Activ
Page 57: Practical Considerations • System
Page 61 and 62: Renogram Components Uptake Eliminat
Page 63 and 64: Quantifying Absolute Function • A
Page 65 and 66: We have looked at two Methods • T
Page 67 and 68: Summary Real renogram Blood Activit
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Quantitative Methods in Renography - Nucleus

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