Quantitative Methods in Renography - Nucleus

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Quantifying Elimination Integrate blood input and fit to uptake phase (Rutland plot) Extrapolate to later times = Zero output curve Activity Uptake phase Difference between zero output and Renogram = Urine output Urine Output / Zero Output = Renal Output Efficiency * Renogram Blood (input) * Chaiwatanarat et. al. J.Nucl.Med. 1993, 34: 845-848 Time Richard Lawson Central Manchester Nuclear Medicine Centre
We have looked at two Methods • The problem • Variable input function Complex curve shape & superimposed background • The solution • Standardise input function Simpler curve shape with separable background • Delta function input • Perfect bolus injection Impossible in practice Bolus spreading and recirculation Calculate using: Deconvolution • Constant input • Continuous infusion Possible but complicated Rutland plot Richard Lawson Central Manchester Nuclear Medicine Centre
Page 1 and 2:
Radionuclides in Nephrourology, Mik
Page 3 and 4:
Renography • Renography is a dyna
Page 5 and 6:
Background Subtraction
Page 7 and 8:
Renogram Model Extravascular Tissue
Page 9 and 10:
Background Subtraction Kidney ROI c
Page 11 and 12:
Recognising Correct Subtraction Cur
Page 13 and 14: Recognising Correct Subtraction 0 1
Page 15 and 16: Three Phases of the Renogram Phase
Page 17 and 18: Background Subtraction Examples
Page 19 and 20: Example 1 - Background below kidney
Page 21 and 22: Example 1 - Rutland method L R Rela
Page 23 and 24: Example 2 • 50MBq 99m Tc MAG3 •
Page 25 and 26: Example 2 - Peri-renal background L
Page 27 and 28: Teaching Point • If using MAG3 an
Page 29 and 30: Example 3 - Background below kidney
Page 31 and 32: Example 3 - Rutland method L R Righ
Page 33 and 34: The Rutland Method
Page 35 and 36: Constant Infusion Model Extravascul
Page 37 and 38: Rutland Practice • Draw regions o
Page 39 and 40: Rutland Practice (continued) • Ca
Page 41 and 42: Deconvolution
Page 43 and 44: Mean Transit Time Impulse Retention
Page 45 and 46: But what about the real renogram ?
Page 47 and 48: Deconvolution 100 70 50 100 50 100
Page 49 and 50: Deconvolution Bolus R 4 R 3 I(t) R
Page 51 and 52: How to do it R ( t) = I( t) * H ( t
Page 53 and 54: Effect of Vascular Background Befor
Page 55 and 56: Renogram Example - Raw Curves Activ
Page 57 and 58: Practical Considerations • System
Page 59 and 60: Summary - Deconvolution Deconvoluti
Page 61 and 62: Renogram Components Uptake Eliminat
Page 63: Quantifying Absolute Function • A
Page 67 and 68: Summary Real renogram Blood Activit
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Quantitative Methods in Renography - Nucleus

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