Managing Long-Term Issues – Post Lung Transplant
Managing Long-Term Issues – Post Lung Transplant
Managing Long-Term Issues – Post Lung Transplant
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<strong>Lung</strong> <strong>Transplant</strong>ation<br />
“In it for the <strong>Long</strong> Haul:<br />
<strong>Long</strong>-<strong>Term</strong> Management”<br />
<strong>Lung</strong> <strong>Transplant</strong>ation<br />
“In it for the <strong>Long</strong> Haul:<br />
<strong>Long</strong>-<strong>Term</strong> Management”<br />
•50% Five Year Survival<br />
<strong>–</strong>15 - 20 years without improvement in five year survival<br />
<strong>–</strong>Risks to Improvement of <strong>Long</strong> <strong>Term</strong> Survival<br />
RISK TO LONG TERM OUTCOME<br />
Immunosuppression rather than understanding of mechanisms<br />
Bronchiolitis Obliterans - Chronic Rejection<br />
Challenges of newer categories of recipients<br />
<strong>Lung</strong> <strong>Transplant</strong>ation<br />
“In it for the <strong>Long</strong> Haul:<br />
<strong>Long</strong>-<strong>Term</strong> Management”<br />
BRONCHIOLITIS OBLITERANS<br />
PROGRESSION OF SCAR<br />
Outline<br />
•Bronchiolitis Obliterans Syndrome (BOS)<br />
-Mortality & Morbidity<br />
- Mechanism - Immune and non-immune<br />
- Interventions<br />
<strong>–</strong>Complications <strong>Post</strong>-transplantation<br />
-Immunosuppression and morbidity<br />
i.e. Infection, cancer<br />
•New categories of recipients<br />
future management challenges<br />
What used to be the size of<br />
the dotted line has been<br />
scarred down to the central<br />
dark lumen<br />
2
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