guide to gentamicin: convetional multiple daily dosing (adults) - ICID
guide to gentamicin: convetional multiple daily dosing (adults) - ICID
guide to gentamicin: convetional multiple daily dosing (adults) - ICID
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Level Interpretation Advice: High Dose 5mg/kg Gentamicin (Adults)<br />
Prescribed 36 hourly<br />
Reported<br />
Trough level<br />
2 <strong>to</strong> 3mg/L<br />
1 <strong>to</strong> 2mg/L<br />
Continue current<br />
36 hourly dosage<br />
interval<br />
Ensure treatment s appropriate<br />
Check: indication<br />
Age, weight<br />
Serum creatinine<br />
Consider:<br />
patients’ clinical condition<br />
& renal function<br />
Trough<br />
1 <strong>to</strong> 1.2 mg/L<br />
Level<br />
>1.2 <strong>to</strong> 2mg/L<br />
If renal function is<br />
stable, continue with<br />
36 hourly dosage<br />
interval<br />
Re-check level after<br />
a further 6 <strong>to</strong> 12<br />
hours, at next<br />
practical time<br />
1mg/L<br />
Second dose can be<br />
prescribed and<br />
administered 48<br />
hours after first dose<br />
after 48 hours, advise<br />
that high dose<br />
<strong>gentamicin</strong> treatment is<br />
inappropriate. If<br />
<strong>gentamicin</strong> treatment is<br />
indicated advise the use<br />
of conventional <strong>dosing</strong><br />
Re-check level<br />
after 2 doses<br />
Re-check level<br />
prior <strong>to</strong> next 36<br />
hourly dose<br />
Re-check level<br />
prior <strong>to</strong> next 48<br />
hourly dose<br />
S<strong>to</strong>p high dose<br />
<strong>gentamicin</strong><br />
treatment
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