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International Research and Development Corporation Page 11 Incidental findings, not related to compound administration, included slight bilirubinuria for one control (65-086, male) and 3 treated (65-078, 65-079 and 65-087, males) dogs at the 2-month examina¬ tion period. Bilirubinuria again was found at the terminal examination, - for one of these dogs (65-079, male; 500 1000 ppm.)
International Research and Development Corporation Page 12 IV. PATHOLOGICAL STUDIES A. METHODS; 1. Gross Examination; At the completion of the compound administration period, all dogs were anesthetized with sodium pentobarbital, sacrificed by exsanguination and subjected to necropsy examination. Major organs were weighed and representative tissues were collected into 10 per cent buffered neutral formalin for subsequent histologic processing and microscopic examination. Fresh specimens of brain, liver, kidneys, spleen, fat, muscle, testes and blood were collected from each dog, frozen and forwarded to the sponsor. 2. Microscopic Examination: The following tissues from each of the control and 5000 ppm. dosage group dogs were paraffin embedded, sectioned, stained with hematoxylin and eosin and examined microscopically: brain spinal cord peripheral nerve eye pituitary thyroid parathyroid adrenal trachea lung heart aorta spleen lymph node thymus bone marrow salivary gland esophagus s tomach small intestine large intestine pancreas liver gall bladder kidney urinary bladder testes or ovary prostate or uterus skeletal muscle skin bone Liver sections from all 100 and 1000 ppm. dosage level dogs were also processed as above and examined microscopically. Company Sanitized. Does nol contain TSCA CBl
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