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International Research and Development Corporation
Page 13
B. RESULTS;
1. Gross Pathology (Table 29) and Organ Weights (Table 30):
No compound-related gross pathologic lesions were observed in
any dogs subjected to necropsy examination.
Organ weights of treated
dogs were within the normal range except the liver weights of the
5000 ppm. dosage group dogs which were slightly increased. The liver
weights of the 1000 ppm. dosage group dogs were also greater than the
liver weights of the control dogs in this study although they were
still within the normal range.
2. Histopathology (Tables 31 and 32):
Compound-related changes were limited to the liver of 3-of-3
male and l-of-3 female dogs from the 5000 ppm. dosage level group.
These changes consisted of slight hypertrophy of centrolobular paren-
chymal cells.
The cytoplasm of affected cells was more homogeneous
and less coarsely granular than the cytoplasm of hepatocytes at the
periphery of the lobule or of hepatocytes in control livers.
These
changes were not seen in any of the livers from the 100 or 1000 ppm.
dosage level dogs.
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