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Page 5
After 90 consecutive days of compound administration, all
dogs were sacrificed and subjected to necropsy examination.(see
section on Pathology for detailed methodology.)
2. Laboratory Tests:
At least 3 times during the control period, and again after
1, 2 and 3 months of compound administration,
blood and 24-hour urine
samples were obtained for clinical laboratory studies.
%
a.
Hematology:
Routine hematologic studies
2
included total
and
differ-
ential leucocyte counts, hematocrits hemoglobin concentrations ,
,
1
4
erythrocyte sedimentation rates and total erythrocyte counts .
,
b. Biochemical Studies:
(1) Plasma: Chemical determination on plasma routinely
included quantitative tests for glucose , total protein , total
7
albumin , and urea nitrogen
.
calculated.
ft
Albumin-to-globulin
ratios were
Coulter Particle Size Counter, Model A., Coulter Electronics,
590 W. 20th Street, Hialeah, Florida.
2
Miller, S., Microcapillary Method, Textbook of Clinical Pathology,
1960, Williams and Wilkins Company, Philadelphia, Pa., p. 43.
3
Miller, S., Cyanmethemoglobin Method, Textbook of Clinical Pathology,
1960, Williams and Wilkins Company, Philadelphia, Pa., p. 35.
4
5
Q
Miller, S., Westergren Method, Textbook of Clinical Pathology, 1960,
Williams and Wilkins Company, Philadelphia, Pa., p. 48.
Hoffman, W. S., Modified Hoffman Method, J. Biol. Chem., 120; 51,
1937. (Auto Analyzer).
Stevens, D. L., Modified Biuret Method, Amer. J. Clin. Path. T_: 40,
1946. (Auto Analyzer).
Stevens, D. L., Stevens Adaptation for Auto Analyzer, J. Clin.
Invest., 3^: 211, 1954.
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Skeggs, L. T., Diacetyl Monoxime Method, Amer. J. Clin. Path. 28:
311, 1957. (Auto Analyzer).
3
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