Dicoumarol - コスモ・バイオ

Dicoumarol
Size
Cat. No. 287897 500 mg
Synonyms:
Description:
Form:
Dicumarol; 3,3’-Methylenebis-(4-hydroxycoumarin); Bishydroxycoumarin
A quinone reductase inhibitor with anti-coagulant properties. Binds
competitively with NADH or NADPH to inhibit NAD(P)H:quinone
oxidoreductase (NQO1). Shown to inhibit IGF-I-, menadione-, and
DMNQ-mediated activation of stress-activated protein kinase/c-jun NH 2 -
terminal kinase (SAPK/JNK) and subsequent phosphorylation of c-Jun,
as well as stress-induced activation (hypertonic sorbitol) of SAPK/JNK.
Does not affect p38 phosphorylation or protein kinase B (AKT)
activation. Also shown to induce apoptosis in MCF7 breast carcinoma
cells. Inhibits glutathione-S transferase (GST) A1-1 enzyme (K iu = 4.4
µM, K ic = 3.6 µM) in vitro and in MCF7/VPα cells (a multidrug resistant
derivative of MCF7 transfected with GST A1-1). Blocks brefeldin A-
dependent mono-ADP-ribosylation in vitro and Golgi disassembly in
living cells (IC 50 = 180 µM and 150 µM, respectively).
Solid. Packaged under an inert gas.
CAS Number: 66-76-2
RTECS:
GN7875000
Molecular Weight: 336.3
Molecular Formula: C 19 H 12 O 6
Structure:
Purity:
Solubility:
Storage:
≥98% by titration
0.1 N NaOH (15 mg/ml) or Pyridine (50 mg/ml)
Refrigerate (+4°C). Protect from light. Unstable in solution; reconstitute
Germany
Tel 0800 6931 000
USA & Canada
Tel (800) 628-8470
United Kingdom
Tel 0115 9430 840
E-mail address for technical inquiries: technical@calbiochem.com
Find our current product data sheets on the web: http://www.calbiochem.com
Revised: 08-July-03

CN: 287897
just prior to use. This product is stable for 2 years as supplied.
Toxicity:
MSDS available upon request.
Merck Index: 13: 3117
References: Seanor, K.L., et al. 2003. Antioxid. Redox. Signal 5, 103.
Krause, D., et al. 2001. J. Biol. Chem. 276, 19244.
Pink, J.J., et al. 2000. J. Biol. Chem. 275, 5416.
Cross, J.V., et al. 1999. J. Biol. Chem. 274, 31150.
Morrow, C.S., et al. 1998. J. Biol. Chem. 273, 20114.
Weigert, R., et al. 1997. J. Biol. Chem. 272, 14200.
FOR RESEARCH USE ONLY. NOT FOR HUMAN OR DRUG USE.