Western researchers meeting 'Grand Challenges' - Western News ...

Western News at The University of Western Ontario
Western researchers meeting 'Grand Challenges'
April 30, 2013
With four entries in Round 5 of the Grand Challenges Canada Stars in Global Health
competition, Western is showcasing innovative research, expected to significantly
impact health care around the world.
Western’s David Spence and Daniel Hackam have already proven successful in the
grant competition – funded by the Canadian government – garnering $100,000 in
Round 4 for a research project meant to lower the risk of stroke by addressing the
issue of resistant hypertension in Africa. The project will also be applicable to African-
Canadians suffering from hypertension who are twice as likely to suffer a stroke,
Spence explained.
“The risk of stroke in Africa is much higher. And patients there are taking a bunch
of different medications, but their blood pressure isn’t controlled. Black people have
different causes of high blood pressure that aren’t treated properly,” he said, adding a
genetic mutation could be a contributing factor.
“Current (treatment) guidelines assume everyone is the same. Ours is individualized
therapy versus shot-in-the-dark therapy,” said Spence, a professor of Neurology and
Clinical Pharmacology, and director of the Stroke Prevention and Atherosclerosis
Research Centre at Robarts Research Institute.
Resistant hypertension, defined as blood pressure higher than 140/90 even with
treatment, is the major cause of stroke, heart disease and kidney failure.
Spence and his research team will work with four clinics in Africa, doing genetic
testing with four different tribes, trying to isolate genes responsible for the patients’
predisposition to resistant hypertension. From there, they will tailor treatment to address
the condition. The number of patients able to gain control of their blood pressure is
expected to more than double, lowering the risk of stroke, heart and renal failure by
more than half.
The project is an unprecedented randomized clinical trial, Spence said, involving 40
patients from clinics in Kenya, Nigeria, Rwanda and South Africa.
“We hope to help physicians in Africa control blood pressure and reduce the risk of
stroke. And we hope to bring (the treatment approach) back to North America and
convince physicians (here),” he added.
The idea for this project came to Spence after working with black patients from North
Buxton, Ont., a community descended from slaves who escaped the United States via
the underground railroad.
The project will use point-of-care devices that can be powered by solar energy in
remote clinics to measure an enzyme called plasma renin, which helps regulate blood
pressure, and a steroid hormone called aldersterone that stimulates the absorption
of sodium by the kidneys. The gene sequencing will be done at the London Regional
Genomics Centre at Robarts.
Among Western’s other entries in Round 5 of the Grand Challenges Canada Stars in
Global Health competition:
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� Computer Science professor Charles Ling and his research team have developed a
mobile smartphone application meant to help patients with Type 2 diabetes.Called
Cluco Guide, the application targets patients newly diagnosed with Type 2
diabetes, aiming to teach them skills they need to manage their blood sugar
and prevent complications from diabetes down the road.The app is user-friendly
and patients are asked to input information into the app, including daily diet
and exercise information, as well as their blood sugar levels, explained Jody
Schuurman, a second-year MSc candidate at Western and part of Ling’s research
team.What makes the app unlike any other is the fact that the information from
the patient is transmitted wirelessly to Ling’s lab where data mining looks for
correlations between the patient’s lifestyle and glucose levels, finding a pattern
to help patients see what they should and shouldn’t do to reduce their blood
sugar.“There have a handful of different lifestyle apps like this tested out in Canada
but this one goes beyond the recommendations, taking it to the next step and
collecting data and giving feedback as well,” Schuurman said.
� Mandar Jog, a Neurology professor at Western, is also in the running with his
Augmented Immersion Virtual Reality (AIVR) system, one he and his collaborators
created as a safe and cost-effective tool to help rehabilitate patients with mobility
dysfunctions and conditions such as Parkinson’s disease.AVIR, a virtual reality
world, takes occupational therapy to the next level, providing fully interactive,
customizable environments and rehabilitation scenarios that can mimic day-to-day
tasks and activities for patients, allowing them to learn and become comfortable
performing the task safely, anywhere.Learning how to do something like crossing
a busy street, unsafe for some patients in the real world, is made safe and
accessible by AVIR, Jog said.“In (occupational therapy), how are you going to show
someone how to do groceries, make the bed, clean the kitchen? I don’t know what
challenges (a patient) faces in their environment. I need to logically, at least, come
close to simulating your environment. What this (AVIR) is going towards very fast is
personalized medicine,” he explained.
� Probiotic yogurt containing bacteria that can help break down toxins, pesticides and
heavy metals, meant to ultimately decrease associated deaths in Africa, developed
by Western Microbiology and Immunology professor Gregor Reid and his research
team, is also a finalist in Round 5 of the competition.The bacteria developed by
Reid and his team can be added to locally produced foods in African countries,
helping to break down environmental pollutants, toxins and heavy metals that
contaminate crops, killing and debilitating children in Africa.Consuming this bacteria
helps to break down these toxins, removing them from the body along with waste,
ultimately deceasing the morbidity rate associated with the consumption of toxins
and pollutants, explained Nicholas Nduti, a PhD candidate at Western and part of
Reid’s research team, now working with the Kenyan Ministry of Agriculture.
Videos will be available online until May 31 and applicants will be notified of their
application’s status this summer. Voting for an application is open to the public.
The Department of Communications and Public Affairs
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