Title Increased serum levels of a proliferation-inducing ligand in ...

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correlation with serum BAFF levels (r=0.46, p
Discussion In the current study, we demonstrated that serum APRIL levels were elevated in patients with BP. This is the first report demonstrating elevated serum APRIL levels in organ-specific autoimmune diseases. Although there was no statistical relationship proven between serum APRIL levels and anti-BP180 antibody titers (Figure 2C), longitudinal analysis in three BP patients suggested that serum APRIL levels tended to be high in the early stage of disease and reduced in response to treatment with oral corticosteroid, ahead of the changes in anti-BP180 antibody titiers (Figure 2E). In especial, serum APRIL level of patient 3 turned out to have been elevated even before the manifestation of skin lesion. Furthermore, while serum APRIL levels decreased rapidly, anti-BP180 antibody titers remained higher even after serum APRIL levels declined. In patient 2, we unfortunately could not follow up the change of anti-BP180 antibody titers or serum APRIL levels from day 14 to day 529, due to the absence of - 20 -
Page 1 and 2: Title Author(s) Citation Increased
Page 3 and 4: APRIL, pemphigus vulgaris, bullous
Page 5 and 6: levels. Results and Conclusions: Ci
Page 7 and 8: autoimmune diseases, including auto
Page 9 and 10: - 8 -
Page 11 and 12: Diagnosis of PV was based on the fo
Page 13 and 14: 1 M phosphoric acid, absorbance of
Page 15 and 16: ank test. A p-value less than 0.05
Page 17 and 18: shown). Accordingly, it can be conc
Page 19: or anti-BP180 antibody levels of di
Page 23 and 24: supported by the result that serum
Page 25 and 26: additional factors might determine
Page 27 and 28: functions. In summary, serum APRIL
Page 29 and 30: 5. Rico MJ, Korman NJ, Stanley JR,
Page 31 and 32: 14. Morrison LH: Therapy of refract
Page 33 and 34: on B cell survival. Annu Rev Immuno
Page 35 and 36: autoimmune diseases. Arthritis Res
Page 37 and 38: Figure legends Figure 1. Serum leve
Page 39 and 40: 250 *P
Page 41: 20 15 BAFF (ng/ml) 10 5 0 50 100 20

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