CURRICULUM VITAE Mr. Sandip Ashok Shelke

Mr. Sandip Ashok Shelke
Altana Pharma Pvt Ltd,
(A Nycomed Company)
Plot No 29-31,Suren Road,
Andheri (E),Mumbai,
Pin:400093, India.
Ph. No. +919890155291
E-mail: sannishelke@yahoo.co.in
Sannishelke@gamail.com
CURRICULUM VITAE
OBJECTIVE:
To pursue a doctoral studies in frontier areas of Synthetic Organic Chemistry.
RESEARCH INTEREST:
Synthetic Organic Chemistry, Carbohydrate Chemistry, Heterocyclic Chemistry, Medicinal Chemistry,
Bio-organic chemistry and Peptide Synthesis.
ACADEMIC QUALIFICATION:
M.Sc. (Organic Chemistry):
Pune University, Pune, Maharashtra, India, 2003, first class with distinction.
B.Sc. (Chemistry):
Pune University, Pune, Maharashtra, India, 2001, first class with distinction.
AWARDS:
• First rank in M.Sc. at Fergusson College, Pune, Maharastra, India.
• First rank in B.Sc. at Shri Dnyaneshwar Mahavidyalaya, Newasa, Pune University,
Maharastra, India, 2001.
HIGHLIGHTS:
• Excellent skills in handling moisture sensitive, air sensitive, light sensitive reagents.
• Experience of working on various organic transformations.
• Expertise in modern spectroscopic and chromatographic techniques and interpretation of spectral
data viz. 1HNMR, 13CMR, MASS, LC-MS, GC-MS, HPLC etc.
• Well versed with chemistry related software’s like ISIS draw, Chem Draw and NMR software.
• Also acquaintances in scientific soft ware databases like Beilstine Crossfire, ISIS Base,CA on CD
and Sci.finder. Exposed to retrieve the data from Chemical abstracts, Journals, patents etc
• Possessing excellent communication and interpersonal skills.
• Capable of doing collaborative and independent research work.
RESEARCH EXPERIENCE:
1. Aug2003 to April2004- Project student at National Chemical Laboratory (NCL), Pune, on the
project entitled “An Efficient One-Pot Synthesis of Azidoformates from Alcohols Using

Triphosgene: Synthesis of N1-Carbobenzyloxy Azetidin-2-ones” funded by Indian Council of
Agriculture Research, INDIA, under the supervision of Dr. A. R .A. S. Deshmukh.
2. June2003toFeb2006- Research Assistant, R&D, Oncology operations, Dr. Reddy’s Laboratories
Ltd, Hyderabad, (AP) India.
3. Feb’2006 to till date: Senior Research Associate, Chemical Research, Altana Pharma Pvt. Ltd.
Andheri (E), Mumbai-400093. India.
PUBLICATIONS:
• A process patent US2007/100149/A1 Published for the synthesis of Letrozole a anticancer agent
used in Harmaonal therapy.
EXTRA CURRCULAM ACTIVITIES:
• Participated in Arnekar lecture completion held in University of Pune 2002.
• Attended Pharmacophore 2004 held in Hyderabad, India.
PROFESSIONAL REFERENCES:
Dr. A.R.A. S. Deshmukh
Scientist
Organic Chemistry Synthesis Division.
National Chemical Laboratory
Dr. Homi Bhabha road,
Pune, 411008.(MS) INDIA
Tel.: 0091 –20- 5893300
Fax: 0091-20-5893614
E-mail: aras.deshmukh@ncl.res.in
Dr. Anil Gajare
Senior research Scientist,
Altana Pharma Pvt Ltd, (A Nycomed Company)
Plot No 29-31,Suren Road,
Andheri (E),Mumbai,
Pin:400093, India.
Tel: 0091-22-66463859
Fax: 0091-22-66463860
E Mial:anil.gajare@altanapharma.in
ACADEMIC REFERENCES:
Dr. B. G. Mahamulkar
Reader in Organic Chemistry,
Department Of Chemistry,
Fergusson College, Pune.
Pune 410004. (MS) INDIA
Tel.: 0091-20-5468626
Dr. R. S. Kondedeshmukh
Reader in Organic Chemistry,
Department Of Chemistry,
Fergusson College, Pune.
Pune 410004(MS) INDIA
Tel.0091-20-5280742
PERSONAL DETAILS:
• Date of Birth : 30 th sep.1979
• Citizenship : Indian.
• Languages Known : English, Hindi, and Marathi.
• Gender : Male
• Marital Status : Married
• Permanent address : At/P Vadala mission,
Newasa,Dist Ahmednagar,
Maharshtra,India,414602

SUMMARY OF RESEARCH WORK
1. Summary of the project “An Efficient One-Pot Synthesis of Azidoformates from Alcohols Using
Triphosgene: Synthesis of N1-Carbobenzyloxy Azetidin-2-ones”at National Chemical
Laboratory: -
During this project I had synthesized an azidoformates from alcohols using triphosgene.
And which was utilized in synthesis of N1-Carbobenzyloxy Azetidin-2-ones.This is a noval
route of synthesis of of the ß-Lactums having activity against bacteria.
Structure of one of the analogue.
O
H
H
O
N
O
O
N1-Carbobenzyloxy Azetidin-2-ones
2. Summary of the project synthesis of analogues of Taxol at Dr.Reddys Oncology research and
development department. -
During this project we have synthesized analogues of 10 DAB III which is a starting material for
the synthesis of taxanes like Docetaxel and Paclitaxel. The principal mechanism of the taxane
class is inhibition of microtubule function. Microtubules are essential to cell division, and taxanes
therefore stop cells from properly dividing. Taxanes are also felt to be radio sensitizing.
Structure:
O
O
NH
O
H 3 C
HO
O
OH
O
NH
O
H 3 C
O
O
O
OH
OH
O
OH
CH 3
CH 3
O
O
O
OH
O
OH
CH 3
CH 3
O
O
O
O
Docetaxel
O CH 3
Paclitaxel
CH 3
O CH 3
O
3. Summary of the project “Synthesis Camptothecin analogues” at Dr.Reddys Oncology research and
development department. –

Camptothecin is an anti-cancer agent that damages DNA, leading to the destruction of the cell.
Camptothecin affects the activity of the enzyme topoisomerase I, whose normal action is to
cleave, unwind, and relegate DNA. When camptothecin binds to topoisomerase I, it will be able to
cleave but not to relegate DNA. Thereby, camptothecin causes single strand breaks in DNA.The
well known analogues like Irinotecan and Topotecan were synthesized.
N
N
O
O
O OH Camptothecin
4. Summary of the project “Synthesis of Bicalutamide and Letrozole” at Dr.Reddys Oncology research
and development department
Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It was first launched in
1995 as a combination treatment (with surgical or medical castration) for advanced prostate
cancer and subsequently launched as monotherapy for the treatment of earlier stages of the disease
5.Letrozole is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant
treatment of hormonally responsive breast cancer.
6. presently working on A Toll Like recepotar agoist a naphthyridine derivative synthesis.