INSITU Oct 2006 - Vol 2 - Institute of Chemical & Engineering ...

5
Crystallisation and Formulation Facilities Development
and
Infrastructure
in-situ crystallisation monitoring & control
Applications
A) In-situ crystallisation monitoring and control facilities
In-situ crystallisation facilities have been set up to develop
and optimise crystallisation processes to obtain crystal
products with desired properties. The facilities also help in
advancing fundamental understanding of crystal growth
and nucleation phenomena.
B) Formulation science laboratory
This laboratory is set up to develop scientific understanding
of how particle properties affect formulability and
bioavailability. These tools are also useful for the design
of novel formulation techniques and to optimise existing
manufacturing processes for the pharmaceutical, specialty
chemicals, food & beverages industries.
C) Milling and granulation laboratory
The laboratory addresses the needs of secondary
pharmaceutical manufacture as well as industries that
require general solid processing.
Reaction Engineering, Reactor Development
A) In-situ reaction monitoring laboratory
To study synthetic organic reactions for the fine chemical
and pharmaceutical industries using state-of-the-art leading
edge spectrometers and physical property measurement,
all on-line and in-situ. The available techniques include
Raman optical activity for real time
enantiomer determination, Mid-Infrared
(MIR), Far-Infrared (FIR), Fourier Transform
Infrared (FTIR), Raman, supported by
novel chemometrics software.
B) Reaction calorimetry
The reaction calorimetry facility is
designed to study thermal events
involved in reactions and processing of
solids, to enable the design of cooling
and safety protection systems for pilot
scale and full scale operation.
C) Mixing and scale up laboratory
The mixing laboratory is equipped with tools necessary to
study the effects of mixing and fluid dynamics on reactions
and processes when scaling up.
On-line reaction monitoring set up (FIR and MIR)