C.I. Pigment Brown 24 CAS NÂ°: 68186-90-3

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OECD SIDS C.I. PIGMENT BROWN 24 ECOTOXICITY ID 68186-90-3 DATE: 26-NOV-2004 TERRESTRIAL ORGANISMS 4.6.1 Toxicity to Sediment Dwelling Organisms 4.6.2 Toxicity to Terrestrial Plants 4.6.3 Toxicity to Soil Dwelling Organisms 4.6.4 Toxicity to other Non-Mamm. Terrestrial Species 4.7 Biological Effects Monitoring 4.8 Biotransformation and Kinetics 4.9 Additional Remarks Memo: 1 Remark: Sicotan Gelb K 2011 verhaelt sich in einem Organismus und in der Umwelt praktisch inert bzw. ist nicht bioverfuegbar. Dies wird bestaetigt durch die toxikologischen Daten und Daten zur oekotoxischen Wirkung. 30 UNEP PUBLICATIONS
OECD SIDS C.I. PIGMENT BROWN 24 TOXICITY ID 68186-90-3 DATE: 26-NOV-2004 5.0 Toxicokinetics, Metabolism and Distribution Type: Toxicokinetics Species: rat No. of animals, males: 5 No. of animals, females: 5 Doses, males: 10, 100, 1000, 10000 mg/kg diet (0.5, 5, 50, 500 mg/kg bw/day) Doses, females: 10, 100, 1000, 10000 mg/kg diet (0.5, 5, 50, 500 mg/kg bw/day) Route of administration: oral feed Exposure time: 90 day(s) Method: other:comparable to OECD guideline 408 GLP: no data Remark: Result: The detected traces of antimony (see results) most likely originate from the acid-soluble impurities of the pigment (10-20 mg antimony/kg pigment, that is 5-10 microgram/kg bw or 125-250 microgram/kg organ weights at the highest dose) and therefore do not indicate bioavailability of the pigment itself. TOXICICITY No deaths, no overt signs of reactions to the treatment, no effects on body weight gain (similar food consumption in all groups) or organ weight, no treatment related findings from haematological or biochemical investigations and urinalysis. No macroscopic pathological changes attributable to treatment. No treatment related effects observed in histopathology. CHEMICAL ANALYSIS Antimony In males and females the Sb concentrations in liver and kidney were below the detection limit at doses up to 1000 ppm. In the high dose groups the Sb levels slightly increased with exposure duration and reached max. 27 ppb in the liver (3 mo) of males (range 15-40 ppb) and 17 ppb in females (kidney 14 ppb in males and 15 ppb in females). Chromium No measurable effect on chromium content of liver and kidney at any dose level and exposure duration. Test condition: AUTHORS CONCLUSION The bioavailable traces of metals are considered to have no toxicological significance. EXPERIMENTAL DESIGN 15 animals per dose per gender for toxicological investigations and 30 animals per gender in the control group; additionally 10 animals per dose and gender for analytical investigations and 20 animals per gender in the control group. Tests started at the age of 4- 5 weeks; TS given in powdered food (Altromin); feed and tape water ad libitum. General observations: Rats observed daily; food consumption and body weight gain determined once per week. UNEP PUBLICATIONS 31
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C.I. Pigment Brown 24 CAS NÂ°: 68186-90-3

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