TEXANOL CAS N°: 25265-77-4

Mutagenicity 99
Study
End Point : MUTAGENICITY
Chemical Name : Texanol
CAS Number : 25265-77-4
Study type : LAB
Test Subject
Organism Medium Specification Route Lifestage Sex Number exposed Number controls
MOUSE
Species/strain/system : Swiss CD-1 mice
Test Substance
Purity Grade : 99%
Test Method and Conditions
Test method :
description
Exposure
Micronucleus Test; OECD Guideline 474 (limit dose of 2000 mg/kg); GLP: yes
Dose / Concentration : 200-2000 mg/kg BW
Exposure comments : Groups of animals were dosed with 0, 200, 1000, or 2000 mg/kg of test
chemical.
Test Results
Affected in
Organ Effect Rev. OnSet Sex Exposed - Controls
--------- ----------- ------- ------------------- ------- -----------------------------
NEF
No significant increase in micronuclei in bone marrow polychromatic erthrocytes was seen under the conditions
of this assay in any dose group at any harvested time.
NEF
No effect on Mitotic Index or P/N Ratio was seen at any dose level.
2000 mg/kg produced transient acute toxicity in female mice.
General Comments : Under the conditions employed, the test article is negative in the in vivo
mammalian bone marrow micronucleus assay.
References
Primary Reference : #URKOD*
Barber, E. D. et al. Eastman Kodak Company Reports, TX-91-309, (1992)
Secondary Reference : !SIDSP*
OECD/SIDS. Screening Information Data Set (SIDS) of OECD High
Production Volume Chemicals Programme, (1994)
IRPTC Data Profile