TEXANOL CAS NÂ°: 25265-77-4

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Mutagenicity 99 Study End Point : MUTAGENICITY Chemical Name : Texanol CAS Number : 25265-77-4 Study type : LAB Test Subject Organism Medium Specification Route Lifestage Sex Number exposed Number controls MOUSE Species/strain/system : Swiss CD-1 mice Test Substance Purity Grade : 99% Test Method and Conditions Test method : description Exposure Micronucleus Test; OECD Guideline 474 (limit dose of 2000 mg/kg); GLP: yes Dose / Concentration : 200-2000 mg/kg BW Exposure comments : Groups of animals were dosed with 0, 200, 1000, or 2000 mg/kg of test chemical. Test Results Affected in Organ Effect Rev. OnSet Sex Exposed - Controls --------- ----------- ------- ------------------- ------- ----------------------------- NEF No significant increase in micronuclei in bone marrow polychromatic erthrocytes was seen under the conditions of this assay in any dose group at any harvested time. NEF No effect on Mitotic Index or P/N Ratio was seen at any dose level. 2000 mg/kg produced transient acute toxicity in female mice. General Comments : Under the conditions employed, the test article is negative in the in vivo mammalian bone marrow micronucleus assay. References Primary Reference : #URKOD* Barber, E. D. et al. Eastman Kodak Company Reports, TX-91-309, (1992) Secondary Reference : !SIDSP* OECD/SIDS. Screening Information Data Set (SIDS) of OECD High Production Volume Chemicals Programme, (1994) IRPTC Data Profile
100 Sensitization Study End Point : SENSITIZATION Chemical Name : Texanol CAS Number : 25265-77-4 Study type : LAB Test Subject Organism Medium Specification Route Lifestage Sex Number exposed Number controls Test Substance Purity Grade : 99% Test Method and Conditions Test method : description Test Results SKN OECD Guideline 406 (Annex) (dated 12 May, 1981). GLP: yes Affected in Organ Effect Rev. OnSet Sex Exposed - Controls --------- ----------- ------- ------------------- ------- ----------------------------- NEF Negative result for sensitization. Number of animals with skin reaction at challenge: 0. Number of animals with skin reaction in control group at challenge: 0. General Comments : An earlier study using a standardized topical method of induction was negative for sensitization (see Eastman Kodak Company, Laboratory of Industrial Medicine Toxicity Report, Dated February 12, 1984). References Primary Reference : #URKOD* O'Donoghue, J. L. Eastman Kodak Company Reports, (1984) Secondary Reference : !SIDSP* OECD/SIDS. Screening Information Data Set (SIDS) of OECD High Production Volume Chemicals Programme, (1994) IRPTC Data Profile
Page 1 and 2: OECD SIDS TEXANOL FOREWORD INTRODUC
Page 3 and 4: 74 Identifiers, Physical and Chemic
Page 5 and 6: 76 Processes Processes Chemical Nam
Page 7 and 8: 78 Pathways into the Environment an
Page 9 and 10: 80 Concentration References Primary
Page 11 and 12: 82 Human Intake and Exposure Test R
Page 13 and 14: 84 Biodegradation Study End Point :
Page 15 and 16: 86 Photodegradation Study End Point
Page 17 and 18: 88 Hydrolysis Study End Point : HYD
Page 19 and 20: 90 Mammalian Acute Toxicity Study E
Page 25 and 26: 96 Mammalian Toxicity KIDNY SIZE M
Page 27: 98 Mutagenicity Study End Point : M
Page 31 and 32: 102 Irritation Study End Point : IR
Page 33 and 34: 104 Irritation Test Substance Purit
Page 35 and 36: 106 Reproduction Study End Point :
Page 37 and 38: 108 Teratogenicity References Prima
Page 39 and 40: 110 Aquatic Acute Toxicity Test Met
Page 41 and 42: 112 Aquatic Toxicity Study End Poin
Page 43 and 44: 114 Aquatic Toxicity References Pri
Page 45 and 46: 116 Terrestrial Toxicity Study End

TEXANOL CAS NÂ°: 25265-77-4

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