The Clinical Utility Index, a Method for Balancing Efficacy and Safety ...

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NUTS AND BOLTS (DISCLAIMER: I WILL DESCRIBE THE APPROACH IMPLEMENTED BY MYSELF AND MY COLLEAGUES AT PHARSIGHT.) Slide 14 © Tripos, L.P. All Rights Reserved
The CUI is an additive multivariate utility function n CUI ( x , x , x | treatment) wU x | treatment 1 2 n i i i i 1 Each attribute has a utility function, U i (x), that transforms the attribute from its original scale into the (0,1) scale of utility. For a given joint outcome of attributes, we • Calculate the utility achieved for each attribute ->(0,1) scale • Multiply each attribute‘s utility by that attribute‘s weight, w i • Add them all together in a weighted sum Thus, the math is easy. Defining the function (crossattribute weights and individual utility functions) requires a careful and proper process. Slide 15 © Tripos, L.P. All Rights Reserved
Page 1 and 2: The Clinical Utility Index, a Metho
Page 3 and 4: MOTIVATION Slide 3 © Tripos, L.P.
Page 5 and 6: Motivation - Each drug has a list o
Page 7 and 8: Motivation - ―What is so?‖ vers
Page 9 and 10: INTRODUCTION TO THE CUI Slide 9 ©
Page 11 and 12: Utility The Clinical Utility Index
Page 13: The underpinnings of CUI are severa
Page 17 and 18: Construction of a CUI function take
Page 19 and 20: Construction of a CUI function take
Page 21 and 22: CASE STUDY Slide 21 © Tripos, L.P.
Page 23 and 24: SES (cfb) SES (cfb) We explored the
Page 25 and 26: CUI allowed us to link our pharmaco
Page 27 and 28: The Clinical Utility Index reduces
Page 29 and 30: Putting CUI into Practice A relativ
Page 31 and 32: BACKUP Slide 31 © Tripos, L.P. All
Page 33: Extensions of CUI Slide 33 © Tripo

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