The Clinical Utility Index, a Method for Balancing Efficacy and Safety ...
The Clinical Utility Index, a Method for Balancing Efficacy and Safety ...
The Clinical Utility Index, a Method for Balancing Efficacy and Safety ...
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SES (cfb)<br />
SES (cfb)<br />
We explored the effects of altering PK characteristics<br />
Graphs show increased duration of effect at a higher dose, with<br />
absorption rate decreased by 75%<br />
SES (cfb) vs Time (h)<br />
Ka factor: 1.00<br />
Dopahexidine: 8<br />
0<br />
SES (cfb) vs Time (h)<br />
Ka factor: 0.25<br />
Dopahexidine: 24<br />
0<br />
-0.2<br />
-0.2<br />
-0.4<br />
-0.4<br />
-0.6<br />
-0.6<br />
-0.8<br />
-0.8<br />
-1<br />
0 2 4 6 8 10 12<br />
Time (h)<br />
-1<br />
0 2 4 6 8 10 12<br />
Time (h)<br />
Time of onset (not mentioned in CUI) <strong>and</strong> maximal change in SES are similar<br />
Duration of efficacy is substantially increased
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