Ph.D. Thesis_AS_Publishing version for IRC_12 ... - Jacobs University
Ph.D. Thesis_AS_Publishing version for IRC_12 ... - Jacobs University
Ph.D. Thesis_AS_Publishing version for IRC_12 ... - Jacobs University
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Table of Contents<br />
Chapter 1. Introduction ........................................................................................................... 1<br />
1.1 Organocatalysis ........................................................................................................... 2<br />
1.2 Enamine catalysis ........................................................................................................ 4<br />
1.3 First asymmetric examples of various enamine based reactions ................................. 6<br />
1.3.1 Enamine promoted asymmetric Aldol reaction ........................................................... 6<br />
1.3.2 Enamine promoted asymmetric Michael reaction ....................................................... 7<br />
1.3.3 Enamine promoted asymmetric Mannich reaction ...................................................... 8<br />
1.3.4 Enamine promoted asymmetric α-amination .............................................................. 9<br />
1.3.5 Enamine promoted asymmetric α-alkylation .............................................................. 9<br />
1.4 Asymmetric Michael addition ................................................................................... 10<br />
1.4.1 Generic mechanism of bifunctional catalysts ............................................................ 11<br />
1.4.2 Classification of organocatalysts ............................................................................... 13<br />
1.4.2.1 Steric based catalysts .......................................................................................... 15<br />
1.4.2.2 Thiourea based bifunctional catalysts ................................................................ 17<br />
1.4.2.3 Amino-sulfonamides, Amino-thiophosphoramides and Amino-amides ............ 19<br />
1.4.2.4 Proline based diamine catalysts .......................................................................... 21<br />
1.4.2.5 Cinchona based bifunctional catalysts ............................................................... 23<br />
1.4.2.6 Miscellaneous bifunctional catalysts .................................................................. 23<br />
1.4.2.7 Proline based electrostatic catalysts ................................................................... 24<br />
1.4.3 Asymmetric Michael addition to nitroolefins ............................................................ 25<br />
1.4.4 Asymmetric Michael addition to maleimides ............................................................ 30<br />
VII