MAKETA 5/3

20
A C T A M E D I C A M A R T I N I A N A 2 0 0 5 5/3
ters when comparing to other three drugs, least of all. We enrolled in our transversal study all
registered patients with JIA who met the basic research requirements. Six of them were treated
with triamcinolone before. Cumulative doses and duration of each drug administration were studied
retrospectively. This is the reason why also patients treated with this drug were enrolled.
Duration of corticosteroid therapy influenced somatic parameters in a very interesting way.
Children treated with prednisone were expected to be influenced negatively most of all, but only
two significant correlations of duration of prednisone therapy were found in oligoarticular patients.
The most significant dependences of somatic parameters on duration of administration
were found in children with systemic JIA form treated with methylprednisone.
For comparing somatic parameters of individual JIA forms within the whole group of 81 children
the analysis of variance was used. Systemic JIA was statistically different from oligoarticular
and polyarticular in thirteen somatic parameters (81%). Only in wrist circumference and BMI
no statistically significant differences were found.
Statistically significant differences between JIA types in children treated with corticoids were
found in ten somatic parameters (62.5%), always in relation to the systemic disease. Our results
show that in children treated with corticoids there were no statistically significant differences
among JIA types in six somatic parameters only. We found out, that systemic JIA differed from
oligoarticular and polyarticular in all other parameters.
The results of our study confirm the negative influence of corticoids on the body growth of
children with JIA. No statistically significant differences in somatic parameters were found between
boys and girls. Neither the child’s age of illness manifestation, nor the illness duration
influenced somatic parameters of our patients with JIA. The most negative influence was proved
in methylprednisone and systemic JIA form.
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Received:August, 8, 2005
Accepted: October, 27, 2005