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Transcription Factors RNA Binding <strong>Protein</strong>s mRNAs miRNAs
Sequencing cost (nucleotides/dollar) 10 6 10 4 10 2 10 0 10 6 10 4 10 2 10 0 Storage cost (megabytes/dollars) 1990 1995 2000 2005 2010 Year
Page 1: Towards Quantitative Biology Robin
Page 5 and 6: ATG ACG AAG... Methionine Lysine Th
Page 9 and 10: Number of genes Organismal complexi
Page 11 and 12: Species Number of Neurons Number of
Page 16 and 17: Nucleus Cytoplasm DNA pre-mRNA tran
Page 18 and 19: Transcription Factors RNA Binding P
Page 22: Transcription Factors RNA Binding P
Page 25 and 26: Electrophoretic mobility shift assa
Page 27 and 28: Illumina Genome Analyzer GCC AGA TT
Page 33 and 34: Illumina Genome Analyzer A channel
Page 35 and 36: HiTS-FLIP method High-Throughput Se
Page 37 and 38: HiTS-FLIP method High-Throughput Se
Page 39 and 40: GCN4 HiTS-FLIP method
Page 41 and 42: HiTS-FLIP method GCN4 Merge
Page 43 and 44: GCN4 master regulator of amino acid
Page 45 and 46: GCN4 binds its canonical motif 440,
Page 47 and 48: Concentration-dependent GCN4 bindin
Page 49 and 50: Dissociation constants 1000 HiTS−
Page 51 and 52: Conclusion
Page 53 and 54: Conclusion Colected a half billion

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