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<strong>KSEA</strong> LETTERS<br />

Journal of the <strong>Korean</strong>-<strong>American</strong> Scientists and Engineers Association<br />

april <strong>2012</strong><br />

Vol. <strong>40</strong> No. 3 (Serial No. 217)<br />

WWW.<strong>KSEA</strong>.ORG<br />

MOU WITH ADVANCED TECHNOLOGY CENTER<br />

ASSOCIATION (ATCA) &<br />

ADVISORY COMMITTEE MEETING FOR IBS<br />

KSTLC <strong>2012</strong> IN CHICAGO<br />

MARCH 16-18, <strong>2012</strong>


Korea-US Science Cooperation Center<br />

Established as a non-profit in 1997 for fostering science & technology cooperation<br />

between the U.S. and Korea through a variety of programs<br />

S&T Program<br />

Supporting S&T meetings<br />

KUSCO scholarship for Science-majored graduate students<br />

KUSCO-NRF-NSF Summer Institute Program<br />

National Math and Science Competition<br />

WEST Program<br />

What is WEST program?<br />

The WEST program is an exchange program created between the governments of the U.S.<br />

and Republic of Korea. The program will allow qualified university students from Korea to<br />

enter the United States for a period up to 18 months as Exchange Visitors on the J-1 visa.<br />

Parties Names and type Major responsibilities<br />

Host The US organizations Provide work experience<br />

Sponsor KUSCO Visa, Insurance, and administration<br />

Participants University students from Korea Travel, housing and living expense<br />

Benefit Comparison between WEST and other J-1 program<br />

Items WEST Program Generic J-1 program<br />

Visa KUSCO applies Host applies through sponsors<br />

Program KUSCO provides ESL and placement works<br />

Host is responsible for the training<br />

program<br />

Cost<br />

KUSCO and Participants pay for travel, visa Host may be responsible for the travel and<br />

and ESL. No cost to the host.<br />

visa application.<br />

The Current Participating US host institutions<br />

For further information as to WEST program at west@kusco.org<br />

1952 Gallows Road. Suite 330 Vienna Virginia U.S.A. | (703) 893-9772 | www.kusco.org


TABLE OF CONTENTS<br />

Editorial Note 3<br />

Message from the <strong>40</strong> th President 4<br />

President of <strong>KSEA</strong> Visits the NIH Pioneer at Harvard 5<br />

Featured Articles<br />

Nano-Bio Interfacing: Leveraging Advances in Semiconductor Technology for Biological Research 6<br />

Single Molecule Biology: One, Two, Three & Four 8<br />

Technical Articles<br />

Microstructurally Designed Hierarchal Aluminum Metal Matrix Composites 10<br />

Micro Gas Chromatography System For Distributed Environmental Awareness 12<br />

Interconnected Network of the Cell Cycle, Circadian Rhythms, and DNA Damage Response 14<br />

Cooperative Control at Traffic Light Harnessed by Wireless Cars 16<br />

Workshop on Introduction to Institute for Basic Science 18<br />

MOU Signed with Advanced Technology Center Association (ATCA) 19<br />

UKC <strong>2012</strong> Advertisement 20<br />

Highlights of KSTLC <strong>2012</strong><br />

Message from the Conference Co-Chairs & Welcoming Reception 21<br />

Plenary Presentations & Poster Session 22<br />

Sessions and Workshops 23<br />

Awards 25<br />

Post-YGTLC <strong>2012</strong> Comments & Testimonials 26<br />

Testimonials 27<br />

Sponsor News - Ho-am Prize Recipients 29<br />

Events<br />

Local Chapters 30<br />

Affiliated Professional Societies 31<br />

<strong>KSEA</strong> Organizational Structure 55<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 1


Pilot High School Physics Contest (HSPC)<br />

Open to 9 th to 12 th graders<br />

Exclusively in<br />

NC & North Texas Region<br />

Organizer:<br />

<strong>KSEA</strong><br />

<strong>Korean</strong>-american ScientiStS and engineerS aSSociation<br />

Co-Organizer:


EDITORIAL NOTE FOR <strong>KSEA</strong> LETTERS: JOURNAL OF THE<br />

KOREAN-AMERICAN SCIENTISTS AND ENGINEERS ASSOCIATION<br />

This <strong>Apr</strong>il issue features articles from two world-renowned scholars:<br />

Dr. Hongkun Park , Professor of Chemistry and Chemical Biology at Harvard<br />

University, presents a breakthrough in developing nano-bio interfaces<br />

that maximally utilize the advantages offered by silicone nanostructures by<br />

employing nanoscale needles.<br />

Dr. Taekjip Ha, Professor of Physics at University of Illinois, made a discovery<br />

that a protein can store elastic energy through multiple cycles of chemical<br />

energy release that can be released in a single burst.<br />

<strong>KSEA</strong> LETTERS<br />

Vol. <strong>40</strong> No. 3 (Serial No. 217)<br />

APRIL <strong>2012</strong><br />

Publisher and Editor<br />

Hosin “David” Lee<br />

Editorial Board<br />

John Kim<br />

Philip Kim<br />

Luke Lee<br />

Hongkun Park<br />

Publications Directors<br />

Byungkyu “Brian” Park<br />

Hyunggun Kim<br />

Jaehoon Yu<br />

Staff Editor<br />

Euna Yoon<br />

Staff Designer<br />

Yoon Hee Chang<br />

Publication Date<br />

<strong>Apr</strong>il <strong>2012</strong><br />

Published by the <strong>Korean</strong>-<strong>American</strong> Scientists<br />

and Engineers Association. All rights<br />

reserved. No part of this publication may be<br />

reproduced, in any form or any means, without<br />

the prior written permission of <strong>KSEA</strong>.<br />

<strong>KSEA</strong> assumes no responsibility for statements<br />

and opinions expressed in this publication.<br />

Four distinguished and rising scholars were selected to contribute their frontier research<br />

projects.<br />

Dr. Yongho Sohn, Professor of Materials Science and Engineering at University<br />

of Central Florida, performed extensive microscopic and spectroscopic<br />

analyses to characterize microstructural features of hierarchal composites.<br />

Dr. Hanseup Kim, USTAR Assistant Professor of Electrical and Computer<br />

Engineering at University of Utah and the <strong>2012</strong> recipient of NSF Career<br />

Award, presents his futuristic research on developing micro gas chromatography<br />

system as a ‘wearable’ VOC measurement tool.<br />

Dr. Christian Hong, Assistant Professor of Molecular and Cellular Physiology<br />

at University of Cincinnati and a winner of $3.6 Million DARPA grant,<br />

investigates connections between circadian rhythms, cell cycle, and DNA<br />

damage response as interconnected networks.<br />

Dr. Byungkyu “Brian” Park, Associate Professor of Civil and Environmental<br />

Engineering at University of Virginia, presents a “school of fish” solution to<br />

the traffic congestion by developing a cooperative control algorithm based<br />

on wireless communications among vehicles and infrastructure.<br />

This issue also covers:<br />

▶ Highlights of the 1 st <strong>Korean</strong> Student Technical Leadership Conference (KSTLC) in<br />

Chicago on March 16-18, where over 100 <strong>Korean</strong> students studying in America attended:<br />

technical presentations, posters, Dale Carnegie training, presentation skill<br />

workshop, career development workshop, poster competition, and candid testimonials<br />

from participants.<br />

▶ MOU ceremony with Advanced Technology Center Association (ATCA) at Silicon<br />

Valley on March 5 th to establish a cooperative relationship to exchange research ideas<br />

in cutting-edge industrial technologies.<br />

▶ Advisory committee meeting and workshop for Institution of Basic Science (IBS)<br />

and Ministry of Education, Science and Technology (MEST) in Boston on Feb 9 th to<br />

help them recruit team leaders and young scholars (Vice Minister Chang-Kyung Kim<br />

of MEST and top officials from IBS sought inputs from the advisory committee of<br />

senior and distinguished <strong>KSEA</strong> members in establishing IBS as a world premier basic<br />

science research institute)<br />

▶ Pictures of events organized by local chapters and affiliated professional societies<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 3


MESSAGE FROM THE <strong>40</strong> TH PRESIDENT<br />

Message from the Father of TLC (YG and KS)<br />

<strong>40</strong>th <strong>KSEA</strong> President,<br />

Hosin “David” Lee<br />

It is 2:00 a.m. Tuesday on <strong>Apr</strong>il 10 in Iowa City, after finishing grading the exams, I am back to<br />

work on what I like the most, the <strong>KSEA</strong> business. I am glad to report that we have successfully organized<br />

the first KSTLC in Chicago for the 1 st Generation <strong>Korean</strong> students in March. After having<br />

delivered the first YGTLC for the 2 nd Generation <strong>Korean</strong>-<strong>American</strong>s 8 years ago, it was about time<br />

to deliver the second child. I have a feeling that the second child will grow even bigger than the<br />

first child because it was born twice as large as the first one. I would like to recognize the dedicated<br />

contribution from Dr. Byoung-Do Kim, YG director 1, Dr. Benjamin Lee, general director and Mr.<br />

Israel Jung, YG director 2, in guiding 25 organizers including three outstanding co-chairs of Kathy<br />

Lee, Rachel Park and Sarah Rhee. Who said the second child is more precious than the first one?<br />

I would like to congratulate all students from 4 th to 11 th grades who participated at the <strong>2012</strong> National<br />

Math & Science Competition (NMSC) on <strong>Apr</strong>il 21, co-organized by KUSCO. First, I would like to<br />

thank Dr. Kookjoon Ahn, Vice President 1, Dr. Yongho Sohn, executive director, Dr. Wookeun Shin,<br />

chair of the chapter presidents committee, chapter presidents and members of participating local<br />

chapters, and many more volunteers for the successful planning and execution of the NMSC. This year’s problem sets were prepared<br />

by the math and science educators from University of Iowa: Dr. Soonhye Park, Chair, and Dr. Kyong Mi Choi, Co-Chair,<br />

and members of the NMSC Committee. We added a new high school physics contest, led by Dr. Jae Yu, Publication Director 3,<br />

in collaboration with the Association of <strong>Korean</strong> Physicists in America (AKPA), one of our 23 affiliated professional societies.<br />

This year, all national award recipients and their parents are invited to attend the NMSC award ceremony at 11:00 a.m. on May<br />

12, Saturday, followed by a luncheon with a keynote speech from Dr. Jim Gates, Jr., member of the President Obama’s Council<br />

of Advisors in Science and Technology (PCAST) and advisor of <strong>KSEA</strong>, at Marriott Hotel at Tyson Corner in Washington. We<br />

invited the Ambassador Young-jin Choi of Korea and an administrator from University of Pennsylvania to give welcoming remarks.<br />

Yes, with your active participation, we broke the record of the participation at the NMSC.<br />

We organized the workshop to introduce the Institute of Basic Science (IBS) to young scientists and the advisory committee<br />

meeting for Dr. Chang Kyung Kim, Vice Minister of Education, Science and Technology of Korea, and top officials of IBS in Boston<br />

in February. In March, we signed the ninth MOU with Advanced Technology Center Association (ATCA) and have already<br />

started working with ATCA by connecting our members to their company members for research collaboration. In <strong>Apr</strong>il, our<br />

organization was selected to give a presentation at the heritage community liaison council meeting as the “Spotlight” organization<br />

to other council member organizations and top officials of Office of Director of National Intelligence (ODNI). I am proud<br />

to say that <strong>KSEA</strong> was recognized as a role model heritage organization in America.<br />

Since signing our first MOU with Korea Evaluation Institute of Industrial Technology (KEIT) on July 1, 2011, we continued to<br />

work with them throughout the year starting with training of their employees in December, participation and sponsorship of<br />

YGTLC and KSTLC, participation of our members in the research proposals to KEIT, and a contract to develop research need<br />

statements. It is a win-win situation for both <strong>KSEA</strong> and KEIT, and, like Rick said in Casablanca, Keit, I think this is only the<br />

beginning of a beautiful relationship.<br />

I cannot end my remarks without giving you an update on the membership status and budget situation. Yes, we set a new record<br />

of over 4,100 members, Yeah! And the all-time high revenue of $2.4 Million, including an unprecedented amount of donation of<br />

$37,680 from our own members and still growing! Do the math! We invested nearly $600 per member this year! Ask the question<br />

to your <strong>American</strong> colleagues! Which organization in America invests in its members more than <strong>KSEA</strong>?<br />

<strong>KSEA</strong> is a drawing board for you and I hope your participation at the UKC, YGTLC, KSTLC, NMSC as well as other <strong>KSEA</strong><br />

events is a very large dot that you can connect looking back later. As Steve Jobs said, you cannot connect the dots looking forward<br />

but you should create as many diverse dots now. <strong>KSEA</strong> exists to help its members succeed in the main stream of America.<br />

To help you find what you look for, <strong>KSEA</strong> will leave a light on for you. It is 3:<strong>40</strong> a.m. in Iowa City and I have just received this<br />

email from a member, “Thanks for your great work for <strong>KSEA</strong>. I was impressed with your talk. Of course, I am impressed with<br />

your passion and leadership. I heard <strong>KSEA</strong>’s great growth under your leadership.”<br />

Yeah! This will keep me going and going …<br />

4<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>


PRESIDENT OF <strong>KSEA</strong> VISITS THE NIH PIONEER AT HARVARD<br />

PRESIDENT OF <strong>KSEA</strong> VISITS THE NIH PIONEER AT HARVARD<br />

[Kyungjae Myung, <strong>KSEA</strong> Headquarter Operation Director]<br />

Senior Investigator<br />

National Human Genome Research Institute, NIH<br />

On a beautiful afternoon of February 9 th , after passing through historical brick<br />

buildings, I followed President Hosin Lee to the Cambridge Street where scientific<br />

department buildings with more modern styles are located. I read two previous<br />

interviews with Prof. Philip Kim of Columbia and Prof. John Kim of UCLA and I<br />

was excited to be a writer for this third article for Prof. Hongkun Park whom I call<br />

“Hyung”. He is not only a world-renowned scholar but also my staunch alumnus<br />

of elementary, middle school and college.<br />

The first impression I have received walking into Dr. Park’s office was “clean, neat,<br />

and organized.” President Lee quickly asked the first question, the same one that he<br />

asked to two previous interviewees, what his secrets are to achieve such a great success in his career. Dr. Park was very modest by<br />

saying “I do not believe I am successful yet.” However, thanks to our curious President, who kept insisting that it would help other<br />

<strong>KSEA</strong> members especially those in early career, Dr. Park told us that one major reason for his success was due to the people with<br />

whom he encountered; his mentors, colleagues, and students/fellows worked in his laboratory.<br />

President Lee asked his second question why he chose Stanford for his graduate study. Dr. Park told us, without hesitation, “because<br />

I was truly excited about the project that the professor at Stanford University, who became my Ph.D. advisor later, was working<br />

on.” He also added that he chooses students/fellows in his laboratory only if they express “the true enthusiasm”. (tip to become<br />

his student).<br />

He started as assistant professor at Harvard like everyone else but became a full professor<br />

with tenure in just four years (Note: Harvard university grants tenure to a full professor<br />

only). In President Lee’ opinion, he is the first (maybe second) <strong>Korean</strong>-<strong>American</strong><br />

who received tenure at Harvard. When Dr. Park received tenure, he also received a new<br />

startup fund from Harvard so that he could use it for starting a new line of research<br />

with high-risk and high-impact. Harvard even built a new building section where his 30<br />

students and post-docs are now working with the state-of-art research equipment. So,<br />

he initiated a new line of research in the field of nano-bio interfacing and neuroscience,<br />

where he believed many important scientific questions would still remain. His high-risk<br />

effort to a new direction became very fruitful with many papers published in the most<br />

prestigious journals like Nature, Cell, and Nature Nanotechnology. He also won the NIH’s most prestigious award called “NIH<br />

Pioneer Award.”<br />

Dr. Park then took us out for the most memorable lunch, particularly for President Lee<br />

who took the picture of us, at the Harvard Faculty Club. The atmosphere of the restaurant<br />

was the authentic Ivy League prestige. On the way to his laboratory after lunch, Dr. Park<br />

took us to the statue of the first benefactor of Harvard University, John Harvard. Thanks<br />

to the belief that the person who touches the left shoe of the statue becomes lucky to get<br />

admission to Harvard, the left toe of the statue was very shiny. Our curious President, of<br />

course, touched the shoe with a hope for his son will get an admission to Harvard for his<br />

graduate study.<br />

Dr. Park then gave us a tour of his laboratory. We were impressed with so many expensive<br />

looking research instruments and observed many students and post-doctoral fellows who<br />

were working hard. President Lee asked Dr. Park to pose in front of his instrument, but<br />

Dr. Park humbly declined it. Our tenacious President tried and started to chase Dr. Park<br />

who was running away from him. It was a very funny scene I would never forget. On the<br />

way back to the hotel, President Lee kept saying that he felt so proud to witness an increasing<br />

number of successful young (to him) <strong>Korean</strong>-<strong>American</strong> scientists in the US.<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 5


FEATURED ARTICLES<br />

NANO-BIO INTERFACING: LEVERAGING ADVANCES IN SEMICONDUCTOR TECHNOLOGY FOR<br />

BIOLOGICAL RESEARCH<br />

[Hongkun Park]<br />

Professor, Chemistry and Chemical Biology and Physics<br />

Harvard University<br />

Silicon integrated circuits represent an enormously successful paradigm for electronics – they are mass-produced at low cost in silicon<br />

foundries, and yet a chip with a footprint less than a square inch, is a highly integrated superstructure that contains hundreds of millions<br />

of transistors and can process data at gigahertz rates. Moreover, they contain top-down fabricated nanostructures whose sizes are<br />

comparable to important biological molecules and cells. As such, silicon nanostructures and integrated circuits have the potential to<br />

become a unique tool for interrogating living cells and organisms when a proper interface is developed.<br />

Over the past five years, a part of my group at Harvard has been working toward developing nano-bio interfaces that maximally utilize<br />

the advantages offered by these silicon nanostructures. 1-4 Our efforts have been centered on one particular structure: vertical silicon<br />

nanowire (SiNW) arrays. These nanoscale needles, which can be fabricated en masse using standard silicon processing technology,<br />

penetrate through the cellular membrane without compromising cell viability or function, thus providing direct intracellular access to<br />

a living cell. This unique capability, which is difficult to realize by any other means, provides an exciting opportunity for many branches<br />

of biological research. In my laboratory, we have been employing these nanoscale needles (1) to investigate the intracellular circuits<br />

that are responsible for the functions of immune cells, cancer cells, and stem cells by delivering various biological effectors 1-3 and (2) to<br />

monitor and control activities of brain cells in complex neuronal networks and tissues. 4<br />

SiNW nanoinjection for cell circuit perturbation: Efficient delivery of active biological effectors (DNAs, RNAs, peptides, proteins, or<br />

small molecules) into living cells is central to biological research and pharmaceutical screening. For instance, achieving a mechanistic<br />

understanding of intracellular molecular circuits requires systematic perturbation of circuit components and analysis of the resulting<br />

changes in cellular behavior. The success of this strategy depends critically on delivering various biological perturbants into living cells<br />

without compromising their viability or function.<br />

Because many biological effectors do not spontaneously cross the plasma membrane, a host of methods have been developed to deliver<br />

them into cells. Unfortunately, in a variety of primary cells, especially in resting immune cells, many of these techniques have proven<br />

ineffective, inducing non-specific inflammation or cell death. These limitations have severely restricted the use of perturbations in<br />

uncovering the ways in which these cells respond to extra- and intracellular signals, and have been a major obstacle to elucidating the<br />

molecular biology that underlies many hematological cancers. Clearly,<br />

the resistance of these cells to conventional means necessitates the development<br />

of new approaches.<br />

6<br />

Over the past few years, we have developed a new SiNW-based nanoinjection<br />

method that can serve as a minimally invasive and efficient<br />

method for delivering a variety of biomolecules into hard-to-transfect<br />

cells. 1-3 Specifically, we showed that the surface-coated SiNWs could efficiently<br />

administer active biomolecules directly into the cytoplasm of<br />

virtually any type of cell without impacting its viability or function (Figure<br />

1). 1 We then used the method to discover new components of the<br />

Toll-Like Receptor (TLR) network in mouse dendritic cells. 2 We also<br />

applied the method to investigate patient heterogeneity in chronic lymphocytic<br />

leukemia (CLL), the most common adult leukemia in North<br />

America. 3 By perturbing CLL cells using SiNW-mediated siRNA delivery,<br />

we identified three patient response groups, unclassifiable by known<br />

criteria, that required distinctly different clinical treatment schedules.<br />

These examples show that SiNWs can contribute greatly in cell circuit<br />

studies of otherwise hard-to-transfect cells: starting from the cells taken<br />

from a single blood draw, multiple different knockdowns could be used<br />

to simultaneously probe the importance of multiple potential pathways,<br />

enabling a detailed understanding of the intracellular circuitry critical<br />

for cell function and also the development of patient-specific combinatorial<br />

therapies.<br />

Figure 1. SiNW nanoinjection. Upper Image: a confocal image<br />

of a mouse dendritic cell on top of vertical SiNWs. Magenta: cell<br />

membrane, blue: cell nucleus, whilte: SiNW. Lower diagram: a<br />

model of the Polo-like-kinase-dependent pathway of the antiviral<br />

response in mouse dendritic cells.<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>


FEATURED ARTICLES<br />

Vertical nanowire electrode array for brain-machine interfacing: Neuronal networks – collections of neurons interconnected by<br />

synaptic junctions – form the physical basis of the central and peripheral nervous systems in biological organisms. The particular<br />

function of a neuronal network is determined by the intrinsic properties of its constituent neurons, the spatial connectivity among<br />

them, and the adaptive strengthening/weakening of those connections. Yet, developing a clear understanding of how these properties<br />

encode network function remains one of the major challenges of modern science.<br />

While recent advances in electron and optical microscopy have enabled the physical wiring diagram (the “structural connectome”) to<br />

be determined for small volumes of neural tissue, this structural information does not necessarily provide insight into the network’s<br />

function. Traditionally, functional behavior has been studied by optical imaging through the use of voltage and calcium sensitive dyes<br />

or electrophysiological measurements performed by extracellular electrode arrays. While these methods have significantly expanded<br />

our understanding of neuronal networks, they are fraught with significant shortcomings – for example, optical imaging provides only<br />

a time-averaged approximation of neuronal activity, while extracellular recording fails to provide clear signal-to-cell registry. Generating<br />

a high-resolution “functional connectome” requires the development of new experimental tools.<br />

Recently, we have developed a highly scalable intracellular electrode platform that<br />

is specifically designed to help address this issue by leveraging the same nanofabrication<br />

technology that enables mass-production of integrated silicon electronic<br />

circuits. 4 Our vertical nanowire electrode arrays (VNEAs) can intracellularly record<br />

and stimulate neuronal activity in dissociated cultures of rat cortical neurons and<br />

can also be used to map multiple individual synaptic connections (Figure 2). Moreover<br />

the VNEA platform can be readily coupled with conventional patch measurements,<br />

fluorescence microscopy, and optogenetic techniques, allowing truly multiplexed<br />

interrogation of a neuronal circuit. Although the prototype demonstrated<br />

to date has only 16 stimulation/recording sites, higher numbers and densities can<br />

easily be achieved using standard silicon nanofabrication processes. The integration<br />

of complementary metal-oxide-semiconductor circuitry with a VNEA would<br />

further allow on-chip digitization, signal multiplexing, compression, and telemetry.<br />

The scalability and high fidelity of this platform, combined with its compatibility<br />

with silicon nanofabrication techniques, should enable detailed mapping of synaptic<br />

connectivity in complex neuronal networks, thereby providing a transformative<br />

new tool for functional connectomics. The same platform will also allow the<br />

efficient high-throughput screening of candidate drug treatments for neurological<br />

disorders.<br />

Outlook: Above, I have provided a brief summary of the nano-bio research activities<br />

in my group. I should stress that our efforts represent just a small part of a much<br />

bigger landscape: many outstanding research groups are performing beautiful research<br />

in a closely related area, i.e., in applying nanoscience and technology to solve<br />

important biological problems. Over the past two decades, “nanoscientists” have<br />

amassed an impressive array of materials and tools that, when properly harnessed,<br />

should provide new ways of investigating biological problems. For this nascent field<br />

to flourish, however, more and better collaboration between nanoscientists and biologists<br />

will be essential. We should identify important problems and new opportunities<br />

in concert, and develop tools and perspectives that are designed to address<br />

them. I am confident that we can and, in time, we will.<br />

Figure 2. VNEA for neuronal recording and<br />

excitation. Upper left: an array of SiNWs capped<br />

by gold. The scale bar is 2 μm. Upper right: a rat<br />

cortical neuron on top of a recording/excitation<br />

pad. Lower graph: VNEA devices can be<br />

used to excite and record neuronal action potentials<br />

intracellularly, providing a highly scalable<br />

electrophysiology platform for neuroscience.<br />

References:<br />

1. A. K. Shalek et al. Proc. Natl. Acad. Sci. USA 107, 1870-1875 (2010).<br />

2. N. Chevrier et al. Cell 147, 853-867 (2011).<br />

3. A. K. Shalek et al. submitted (<strong>2012</strong>).<br />

4. J. T. Robinson et al. Nature Nanotech. 7, 180-184 (<strong>2012</strong>).<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 7


FEATURED ARTICLES<br />

SINGLE MOLECULE BIOLOGY: ONE, TWO, THREE & FOUR<br />

[Taekjip Ha]<br />

Professor, Physics<br />

Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Howard Hughes Medical Institute<br />

I call myself an accidental biophysicist. My Physics Ph.D work began in semiconductor physics and through a series of accidents I ended<br />

up developing methods to detect single fluorescence molecules. It turned out that the single molecule fluorescence methods could be<br />

applied to many biological systems and gradually my research topics shifted to biological questions, and although I teach physics in a<br />

physics department, all of the questions that we are addressing are biological in nature.<br />

Why would a physicist want to study biology? First, minimal functional units in biology are molecules and they can range between 1<br />

and 100 nm, the scale of current and future electronics. Second, biomolecules have been optimized through billions of years of evolution<br />

and often biological sensor reach the physical limits of sensitivity. A deep understanding of biological systems may ultimately lead<br />

to development of man-made nanomachines through reverse engineering. But is the population notion that biological molecules, for<br />

example proteins are nanomachines justified? For example, do the nanomachine have what man-made machines have such as engines<br />

and springs?<br />

The answer is a definitive yes for molecular motors that convert chemical energy stored in ATP or another high energy molecules into<br />

mechanical energy. A great example is myosin V which takes a 37 nm step along its track every time it consumes an ATP molecule as<br />

the fuel (Figure 1a). There was, however, a controversy as to whether myosin V walks on the track like a person (two feet alternating in<br />

position) or it crawls like a baby (one foot stays ahead of the other). Single molecule imaging and localization down to 1.5 nm precision<br />

led to a definitive proof that myosin V walks (1). This is an example of using detection of single fluorescent molecule to answer fundamental<br />

questions in biology (‘One’ in the title of this article).<br />

We recently made an exciting discovery that a protein can store elastic energy through multiple cycles of chemical energy release and<br />

that this stored energy can be released in a single burst (Gwangrog Lee et al., submitted). In this work, an enzyme that can digest RNA<br />

strand one base at a time even in the presence of basepaired structures was studied using another single molecule method called single<br />

molecule fluorescence resonance energy transfer (FRET). FRET measures the interaction between two dye molecules attached to a<br />

biological molecule and because FRET is a strong function of distance, it can report on even minute distance changes during biological<br />

reactions. In this particular work, we attached the dyes to the RNA so that FRET would increase during RNA unwinding by the enzyme<br />

(Figure 1b). The surprise was that the enzyme unwound RNA in large steps about 4 base pairs even though the motion is powered<br />

by RNA digestion in single base steps, strong suggesting the enzyme/RNA complex can be viewed as a spring. ‘Two’ in the title of this<br />

article refers to FRET and my laboratory has been fortunate to make several interesting discoveries on enzymes that work on DNA and<br />

RNA using the method.<br />

Figure 1. Protein as a nanomachine (a) A nanoengine.<br />

(b) A nano-spring.<br />

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FEATURED ARTICLES<br />

There is yet another powerful single molecule method called optical tweezers.<br />

Optical tweezers can be viewed as chopsticks made of light and can be used<br />

to apply and measure very small forces down to sub-pico Newtons (< 10 -12<br />

Newton) and measure small movements down to a few angstroms. We combined<br />

optical tweezers and single molecule FRET to measure conformational<br />

changes of a single molecule via FRET as a function of applied force (2). This<br />

led to a number of interesting findings, for example, how a protein that is fully<br />

wrapped by a DNA strand can rapidly migrate on the DNA (3)(Figure 2).<br />

I call this effort “Two+One” because we are combining FRET with an extra<br />

dimension of applied force.<br />

Thus far, most of single molecule biophysics experiments have been performed<br />

on one molecule in isolation largely due to technical difficulties but<br />

these molecules do not function in isolation in the cell. Therefore, in order to<br />

Figure 2. FRET and force. Optical tweezers can apply<br />

force to the DNA and FRET can be used to measure how<br />

the SSB protein’s motion is affected by DNA unraveling.<br />

better mimic the cellular conditions, we need to study biomolecular complexes with multiple components. We and others have made a<br />

technical push in this direction, for example pushing the single molecule fluorescence measurements to three and four colors (“Three<br />

and Four” in the title comes from this)(4), and combining single molecule fluorescence with ultrahigh resolution optical tweezers (5).<br />

Our dream experiment is to measure a complex cellular process such as copying of DNA using multi-dimensional single molecule<br />

techniques. For example, a three-axis optical tweezers can measure the progress of DNA copying with a single base pair resolution<br />

while at the same time, proteins labeled with different dyes can be visualized to report on which proteins participate in which step and<br />

how they change their structures and relative organizations (Figure 3).<br />

Figure 3. Multi-dimensional single molecule measurements<br />

of DNA copying process.<br />

In closing, I would like to emphasize the need to make connection between in vitro biophysical studies and in vivo functions. Systems<br />

biology is another contemporary discipline that rely on physical tools and mathematical modeling to understand the underpinnings<br />

of biological phenomena. There is now a growing connection between the two disciplines, spurred by new developments in cellular<br />

imaging and absolute quantification at the single molecule level, with the potential for facilitating a new quantitative understanding of<br />

biological processes. The interface between these two fields holds a great promise of fertile interaction and new discovery.<br />

REFERENCES<br />

1. A. Yildiz et al., Science 300, 2061 (2003).<br />

2. S. Hohng et al., Science 318, 279 (Oct 12, 2007).<br />

3. R. Zhou et al., Cell 146, 222 (Jul 22, 2011).<br />

4. J. Lee et al., Angew Chem Int Ed Engl 49, 9922 (Nov 23, 2010).<br />

5. M. J. Comstock, T. Ha, Y. R. Chemla, Nature Methods 8, 335 (2011).<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 9


TECHNICAL ARTICLES<br />

MICROSTRUCTURALLY DESIGNED HIERARCHAL ALUMINUM METAL MATRIX COMPOSITES<br />

[Yongho Sohn]<br />

Professor, Materials Science and Engineering<br />

University of Central Florida, Orlando<br />

INTRODUCTION<br />

Nanostructured Al-alloy based MMCs have gained considerable interest due to their excellent properties (i.e., high strength, low<br />

density, good corrosion resistance), and their technical and economical ease of manufacturing. Recently, a hierarchal MMC consisting<br />

of a nanocrystalline Al phase (NC-Al), boron carbide (B4C) reinforcement particles, and a coarse-grain Al phase (CG-Al) has<br />

been successfully fabricated and reported to exhibit extremely high compressive yield strength ( > 1 GPa) and tailorable ductility<br />

(~ 15%) [1,2]. In particular, high strain-rate dependent materials have found their way into aerospace, automotive, biomedical, and<br />

defense application. These properties are achieved through control of the microstructure that is dependent on parameters of materials<br />

processing and manufacturing. The hierarchical Al-MMCs exhibit good thermal stability and microstructural characteristics<br />

that deflect or blunt or bridge crack propagation. The microstructure and properties can be further customized through the use of<br />

friction stir processing [3] which offers a variety of possibilities for joining components of dissimilar geometry, modified and graded<br />

microstructure and composition.<br />

MATERIALS PROCESSING AND MANUFACTURING<br />

The commercial gas-atomized AA5083 Al powder has an average particle size of less than 45 μm with a grain size ranging from 0.2<br />

to 2 μm. The B4C powder has a starting particle size between 1 to 7 μm. The 5083 Al powder is combined with B4C powder and cryomilled<br />

for up to 24 hours. The powders are ball-milled in the presence of liquid N2 to increase friability, prevent oxidation and mitigate<br />

dynamic recrystallization. Commercially available stearic acid is utilized as a process-control agent during milling to prevent excessive<br />

agglomeration of the powders and improve yield. Cryomilling is a key step that produces the Al grain size down to 20-30 nm<br />

[4,5], disperses the B4C into the Al matrix and creates the NC-Al/B4C bond. Other strengthening mechanisms are generated during<br />

this process including dislocation entanglement, dispersoids strengthening and complex interface development. After cryomilling,<br />

additional AA5083 powder (CG-Al) is blended with the cryomilled mixture, which in turn creates the hierarchal MMC powders.<br />

The powder samples are degassed<br />

through a rotary dynamic vacuum<br />

degassing system. The degassed<br />

powders are then consolidated into<br />

billets with established powder metallurgy<br />

techniques such as vacuum<br />

hot pressing, cold isostatic pressing,<br />

or hot isostatic pressing. Secondary<br />

processing is achieved through<br />

conventional wrought processing<br />

techniques such as extrusion, forging,<br />

and/or rolling. Figure 1 illustrates<br />

the complete manufacturing<br />

processing steps of the hierarchal Al<br />

Figure 1. Manufacturing sequence of hierarchal Al metal matrix composites<br />

MMCs examined in this study.<br />

NOVEL MICROSTRUCTURAL FEATURES OF HIERARCHAL COMPOSITES<br />

Extensive microstructural and spectroscopic analyses were carried out as a function of processing parameters. The properties of<br />

hierarchal Al MMCs were influenced by multiple microstructural features including: (1) volume (or weight) fraction of each constituent,<br />

NC-Al, CG-Al and B4C; (2) grain size and distribution of the NC- and CG-Al; (3) size and distribution of the B4C particle<br />

reinforcement; (4) size and distribution of hierarchal microstructural domains, e.g., CG-Al and B4C/ NC-Al agglomerates; (5)<br />

dislocation densities the in NC- and CG-Al; (6) composition, distribution and structure of nitrogen incorporated during cryomilling<br />

either in solution or as a dispersoid reinforcement; (7) characteristics of grain boundaries and interfaces (e.g., NC-Al and B4C,<br />

NC-Al and CG-Al, CG-Al and B4C); (8) other impurity-associated strengthening by solution or dispersion reinforcements.<br />

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TECHNICAL ARTICLES<br />

Characteristic microstructure of consolidated hierarchical<br />

Al MMCs is presented in Figure 2. The light grey region<br />

is the CG AA5083 Al, and the darker grey regions<br />

are the nano-agglomerate that consists of cryolmilled<br />

NC-Al and B4C. The dark “spots” within the nano-agglomerate<br />

are B4C particulates. Grain size within NC-<br />

Al region has been examined by hollow-cone dark field<br />

(HCDF) TEM imaging for statistically confident analyses,<br />

and ranges from 30-50 nm after primary consolidation<br />

as presented in Figure 2 [6]. The primary reinforcement,<br />

B4C is evenly dispersed throughout the NC-Al<br />

agglomerate and typically has a narrow distribution of<br />

size. The typical grain size of the CG-Al is 0.2 to 2 μm.<br />

The CG-Al is added to promote ductility and interact<br />

with cracks propagating through the composite. Cracks<br />

Figure 2. Novel microstructural features of hierarchal Al-MMCs<br />

propagate easily through the brittle NC-Al/B4C region,<br />

but are deflected or blunted or bridged upon reaching the CG as seen in Figure 2 [6]. This behavior gives the composite toughness.<br />

Nitrogen is absorbed by the NC-Al during cryomilling, and manifest as AlN crystals and amorphous, N-rich dispersoids that<br />

are usually found at the NC-Al grain boundaries [5-7]. Nitrogen concentration was found to vary linearly with milling time of<br />

up to 24 hours [8]. Other dispersoids that have been observed through microstructural interrogation are oxides and carbides<br />

[6]. Fe- and Mn-rich dispersoids are also found in both the NC-Al and CG-Al regions. These dispersoids can help contribute<br />

to the excellent thermal stability exhibited by this composite [7]. It is noted, however, that under both thermal and mechanical<br />

deformation, the NC-Al grains can grow significantly. Yao et al. found that the average NC-Al grain size after cryomilling was<br />

about 20 nm, and after secondary processing (high temperature and stress for an extended time), the NC-Al grain size increased<br />

to over 100 nm [8].<br />

As a result of cryomilling the NC-Al grains retain a high strain energy in the form of dislocations. After consolidation, some of<br />

these dislocations are annihilated while deformation during secondary processing can introduce new dislocations into the CG-<br />

Al. Yao et. al estimated, based on HCDF technique, the dislocation density of the NC-Al and CG-Al after secondary processing<br />

to be about 1.9·1016 m-2 and 1.2·1015 m-2 respectively [9].<br />

ACKNOWLEDGEMENT<br />

Research was sponsored by U.S. Army Research Laboratory and was accomplished under Cooperative Agreement<br />

W911NF-08-2-0026. The views, opinions, and conclusions made in this document are those of the authors and should not be<br />

interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government.<br />

The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any<br />

copyright notation herein.<br />

REFERENCES<br />

1. J. Ye, B.Q. Han, Z. Lee, B. Ahn, S.R. Nutt, J.M. Schoenung, Scr. Mater., 53 (2005) 481.<br />

2. H. Zhang, J. Ye, S.P. Joshi, J.M. Schoenung, E.S.C. Chin, K.T. Ramesh, Scr. Mater., 59 (2008), 1139.<br />

3. Y.H. Sohn, T. Patterson, C. Hofmeister, C. Kammerer, W. Mohr, M. van den Bergh, M. Shaeffer, K. Cho, J. Metals,<br />

64 (<strong>2012</strong>) 234.<br />

4. D.B. Witkin, E.J. Lavernia, Prog. Mater. Sci., 51 (2006) 1.<br />

5. E.J. Lavernia, B.Q. Han, J.M. Schoenung, Mater. Sci. Eng. A, 493 (2008) 207.<br />

6. B. Yao, C. Hofmeister, T. Patterson, Y. H. Sohn, M. van den Bergh, T. Delehanty, K. Cho, Composites A, 41 (2010) 933.<br />

7. C. Hofmeister, B. Yao, Y. H. Sohn, T. Delahanty, M. van den Bergh, K. Cho, J. Mater. Sci., 45 (2010) 4871.<br />

8. B. Yao, B. Simkin, B. Majumdar, C. Smith, M. van den Bergh, K. Cho, Y.H. Sohn, Mater. Sci. Eng. A, 536 (<strong>2012</strong>) 103.<br />

9. B. Yao, H. Heinrich, K. Cho, Y.H. Sohn, Micron, 42 (2011) 29.<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 11


TECHNICAL ARTICLES<br />

MICRO GAS CHROMATOGRAPHY SYSTEM FOR DISTRIBUTED ENVIRONMENTAL AWARENESS<br />

[Hanseup Kim, <strong>KSEA</strong> Membership Director]<br />

USTAR Assistant Professor, Electrical and Computer Engineering<br />

University of Utah<br />

INTRODUCTION<br />

The World Health Organization (WHO) states that 2.4 million people die each year worldwide from causes directly attributable to<br />

air pollution (1). In US the fatalities from air pollution, totaling over 70,000 lives in 2002, are twice the number of automobile fatalities<br />

and are equal to deaths from breast cancer and prostate cancer combined (2). Hundreds of scientific studies conducted worldwide<br />

have provided evidences that polluted air has alarming adverse effects on health (3). Clearly, the exposure to air pollution needs<br />

to be dramatically reduced or at least monitored for individuals. While the air pollutants include various chemical compounds, such<br />

as ozone, nitrogen oxides, and sulfur dioxide, Volatile Organic Compounds (VOCs) cover the largest number of >100 pollutants<br />

and are the most common pollutants exposed to humans who spend a significant amount of time indoors. Another report from<br />

EPA states that the indoor air pollution caused by VOCs is ten times higher than outdoor regardless of the building location in rural<br />

or highly industrial areas (4). VOCs are also found to have strong correlation with allergies and asthmas, and each individual has<br />

different levels of responses to specific VOCs (5, 6). Thus, the development of a personal ‘wearable’ warning system against a wide<br />

range of VOCs is much needed to prevent significant harm to public health from nearly inevitable exposure. Currently there are no<br />

viable options for such needs.<br />

MICRO GAS CHROMATOGRAPHY SYSTEM<br />

A micro gas chromatography system (μGC) can be a best option as a ‘wearable’ VOC measurement tool. Compared to commercial<br />

gas sensors that have narrowly-limited detection targets (e.g. carbon monoxide sensor), a gas chromatography (GC) system could<br />

provide much higher detection capacity of >10’s species and seems a more feasible option for miniaturization than mass spectrometry<br />

(MS), because of its ‘less’ requirements for supporting equipments (no vacuum pumps or carrier gases). Indeed a GC is the most<br />

widely used tool in analytical chemistry. Currently MS has proven to be more difficult to miniaturize due to the vacuum pumping<br />

requirements as well as the need to purifying samples before analysis. The state-of-the-art “portable” MS still weighs over 11kg,<br />

consumes >42W, and has the size of a backpack. Note that the miniature GCs also hold significant advantages of high-speed & highresolution<br />

detection, tiny volume, reduced power, as well as the possible ‘wearable’ portability.<br />

Operation Principle: A micro gas chromatograph enables the detection of complex mixtures of ~100 airborne compounds by first<br />

spatially separating and then detecting them along fluidic migration. To do so, it incorporates additional components than the standalone<br />

gas sensor, including a pre-concentrator, a separation column and a fluidic pump (Figure 1). The pre-concentrator collects<br />

targets into high concentration for better sensitivity; the column provides a race track where target species are separated in space<br />

and time to enhance selectivity at the detection sensor; and the micropump forces the target samples to flow at the optimal speed<br />

for efficient separation as well as the rapid detection. Specifically, the spatial separation among compounds is achieved in the column<br />

where special coating inside, called as a stationary phase, adsorbs and releases the different target molecule groups at different<br />

speeds. Resultantly each group of gas molecules becomes apart as they pass through the column. Thus, each group passes by a sensor<br />

at different times and produces a train of peak signals at a micro sensor for detection.<br />

Figure 1. The operation principle of the gas chromatography system: Spatial separation ahead of detection<br />

reduces the burdens on the sensor’s selectivity and sensitivity.<br />

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TECHNICAL ARTICLES<br />

HYBRID MICRO GC<br />

The first micropump-driven micro gas chromatography<br />

system has been demonstrated,<br />

with a total device volume of 0.5 cc (Figure<br />

2). The μGC samples separates and detects airborne<br />

11-mixture VOCs at high-speed (


TECHNICAL ARTICLES<br />

INTERCONNECTED NETWORK OF THE CELL CYCLE, CIRCADIAN RHYTHMS,<br />

AND DNA DAMAGE RESPONSE<br />

[Christian Hong]<br />

Assistant Professor, Molecular and Cellular Physiology<br />

University of Cincinnati College of Medicine<br />

Fundamental cellular processes that maintain most organisms’ health and survival include cell cycle, DNA damage response, and<br />

circadian rhythms. Cell cycle is equipped with multiple checkpoints for controlled growth, DNA replication, and divisions. DNA<br />

damage response (DDR) mechanisms control cell fate by either repairing single or double strand breaks, or triggering apoptosis for<br />

programmed cell death when the damage is fatal. Last, but not least, is circadian rhythm that keeps track of time of a day, and plays a<br />

central role in most organisms for setting the sleep/wake cycle, feeding rhythms, and other daily activities. These distinct molecular<br />

mechanisms communicate with each other and create a complex bio-molecular network to optimize conditions for cells to grow and<br />

adapt to the surrounding environment. Perturbations and dysfunctional cellular responses in this network may lead to diseases such<br />

as cancer, obesity, and sleep disorders among many others.<br />

Figure 1. Simple schematic of<br />

time-delayed negative feedback<br />

loop of Neurospora circadian<br />

rhythms<br />

The mechanistic blueprints of circadian rhythms are similar from Neurospora crassa to Mus musculus<br />

[1]. In Neurospora, the heterodimeric transcription factor, WCC that contains a conserved PAS<br />

domain, activates a core clock component designated frq. The FRQ protein translocates into the<br />

nucleus and inhibits its own transcription factor, WCC. In brief, this creates a time-delayed negative<br />

feedback loop, which is at the heart of circadian rhythms [1] (Figure 1). While this circuit may be<br />

at the core of the circadian clock system, its operation, however, is much more complex involving<br />

interlocked feedback loops, transcriptional, post-transcriptional, and post-translational regulations<br />

[2].<br />

Cell cycle and circadian rhythms are coupled despite their discrete functions. The circadian gated<br />

cell division cycles are observed in various organisms from cyanobacteria to mammals [3-6]. A<br />

mammalian circadian transcription factor, BMAL1/CLOCK, directly binds the E-box in the Wee1<br />

promoter and activates its transcription. WEE1 is one of the key cell cycle kinase that phosphorylates and inactivates the Mitosis<br />

Promoting Factor (MPF) that facilitates the entry into the mitosis. The abundance and activity of WEE1 have been shown to oscillate<br />

and be transiently elevated during the evening in mouse liver [5]. These, in turn, determine the duration of G2-phase. Cells divide<br />

in late evening when the WEE1 level decreases in order to allow cells to enter into the M-phase. The component of the cell cycle<br />

that is controlled by WEE1 operates in concert with another regulatory system that is<br />

periodically imposed on WEE1 by the circadian clock.<br />

The above seemingly unidirectional communication was recently shown to be conditionally<br />

bidirectional. DNA damage induces responses that arrest the cell cycle, or<br />

lead to programmed cell death, e.g. apoptosis. Ionizing radiation causes DNA doublestrand<br />

breaks that trigger signaling cascades via ATM and CHK2 [7]. In Neurospora<br />

crassa (filamentous fungi) and in mammals, the CHK2 checkpoint kinase physically<br />

interacts with a core clock components, FRQ and PER1 [8, 9], respectively, and represents<br />

an intersection point between cell cycle regulation and the circadian clock.<br />

The CHK2 kinase phosphorylates and promotes premature degradations of FRQ/<br />

PER1, which creates phase shifts in the circadian clock (Figure 2). The implications of<br />

such a phenotype raise the hypothesis that the cell cycle machinery utilizes circadian<br />

rhythms to activate WEE1/SWE1 by prematurely degrading FRQ [10]. This degradation<br />

removes the negative feedback on its transcription factor, WCC, which will then<br />

activate Swe1 and arrest cell cycle progression and provide time for DNA repair. There<br />

are additional candidates that participate in the molecular coupling of the cell cycle<br />

and the circadian clock. The transcript of c-Myc oscillates with a circadian period,<br />

and its transcription is suppressed by a heterodimeric circadian transcription factor,<br />

BMAL1/NAPS2 [11]. The molecular details of this coupling, however, remain unex-<br />

Figure 2. DNA damage activates Chk2, which<br />

phosphorylates one of the core circadian clock<br />

component, PER1 in mammals and FRQ in<br />

Neurospora, resulting in phase shifts of circadian<br />

rhythms<br />

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TECHNICAL ARTICLES<br />

plored. Additional cell cycle genes such as CyclinD1, Gadd45α, and Mdm-2 also produce transcripts whose abundance oscillates, but<br />

details of how they are regulated remain unknown [11]. The rhythmic CyclinD1 transcripts suggest a role of the circadian clock at<br />

the G1 to S transition as well as the G2 to M transition due to the activity of WEE1. Furthermore, the rhythmicity of the Gadd45α<br />

and Mdm-2 transcripts suggests that the circadian clock plays a regulatory role in cellular responses to DNA damage.<br />

In our lab, we investigate connections between circadian rhythms, cell cycle, and DNA damage response as interconnected networks.<br />

Each cellular mechanism is complex with multiple feedback loops. Therefore, we use mathematical modeling to investigate<br />

network dynamics arising from these interlinked cellular processes, and experimentally validate model-driven hypotheses in Neurospora<br />

crassa (Figure 3). Iterative approaches of mathematical modeling and experimental validations maximize synergy dissecting<br />

intertwined molecular mechanisms of the above three processes. Detailed investigation of these interactions will lead to better<br />

understanding of functional roles of circadian rhythms in the cell cycle and DNA damage response.<br />

Figure 3. Interdisciplinary approach to dissect molecular mechanisms of circadian rhythms and other cellular processes<br />

such as cell cycle. Molecular wiring is converted into a set of ordinary differential equations that provide hypotheses and<br />

guide experiments.<br />

References:<br />

[1] Dunlap, J. C. 1999. Molecular bases for circadian clocks. Cell 96:271-290.<br />

[2] Heintzen, C., and Y. Liu. 2007. The Neurospora crassa circadian clock. Adv Genet 58:25-66.<br />

[3] Sweeney, B. M., and J. W. Hastings. 1958. Rhythmic cell division in populations of Gonyaulax polyedra. J Protozool 5:217-224.<br />

[4] Edmunds, L. N., Jr. 1974. Phasing effects of light on cell division in exponentially increasing cultures of Tetrahymena grown at<br />

low temperatures. Exp Cell Res 83:367-379.<br />

[5] Matsuo, T., S. Yamaguchi, S. Mitsui, A. Emi, F. Shimoda, and H. Okamura. 2003. Control mechanism of the circadian clock for<br />

timing of cell division in vivo. Science 302:255-259.<br />

[6] Yang, Q., B. F. Pando, G. Dong, S. S. Golden, and A. van Oudenaarden. 2010. Circadian gating of the cell cycle revealed in single<br />

cyanobacterial cells. Science 327:1522-1526.<br />

[7] Pardo, B., B. Gomez-Gonzalez, and A. Aguilera. 2009. DNA repair in mammalian cells: DNA double-strand break repair: how<br />

to fix a broken relationship. Cell Mol Life Sci 66:1039-1056.<br />

[8] Pregueiro, A. M., Q. Liu, C. L. Baker, J. C. Dunlap, and J. J. Loros. 2006. The Neurospora checkpoint kinase 2: a regulatory link<br />

between the circadian and cell cycles. Science 313:644-649.<br />

[9] Gery, S., N. Komatsu, L. Baldjyan, A. Yu, D. Koo, and H. P. Koeffler. 2006. The circadian gene per1 plays an important role in<br />

cell growth and DNA damage control in human cancer cells. Mol Cell 22:375-382.<br />

[10] Hong, C. I., J. Zamborszky, and A. Csikasz-Nagy. 2009. Minimum criteria for DNA damage-induced phase advances in circadian<br />

rhythms. PLoS Comput Biol 5:e1000384.<br />

[11] Fu, L., H. Pelicano, J. Liu, P. Huang, and C. Lee. 2002. The circadian gene Period2 plays an important role in tumor suppression<br />

and DNA damage response in vivo. Cell 111:41-50.<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 15


TECHNICAL ARTICLES<br />

COOPERATIVE CONTROL AT TRAFFIC LIGHT HARNESSED BY WIRELESS CARS<br />

[Byungkyu “Brian” Park, <strong>KSEA</strong> Publication Director I]<br />

Associate Professor and Graduate Program Director, Civil and Environmental Engineering<br />

University of Virginia<br />

INTRODUCTION<br />

Figure 1. Two Schools of Fish Moving<br />

through “Fish Intersection”<br />

Everyone hates waiting at traffic lights. As more cars travel through the urban streets, it<br />

is inevitable that cars have to stop at the intersection – this happens whenever demand<br />

exceeds supply as we understand from the Economics 101 class. This is common at the<br />

intersections in metropolitan areas where an intersection has to serve cars from multiple<br />

approaches. Does it happen to fish? Not really! As shown in Figure 1, anyone enjoys scuba<br />

diving would have seen how two schools of fish moves through “fish intersection” without<br />

collision (IEEE, 2004). One might wonder why cars cannot cooperatively move just like the<br />

fish! Obviously, it is not likely for cars unless human drivers completely give up their egos<br />

and cooperative control becomes possible. To ensure cooperative control, cars should be<br />

able to effectively communicate and an algorithm should be devised. A recent US Department<br />

of Transportation’s initiative on Connected Vehicle technology presents a possibility<br />

of such cooperative control based on wireless communications among vehicles and infrastructure<br />

(US Department of Transportation).<br />

METHODS<br />

A driver may travel through an intersection without stopping when the intersection is controlled by YIELD sign and there is sufficient<br />

gap available. This happens when there are few cars. As more cars try to cross the intersection, drivers have to stop at the intersection<br />

and have to look for safe gaps. What if wireless cars that are capable of communicating each other within a certain distance<br />

are abundant waiting for cooperative control? Then, one can predict car’s trajectory to the intersection area where collision might<br />

occur. As shown in Figure 2, a collision between two conflicting trajectories (i.e., cars movements) at the intersection is about to<br />

happen (see the two trajectories cross at lw area, representing intersection area), but the collision could be avoided with trajectory<br />

adjustments. An easy option would be that one car goes faster and the other car goes slower than their current speeds. The trajectory<br />

adjustments mean that cars will cooperatively adjust their acceleration rates to avoid collision. This approach can be formulated as a<br />

nonlinear constrained optimization (Lee & Park, <strong>2012</strong>). The objective function minimizes overlaps among conflicting cars within the<br />

intersection collision area, while constraints include minimum and maximum acceleration rates, minimum and maximum speeds,<br />

and minimum headway between cars.<br />

Figure 2. Concept of Cooperative Control Algorithm<br />

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TECHNICAL ARTICLES<br />

Figure 3. A Snapshot of an Intersection under Cooperative<br />

Vehicle Intersection Control<br />

There are a few solution approaches to the proposed nonlinear constrained<br />

optimization problem. Both analytical and heuristic approaches<br />

are considered. The former includes active set method (ASM) based on<br />

Sequential Quadratic Programming and interior point method (IPM)<br />

based on the calculation of the Karush-Khun-Tucker (KKT) conditions.<br />

A known limitation in these algorithms is that their solution depends on<br />

an initial solution and may not converge to acceptable solution. The latter<br />

include genetic algorithm and shuffled frog leaping algorithm that are<br />

based on the evolution and natural selection. It is generally understood<br />

that the latter heuristic algorithms have often better chance to find an<br />

acceptable solution while they need longer computation time. Figure 3<br />

shows an example of the proposed cooperative control realized in a virtual<br />

world based on the solutions could be found from these algorithms.<br />

PERFORMANCE EVALUATION<br />

To conduct an evaluation, it is assumed that cars are fully automated, optimal controls are developed and implemented for real-time<br />

cooperative control and no communication latencies exist between cars and infrastructure. To quantify the benefits of the proposed<br />

cooperative control algorithm, mobility and sustainability measures including travel time, stop delay, CO 2<br />

emissions and fuel consumptions<br />

were utilized. A hypothetical intersection was developed using a microscopic traffic simulation model, VISSIM, and multiple<br />

volume scenarios were generated through an experimental design. To establish baseline performance, the intersection control<br />

based on actuated control (AC) was used. It is noted that AC is the state of practice control method most commonly used in the traffic<br />

light control.<br />

The overall performances of the proposed algorithm compared to an actuated control (AC) are summarized in Table 1. The proposed<br />

approach reduced the total stop delay times by 99%. Total travel times and throughputs were also improved by 33% and 8%, respectively.<br />

Air quality and energy savings were also significant: 44% reduction of CO 2<br />

emissions and 44% reduction in fuel consumption.<br />

Measure Measure (Unit) Proposed AC Gain<br />

Mobility Average total stop delay time (Hour) 0.1 12.1 99%<br />

Measures<br />

Average total travel time (Hour) 25.1 37.2 33%<br />

Sustainability Carbon Dioxide (CO2) (ton) 263.7 471.0 44%<br />

Measures<br />

Fuel Consumption (Liter) 120.9 215.2 44%<br />

Table 1. Evaluation Results between the Proposed and Actuated Control<br />

CONCLUDING REMARKS<br />

Based on a simulation-based study at a hypothetical intersection, the potential improvements of the cooperative control over conventional<br />

actuated control were evaluated under varying traffic congestion conditions. The results showed that the cooperative control<br />

outperformed conventional actuated control.<br />

It is recommended several factors should be carefully considered and evaluated through physical and simulation test-beds before<br />

deploying the proposed cooperative control in the real world. These factors including system architecture (i.e., central, distributed or<br />

hybrid controls), protocols on vehicle-to-vehicle and/or vehicle-to-infrastructure communications, solution algorithm and computation<br />

power should be determined to ensure that the feasibility of the real-time implementation is guaranteed.<br />

REFERENCES<br />

IEEE. (2004, February). Cooperative Control School. IEEE Control Magazine, p. 104.<br />

Lee, J., & Park, B. (<strong>2012</strong>). Development and Evaluation of a Cooperative Vehicle Intersection Control Algorithm under the Connected<br />

Vehicles Environment. IEEE Transactions on Intelligent Transportation Systems,, 81-90.<br />

US Department of Transportation. (n.d.). Retrieved March 30, <strong>2012</strong>, from Connected Vehicle Technology Website: http://www.its.dot.<br />

gov/connected_vehicle/connected_vehicle.htm<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 17


WORKSHOP ON INTRODUCTION TO INSTITUTE FOR BASIC SCIENCE<br />

WORKSHOP TO INTRODUCE THE INSTITUTE FOR BASIC SCIENCE (IBS)<br />

AND ADVISORY COMMITTEE MEETING FOR VICE MINISTER CHANG-KYUNG KIM<br />

OF MEST IN BOSTON ON FEBRUARY 8-9, <strong>2012</strong><br />

Administrative Director Kyung-Taek Chung and his staff member of<br />

IBS introduced the newly established research institute that aims at<br />

leading the basic science research in the world. IBS is the first major<br />

establishment as part of the large-scale comprehensive International<br />

Science and Business Belt (ISBB) project in Korea. Audience was impressed<br />

about the opportunity and felt that IBS is destined to become<br />

a “research institute of scientists’ dream” where world-class scientists<br />

can undertake research with the utmost freedom and autonomy. As<br />

you can see in the photo, IBS provided a dinner to all participants at<br />

the Inn at Harvard.<br />

A workshop for introducing Institute for Basic Science (IBS, www.ibs.re.kr),<br />

Daejeon, Korea, was held at the Inn at Harvard on February 8-9, <strong>2012</strong>. Nearly<br />

100 young scientists and engineers were in attendance for the introduction<br />

of IBS event on the February 8 th , and 15 distinguished scientists and<br />

engineers attended the advisory committee meeting for IBS on February<br />

9 th . Both events started with a motivational speech by Vice Minister Chang-<br />

Kyung Kim of Ministry of Education, Science and Technology, wearing a<br />

red MIT alumnus shirt, who captivated the audience about the opportunity<br />

for basic research in Korea with his humor. During the Q&A session, he<br />

took off his jacket to show off his red shirt with a MIT logo saying it is too<br />

hot in the room. Young scholars were impressed with his straightforward<br />

answers to their pointed questions.<br />

Next day, 15 distinguished scholars were invited to give inputs to Dr. Chang-Kyung Kim and top officials of IBS. President Hosin<br />

Lee, Advisor Jim Gates, Editorial Board Hongkun Park, Former President Nakho Sung, Former President Kang-Won Wayne Lee,<br />

Executive Director Yongho Sohn, TG Director Eun-Suk Seo, HO Director Kyungjae Myung (NIH) and other distinguished scholars<br />

from Harvard took their time to help them start a world-class basic research institute with new perspectives. The meeting lasted<br />

nearly three hours and covered many different aspects of IBS from philosophy of research to very-detailed-practical operations.<br />

Each advisory committee member gave her/his advice on the operation of IBS and Vice Minister Kim took his time in responding<br />

to each piece of advice. All participants came away with the positive perspective for the new research institute that would lead the<br />

world with a great leadership.<br />

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<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>


MOU SIGNED WITH ADVANCED TECHNOLOGY CENTER ASSOCIATION (ATCA)<br />

MOU BETWEEN <strong>KSEA</strong> AND ATCA<br />

DURING A WORKSHOP AT SILICON VALLEY ON MARCH 5, <strong>2012</strong><br />

Advanced Technology Center Association (ATCA) (atca.or.kr) is an invitation-only association that consists of “World-Class” companies<br />

(typically small to medium sized) that strive for world’s largest market share for their products. More than 30 CEOs and<br />

Chief Technologists from ATCA members seeking recent technology trends and business opportunities gathered at KOTRA office<br />

in Silicon Valley for a workshop on March 5, <strong>2012</strong>.<br />

The workshop began with three technical presentations covering IT, Device Technology and<br />

Materials. Prof. Simon Shim from San Jose State University presented recent trends on computing<br />

technology with emphasis on storage technology and planning along with future strategies<br />

for business start-up and IP development. Then, Prof. Hanseup Kim (<strong>KSEA</strong> Membership Director)<br />

from University of Utah presented an overview of micro-devices and materials needs<br />

for energy and biological applications including optimization of energy harvesting. He also<br />

presented a world of biological system as fascinating electrical systems signals and chemical<br />

signals, where fluid control is critical to emulate.<br />

Finally, Prof. Yongho Sohn (<strong>KSEA</strong> Executive Director) from University of Central Florida presented<br />

a perspective on world’s energy production and recent research trends for coatings in<br />

advanced gas turbines and superlight-weight hierarchal hybrid composites.<br />

President Hosin Lee gave an introduction of <strong>KSEA</strong> and concluding remarks. The workshop<br />

concluded with a signing ceremony of MOU between <strong>KSEA</strong> and ATCA. Chapter President Jun<br />

Young Huh of <strong>KSEA</strong> Silicon Valley Chapter and his staff joined us for the MOU ceremony. The<br />

event was capped with a dinner hosted by ATCA. During a dinner time representatives from<br />

participating companies briefly introduced their product lines and future R&D interests.<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong><br />

19


KSTLC <strong>2012</strong><br />

MESSAGE FROM THE CONFERENCE CO-CHAIRS & WELCOMING RECEPTION<br />

SUMMARY OF KSTLC <strong>2012</strong><br />

“PIONEERING THE FUTURE”<br />

Conference Co-Chairs<br />

Hyunkyung Kathy Lee, DaEun Rachel Park, YeEun Sarah Rhee<br />

The 1 st <strong>Korean</strong> Student Technical and Leadership Conference (KSTLC) held in Chicago during March 16-18, <strong>2012</strong> was a great success<br />

with over a hundred students and young professionals from all across the US. All programs including the welcoming reception,<br />

keynote speaker presentations, career panels, technical poster session, advanced presentation workshop, and even the evening<br />

social events could not have been possible without the great leadership of Dr. Byoung-Do Kim (<strong>KSEA</strong> YG Director 1) and the many<br />

hours put in by our 25+ dedicated volunteer organizers.<br />

KSTLC <strong>2012</strong> rang its starting bell with an opening remark by <strong>KSEA</strong> President Hosin “David” Lee (University of Iowa). Along with<br />

his expression of <strong>KSEA</strong>’s devotion to the YG movement, our two distinguished keynote speakers, Dr. Chul Ahn (UT Southwestern)<br />

and Dr. Esther Yang (Abbott Lab), gave insightful presentations on how to construct successful lives as scientists and engineers and<br />

on the expanding roles of scientists and engineers in global economy. Beyond speaker presentations, our participants were privileged<br />

to attend special workshops on networking and presentation skills by Mr. Dan Conrod (Dale Carnegie) and Dr. Dan Moser<br />

(Northwestern University). Additionally, through the Career Development Workshop, the participants were able to attend a panel<br />

discussion consisting of distinguished members from academia, industry, national research, or medicine and pharmaceutics. The<br />

participants had opportunities to interact with the panels by asking questions and expressing their concerns on specific topics that<br />

are related to corresponding area of interest. Afterwards, the poster presentation session was held for about two hours and over<br />

sixty participants presented their research findings to the fellow peers at the conference.<br />

On behalf of the <strong>KSEA</strong>, 25 volunteer organizers, and over a hundred KSTLC participants, we would like to send our sincere appreciation<br />

to our our corporate sponsors of KEIT, KOSEN21, KWiSE, and LG Electronics as well as patrons of Chul Ahn, Hosin<br />

Lee, Hanseup Kim and Yongho Sohn for financial support of KSTLC <strong>2012</strong>.. Lastly, to all attendees, we would like to thank you for<br />

all the effort and active participation which allowed KSTLC <strong>2012</strong> to have a great start. Each individual’s presence was an asset to the<br />

conference in creating an exciting, nurturing, and diverse atmosphere among the most talented <strong>Korean</strong>-<strong>American</strong> future leaders<br />

in science and engineering field. We truly hope this conference was guidance in shaping you into the future pioneers of the world.<br />

Let us meet all again in KSTLC 2013.<br />

WELCOMING RECEPTION<br />

[Session Chairs: Tae Gyun Chung, Dongjun Kim]<br />

Undergraduate Students, University of Southern California<br />

The 1 st KSTLC welcomed its participants at the reception with a welcoming<br />

speech by <strong>KSEA</strong> <strong>40</strong> th President Hosin “David” Lee. The first official program of<br />

the conference started out with the speed networking session which provided<br />

quick greetings among participants in which they could share their name and<br />

short background. After the short introduction of YG directors and committee<br />

members, everyone moved onto the ice-breaking games. Grouping approximately<br />

twelve people per team, the setting endorsed building up close<br />

relationship among the team members. Even some of the panels joined the<br />

event and doubled the fun. This session was informal, but at the same time it<br />

was very engaging. And everyone just simply loved it!<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 21


KSTLC <strong>2012</strong><br />

PLENARY PRESENTATIONS & POSTER SESSION<br />

PLENARY PRESENTATIONS<br />

Hosin “David” Lee, President of <strong>KSEA</strong> and Professor of Civil and Environmental Engineering at University of Iowa<br />

At KSTLC <strong>2012</strong>, Dr. Lee gave an inspiring speech about his life time experience along with his association with <strong>KSEA</strong>.<br />

He also shared the activities of <strong>KSEA</strong> and its record breaking statistics on membership and funding. Dr. Lee’s sense<br />

of humor captured all the audiences’ attention and made them start this memorable event with a smile on their face.<br />

Chul Ahn, Professor of Clinical Science at UT Southwestern Medical School & Director of Biostatistics Core at Simmons<br />

Cancer Center<br />

At KSTLC <strong>2012</strong>, as a keynote speaker, Dr. Ahn gave a speech on how to construct a successful life. He described an individual’s<br />

life as connecting dots by referring to Steve Jobs. As if more dots depict more complex and detailed pictures<br />

in a dot-to-dot puzzle, the diverse experiences enrich the quality of lives and pave the way for the time that is to come.<br />

Se-Chan Jang, Team Lead, Office of R&D Program Management, KEIT<br />

Korea Evaluation Institute of Industrial Technology (KEIT) presented international research collaboration opportunities<br />

in various science and engineering fields. KEIT awards and manages more than $1.65B annually to the private and<br />

public sectors, focusing on fostering emerging technologies.<br />

Sang-Il Lee, Vice President of KEIT<br />

As a representative of KEIT, Mr. Lee gave a warm welcoming and congratulation on the first KSTLC, and expressed<br />

his pleasure of supporting its great start. This year, KEIT has made a generous donation to provide young students a<br />

unique atmosphere to enjoy meals with panels and other peers at a networking lunch and a dinner banquet.<br />

Esther Yang, Sr. R&D Director in Diagnostic Division at Abbott Lab<br />

At KSTLC <strong>2012</strong>, as a keynote speaker, Dr. Yang shared about the role of health-care careers in global economy. She<br />

pointed out that in rapidly growing world economy, the goal of science and engineering should be as followed: differentiated<br />

knowledge integrator, value creator, systems thinker, and servant leader. She also stressed out the importance<br />

of exceptional communication skills for the transfer of the usefulness and assessment of technology<br />

Sang Hee Yoo, President of <strong>Korean</strong>-<strong>American</strong> Women in Science and Engineering (KWiSE); Vertex Pharmaceuticals<br />

Dr. Yoo introduced the variety of opportunities available for our future female leaders in science and engineering field.<br />

KWiSE is active over the entire nation, seeking to promote the development of female <strong>Korean</strong>-<strong>American</strong> scientist and<br />

engineer community as a whole group by sponsoring conferences, including KSTLC.<br />

John Lee, YG Committee Chair of <strong>KSEA</strong><br />

John held a special report session on UKC <strong>2012</strong> and <strong>KSEA</strong>-YG activities. He encouraged the participants to apply for<br />

UKC <strong>2012</strong>, the largest <strong>KSEA</strong> annual conference, which will be held in L.A. in August 8th-11th, <strong>2012</strong>. Many YG activities<br />

including YGTLC, YGF and KSTLC were highlighted.<br />

POSTER SESSION<br />

[Session Chairs: Pilbum Kim, Kyungsoo Kim, Kyoungsun Rha]<br />

Ph.D. Candidate, UCLA & Ph.D. Student Penn State University & Undergraduate Student, University of Utah<br />

A great number of the first generation <strong>Korean</strong> students, due to the language barrier and<br />

the cultural differences, face the challenge of becoming active and extrovert. It is unfortunate<br />

that their wisdom, intelligence, and creativity remain in shade. KSTLC has been<br />

established with a mission to help those students pursue professional careers in the US.<br />

Along with many beneficial programs of KSTLC, the technical poster session provided<br />

participants with the opportunities to improve their presentation skills in an Englishspeaking<br />

professional setting. There were more than 60 posters from a variety of research disciplines. The presenters were passionate<br />

about their research projects and excited to share their hard-earned knowledge with others. Concerning the fact that most<br />

presenters were the first generation, despite the hardship in having to present in non-native language, the contents of the posters<br />

were very well delivered in general. It was truly inspiring to see many outstanding <strong>Korean</strong> students strive for their dreams, and it<br />

showed the bright future ahead for the <strong>Korean</strong> scientists and engineers working in the country.<br />

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<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>


KSTLC <strong>2012</strong><br />

SESSIONS AND WORKSHOPS<br />

DALE CARNEGIE INSTITUTE SPECIAL SEMINAR: CREATING CONNECTION<br />

[Conference Co-Chair & Session Chair: YeEun Sarah Rhee, Jungsook Yang]<br />

Undergraduate Student, University of Michigan & Software Engineer, Netapp<br />

After <strong>KSEA</strong> President Hosin “David” Lee opened up the first door of KSTLC, Mr. Dan Conrod took the<br />

lead and gave us a special privilege to learn the methods of communications. He discussed the importance<br />

of social networking and presented the ideas of the ‘good communication.’ As a program that started<br />

off the entire conference, it set a very welcoming and open environment. The speaker, Dan, had everyone<br />

to stand up and practice communication skills which encouraged the participants to actively engage<br />

themselves in conversations with brief self-introductions. Though “creating connection” was mainly about<br />

networking, it rather promoted a necessity<br />

of self-reflection. According to Dan,<br />

a successful networking requires confidence,<br />

patience, enthusiasm and perseverance. To build a great<br />

relationship with people, we need to be open and approachable<br />

to others first which requires the confidence and courage. Then<br />

the conversation needs to be followed by patience such as being<br />

a good listener and letting the opponent become a focus of the<br />

conversation. The participants discussed about these practical<br />

skills and values for the effective ways of communications, and<br />

tried to apply these at a personal level. This session was well suited<br />

for the purpose of the conference which promotes networking<br />

among <strong>Korean</strong>-<strong>American</strong> students on the paths to become the<br />

pioneers of the future.<br />

ADVANCED PROFESSIONAL PRESENTATION SKILLS<br />

[Session Chair: Yoomin Ahn, Wonjae Lee]<br />

R&D Chemist, BISCO, Inc & Ph.D. Student, University of Pennsylvania<br />

This was a unique session for KSTLC with the purpose of helping first generation <strong>Korean</strong> students improve<br />

their presentation skills. Our goal was to have a before and after presentation of students to show<br />

the improvement through a professional workshop in public speaking. Dr. Dan Moser worked with<br />

our two volunteers, Tae Gyu Kim and Youngbum Jun, in perfecting their speeches and powerpoints.<br />

The preparation for this session began a month before the conference. And throughout February, the<br />

volunteers sent Dr. Moser their original videos and slides, and received feedback from him. On the<br />

night before the presentation, the volunteers worked with Dr. Moser one-on-one for a couple of hours.<br />

On the day of the workshop, Dr. Moser started off the session with a short speech on the important<br />

factors in public speaking which was followed by the actual presentations. After showing the before<br />

videos, two volunteers stood up in front of a hundred students and performed the improved presentations. As a 1.5 generation<br />

student who came to the United States at the early ages, the only concern Tae Gyu had was a nervousness management when facing<br />

a huge crowd. On the other hand, Yongbum, who came to the U.S. in his mid-twenties, had a language barrier to overcome<br />

and was not confident about his English skills. When they walked up to the stage, however, it was evident that from a month-long<br />

interaction with Dr. Moser, they had gained enough courage and were more than ready for the presentation. Especially, the 1st<br />

generation student, Youngbum, showed a great improvement on public speaking and grabbed everyone’s attention with his sense<br />

of humor, despite his difficulties with the language.<br />

Overall, the lecture had entertaining elements along with useful presentation tips. The volunteers also gave great presentations<br />

that were comical as well. It was helpful to see that the presentation skills can be improved over a course of period. Moreover, the<br />

participants were able to learn the successful and effective skills for the professional presentation.<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong><br />

23


KSTLC <strong>2012</strong><br />

SESSIONS AND WORKSHOPS<br />

CAREER DEVELOPMENT WORKSHOP<br />

[Session Chairs: JaiKyoung Jung, Wendy Shin, Chloe Sonya Kim, Chulwoo Park]<br />

Post-Doc; Virginia Tech, Software Product Manager; Caltech,<br />

Undergraduate Student; Northwestern University, Undergraduate Student; University of Utah<br />

I) Industry- Seung-Woo Choi, RCA Leader, GE Energy; Young Seok Lee, Research Scientist, Motorola; Chul Young Park, Lead Engineer,<br />

Boeing; Paul Park, Engineering Supervisor, Caterpilla Inc.; Sung Kwan Pyun, Lead Systems Engineer, GE Health Care - Surgery<br />

The panels briefly gave self-introductions, which were followed by answers to questions chosen<br />

from a survey conducted prior to the conference. Dr. Paul Park, helped distinguish the<br />

field of industry from academia and emphasized “creativity” and inspired participants with a<br />

quote, “Success is a combination of integrity and confidence”. Then, Dr. CY Park explained the<br />

two different tracks of industry, management and research fellow tracks, and provided tips on<br />

interviewing skills. He encouraged students to follow their passion. Dr. YS Lee described the<br />

team structure of his company and the hiring process. Dr. SW Choi gave talk on communication and presentation skills. Lastly,<br />

Mr. SK Pyun led a discussion on the visa support issues, which grasped the attention from the 1 st generation.<br />

II) Academia- Ken Choi, Assistant Professor of ECE, IIT; Youngjae Chun, Assistant Professor of IE and BE, U. of Pittsburgh; Hyunwoo<br />

Lee, Research Assistant Professor of Biology, U. of Illinois-Chicago; Yong Ho Sohn, Professor of MM and AE, U. of Central Florida<br />

The first panelist, Dr. Choi presented a brief overview on differences between industry and<br />

academia. He mentioned different research styles at industry, which helped him decide to<br />

devote his work to practical studies after he started his career as a professor. Then Dr. Chun<br />

shared his hardships of becoming a professor as a 1 st generation student in US. His life experience<br />

touched a lot of 1 st generation participant’s hearts. He also encouraged students to branch<br />

out the research topics while continuing the work that previous professor has achieved. Dr. Lee<br />

emphasized the importance of professional writing and grant proposal. He advised participants to not be afraid of the critics, but<br />

rather be open to the feedbacks. Lastly, Dr. Sohn gave tips on the grant proposal and the ethics future professors should pursue. He<br />

pointed out the significance of the relationship with senior professors and fund providers.<br />

III) National Research Lab- Seungbum Hong, Materials Scientist, Young Soo Park, Engineering Staff, Argonne National Lab<br />

With about 10 participants, we had a small group which actually allowed for a smooth,<br />

comfortable discussion session. The setting of the room was changed so that everyone<br />

would sit facing each other, instead of separating the panelists and the participants. It<br />

started with simple introduction for each panelist, followed by Dr. Park’s short powerpoint<br />

presentation about his research. Then it went straight into the question and answer portion<br />

of the discussion. With all participants very actively involved, many aspects of the career in<br />

the lab were covered, and a good number of the participants exchanged personal contact information with the panelists.<br />

IV) Medical and Pharmaceutics- Taeok Bae, Assistant Professor, Indiana University- School of Medicine; Hyunyoung Jeong,<br />

Assistant Professor of Pharmaceutics, U. of Illinois-Chicago<br />

A pre-survey was done to collect questions for the following criteria: entrance to the medical schools, M.D./Ph.D. program, research<br />

opportunities in health sciences, and panels’ backgrounds and experiences.<br />

Fortunately, we had current medical school students, which created a unique atmosphere<br />

for both participants and the panels to share their experiences freely. The admission process<br />

was the the most talked about since majority of participants were undergraduate<br />

students. The rest of topics were also covered based on the students’ voluntary questions<br />

which broadened their perspectives on careers in the health sciences field. Overall, this<br />

session was very successful in shaping future doctors, vets and pharmacists and encouraging<br />

them to interact and bond with the panels and other participants.<br />

24<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>


KSTLC <strong>2012</strong><br />

AWARDS<br />

AWARDS CEREMONY<br />

[Conference Co-Chairs: DaEun Rachel Park and YeEun Sarah Rhee]<br />

Undergraduate Students, Johns Hopkins University & University of Michigan<br />

Outstanding poster presentation awards were given out to nine participants, two in each science domain including biological<br />

and medical science (BM), chemical, civil, environmental and material engineering (CM), electrical and computer science engineering<br />

(ES), and mathematics, mechanical engineering and non-natural science (MN). Every poster presentation was evaluated<br />

by our critical reviewers consisting of eighteen panels and speakers from various fields. In addition, three undergraduate<br />

participants were awarded for the three best essays, and three more were honorably mentioned. To make this recognition more<br />

memorable, beautiful roses were also handed to female awardees.<br />

Technical Poster – Biological, Medical<br />

1 st Place ◆ Sa Do Kang, Duke University, "Developing Efficient Methods for Isolation of Endothelial Progenitor Cells"<br />

2 nd Place<br />

◆Ja Kyung Lee, U of Pennsylvania, "RP58 transcription factor inhibits oligodendrocyte differentiation"<br />

◆Bum Jun Kim, U of Utah, “Does ceramide contribute to vascular dysfunction in mice with type 1 diabetes”<br />

Technical Poster – Chemical, Civil, Environmental, Material<br />

1 st Place ◆ Woon-Hong Yeo, UIUC, "Multifunctional, skin-like electronics"<br />

2 nd Place ◆ Seung-Jin Lee, U.S. Environmental Protection Agency, "Biofuels: A Review of a Life Cycle Environmental Impacts"<br />

Technical Poster – Electrical, Computer Science<br />

1 st Place ◆ Jaeyoung Choi, UC Berkeley, "Semantic Computing and Privacy: A Case Study Using Inferred Geo-Location"<br />

2 nd Place ◆ Jaeeun Shim, Georgia Tech, "Biologically-Inspired Deceptive Behavior for a Robot"<br />

Technical Poster – Mechanical, Mathematics, Non-Natural<br />

1 st Place<br />

◆ Jun Suk Rho, UC Berkeley, "Spherical Hyperlens for Two-dimensional Sub-diffractional Imaging at Visible Frequencies"<br />

2 nd Place<br />

◆ Seul Ki Kang, Texas A&M University, "Multiscale simulations for Richard's equation in high-contrast media and<br />

applications"<br />

Essay Contest<br />

1 st Place ◆ Clara E. Park, University of Washington, "Network for Your Success"<br />

2 nd Place ◆ Haena Kim, University of British Columbia, "Questions"<br />

3 rd Place ◆ Soo Yeon Selene Kim, Princeton University, "Ms. Efficiency"<br />

Honoral<br />

Mention<br />

◆ Daniel Young Lee, Andrew Park, Yeo Ho (Patrick) Yoon<br />

Advisory Committee<br />

◆ Byoung-Do Kim ◆ Benjamin C. Lee ◆ Israel ‘Sun Min’ Jung<br />

(YG Director 1) (General Director) (YG Director 2)<br />

Organizer Recognition<br />

DaEun Park, Hyunkyung Lee, YeEun Rhee, JaiKyoung Jung, Pilbum Kim, Yoomin Ahn, Meeae Hong, Yumi Lim, HyounAe Min,<br />

Wendy Shin, Chulwoo Park, Chloe Sonya Kim, Kyungsoo Kim, Dongjun Kim, Kyoungsun Rha, Seung-Jun Kim, Wonjae Lee,<br />

Taewoo Ha, Hea Ryung Kim, Tae Gyun Chung, Youngbum Jun, John S. Lee, Jungsook Yang, John Cho, Steven Chong<br />

Sponsor Recognition<br />

KEIT (Korea Evaluation Institute of Industrial Technology), LG Electronics, KOSEN21(KISTI), KWiSE, Chul Ahn, Hosin ‘David’<br />

Lee, Hanseup Kim, Yongho Sohn<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong><br />

25


KSTLC <strong>2012</strong><br />

POST-KSTLC <strong>2012</strong> COMMENTS & TESTIMONIALS<br />

WHAT THE KSTLC <strong>2012</strong> PARTICIPANTS SAID<br />

It was a truly informative and enjoyable conference and also great to see so many awesome young <strong>Korean</strong> professionals<br />

in science and engineering! I was surprised to have so many outstanding leaders already well-established and stood up<br />

as leaders in their field as well from the panel discussion. I hope that we, as <strong>Korean</strong>-spirited professionals, can build our<br />

strong backgrounds here in the states in this way. Thank you KSTLC and <strong>KSEA</strong> for making this possible!<br />

- Claire Gayoung Jeong (Post-Doc, Duke University, Durham, NC)<br />

It was an awesome and inspiring event again!! <strong>KSEA</strong> events always give me motivation to work hard and study hard<br />

whenever I feel like to settle for the present. Big Thank you, Organizers!<br />

- Hangyeol Ryu (Senior Undergraduate, University of British Columbia, Port Moody, Canada)<br />

I was very honored to be at the very first KSTLC conference! I will for sure remember it forever! I got to meet a lot of<br />

<strong>Korean</strong> students studying abroad like me which was very encouraging and inspiring. I definitely would like to join any<br />

future event of <strong>KSEA</strong>! Good job organizers! I sincerely thank you!<br />

- YeEun Park (Mechanical Engineer - Manufacturing, Ford, Ann Arbor, MI)<br />

KSTLC <strong>2012</strong> was great experience in Chicago. It helped me meet lots of diverse people and inspired me to work harder<br />

for the future, especially in my studies. Thank you for an unforgettable memory!<br />

- Brian Keum (Senior Undergraduate, University of Michigan, Ann Arbor, MI)<br />

Before I attend KSTLC <strong>2012</strong>, I honestly had few expectations about it. I was excited about rather visiting Chicago than<br />

the event. However, I got so much fun and valuable memory after I met nice, handsome people and had awesome<br />

program at KSTLC. Everybody was so nice and fun and the program itself was very productive. I highly recommend<br />

people to participate this awesome event! Two thumbs up!<br />

-Seul Ki Kang (Ph.D. Candidate, Texas A&M University, College Station, TX)<br />

It was amazing experience and I learned a lot by meeting new people during the conference. The industry session was<br />

impressive and I gained practical advices. Thanks for this great opportunity!<br />

- Hyuk-Jin Park (Senior Undergraduate, USC, Los Angeles, CA)<br />

“BEING A STRANGER”<br />

[Yuna Shim]<br />

MS Candidate, University of Washington<br />

Walking into the hotel, waiting for registration, watching people talking to each other, having a strong feeling that everyone<br />

seems to know each other and realizing I know zero people here so there’s no room for me to join. This was not so<br />

pleasant experience when I first participated in YGTLC and this KSTLC was not much different. I barely knew anybody<br />

and felt intimidated again. However, I knew that this would turn out to be really great. YGTLC and KSTLC taught me<br />

that stepping out of my comfort zone and challenging myself to be a total stranger can make differences.<br />

Since KSTLC had the smaller number of participants and was designed for 1 st generation <strong>Korean</strong> students only with the poster<br />

presentation and essay contest, I was able to meet all participants in the same room and was able to talk to them while visiting their<br />

booths. I especially enjoyed the field-specific conversation with the people who have the same interest and future goals with me. This<br />

was the moment that “being a stranger” turns out really great, because I would never be able to meet and network with them if it<br />

were neither <strong>KSEA</strong> nor the conference.<br />

Sharing thoughts and hardships about studying in the US or about our future was another great feature of the conference as the majority<br />

of participants are the students who came to the US alone. I believe the first KSTLC brought different perspective in networking<br />

and building personal bonds depending on the language we use and the culture we grew up. This would be transferable to other<br />

events and might help young generations to better understand each other as <strong>Korean</strong>-<strong>American</strong>s. I really appreciate <strong>KSEA</strong> officers<br />

and KSTLC organizers’ work to put everything together and let me have an amazing experience.<br />

26<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>


KSTLC <strong>2012</strong><br />

TESTIMONIALS<br />

“PATH FINDER”<br />

[Youngbum Jun]<br />

Ph.D. Candidate, Drexel University<br />

As I continue my study at Drexel University as a fourth year Ph.D. student, I realize that the more I get into my own<br />

research field, the narrower my choice on my career gets; the choice between academic career and other options outside<br />

the academia. When I was in much need of guidance and mentorship, KSTLC <strong>2012</strong> was the perfect and fulfilling<br />

opportunity. The academic panel discussion provided participants with extremely useful information on academic<br />

career in the US. All the panelists were very enthusiastic about sharing their know-how’s in their career fields and personal<br />

stories of their success and failures. Through the discussion and Q&A’s, I was able to see the big picture of the academic career.<br />

“SUSPICION TO ADMIRATION”<br />

[Dongjun Kim]<br />

Undergraduate Student, University of Southern California<br />

Despite of my long concern about how I can network with unfamiliar people, the happy hour social enabled me to not<br />

only get to know others but also form an unbreakable, close friendship with them. Everyone in the conference shared<br />

the same hardship in their challenged journey for career in the US whether it’s due to the English as a second language,<br />

different culture, social custom, or academic difficulty. The shared trait of experience and culture was significant<br />

enough to catalyze the highly energized covalent bonds among participants and discover their new stability assisted by new friends.<br />

Moreover, extremely well-organized and brilliantly picked programs like Special Seminar on Networking & Communication by<br />

Dale Carnegie Institute was just perfect for the participants who all suffered from the difficulty of communication and networking<br />

in their 2 nd language. Particularly, Dr. Seungbum Hong, who works at the Argonne National Laboratory, deeply touched my heart<br />

with his infinite passion to help the young; in his national lab technical session, Dr. Hong asked for the phone numbers and e-mail<br />

addresses of every single participant and even took pictures of them so that he can not only help those desperate and hard-working<br />

students but also form a profound, long-term mentor-mentee relationship through which he could constantly support his mentees.<br />

Overall, I feel privileged to say that I leave with strong love toward my new friends, complete respect toward the mentors, and most<br />

importantly, full admiration of the extremely hard-working organizers behind the curtain.<br />

“OFF TO A GREAT START”<br />

[Seung-Jin Lee]<br />

Post-Doc, US Environmental Protection Agency<br />

Prior to attending the conference, I didn’t know what to expect as this was the first KSTLC and I only knew a handful<br />

of people. But once <strong>KSEA</strong> President Hosin Lee stepped onto the podium and delivered his opening speech, I knew we<br />

were all in for something special. As usual, his humor did not fail to amuse us all. And I agree with him on one point:<br />

my best decisions in life were marrying my wife and being a part of <strong>KSEA</strong>. Nothing in life is more valuable than health,<br />

family and the people you’re surrounded by. I believe <strong>KSEA</strong> has provided a big chunk of that value. All the panelists<br />

motivated me to work harder, and their invaluable words of advice were more than helpful in taking the next steps in my career.<br />

Being a 1 st or 1.5 th generation <strong>Korean</strong> in the US can be pretty tough. There are cultural differences and language barriers to adapt to,<br />

all of which can affect our experiences in school or workplace. Whether you’re here to start a business, get an education or simply<br />

turn your life around, life as a foreign minority can be quite challenging, especially when there’s a lack of guidance along the way.<br />

That’s why KSTLC felt very close to my heart. It was an event for people just like me who have had similar experiences and can<br />

share their stories of success and failure. As one of the oldest participants, I felt grateful that I was able to share my experiences with<br />

students and researchers in similar fields. However, in the end, I think I was the one most inspired. It was amazing to learn from all<br />

the hard-working young professionals around the country. They definitely made me proud to be <strong>Korean</strong>.<br />

Time flew by way too fast, and I only wish it had lasted longer. I’d like to thank <strong>KSEA</strong> President Lee, Dr. Byoung-Do Kim, and all<br />

the organizers for putting together a very rewarding conference. Thanks to all the sponsors as well. Our experiences would not<br />

have been so rewarding if not for all the hard work and time they invested. I look forward to being a part of KSTLC and <strong>KSEA</strong> for<br />

a long time coming, so please continue to organize KSTLC and build on its programs. And don’t forget, we are now one big family!<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong><br />

27


KSTLC <strong>2012</strong><br />

TESTIMONIALS<br />

“HELLO TO KSTLC”<br />

[John Cho]<br />

Cost Information Systems Coordinator, Caterpillar Inc.<br />

It was an absolute pleasure and honor to be your host in Chicago for KSTLC! I want to congratulate all the organizers<br />

for their hard work and successfully completing the first ever KSTLC! It was great to meet so many up and coming<br />

young professionals. This wonderful event reminded me to keep striving to challenge myself and to grow others to<br />

become the future leaders of tomorrow. I’m very proud of each and every one of our KSTLC members, and I’m excited<br />

to see what everyone will achieve in the upcoming years. I want to remind everyone that although KSTLC <strong>2012</strong> is over,<br />

this is only the beginning. Reach out and continue networking with your <strong>KSEA</strong> peers!<br />

“A BRIEF REFLECTION ON KSTLC CONFERENCE”<br />

[Daniel Young Lee]<br />

Undergraduate Student, Purdue University<br />

The day before the <strong>Korean</strong> Student Technical and Leadership Conference (KSTLC), I fretted about in my room and regretted<br />

my decision to participate in the conference. As one of the younger participants of the conference, I was afraid<br />

that I was neither technical nor a leader- a shameful contradiction to the qualities the conference convened to celebrate<br />

- and I increasingly doubted that my invitation was a mistake on the part of the admission committee. With no<br />

expectation from the conference; I only hoped to be spared of the embarrassment by my lack of expertise in any field.<br />

How wrong was I to expect nothing from the conference; I may have been the greatest beneficiary. My spirit lifted as I began to engage<br />

in conversations with other delegates and listened to the speeches from the seasoned professionals in variety of fields. I gained<br />

insights on the possibilities I had previously considered for myself, reversed my perceptions on the possibilities I had not wanted<br />

for myself, and learned possibilities I had not imagined were possible for myself. The fear I held before the conference quickly dissipated,<br />

and the energy of the conference, emanating from the enthusiasms of the conference organizers and the delegates themselves,<br />

enabled me to shift my focus from depressing thoughts on what I currently lacked to the immense possibilities what I could achieve.<br />

I return to Purdue University, where I am a sophomore undergraduate in mathematics, with a re-kindled optimism for my possible<br />

contributions to the society. And it is my hope that as I continue my studies in mathematics, I can one day provide the same inspiration<br />

to the younger generations of <strong>Korean</strong>-<strong>American</strong> students as the KSTLC delegates and speakers have done for me.<br />

“WHY AM I HERE AGAIN?”<br />

[Jeehong Peter Kim]<br />

First Year Medical Student, University of Pittsburgh<br />

Starting with the very first event of icebreaker to get to know each participant better, everyone in KSTLC spent the rest<br />

of their three days very productively. Every minute, we were learning, thinking, or laughing during workshops and<br />

various networking and social events. I met a lot of great people and became good friends with some of them including<br />

my roommates who I still keep in touch with. KSTLC also provided me with unique opportunities to meet other<br />

inspiring professionals such as Dr.Ahn Chul Woo, within the field of health care and connect with them.<br />

However, one of the biggest assets I earned during KSTLC would be encouragement and passion for my own career. I was about<br />

to finish my first year in medical school and was very exhausted from its demanding curriculum and highly competitive environment.<br />

I also believed I had some shortcomings in language skills as a first generation student, and was secretly struggling with ideas<br />

whether I could carry on my career successfully. However, after learning so many other fellow <strong>Korean</strong>s working hard and pushing<br />

the boundaries in the frontier of cutting edge science and technology, I find myself more inspired to enjoy what I chose to do and<br />

more confident that I can make the best out of myself. Now I am more motivated than before, and looking forward to finish strong<br />

the rest of my first year and looking forward to participating in UKC in <strong>2012</strong> after completing my summer research. I thank KSTLC<br />

for all the listed things, and all the other things I couldn’t list that are many. It was truly an amazing experience.<br />

28 <strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>


SPONSOR NEWS<br />

<strong>2012</strong> Ho-Am Prize Recipients<br />

☐ The Ho-Am Foundation (Chairman Hyun-Jae Lee, former Prime Minister) announced the <strong>2012</strong> Ho-Am Prize recipients<br />

on <strong>Apr</strong>il 3 rd , <strong>2012</strong>.<br />

This year’s recipients in each field are:<br />

◆ Prize in Science Prof. Minhyong Kim (Univ. of Oxford/POSTECH),<br />

◆ Prize in Engineering Prof. Taeghwan Hyeon (Seoul National Univ.),<br />

◆ Prize in Medicine Prof. Jae Ung Jung (Univ. of Southern California),<br />

◆ Prize in The Arts Composer Unsuk Chin (Seoul Philharmonic Orchestra),<br />

◆ Prize in Community Service Dr. Dong-han Lee (Chairman of Social Welfare Corporation Choon Kang)<br />

☐ The Ho-Am Prize Ceremony is scheduled to be held at 3:00 p.m. on June 1 st , <strong>2012</strong> at Ho-Am Art Hall. Each recipient will<br />

be awarded a diploma and a Ho-Am Prize medal with prize money of KRW 300 million. Prior to and after the ceremony, the<br />

recipients are scheduled to hold commemorative lectures in major universities, high schools and academies across the nation.<br />

<strong>2012</strong> HO-AM PRIZE RECIPIENTS<br />

Prize in Science<br />

Prof. Minhyong Kim<br />

Prize in Engineering<br />

Prof. Taeghwan Hyeon<br />

Prize in Medicine<br />

Prof. Jae Ung Jung<br />

Prize in The Arts<br />

Composer Unsuk Chin<br />

Prize in Community Service<br />

Dr. Dong-han Lee<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong><br />

29


EVENTS<br />

LOCAL CHAPTERS<br />

South Texas<br />

Spring Picnic (March 3, <strong>2012</strong>)<br />

Wisconsin<br />

<strong>KSEA</strong> President Cup Tennis Tournament (<strong>Apr</strong>il 14, <strong>2012</strong>)<br />

Alabama<br />

YG Career Development Seminar (January 13, <strong>2012</strong>)<br />

University of Southern California<br />

Rhythm and Hues Studio Tour (March 9, <strong>2012</strong>)<br />

Kentucky<br />

Kentucky Winter Conference (January 14, <strong>2012</strong>)<br />

Southern Virginia<br />

Tech Seminar with Prof. Philip Kim (March 16, <strong>2012</strong>)<br />

New England<br />

Technical Symposium and YG Forum (February 25, <strong>2012</strong>)<br />

30<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>


EVENTS<br />

AFFILIATED PROFESSIONAL SOCIETIES<br />

<strong>Korean</strong> Pathologists Association of North America (KOPANA)<br />

11 th Spring Seminar (March 15-17, <strong>2012</strong>)<br />

<strong>Korean</strong>-<strong>American</strong> Materials Society (KAMS)<br />

Annual Meeting (TMS <strong>2012</strong>) (March 11, <strong>2012</strong>)<br />

Association of <strong>Korean</strong> Physicists in America (AKPA)<br />

<strong>Korean</strong> Physics Symposium<br />

(March 1, <strong>2012</strong>)<br />

<strong>Korean</strong>-<strong>American</strong> Offshore Engineers Association (KOEA)<br />

& <strong>KSEA</strong> South TX Joint Technical Seminar<br />

(February 16, <strong>2012</strong>)<br />

<strong>Korean</strong> Transportation Association in America (KOTAA)<br />

23 rd KOTAA Annual Meeting (January 24, <strong>2012</strong>)<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 31


SPONSORS OF <strong>KSEA</strong>


<strong>Korean</strong>-<strong>American</strong> Scientists and Engineers Association<br />

1952 Gallows Road, Suite 300, Vienna, VA 22182<br />

Tel: 703-748-1221. Fax: 703-748-1331<br />

Email: sejong@ksea.org. Web: http://www.ksea.org<br />

Directors Committee (<strong>40</strong>th Administration)<br />

President: Hosin “David” Lee, Univ. of Iowa<br />

319-335-6818, ksea<strong>40</strong>p@gmail.com<br />

President-Elect: Hyung-Min Michael Chung, Calif. State Univ.<br />

562-985-7691, ksea<strong>40</strong>pe@gmail.com<br />

Vice President: Kookjoon Ahn, DOT<br />

916-227-9257, ksea<strong>40</strong>vp1@gmail.com<br />

Vice President: Hee-Koo Moon, Solar Turbines<br />

619-544-5226, ksea<strong>40</strong>vp2@gmail.com<br />

Executive Director: Yongho Sohn, Univ. of Central Florida<br />

<strong>40</strong>7-882-1181, ksea<strong>40</strong>ed@gmail.com<br />

Finance Director: Seri Park, Villanova University<br />

610-519-3307, ksea<strong>40</strong>fd@gmail.com<br />

General Director: Benjamin Lee, INVIA Medical Imaging Solutions<br />

734-678-1285, ksea<strong>40</strong>gd@gmail.com<br />

Technical Group Director: Eun-Suk Seo, Univ. of Maryland<br />

301-<strong>40</strong>5-4855, ksea<strong>40</strong>tgd@gmail.com<br />

IT Director: Sung Yi, Portland State Univ., ksea<strong>40</strong>itd@gmail.com<br />

Headquarter Operations Director: Kyungjae Myung, NIH<br />

301-451-8748, ksea<strong>40</strong>hod@gmail.com<br />

Membership Director: Youngsoo Park, Argonne National Lab<br />

630-252-5094, ksea<strong>40</strong>md1@gmail.com<br />

Membership Director: Hanseup Kim, Univ. of Utah<br />

801-587-9497, ksea<strong>40</strong>md2@gmail.com<br />

Membership Director: JungAh Jung, Millennium Pharmaceuticals<br />

973-752-5245, ksea<strong>40</strong>md3@gmail.com<br />

YG Director: Byungdo Kim, Univ. of Texas at Austin<br />

ksea<strong>40</strong>yd1@gmail.com<br />

YG Director: Israel (Sun Min) Jung, The Boeing Company<br />

425-263-2233, ksea<strong>40</strong>yd2@gmail.com<br />

Publications Director: Byungkyu Brian Park, Univ. of VA<br />

434-924-6347, ksea<strong>40</strong>pd1@gmail.com<br />

Publications Director: Hyunggun Kim, Univ. of Texas HSC at Houston,<br />

713-486-2342, ksea<strong>40</strong>pd3@gmail.com<br />

Publications Director: Jaehoon Yu, Univ. of Texas at Arlington<br />

817-272-2814, ksea<strong>40</strong>pd4@gmail.com<br />

Headquarters Staff<br />

IT Manager: Seung Seok Choi, 703-748-1221, it@ksea.org<br />

Finance Manager: Kelly Han, 703-748-1221,finance@ksea.org<br />

Admin Manager: Euna Yoon, 703-748-1221, admin@ksea.org<br />

Accounting Administrator: Yoon Hee Chang, 703-748-1221,<br />

database@ksea.org<br />

Auditors<br />

Gye Won Han, 858-784-7189, gyewon@scripps.edu<br />

Sam Ryu, 832-377-7267, sam.s.ryu@gmail.com<br />

Myung Jong Lee, 212-650-7260, mjlee999@yahoo.com<br />

Elected Councilors<br />

Group A: Physics<br />

Eun-Suk Seo, 301-<strong>40</strong>5-4855, ksea<strong>40</strong>tgd@gmail.com<br />

Group B: Chemistry<br />

Seogjoo Jang, 718-997-4110, seogjoo.jang@qc.cuny.edu<br />

Group C: Mathematics, Geology, Meteorology, Statistics, Others<br />

Yonil Park, 301-<strong>40</strong>2-1438, yonil.park@gmail.com<br />

Group D: Biology, Botany, Zoology, Biomedical Engineering,<br />

Genetic Engineering<br />

Jung Hyeob Roh, 713-500-6756, jung.h.roh@uth.tmc.edu<br />

Chul Hee Kang, 509-335-1<strong>40</strong>9, chkang@wsu.edu<br />

Group E: Agriculture, Ecology, Food, Nutrition<br />

Haejung An, 949-608-4<strong>40</strong>8, haejung.an@FDA.HHS.gov<br />

Group F: Medical Science, Pharmaceutical Science, Veterinary Medicine,<br />

Physical Education<br />

Kyoung-Jin Yoon, 515-294-1083, kyoon@iastate.edu<br />

Group G: Chemical Engineering, Textile Engineering, Nuclear<br />

Engineering, Petroleum Engineering, Applied Chemistry<br />

Inchan Kwon, 434-243-1822, ik4t@virginia.edu<br />

Group H: Mechanical Engineering, Aerospace Engineering, Naval<br />

Architecture<br />

Mun Y. Choi, 860-230-7003, choi@engr.uconn.edu<br />

Bongtae Han, 301-<strong>40</strong>5-5255, bthan@umd.edu<br />

Group I: Materials Science, Metallurgy, Mining Engineering<br />

Kyeong-Ook Lee, 630-252-9<strong>40</strong>3, klee@anl.gov<br />

Group J: Civil Engineering, Architecture, Environmental Engineering<br />

Jun-Seok Oh, 269-276-3216, junoh3@gmail.com<br />

Youngsoo (Richard) Kim, 919-515-7758, kim@ncsu.edu<br />

Group K: Electrical & Electronics Engineering, Communication Engineering<br />

Ki Wook Kim, 919-515-5229, kwk@ncsu.edu<br />

Taek Jin Kwon, 732-758-3242, taekjkwon@yahoo.com<br />

Group L: Computer Science, Systems Engineering<br />

Kyung Dong Ryu, 914-945-2502, kdryu2000@gmail.com<br />

Sam-Joo Doh, 781-565-5229, samjoodoh@yahoo.com<br />

Group M: Industrial Engineering and Mgmt Science<br />

Sunghoon Kim, 201-988-9094, stevekim.jsi@gmail.com<br />

Former President Councilors<br />

Jae Hoon Kim, The Boeing Company, 425-786-7723, jkim1@ieee.org<br />

Chin Ok Lee, Rockefeller University, 212-327-8617, leech@mail.rockefeller.edu<br />

Kang-Won Wayne Lee, Univ. of Rhode Island, <strong>40</strong>1-874-2695,<br />

kwaynel@gmail.com<br />

Chapter Presidents<br />

Central Penn (1) Jungwoo Ryoo, 814-949-5243, jryoo@psu.edu<br />

Georgia (3) Chulsung Kim, 678-<strong>40</strong>7-5776, ckim@ggc.usg.edu<br />

Indiana (4) Chan Kyoo Choi, choi@purdue.edu<br />

Michigan (6) Hahnsang Kim, 734-223-7284, hahnsang.kim@gmail.com<br />

Chicagoland (7) Duck Young Chung, 630-252-4907,<br />

dychung.ksea@gmail.com<br />

Minnesota (8) Yunje Oh, 952-835-6366, ohyunje@hotmail.com<br />

New England (9) Sangun Lee, 508-887-4564, sangun69@gmail.com<br />

New Jersey (10) Hong-Yong Kim, hongyong.kim@novartis.com<br />

NY Metro (11) Jun Ho Shin, 718-631-6255, jshin@qcc.cuny edu<br />

N. Carolina (12) Sung Woo Kim, 919-513-1494, swk.ncsu@gmail.com<br />

Ohio (14) Bomjun Kwon, 614-366-8377, bjkwon@gmail.com<br />

Seattle WA (15) Wookuen Shin, geoshin@gmail.com<br />

Philadelphia (16) Jin S. Kang, jinkang@drexel.edu<br />

St. Louis (17) Jayoung Choi, 310-562-7917, kseastl@gmail.com<br />

Southern CA (18) Chan Seung Park, 951-781-5771, cspark@cert.ucr.edu<br />

South Texas (19) Sukjoo Choi, 281-249-8732, sukjoo.choi@gmail.com<br />

Wash. Metro (21) June M Kwak, 301-<strong>40</strong>5-9726, jkwak@umd.edu<br />

Alabama (23) Dong Joo Daniel Kim, 334-844-4864, dkim@eng.auburn.edu<br />

Austin TX (24) Jinwoo Lee, 512-785-2098, jinwoo@mail.utexas.edu<br />

Silicon Valley (30) Jun Young Huh, heymosoo@yahoo.com<br />

Baltimore (31) Mihyun Bae, 443-804-7507, niceangel075@hotmail.com<br />

Tennessee (32) Thak Sang Byun, byunts@ornl.gov<br />

N. Texas (<strong>40</strong>) Jiyoung Kim, 972-883-6412, jiyoung.kim@utdallas.edu<br />

Central VA (41) Jungwook Jun, jungwook.jun@vdot.virginia.gov<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 55


Central IL (42) Seung-Yul Yun, 217-255-85<strong>40</strong>, Yes.Andrew@gmail.com<br />

Southern VA (49) Dong S. Ha, 5<strong>40</strong>-552-1965, ha@vt.edu<br />

Iowa City (52) Yang Oh Jin, yangoh.jin@gmail.com<br />

Utah (56) You Han Bae, 801-474-1945, you.bae@utah.edu<br />

Sacramento (58) Young Lee, 916-227-7645, ylee0617@hanmail.net<br />

San Diego (60) Yongkyoon In, 858-455-6655, yongkin@alum.mit.edu<br />

Oregon (62) Sung Yi, sungyi19@hanmail.net<br />

North Dakota (65) Chiwon W. Lee, 701-361-9411, chiwon.lee@ndsu.edu<br />

Central FL (67) Hyoungjin Cho, <strong>40</strong>7-927-4301, joehcho@gmail.com<br />

Tampa Bay (68) Myung Kim, mkkim@usf.edu<br />

Kentucky (903) Duk-Hyung Lee, 859-858-3511, duk.lee@asbury.edu<br />

<strong>KSEA</strong> Korea (905) Tammy Cho, 82-18-282-7995, btheb_02@naver.com<br />

Committee Chairs<br />

Contest Committee:<br />

Kookjoon Ahn, 916-227-8357, kookjoon_ahn@dot.ca.gov<br />

Election Committee:<br />

James Song, 301-602-2206, james.song.nih@gmail.com<br />

Fund Management Committee:<br />

Kang-Wook Lee, 914-945-3070, kangwook.lee.ibm@gmail.com<br />

History Committee:<br />

Yong Nak Lee, 847-577-5967, ynlee@htrdltd.com<br />

Honors and Awards Committee:<br />

Sung Kwon Kang, 914-945-3932, sungkang.ksea@gmail.com<br />

Long-range Planning Committee:<br />

Saeyoung Ahn, 301-646-6602, saeyounga@yahoo.com<br />

Nomination Committee:<br />

Jae Hoon Kim, 425-786-7723, jae.h.kim@boeing.com<br />

Rules Committee:<br />

Nak Ho Sung, 617-627-3447, nsung@tufts.edu<br />

Scholarship Committee:<br />

Seong Gon Kong, 215-204-7932, skong@temple.edu<br />

Young Generation Committee:<br />

John Hyung Lee, 310-280-8269, johnleelp@gmail.com<br />

Local Chapter Presidents Committee:<br />

Wookeun Shin, 206-714-4110, geoshin@gmail.com<br />

Affiliated Professional Society (APS) Presidents<br />

Association of <strong>Korean</strong> Neuroscientists (AKN)<br />

Jin Mo Chung, University of Texas, jmchung@utmb.edu<br />

Association of <strong>Korean</strong> Physicists in America (AKPA)<br />

Eun-Suk Seo, University of Maryland, seo@umd.edu<br />

Baltimore Life Scientists Association (BLSA)<br />

Woochang Hwang, Johns Hopkins University, whwang2@gmail.com<br />

<strong>Korean</strong> <strong>American</strong> Construction, Engineering, and Project Management<br />

Association (KACEPMA)<br />

Young Hoon Kwak, George Washington University, kwak@gwu.edu<br />

<strong>Korean</strong>-<strong>American</strong> Food Technologists Association (KAFTA)<br />

Youngmo Yoon, Sensient Flavors LLC, flavor331@yahoo.com<br />

<strong>Korean</strong>-<strong>American</strong> Intellectual Property Lawyers Association (KAIPLA)<br />

Joo Mee Kim, Rothwell, Figg, Ernst & Manbeck, P.C., jkim@rfem.com<br />

<strong>Korean</strong>-<strong>American</strong> Materials Society (KAMS)<br />

Jiyoung Kim, University of Texas at Dallas, jiyoung.kim@utdallas.edu<br />

<strong>Korean</strong>-<strong>American</strong> Mathematical Scientists Association (KAMSA)<br />

Hae Soo Oh, University of North Carolina at Charlotte, hso@uncc.edu<br />

<strong>Korean</strong>-<strong>American</strong> Society for Biomedical Informatics (KASBI)<br />

James S. Song, National Center for Biotechnology Information<br />

National Institutes of Health, james.Song@nih.gov<br />

<strong>Korean</strong> <strong>American</strong> Society for Biotech & Phamaceuticals (KASBP)<br />

Yong-Hae Han, Bristol-Myers Squibb, yong-hae.han@bms.com<br />

<strong>Korean</strong>-<strong>American</strong> Energy Exploration & Production Society (KEPS)<br />

Sam Jae Cho, Ryder Scott Company, chosj@blackmidas.com<br />

<strong>Korean</strong> Computer Scientists & Engineers Association in America (KOCSEA)<br />

Yoohwan Kim, University of Nevada, Las Vegas, yoohwan@cs.unlv.edu<br />

<strong>Korean</strong>-<strong>American</strong> Offshore Engineers Association (KOEA)<br />

Yong Lae Shim, ABS Technology, YShim@Eagle.org<br />

<strong>Korean</strong> Life Scientists at UCSF (KOLIS)<br />

Dae Hwi Park, University of California- San Francisco,<br />

Daehwi.park@ucsf.edu<br />

<strong>Korean</strong> Pathologists Association of North America (KOPANA)<br />

Eun Young Lee, University of Kentucky , eylee@uky.edu<br />

<strong>Korean</strong> Transportation Association in America (KOTAA)<br />

Alex Hak-Chul Shin, Louisiana State University, shin@lsu.edu<br />

<strong>Korean</strong>-<strong>American</strong> Society of Civil and Environmental Engineers (KSCEE)<br />

Myong Ho Steve Ro, Lee & Ro, Inc., steve-ro@lee-ro.com<br />

<strong>Korean</strong>-<strong>American</strong> Women in Science and Engineering (KWiSE)<br />

Sanghee Yoo, Vertex Pharmaceuticals, sanghee_yoo@yahoo.com<br />

NIH-<strong>Korean</strong> Scientists Association (NIH-KSA)<br />

Jung Hyung Park , National Institutes of Health, parkhy@mail.nih.gov<br />

New York <strong>Korean</strong> Biologists (NYKB)<br />

Sae Woong Park, Weill Cornell, sap2015@med.cornell.edu<br />

Research Triangle Park Bioscience and Biotechnology Meeting (RTP B&B)<br />

Hangsik Moon, Syngenta Biotechnology, Inc., hangsik.moon@syngenta.com<br />

San Diego <strong>Korean</strong> Biomedical Association (SDKoBA)<br />

Jongdae Lee, UCSD, j142lee@gmail.com<br />

The Society of <strong>Korean</strong> Statisticians in America (SKSA)<br />

Sin-Ho Jung, Duke University, jung0005@mc.duke.edu<br />

Ex-Presidents<br />

Kiuck Lee, Marquette Univ., 312-787-7060, kiucklee@aol.com<br />

Young Bae Kim, USC, 213-7<strong>40</strong>-2311<br />

Sang Il Choi, POSTECH, 919-357-7018, sangil@postech.ac.kr<br />

Kwang Bang Woo, Yonsei Univ., 82-2-2123-3555, kbwoo@yonsei.ac.kr<br />

Yong Nak Lee, HTRD, 847-577-5967,ynlee@htrdltd.com<br />

Jae Young Park, NC State Univ., 919-848-6110, JAEYPARK30@aol.com<br />

Chan-Mo Park, POSTECH, 82-11-521-8909, parkcm@postech.ac.kr<br />

Dong Han Kim, POSTECH, 82-54-279-2101, dhkim@postech.edu<br />

Ki-Hyon Kim, NC Central Univ., 919-530-6451, khk@nccu.edu<br />

Kwang Kuk Koh, Chrysan Ind., kwang@chrysanindustries.com<br />

Chin Ok Lee, Rockefeller Univ., 212-327-8617, leech@rockefeller.edu<br />

Chai Chin Suh, 610-678-0534, chaisuh@gmail.com<br />

Moo Young Han, Duke Univ., 919-660-2575, myhan@phy.duke.edu<br />

Kun Sup Hyun, Polymer Processing Institute, kshyun@polymers-ppi.org<br />

Hyo-Gun Kim, K-JIST, 703-663-8803, hkim@gist.ac.kr<br />

Moon Won Suh, NC State Univ., 919-515-6580, moon_suh@ncsu.edu<br />

Dewey Doo-Young Ryu, UC Davis, 530-752-8954, ddyryu@ucdavis.edu<br />

Saeyoung Ahn, Fuzbien Tech. Institute, saeyounga@yahoo.com<br />

Kyong Chul Chun, 301-598-3396, kcchun1@comcast.net<br />

Ki Dong Lee, Univ. of Illinois, Urbana-Champaign, kdlee@uiuc.edu<br />

Hong Taik (Thomas) Hahn, 310-825-2383, hahn@seas.ucla.edu<br />

Howard Ho Chung, Argonne National Lab., chung.ksea@gmail.com<br />

Nak Ho Sung, Tufts University, 617-627-3447, nsung@tufts.edu<br />

Chan I. Chung, Rensselaer Polytechnic Institute, chungc@rpi.edu<br />

Quiesup Kim, JPL/NASA, 818-354-8612, quiesup.kim@sbcglobal.net<br />

Sung Won Lee, Univ. of Maryland, 301-<strong>40</strong>5-1128, swlee@umd.edu<br />

Sung K. Kang, IBM T.J. Watson Research Ctr., sungkang.ksea@gmail.com<br />

Kang-Won Wayne Lee, Univ. of Rhode Island, kwaynel@gmail.com<br />

Kang-Wook Lee, IBM T.J. Watson Research Ctr., 914-945-3070,<br />

kangwook.lee.ibm@gmail.com<br />

Chueng-Ryong Ji, North Carolina State Univ., chueng.ji@gmail.com<br />

Jae Hoon Kim, The Boeing Company, 425-786-7723, jkim1@ieee.org<br />

Ex-Presidents (Deceased)<br />

Shoon Kyung Kim<br />

Inyong Ham<br />

Chong Wha Pyun<br />

Hogil Kim<br />

Je Hyun Kim<br />

Kyungsik Kang<br />

Soon Kyu Kim<br />

Kwang-Hae (Kane) Kim<br />

56<br />

<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>


www.kofst.or.kr<br />

KOFST will play a crucial role in leading<br />

the science and technology renaissance of Korea<br />

THE KOREAN FEDERATION OF SCIENCE AND TECHNOLOGY SOCIETIES<br />

KOFST is firmly committed to enriching and supporting science and<br />

technology societies; encouraging scientists to engage with society;<br />

protecting the rights and interests of scientists;<br />

and increasing public understanding of scientific discoveries<br />

and theories to reap even greater benefits for Korea.

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