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<strong>KSEA</strong> LETTERS<br />
Journal of the <strong>Korean</strong>-<strong>American</strong> Scientists and Engineers Association<br />
april <strong>2012</strong><br />
Vol. <strong>40</strong> No. 3 (Serial No. 217)<br />
WWW.<strong>KSEA</strong>.ORG<br />
MOU WITH ADVANCED TECHNOLOGY CENTER<br />
ASSOCIATION (ATCA) &<br />
ADVISORY COMMITTEE MEETING FOR IBS<br />
KSTLC <strong>2012</strong> IN CHICAGO<br />
MARCH 16-18, <strong>2012</strong>
Korea-US Science Cooperation Center<br />
Established as a non-profit in 1997 for fostering science & technology cooperation<br />
between the U.S. and Korea through a variety of programs<br />
S&T Program<br />
Supporting S&T meetings<br />
KUSCO scholarship for Science-majored graduate students<br />
KUSCO-NRF-NSF Summer Institute Program<br />
National Math and Science Competition<br />
WEST Program<br />
What is WEST program?<br />
The WEST program is an exchange program created between the governments of the U.S.<br />
and Republic of Korea. The program will allow qualified university students from Korea to<br />
enter the United States for a period up to 18 months as Exchange Visitors on the J-1 visa.<br />
Parties Names and type Major responsibilities<br />
Host The US organizations Provide work experience<br />
Sponsor KUSCO Visa, Insurance, and administration<br />
Participants University students from Korea Travel, housing and living expense<br />
Benefit Comparison between WEST and other J-1 program<br />
Items WEST Program Generic J-1 program<br />
Visa KUSCO applies Host applies through sponsors<br />
Program KUSCO provides ESL and placement works<br />
Host is responsible for the training<br />
program<br />
Cost<br />
KUSCO and Participants pay for travel, visa Host may be responsible for the travel and<br />
and ESL. No cost to the host.<br />
visa application.<br />
The Current Participating US host institutions<br />
For further information as to WEST program at west@kusco.org<br />
1952 Gallows Road. Suite 330 Vienna Virginia U.S.A. | (703) 893-9772 | www.kusco.org
TABLE OF CONTENTS<br />
Editorial Note 3<br />
Message from the <strong>40</strong> th President 4<br />
President of <strong>KSEA</strong> Visits the NIH Pioneer at Harvard 5<br />
Featured Articles<br />
Nano-Bio Interfacing: Leveraging Advances in Semiconductor Technology for Biological Research 6<br />
Single Molecule Biology: One, Two, Three & Four 8<br />
Technical Articles<br />
Microstructurally Designed Hierarchal Aluminum Metal Matrix Composites 10<br />
Micro Gas Chromatography System For Distributed Environmental Awareness 12<br />
Interconnected Network of the Cell Cycle, Circadian Rhythms, and DNA Damage Response 14<br />
Cooperative Control at Traffic Light Harnessed by Wireless Cars 16<br />
Workshop on Introduction to Institute for Basic Science 18<br />
MOU Signed with Advanced Technology Center Association (ATCA) 19<br />
UKC <strong>2012</strong> Advertisement 20<br />
Highlights of KSTLC <strong>2012</strong><br />
Message from the Conference Co-Chairs & Welcoming Reception 21<br />
Plenary Presentations & Poster Session 22<br />
Sessions and Workshops 23<br />
Awards 25<br />
Post-YGTLC <strong>2012</strong> Comments & Testimonials 26<br />
Testimonials 27<br />
Sponsor News - Ho-am Prize Recipients 29<br />
Events<br />
Local Chapters 30<br />
Affiliated Professional Societies 31<br />
<strong>KSEA</strong> Organizational Structure 55<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 1
Pilot High School Physics Contest (HSPC)<br />
Open to 9 th to 12 th graders<br />
Exclusively in<br />
NC & North Texas Region<br />
Organizer:<br />
<strong>KSEA</strong><br />
<strong>Korean</strong>-american ScientiStS and engineerS aSSociation<br />
Co-Organizer:
EDITORIAL NOTE FOR <strong>KSEA</strong> LETTERS: JOURNAL OF THE<br />
KOREAN-AMERICAN SCIENTISTS AND ENGINEERS ASSOCIATION<br />
This <strong>Apr</strong>il issue features articles from two world-renowned scholars:<br />
Dr. Hongkun Park , Professor of Chemistry and Chemical Biology at Harvard<br />
University, presents a breakthrough in developing nano-bio interfaces<br />
that maximally utilize the advantages offered by silicone nanostructures by<br />
employing nanoscale needles.<br />
Dr. Taekjip Ha, Professor of Physics at University of Illinois, made a discovery<br />
that a protein can store elastic energy through multiple cycles of chemical<br />
energy release that can be released in a single burst.<br />
<strong>KSEA</strong> LETTERS<br />
Vol. <strong>40</strong> No. 3 (Serial No. 217)<br />
APRIL <strong>2012</strong><br />
Publisher and Editor<br />
Hosin “David” Lee<br />
Editorial Board<br />
John Kim<br />
Philip Kim<br />
Luke Lee<br />
Hongkun Park<br />
Publications Directors<br />
Byungkyu “Brian” Park<br />
Hyunggun Kim<br />
Jaehoon Yu<br />
Staff Editor<br />
Euna Yoon<br />
Staff Designer<br />
Yoon Hee Chang<br />
Publication Date<br />
<strong>Apr</strong>il <strong>2012</strong><br />
Published by the <strong>Korean</strong>-<strong>American</strong> Scientists<br />
and Engineers Association. All rights<br />
reserved. No part of this publication may be<br />
reproduced, in any form or any means, without<br />
the prior written permission of <strong>KSEA</strong>.<br />
<strong>KSEA</strong> assumes no responsibility for statements<br />
and opinions expressed in this publication.<br />
Four distinguished and rising scholars were selected to contribute their frontier research<br />
projects.<br />
Dr. Yongho Sohn, Professor of Materials Science and Engineering at University<br />
of Central Florida, performed extensive microscopic and spectroscopic<br />
analyses to characterize microstructural features of hierarchal composites.<br />
Dr. Hanseup Kim, USTAR Assistant Professor of Electrical and Computer<br />
Engineering at University of Utah and the <strong>2012</strong> recipient of NSF Career<br />
Award, presents his futuristic research on developing micro gas chromatography<br />
system as a ‘wearable’ VOC measurement tool.<br />
Dr. Christian Hong, Assistant Professor of Molecular and Cellular Physiology<br />
at University of Cincinnati and a winner of $3.6 Million DARPA grant,<br />
investigates connections between circadian rhythms, cell cycle, and DNA<br />
damage response as interconnected networks.<br />
Dr. Byungkyu “Brian” Park, Associate Professor of Civil and Environmental<br />
Engineering at University of Virginia, presents a “school of fish” solution to<br />
the traffic congestion by developing a cooperative control algorithm based<br />
on wireless communications among vehicles and infrastructure.<br />
This issue also covers:<br />
▶ Highlights of the 1 st <strong>Korean</strong> Student Technical Leadership Conference (KSTLC) in<br />
Chicago on March 16-18, where over 100 <strong>Korean</strong> students studying in America attended:<br />
technical presentations, posters, Dale Carnegie training, presentation skill<br />
workshop, career development workshop, poster competition, and candid testimonials<br />
from participants.<br />
▶ MOU ceremony with Advanced Technology Center Association (ATCA) at Silicon<br />
Valley on March 5 th to establish a cooperative relationship to exchange research ideas<br />
in cutting-edge industrial technologies.<br />
▶ Advisory committee meeting and workshop for Institution of Basic Science (IBS)<br />
and Ministry of Education, Science and Technology (MEST) in Boston on Feb 9 th to<br />
help them recruit team leaders and young scholars (Vice Minister Chang-Kyung Kim<br />
of MEST and top officials from IBS sought inputs from the advisory committee of<br />
senior and distinguished <strong>KSEA</strong> members in establishing IBS as a world premier basic<br />
science research institute)<br />
▶ Pictures of events organized by local chapters and affiliated professional societies<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 3
MESSAGE FROM THE <strong>40</strong> TH PRESIDENT<br />
Message from the Father of TLC (YG and KS)<br />
<strong>40</strong>th <strong>KSEA</strong> President,<br />
Hosin “David” Lee<br />
It is 2:00 a.m. Tuesday on <strong>Apr</strong>il 10 in Iowa City, after finishing grading the exams, I am back to<br />
work on what I like the most, the <strong>KSEA</strong> business. I am glad to report that we have successfully organized<br />
the first KSTLC in Chicago for the 1 st Generation <strong>Korean</strong> students in March. After having<br />
delivered the first YGTLC for the 2 nd Generation <strong>Korean</strong>-<strong>American</strong>s 8 years ago, it was about time<br />
to deliver the second child. I have a feeling that the second child will grow even bigger than the<br />
first child because it was born twice as large as the first one. I would like to recognize the dedicated<br />
contribution from Dr. Byoung-Do Kim, YG director 1, Dr. Benjamin Lee, general director and Mr.<br />
Israel Jung, YG director 2, in guiding 25 organizers including three outstanding co-chairs of Kathy<br />
Lee, Rachel Park and Sarah Rhee. Who said the second child is more precious than the first one?<br />
I would like to congratulate all students from 4 th to 11 th grades who participated at the <strong>2012</strong> National<br />
Math & Science Competition (NMSC) on <strong>Apr</strong>il 21, co-organized by KUSCO. First, I would like to<br />
thank Dr. Kookjoon Ahn, Vice President 1, Dr. Yongho Sohn, executive director, Dr. Wookeun Shin,<br />
chair of the chapter presidents committee, chapter presidents and members of participating local<br />
chapters, and many more volunteers for the successful planning and execution of the NMSC. This year’s problem sets were prepared<br />
by the math and science educators from University of Iowa: Dr. Soonhye Park, Chair, and Dr. Kyong Mi Choi, Co-Chair,<br />
and members of the NMSC Committee. We added a new high school physics contest, led by Dr. Jae Yu, Publication Director 3,<br />
in collaboration with the Association of <strong>Korean</strong> Physicists in America (AKPA), one of our 23 affiliated professional societies.<br />
This year, all national award recipients and their parents are invited to attend the NMSC award ceremony at 11:00 a.m. on May<br />
12, Saturday, followed by a luncheon with a keynote speech from Dr. Jim Gates, Jr., member of the President Obama’s Council<br />
of Advisors in Science and Technology (PCAST) and advisor of <strong>KSEA</strong>, at Marriott Hotel at Tyson Corner in Washington. We<br />
invited the Ambassador Young-jin Choi of Korea and an administrator from University of Pennsylvania to give welcoming remarks.<br />
Yes, with your active participation, we broke the record of the participation at the NMSC.<br />
We organized the workshop to introduce the Institute of Basic Science (IBS) to young scientists and the advisory committee<br />
meeting for Dr. Chang Kyung Kim, Vice Minister of Education, Science and Technology of Korea, and top officials of IBS in Boston<br />
in February. In March, we signed the ninth MOU with Advanced Technology Center Association (ATCA) and have already<br />
started working with ATCA by connecting our members to their company members for research collaboration. In <strong>Apr</strong>il, our<br />
organization was selected to give a presentation at the heritage community liaison council meeting as the “Spotlight” organization<br />
to other council member organizations and top officials of Office of Director of National Intelligence (ODNI). I am proud<br />
to say that <strong>KSEA</strong> was recognized as a role model heritage organization in America.<br />
Since signing our first MOU with Korea Evaluation Institute of Industrial Technology (KEIT) on July 1, 2011, we continued to<br />
work with them throughout the year starting with training of their employees in December, participation and sponsorship of<br />
YGTLC and KSTLC, participation of our members in the research proposals to KEIT, and a contract to develop research need<br />
statements. It is a win-win situation for both <strong>KSEA</strong> and KEIT, and, like Rick said in Casablanca, Keit, I think this is only the<br />
beginning of a beautiful relationship.<br />
I cannot end my remarks without giving you an update on the membership status and budget situation. Yes, we set a new record<br />
of over 4,100 members, Yeah! And the all-time high revenue of $2.4 Million, including an unprecedented amount of donation of<br />
$37,680 from our own members and still growing! Do the math! We invested nearly $600 per member this year! Ask the question<br />
to your <strong>American</strong> colleagues! Which organization in America invests in its members more than <strong>KSEA</strong>?<br />
<strong>KSEA</strong> is a drawing board for you and I hope your participation at the UKC, YGTLC, KSTLC, NMSC as well as other <strong>KSEA</strong><br />
events is a very large dot that you can connect looking back later. As Steve Jobs said, you cannot connect the dots looking forward<br />
but you should create as many diverse dots now. <strong>KSEA</strong> exists to help its members succeed in the main stream of America.<br />
To help you find what you look for, <strong>KSEA</strong> will leave a light on for you. It is 3:<strong>40</strong> a.m. in Iowa City and I have just received this<br />
email from a member, “Thanks for your great work for <strong>KSEA</strong>. I was impressed with your talk. Of course, I am impressed with<br />
your passion and leadership. I heard <strong>KSEA</strong>’s great growth under your leadership.”<br />
Yeah! This will keep me going and going …<br />
4<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>
PRESIDENT OF <strong>KSEA</strong> VISITS THE NIH PIONEER AT HARVARD<br />
PRESIDENT OF <strong>KSEA</strong> VISITS THE NIH PIONEER AT HARVARD<br />
[Kyungjae Myung, <strong>KSEA</strong> Headquarter Operation Director]<br />
Senior Investigator<br />
National Human Genome Research Institute, NIH<br />
On a beautiful afternoon of February 9 th , after passing through historical brick<br />
buildings, I followed President Hosin Lee to the Cambridge Street where scientific<br />
department buildings with more modern styles are located. I read two previous<br />
interviews with Prof. Philip Kim of Columbia and Prof. John Kim of UCLA and I<br />
was excited to be a writer for this third article for Prof. Hongkun Park whom I call<br />
“Hyung”. He is not only a world-renowned scholar but also my staunch alumnus<br />
of elementary, middle school and college.<br />
The first impression I have received walking into Dr. Park’s office was “clean, neat,<br />
and organized.” President Lee quickly asked the first question, the same one that he<br />
asked to two previous interviewees, what his secrets are to achieve such a great success in his career. Dr. Park was very modest by<br />
saying “I do not believe I am successful yet.” However, thanks to our curious President, who kept insisting that it would help other<br />
<strong>KSEA</strong> members especially those in early career, Dr. Park told us that one major reason for his success was due to the people with<br />
whom he encountered; his mentors, colleagues, and students/fellows worked in his laboratory.<br />
President Lee asked his second question why he chose Stanford for his graduate study. Dr. Park told us, without hesitation, “because<br />
I was truly excited about the project that the professor at Stanford University, who became my Ph.D. advisor later, was working<br />
on.” He also added that he chooses students/fellows in his laboratory only if they express “the true enthusiasm”. (tip to become<br />
his student).<br />
He started as assistant professor at Harvard like everyone else but became a full professor<br />
with tenure in just four years (Note: Harvard university grants tenure to a full professor<br />
only). In President Lee’ opinion, he is the first (maybe second) <strong>Korean</strong>-<strong>American</strong><br />
who received tenure at Harvard. When Dr. Park received tenure, he also received a new<br />
startup fund from Harvard so that he could use it for starting a new line of research<br />
with high-risk and high-impact. Harvard even built a new building section where his 30<br />
students and post-docs are now working with the state-of-art research equipment. So,<br />
he initiated a new line of research in the field of nano-bio interfacing and neuroscience,<br />
where he believed many important scientific questions would still remain. His high-risk<br />
effort to a new direction became very fruitful with many papers published in the most<br />
prestigious journals like Nature, Cell, and Nature Nanotechnology. He also won the NIH’s most prestigious award called “NIH<br />
Pioneer Award.”<br />
Dr. Park then took us out for the most memorable lunch, particularly for President Lee<br />
who took the picture of us, at the Harvard Faculty Club. The atmosphere of the restaurant<br />
was the authentic Ivy League prestige. On the way to his laboratory after lunch, Dr. Park<br />
took us to the statue of the first benefactor of Harvard University, John Harvard. Thanks<br />
to the belief that the person who touches the left shoe of the statue becomes lucky to get<br />
admission to Harvard, the left toe of the statue was very shiny. Our curious President, of<br />
course, touched the shoe with a hope for his son will get an admission to Harvard for his<br />
graduate study.<br />
Dr. Park then gave us a tour of his laboratory. We were impressed with so many expensive<br />
looking research instruments and observed many students and post-doctoral fellows who<br />
were working hard. President Lee asked Dr. Park to pose in front of his instrument, but<br />
Dr. Park humbly declined it. Our tenacious President tried and started to chase Dr. Park<br />
who was running away from him. It was a very funny scene I would never forget. On the<br />
way back to the hotel, President Lee kept saying that he felt so proud to witness an increasing<br />
number of successful young (to him) <strong>Korean</strong>-<strong>American</strong> scientists in the US.<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 5
FEATURED ARTICLES<br />
NANO-BIO INTERFACING: LEVERAGING ADVANCES IN SEMICONDUCTOR TECHNOLOGY FOR<br />
BIOLOGICAL RESEARCH<br />
[Hongkun Park]<br />
Professor, Chemistry and Chemical Biology and Physics<br />
Harvard University<br />
Silicon integrated circuits represent an enormously successful paradigm for electronics – they are mass-produced at low cost in silicon<br />
foundries, and yet a chip with a footprint less than a square inch, is a highly integrated superstructure that contains hundreds of millions<br />
of transistors and can process data at gigahertz rates. Moreover, they contain top-down fabricated nanostructures whose sizes are<br />
comparable to important biological molecules and cells. As such, silicon nanostructures and integrated circuits have the potential to<br />
become a unique tool for interrogating living cells and organisms when a proper interface is developed.<br />
Over the past five years, a part of my group at Harvard has been working toward developing nano-bio interfaces that maximally utilize<br />
the advantages offered by these silicon nanostructures. 1-4 Our efforts have been centered on one particular structure: vertical silicon<br />
nanowire (SiNW) arrays. These nanoscale needles, which can be fabricated en masse using standard silicon processing technology,<br />
penetrate through the cellular membrane without compromising cell viability or function, thus providing direct intracellular access to<br />
a living cell. This unique capability, which is difficult to realize by any other means, provides an exciting opportunity for many branches<br />
of biological research. In my laboratory, we have been employing these nanoscale needles (1) to investigate the intracellular circuits<br />
that are responsible for the functions of immune cells, cancer cells, and stem cells by delivering various biological effectors 1-3 and (2) to<br />
monitor and control activities of brain cells in complex neuronal networks and tissues. 4<br />
SiNW nanoinjection for cell circuit perturbation: Efficient delivery of active biological effectors (DNAs, RNAs, peptides, proteins, or<br />
small molecules) into living cells is central to biological research and pharmaceutical screening. For instance, achieving a mechanistic<br />
understanding of intracellular molecular circuits requires systematic perturbation of circuit components and analysis of the resulting<br />
changes in cellular behavior. The success of this strategy depends critically on delivering various biological perturbants into living cells<br />
without compromising their viability or function.<br />
Because many biological effectors do not spontaneously cross the plasma membrane, a host of methods have been developed to deliver<br />
them into cells. Unfortunately, in a variety of primary cells, especially in resting immune cells, many of these techniques have proven<br />
ineffective, inducing non-specific inflammation or cell death. These limitations have severely restricted the use of perturbations in<br />
uncovering the ways in which these cells respond to extra- and intracellular signals, and have been a major obstacle to elucidating the<br />
molecular biology that underlies many hematological cancers. Clearly,<br />
the resistance of these cells to conventional means necessitates the development<br />
of new approaches.<br />
6<br />
Over the past few years, we have developed a new SiNW-based nanoinjection<br />
method that can serve as a minimally invasive and efficient<br />
method for delivering a variety of biomolecules into hard-to-transfect<br />
cells. 1-3 Specifically, we showed that the surface-coated SiNWs could efficiently<br />
administer active biomolecules directly into the cytoplasm of<br />
virtually any type of cell without impacting its viability or function (Figure<br />
1). 1 We then used the method to discover new components of the<br />
Toll-Like Receptor (TLR) network in mouse dendritic cells. 2 We also<br />
applied the method to investigate patient heterogeneity in chronic lymphocytic<br />
leukemia (CLL), the most common adult leukemia in North<br />
America. 3 By perturbing CLL cells using SiNW-mediated siRNA delivery,<br />
we identified three patient response groups, unclassifiable by known<br />
criteria, that required distinctly different clinical treatment schedules.<br />
These examples show that SiNWs can contribute greatly in cell circuit<br />
studies of otherwise hard-to-transfect cells: starting from the cells taken<br />
from a single blood draw, multiple different knockdowns could be used<br />
to simultaneously probe the importance of multiple potential pathways,<br />
enabling a detailed understanding of the intracellular circuitry critical<br />
for cell function and also the development of patient-specific combinatorial<br />
therapies.<br />
Figure 1. SiNW nanoinjection. Upper Image: a confocal image<br />
of a mouse dendritic cell on top of vertical SiNWs. Magenta: cell<br />
membrane, blue: cell nucleus, whilte: SiNW. Lower diagram: a<br />
model of the Polo-like-kinase-dependent pathway of the antiviral<br />
response in mouse dendritic cells.<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>
FEATURED ARTICLES<br />
Vertical nanowire electrode array for brain-machine interfacing: Neuronal networks – collections of neurons interconnected by<br />
synaptic junctions – form the physical basis of the central and peripheral nervous systems in biological organisms. The particular<br />
function of a neuronal network is determined by the intrinsic properties of its constituent neurons, the spatial connectivity among<br />
them, and the adaptive strengthening/weakening of those connections. Yet, developing a clear understanding of how these properties<br />
encode network function remains one of the major challenges of modern science.<br />
While recent advances in electron and optical microscopy have enabled the physical wiring diagram (the “structural connectome”) to<br />
be determined for small volumes of neural tissue, this structural information does not necessarily provide insight into the network’s<br />
function. Traditionally, functional behavior has been studied by optical imaging through the use of voltage and calcium sensitive dyes<br />
or electrophysiological measurements performed by extracellular electrode arrays. While these methods have significantly expanded<br />
our understanding of neuronal networks, they are fraught with significant shortcomings – for example, optical imaging provides only<br />
a time-averaged approximation of neuronal activity, while extracellular recording fails to provide clear signal-to-cell registry. Generating<br />
a high-resolution “functional connectome” requires the development of new experimental tools.<br />
Recently, we have developed a highly scalable intracellular electrode platform that<br />
is specifically designed to help address this issue by leveraging the same nanofabrication<br />
technology that enables mass-production of integrated silicon electronic<br />
circuits. 4 Our vertical nanowire electrode arrays (VNEAs) can intracellularly record<br />
and stimulate neuronal activity in dissociated cultures of rat cortical neurons and<br />
can also be used to map multiple individual synaptic connections (Figure 2). Moreover<br />
the VNEA platform can be readily coupled with conventional patch measurements,<br />
fluorescence microscopy, and optogenetic techniques, allowing truly multiplexed<br />
interrogation of a neuronal circuit. Although the prototype demonstrated<br />
to date has only 16 stimulation/recording sites, higher numbers and densities can<br />
easily be achieved using standard silicon nanofabrication processes. The integration<br />
of complementary metal-oxide-semiconductor circuitry with a VNEA would<br />
further allow on-chip digitization, signal multiplexing, compression, and telemetry.<br />
The scalability and high fidelity of this platform, combined with its compatibility<br />
with silicon nanofabrication techniques, should enable detailed mapping of synaptic<br />
connectivity in complex neuronal networks, thereby providing a transformative<br />
new tool for functional connectomics. The same platform will also allow the<br />
efficient high-throughput screening of candidate drug treatments for neurological<br />
disorders.<br />
Outlook: Above, I have provided a brief summary of the nano-bio research activities<br />
in my group. I should stress that our efforts represent just a small part of a much<br />
bigger landscape: many outstanding research groups are performing beautiful research<br />
in a closely related area, i.e., in applying nanoscience and technology to solve<br />
important biological problems. Over the past two decades, “nanoscientists” have<br />
amassed an impressive array of materials and tools that, when properly harnessed,<br />
should provide new ways of investigating biological problems. For this nascent field<br />
to flourish, however, more and better collaboration between nanoscientists and biologists<br />
will be essential. We should identify important problems and new opportunities<br />
in concert, and develop tools and perspectives that are designed to address<br />
them. I am confident that we can and, in time, we will.<br />
Figure 2. VNEA for neuronal recording and<br />
excitation. Upper left: an array of SiNWs capped<br />
by gold. The scale bar is 2 μm. Upper right: a rat<br />
cortical neuron on top of a recording/excitation<br />
pad. Lower graph: VNEA devices can be<br />
used to excite and record neuronal action potentials<br />
intracellularly, providing a highly scalable<br />
electrophysiology platform for neuroscience.<br />
References:<br />
1. A. K. Shalek et al. Proc. Natl. Acad. Sci. USA 107, 1870-1875 (2010).<br />
2. N. Chevrier et al. Cell 147, 853-867 (2011).<br />
3. A. K. Shalek et al. submitted (<strong>2012</strong>).<br />
4. J. T. Robinson et al. Nature Nanotech. 7, 180-184 (<strong>2012</strong>).<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 7
FEATURED ARTICLES<br />
SINGLE MOLECULE BIOLOGY: ONE, TWO, THREE & FOUR<br />
[Taekjip Ha]<br />
Professor, Physics<br />
Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Howard Hughes Medical Institute<br />
I call myself an accidental biophysicist. My Physics Ph.D work began in semiconductor physics and through a series of accidents I ended<br />
up developing methods to detect single fluorescence molecules. It turned out that the single molecule fluorescence methods could be<br />
applied to many biological systems and gradually my research topics shifted to biological questions, and although I teach physics in a<br />
physics department, all of the questions that we are addressing are biological in nature.<br />
Why would a physicist want to study biology? First, minimal functional units in biology are molecules and they can range between 1<br />
and 100 nm, the scale of current and future electronics. Second, biomolecules have been optimized through billions of years of evolution<br />
and often biological sensor reach the physical limits of sensitivity. A deep understanding of biological systems may ultimately lead<br />
to development of man-made nanomachines through reverse engineering. But is the population notion that biological molecules, for<br />
example proteins are nanomachines justified? For example, do the nanomachine have what man-made machines have such as engines<br />
and springs?<br />
The answer is a definitive yes for molecular motors that convert chemical energy stored in ATP or another high energy molecules into<br />
mechanical energy. A great example is myosin V which takes a 37 nm step along its track every time it consumes an ATP molecule as<br />
the fuel (Figure 1a). There was, however, a controversy as to whether myosin V walks on the track like a person (two feet alternating in<br />
position) or it crawls like a baby (one foot stays ahead of the other). Single molecule imaging and localization down to 1.5 nm precision<br />
led to a definitive proof that myosin V walks (1). This is an example of using detection of single fluorescent molecule to answer fundamental<br />
questions in biology (‘One’ in the title of this article).<br />
We recently made an exciting discovery that a protein can store elastic energy through multiple cycles of chemical energy release and<br />
that this stored energy can be released in a single burst (Gwangrog Lee et al., submitted). In this work, an enzyme that can digest RNA<br />
strand one base at a time even in the presence of basepaired structures was studied using another single molecule method called single<br />
molecule fluorescence resonance energy transfer (FRET). FRET measures the interaction between two dye molecules attached to a<br />
biological molecule and because FRET is a strong function of distance, it can report on even minute distance changes during biological<br />
reactions. In this particular work, we attached the dyes to the RNA so that FRET would increase during RNA unwinding by the enzyme<br />
(Figure 1b). The surprise was that the enzyme unwound RNA in large steps about 4 base pairs even though the motion is powered<br />
by RNA digestion in single base steps, strong suggesting the enzyme/RNA complex can be viewed as a spring. ‘Two’ in the title of this<br />
article refers to FRET and my laboratory has been fortunate to make several interesting discoveries on enzymes that work on DNA and<br />
RNA using the method.<br />
Figure 1. Protein as a nanomachine (a) A nanoengine.<br />
(b) A nano-spring.<br />
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There is yet another powerful single molecule method called optical tweezers.<br />
Optical tweezers can be viewed as chopsticks made of light and can be used<br />
to apply and measure very small forces down to sub-pico Newtons (< 10 -12<br />
Newton) and measure small movements down to a few angstroms. We combined<br />
optical tweezers and single molecule FRET to measure conformational<br />
changes of a single molecule via FRET as a function of applied force (2). This<br />
led to a number of interesting findings, for example, how a protein that is fully<br />
wrapped by a DNA strand can rapidly migrate on the DNA (3)(Figure 2).<br />
I call this effort “Two+One” because we are combining FRET with an extra<br />
dimension of applied force.<br />
Thus far, most of single molecule biophysics experiments have been performed<br />
on one molecule in isolation largely due to technical difficulties but<br />
these molecules do not function in isolation in the cell. Therefore, in order to<br />
Figure 2. FRET and force. Optical tweezers can apply<br />
force to the DNA and FRET can be used to measure how<br />
the SSB protein’s motion is affected by DNA unraveling.<br />
better mimic the cellular conditions, we need to study biomolecular complexes with multiple components. We and others have made a<br />
technical push in this direction, for example pushing the single molecule fluorescence measurements to three and four colors (“Three<br />
and Four” in the title comes from this)(4), and combining single molecule fluorescence with ultrahigh resolution optical tweezers (5).<br />
Our dream experiment is to measure a complex cellular process such as copying of DNA using multi-dimensional single molecule<br />
techniques. For example, a three-axis optical tweezers can measure the progress of DNA copying with a single base pair resolution<br />
while at the same time, proteins labeled with different dyes can be visualized to report on which proteins participate in which step and<br />
how they change their structures and relative organizations (Figure 3).<br />
Figure 3. Multi-dimensional single molecule measurements<br />
of DNA copying process.<br />
In closing, I would like to emphasize the need to make connection between in vitro biophysical studies and in vivo functions. Systems<br />
biology is another contemporary discipline that rely on physical tools and mathematical modeling to understand the underpinnings<br />
of biological phenomena. There is now a growing connection between the two disciplines, spurred by new developments in cellular<br />
imaging and absolute quantification at the single molecule level, with the potential for facilitating a new quantitative understanding of<br />
biological processes. The interface between these two fields holds a great promise of fertile interaction and new discovery.<br />
REFERENCES<br />
1. A. Yildiz et al., Science 300, 2061 (2003).<br />
2. S. Hohng et al., Science 318, 279 (Oct 12, 2007).<br />
3. R. Zhou et al., Cell 146, 222 (Jul 22, 2011).<br />
4. J. Lee et al., Angew Chem Int Ed Engl 49, 9922 (Nov 23, 2010).<br />
5. M. J. Comstock, T. Ha, Y. R. Chemla, Nature Methods 8, 335 (2011).<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 9
TECHNICAL ARTICLES<br />
MICROSTRUCTURALLY DESIGNED HIERARCHAL ALUMINUM METAL MATRIX COMPOSITES<br />
[Yongho Sohn]<br />
Professor, Materials Science and Engineering<br />
University of Central Florida, Orlando<br />
INTRODUCTION<br />
Nanostructured Al-alloy based MMCs have gained considerable interest due to their excellent properties (i.e., high strength, low<br />
density, good corrosion resistance), and their technical and economical ease of manufacturing. Recently, a hierarchal MMC consisting<br />
of a nanocrystalline Al phase (NC-Al), boron carbide (B4C) reinforcement particles, and a coarse-grain Al phase (CG-Al) has<br />
been successfully fabricated and reported to exhibit extremely high compressive yield strength ( > 1 GPa) and tailorable ductility<br />
(~ 15%) [1,2]. In particular, high strain-rate dependent materials have found their way into aerospace, automotive, biomedical, and<br />
defense application. These properties are achieved through control of the microstructure that is dependent on parameters of materials<br />
processing and manufacturing. The hierarchical Al-MMCs exhibit good thermal stability and microstructural characteristics<br />
that deflect or blunt or bridge crack propagation. The microstructure and properties can be further customized through the use of<br />
friction stir processing [3] which offers a variety of possibilities for joining components of dissimilar geometry, modified and graded<br />
microstructure and composition.<br />
MATERIALS PROCESSING AND MANUFACTURING<br />
The commercial gas-atomized AA5083 Al powder has an average particle size of less than 45 μm with a grain size ranging from 0.2<br />
to 2 μm. The B4C powder has a starting particle size between 1 to 7 μm. The 5083 Al powder is combined with B4C powder and cryomilled<br />
for up to 24 hours. The powders are ball-milled in the presence of liquid N2 to increase friability, prevent oxidation and mitigate<br />
dynamic recrystallization. Commercially available stearic acid is utilized as a process-control agent during milling to prevent excessive<br />
agglomeration of the powders and improve yield. Cryomilling is a key step that produces the Al grain size down to 20-30 nm<br />
[4,5], disperses the B4C into the Al matrix and creates the NC-Al/B4C bond. Other strengthening mechanisms are generated during<br />
this process including dislocation entanglement, dispersoids strengthening and complex interface development. After cryomilling,<br />
additional AA5083 powder (CG-Al) is blended with the cryomilled mixture, which in turn creates the hierarchal MMC powders.<br />
The powder samples are degassed<br />
through a rotary dynamic vacuum<br />
degassing system. The degassed<br />
powders are then consolidated into<br />
billets with established powder metallurgy<br />
techniques such as vacuum<br />
hot pressing, cold isostatic pressing,<br />
or hot isostatic pressing. Secondary<br />
processing is achieved through<br />
conventional wrought processing<br />
techniques such as extrusion, forging,<br />
and/or rolling. Figure 1 illustrates<br />
the complete manufacturing<br />
processing steps of the hierarchal Al<br />
Figure 1. Manufacturing sequence of hierarchal Al metal matrix composites<br />
MMCs examined in this study.<br />
NOVEL MICROSTRUCTURAL FEATURES OF HIERARCHAL COMPOSITES<br />
Extensive microstructural and spectroscopic analyses were carried out as a function of processing parameters. The properties of<br />
hierarchal Al MMCs were influenced by multiple microstructural features including: (1) volume (or weight) fraction of each constituent,<br />
NC-Al, CG-Al and B4C; (2) grain size and distribution of the NC- and CG-Al; (3) size and distribution of the B4C particle<br />
reinforcement; (4) size and distribution of hierarchal microstructural domains, e.g., CG-Al and B4C/ NC-Al agglomerates; (5)<br />
dislocation densities the in NC- and CG-Al; (6) composition, distribution and structure of nitrogen incorporated during cryomilling<br />
either in solution or as a dispersoid reinforcement; (7) characteristics of grain boundaries and interfaces (e.g., NC-Al and B4C,<br />
NC-Al and CG-Al, CG-Al and B4C); (8) other impurity-associated strengthening by solution or dispersion reinforcements.<br />
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Characteristic microstructure of consolidated hierarchical<br />
Al MMCs is presented in Figure 2. The light grey region<br />
is the CG AA5083 Al, and the darker grey regions<br />
are the nano-agglomerate that consists of cryolmilled<br />
NC-Al and B4C. The dark “spots” within the nano-agglomerate<br />
are B4C particulates. Grain size within NC-<br />
Al region has been examined by hollow-cone dark field<br />
(HCDF) TEM imaging for statistically confident analyses,<br />
and ranges from 30-50 nm after primary consolidation<br />
as presented in Figure 2 [6]. The primary reinforcement,<br />
B4C is evenly dispersed throughout the NC-Al<br />
agglomerate and typically has a narrow distribution of<br />
size. The typical grain size of the CG-Al is 0.2 to 2 μm.<br />
The CG-Al is added to promote ductility and interact<br />
with cracks propagating through the composite. Cracks<br />
Figure 2. Novel microstructural features of hierarchal Al-MMCs<br />
propagate easily through the brittle NC-Al/B4C region,<br />
but are deflected or blunted or bridged upon reaching the CG as seen in Figure 2 [6]. This behavior gives the composite toughness.<br />
Nitrogen is absorbed by the NC-Al during cryomilling, and manifest as AlN crystals and amorphous, N-rich dispersoids that<br />
are usually found at the NC-Al grain boundaries [5-7]. Nitrogen concentration was found to vary linearly with milling time of<br />
up to 24 hours [8]. Other dispersoids that have been observed through microstructural interrogation are oxides and carbides<br />
[6]. Fe- and Mn-rich dispersoids are also found in both the NC-Al and CG-Al regions. These dispersoids can help contribute<br />
to the excellent thermal stability exhibited by this composite [7]. It is noted, however, that under both thermal and mechanical<br />
deformation, the NC-Al grains can grow significantly. Yao et al. found that the average NC-Al grain size after cryomilling was<br />
about 20 nm, and after secondary processing (high temperature and stress for an extended time), the NC-Al grain size increased<br />
to over 100 nm [8].<br />
As a result of cryomilling the NC-Al grains retain a high strain energy in the form of dislocations. After consolidation, some of<br />
these dislocations are annihilated while deformation during secondary processing can introduce new dislocations into the CG-<br />
Al. Yao et. al estimated, based on HCDF technique, the dislocation density of the NC-Al and CG-Al after secondary processing<br />
to be about 1.9·1016 m-2 and 1.2·1015 m-2 respectively [9].<br />
ACKNOWLEDGEMENT<br />
Research was sponsored by U.S. Army Research Laboratory and was accomplished under Cooperative Agreement<br />
W911NF-08-2-0026. The views, opinions, and conclusions made in this document are those of the authors and should not be<br />
interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government.<br />
The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any<br />
copyright notation herein.<br />
REFERENCES<br />
1. J. Ye, B.Q. Han, Z. Lee, B. Ahn, S.R. Nutt, J.M. Schoenung, Scr. Mater., 53 (2005) 481.<br />
2. H. Zhang, J. Ye, S.P. Joshi, J.M. Schoenung, E.S.C. Chin, K.T. Ramesh, Scr. Mater., 59 (2008), 1139.<br />
3. Y.H. Sohn, T. Patterson, C. Hofmeister, C. Kammerer, W. Mohr, M. van den Bergh, M. Shaeffer, K. Cho, J. Metals,<br />
64 (<strong>2012</strong>) 234.<br />
4. D.B. Witkin, E.J. Lavernia, Prog. Mater. Sci., 51 (2006) 1.<br />
5. E.J. Lavernia, B.Q. Han, J.M. Schoenung, Mater. Sci. Eng. A, 493 (2008) 207.<br />
6. B. Yao, C. Hofmeister, T. Patterson, Y. H. Sohn, M. van den Bergh, T. Delehanty, K. Cho, Composites A, 41 (2010) 933.<br />
7. C. Hofmeister, B. Yao, Y. H. Sohn, T. Delahanty, M. van den Bergh, K. Cho, J. Mater. Sci., 45 (2010) 4871.<br />
8. B. Yao, B. Simkin, B. Majumdar, C. Smith, M. van den Bergh, K. Cho, Y.H. Sohn, Mater. Sci. Eng. A, 536 (<strong>2012</strong>) 103.<br />
9. B. Yao, H. Heinrich, K. Cho, Y.H. Sohn, Micron, 42 (2011) 29.<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 11
TECHNICAL ARTICLES<br />
MICRO GAS CHROMATOGRAPHY SYSTEM FOR DISTRIBUTED ENVIRONMENTAL AWARENESS<br />
[Hanseup Kim, <strong>KSEA</strong> Membership Director]<br />
USTAR Assistant Professor, Electrical and Computer Engineering<br />
University of Utah<br />
INTRODUCTION<br />
The World Health Organization (WHO) states that 2.4 million people die each year worldwide from causes directly attributable to<br />
air pollution (1). In US the fatalities from air pollution, totaling over 70,000 lives in 2002, are twice the number of automobile fatalities<br />
and are equal to deaths from breast cancer and prostate cancer combined (2). Hundreds of scientific studies conducted worldwide<br />
have provided evidences that polluted air has alarming adverse effects on health (3). Clearly, the exposure to air pollution needs<br />
to be dramatically reduced or at least monitored for individuals. While the air pollutants include various chemical compounds, such<br />
as ozone, nitrogen oxides, and sulfur dioxide, Volatile Organic Compounds (VOCs) cover the largest number of >100 pollutants<br />
and are the most common pollutants exposed to humans who spend a significant amount of time indoors. Another report from<br />
EPA states that the indoor air pollution caused by VOCs is ten times higher than outdoor regardless of the building location in rural<br />
or highly industrial areas (4). VOCs are also found to have strong correlation with allergies and asthmas, and each individual has<br />
different levels of responses to specific VOCs (5, 6). Thus, the development of a personal ‘wearable’ warning system against a wide<br />
range of VOCs is much needed to prevent significant harm to public health from nearly inevitable exposure. Currently there are no<br />
viable options for such needs.<br />
MICRO GAS CHROMATOGRAPHY SYSTEM<br />
A micro gas chromatography system (μGC) can be a best option as a ‘wearable’ VOC measurement tool. Compared to commercial<br />
gas sensors that have narrowly-limited detection targets (e.g. carbon monoxide sensor), a gas chromatography (GC) system could<br />
provide much higher detection capacity of >10’s species and seems a more feasible option for miniaturization than mass spectrometry<br />
(MS), because of its ‘less’ requirements for supporting equipments (no vacuum pumps or carrier gases). Indeed a GC is the most<br />
widely used tool in analytical chemistry. Currently MS has proven to be more difficult to miniaturize due to the vacuum pumping<br />
requirements as well as the need to purifying samples before analysis. The state-of-the-art “portable” MS still weighs over 11kg,<br />
consumes >42W, and has the size of a backpack. Note that the miniature GCs also hold significant advantages of high-speed & highresolution<br />
detection, tiny volume, reduced power, as well as the possible ‘wearable’ portability.<br />
Operation Principle: A micro gas chromatograph enables the detection of complex mixtures of ~100 airborne compounds by first<br />
spatially separating and then detecting them along fluidic migration. To do so, it incorporates additional components than the standalone<br />
gas sensor, including a pre-concentrator, a separation column and a fluidic pump (Figure 1). The pre-concentrator collects<br />
targets into high concentration for better sensitivity; the column provides a race track where target species are separated in space<br />
and time to enhance selectivity at the detection sensor; and the micropump forces the target samples to flow at the optimal speed<br />
for efficient separation as well as the rapid detection. Specifically, the spatial separation among compounds is achieved in the column<br />
where special coating inside, called as a stationary phase, adsorbs and releases the different target molecule groups at different<br />
speeds. Resultantly each group of gas molecules becomes apart as they pass through the column. Thus, each group passes by a sensor<br />
at different times and produces a train of peak signals at a micro sensor for detection.<br />
Figure 1. The operation principle of the gas chromatography system: Spatial separation ahead of detection<br />
reduces the burdens on the sensor’s selectivity and sensitivity.<br />
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HYBRID MICRO GC<br />
The first micropump-driven micro gas chromatography<br />
system has been demonstrated,<br />
with a total device volume of 0.5 cc (Figure<br />
2). The μGC samples separates and detects airborne<br />
11-mixture VOCs at high-speed (
TECHNICAL ARTICLES<br />
INTERCONNECTED NETWORK OF THE CELL CYCLE, CIRCADIAN RHYTHMS,<br />
AND DNA DAMAGE RESPONSE<br />
[Christian Hong]<br />
Assistant Professor, Molecular and Cellular Physiology<br />
University of Cincinnati College of Medicine<br />
Fundamental cellular processes that maintain most organisms’ health and survival include cell cycle, DNA damage response, and<br />
circadian rhythms. Cell cycle is equipped with multiple checkpoints for controlled growth, DNA replication, and divisions. DNA<br />
damage response (DDR) mechanisms control cell fate by either repairing single or double strand breaks, or triggering apoptosis for<br />
programmed cell death when the damage is fatal. Last, but not least, is circadian rhythm that keeps track of time of a day, and plays a<br />
central role in most organisms for setting the sleep/wake cycle, feeding rhythms, and other daily activities. These distinct molecular<br />
mechanisms communicate with each other and create a complex bio-molecular network to optimize conditions for cells to grow and<br />
adapt to the surrounding environment. Perturbations and dysfunctional cellular responses in this network may lead to diseases such<br />
as cancer, obesity, and sleep disorders among many others.<br />
Figure 1. Simple schematic of<br />
time-delayed negative feedback<br />
loop of Neurospora circadian<br />
rhythms<br />
The mechanistic blueprints of circadian rhythms are similar from Neurospora crassa to Mus musculus<br />
[1]. In Neurospora, the heterodimeric transcription factor, WCC that contains a conserved PAS<br />
domain, activates a core clock component designated frq. The FRQ protein translocates into the<br />
nucleus and inhibits its own transcription factor, WCC. In brief, this creates a time-delayed negative<br />
feedback loop, which is at the heart of circadian rhythms [1] (Figure 1). While this circuit may be<br />
at the core of the circadian clock system, its operation, however, is much more complex involving<br />
interlocked feedback loops, transcriptional, post-transcriptional, and post-translational regulations<br />
[2].<br />
Cell cycle and circadian rhythms are coupled despite their discrete functions. The circadian gated<br />
cell division cycles are observed in various organisms from cyanobacteria to mammals [3-6]. A<br />
mammalian circadian transcription factor, BMAL1/CLOCK, directly binds the E-box in the Wee1<br />
promoter and activates its transcription. WEE1 is one of the key cell cycle kinase that phosphorylates and inactivates the Mitosis<br />
Promoting Factor (MPF) that facilitates the entry into the mitosis. The abundance and activity of WEE1 have been shown to oscillate<br />
and be transiently elevated during the evening in mouse liver [5]. These, in turn, determine the duration of G2-phase. Cells divide<br />
in late evening when the WEE1 level decreases in order to allow cells to enter into the M-phase. The component of the cell cycle<br />
that is controlled by WEE1 operates in concert with another regulatory system that is<br />
periodically imposed on WEE1 by the circadian clock.<br />
The above seemingly unidirectional communication was recently shown to be conditionally<br />
bidirectional. DNA damage induces responses that arrest the cell cycle, or<br />
lead to programmed cell death, e.g. apoptosis. Ionizing radiation causes DNA doublestrand<br />
breaks that trigger signaling cascades via ATM and CHK2 [7]. In Neurospora<br />
crassa (filamentous fungi) and in mammals, the CHK2 checkpoint kinase physically<br />
interacts with a core clock components, FRQ and PER1 [8, 9], respectively, and represents<br />
an intersection point between cell cycle regulation and the circadian clock.<br />
The CHK2 kinase phosphorylates and promotes premature degradations of FRQ/<br />
PER1, which creates phase shifts in the circadian clock (Figure 2). The implications of<br />
such a phenotype raise the hypothesis that the cell cycle machinery utilizes circadian<br />
rhythms to activate WEE1/SWE1 by prematurely degrading FRQ [10]. This degradation<br />
removes the negative feedback on its transcription factor, WCC, which will then<br />
activate Swe1 and arrest cell cycle progression and provide time for DNA repair. There<br />
are additional candidates that participate in the molecular coupling of the cell cycle<br />
and the circadian clock. The transcript of c-Myc oscillates with a circadian period,<br />
and its transcription is suppressed by a heterodimeric circadian transcription factor,<br />
BMAL1/NAPS2 [11]. The molecular details of this coupling, however, remain unex-<br />
Figure 2. DNA damage activates Chk2, which<br />
phosphorylates one of the core circadian clock<br />
component, PER1 in mammals and FRQ in<br />
Neurospora, resulting in phase shifts of circadian<br />
rhythms<br />
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plored. Additional cell cycle genes such as CyclinD1, Gadd45α, and Mdm-2 also produce transcripts whose abundance oscillates, but<br />
details of how they are regulated remain unknown [11]. The rhythmic CyclinD1 transcripts suggest a role of the circadian clock at<br />
the G1 to S transition as well as the G2 to M transition due to the activity of WEE1. Furthermore, the rhythmicity of the Gadd45α<br />
and Mdm-2 transcripts suggests that the circadian clock plays a regulatory role in cellular responses to DNA damage.<br />
In our lab, we investigate connections between circadian rhythms, cell cycle, and DNA damage response as interconnected networks.<br />
Each cellular mechanism is complex with multiple feedback loops. Therefore, we use mathematical modeling to investigate<br />
network dynamics arising from these interlinked cellular processes, and experimentally validate model-driven hypotheses in Neurospora<br />
crassa (Figure 3). Iterative approaches of mathematical modeling and experimental validations maximize synergy dissecting<br />
intertwined molecular mechanisms of the above three processes. Detailed investigation of these interactions will lead to better<br />
understanding of functional roles of circadian rhythms in the cell cycle and DNA damage response.<br />
Figure 3. Interdisciplinary approach to dissect molecular mechanisms of circadian rhythms and other cellular processes<br />
such as cell cycle. Molecular wiring is converted into a set of ordinary differential equations that provide hypotheses and<br />
guide experiments.<br />
References:<br />
[1] Dunlap, J. C. 1999. Molecular bases for circadian clocks. Cell 96:271-290.<br />
[2] Heintzen, C., and Y. Liu. 2007. The Neurospora crassa circadian clock. Adv Genet 58:25-66.<br />
[3] Sweeney, B. M., and J. W. Hastings. 1958. Rhythmic cell division in populations of Gonyaulax polyedra. J Protozool 5:217-224.<br />
[4] Edmunds, L. N., Jr. 1974. Phasing effects of light on cell division in exponentially increasing cultures of Tetrahymena grown at<br />
low temperatures. Exp Cell Res 83:367-379.<br />
[5] Matsuo, T., S. Yamaguchi, S. Mitsui, A. Emi, F. Shimoda, and H. Okamura. 2003. Control mechanism of the circadian clock for<br />
timing of cell division in vivo. Science 302:255-259.<br />
[6] Yang, Q., B. F. Pando, G. Dong, S. S. Golden, and A. van Oudenaarden. 2010. Circadian gating of the cell cycle revealed in single<br />
cyanobacterial cells. Science 327:1522-1526.<br />
[7] Pardo, B., B. Gomez-Gonzalez, and A. Aguilera. 2009. DNA repair in mammalian cells: DNA double-strand break repair: how<br />
to fix a broken relationship. Cell Mol Life Sci 66:1039-1056.<br />
[8] Pregueiro, A. M., Q. Liu, C. L. Baker, J. C. Dunlap, and J. J. Loros. 2006. The Neurospora checkpoint kinase 2: a regulatory link<br />
between the circadian and cell cycles. Science 313:644-649.<br />
[9] Gery, S., N. Komatsu, L. Baldjyan, A. Yu, D. Koo, and H. P. Koeffler. 2006. The circadian gene per1 plays an important role in<br />
cell growth and DNA damage control in human cancer cells. Mol Cell 22:375-382.<br />
[10] Hong, C. I., J. Zamborszky, and A. Csikasz-Nagy. 2009. Minimum criteria for DNA damage-induced phase advances in circadian<br />
rhythms. PLoS Comput Biol 5:e1000384.<br />
[11] Fu, L., H. Pelicano, J. Liu, P. Huang, and C. Lee. 2002. The circadian gene Period2 plays an important role in tumor suppression<br />
and DNA damage response in vivo. Cell 111:41-50.<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 15
TECHNICAL ARTICLES<br />
COOPERATIVE CONTROL AT TRAFFIC LIGHT HARNESSED BY WIRELESS CARS<br />
[Byungkyu “Brian” Park, <strong>KSEA</strong> Publication Director I]<br />
Associate Professor and Graduate Program Director, Civil and Environmental Engineering<br />
University of Virginia<br />
INTRODUCTION<br />
Figure 1. Two Schools of Fish Moving<br />
through “Fish Intersection”<br />
Everyone hates waiting at traffic lights. As more cars travel through the urban streets, it<br />
is inevitable that cars have to stop at the intersection – this happens whenever demand<br />
exceeds supply as we understand from the Economics 101 class. This is common at the<br />
intersections in metropolitan areas where an intersection has to serve cars from multiple<br />
approaches. Does it happen to fish? Not really! As shown in Figure 1, anyone enjoys scuba<br />
diving would have seen how two schools of fish moves through “fish intersection” without<br />
collision (IEEE, 2004). One might wonder why cars cannot cooperatively move just like the<br />
fish! Obviously, it is not likely for cars unless human drivers completely give up their egos<br />
and cooperative control becomes possible. To ensure cooperative control, cars should be<br />
able to effectively communicate and an algorithm should be devised. A recent US Department<br />
of Transportation’s initiative on Connected Vehicle technology presents a possibility<br />
of such cooperative control based on wireless communications among vehicles and infrastructure<br />
(US Department of Transportation).<br />
METHODS<br />
A driver may travel through an intersection without stopping when the intersection is controlled by YIELD sign and there is sufficient<br />
gap available. This happens when there are few cars. As more cars try to cross the intersection, drivers have to stop at the intersection<br />
and have to look for safe gaps. What if wireless cars that are capable of communicating each other within a certain distance<br />
are abundant waiting for cooperative control? Then, one can predict car’s trajectory to the intersection area where collision might<br />
occur. As shown in Figure 2, a collision between two conflicting trajectories (i.e., cars movements) at the intersection is about to<br />
happen (see the two trajectories cross at lw area, representing intersection area), but the collision could be avoided with trajectory<br />
adjustments. An easy option would be that one car goes faster and the other car goes slower than their current speeds. The trajectory<br />
adjustments mean that cars will cooperatively adjust their acceleration rates to avoid collision. This approach can be formulated as a<br />
nonlinear constrained optimization (Lee & Park, <strong>2012</strong>). The objective function minimizes overlaps among conflicting cars within the<br />
intersection collision area, while constraints include minimum and maximum acceleration rates, minimum and maximum speeds,<br />
and minimum headway between cars.<br />
Figure 2. Concept of Cooperative Control Algorithm<br />
16 <strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>
TECHNICAL ARTICLES<br />
Figure 3. A Snapshot of an Intersection under Cooperative<br />
Vehicle Intersection Control<br />
There are a few solution approaches to the proposed nonlinear constrained<br />
optimization problem. Both analytical and heuristic approaches<br />
are considered. The former includes active set method (ASM) based on<br />
Sequential Quadratic Programming and interior point method (IPM)<br />
based on the calculation of the Karush-Khun-Tucker (KKT) conditions.<br />
A known limitation in these algorithms is that their solution depends on<br />
an initial solution and may not converge to acceptable solution. The latter<br />
include genetic algorithm and shuffled frog leaping algorithm that are<br />
based on the evolution and natural selection. It is generally understood<br />
that the latter heuristic algorithms have often better chance to find an<br />
acceptable solution while they need longer computation time. Figure 3<br />
shows an example of the proposed cooperative control realized in a virtual<br />
world based on the solutions could be found from these algorithms.<br />
PERFORMANCE EVALUATION<br />
To conduct an evaluation, it is assumed that cars are fully automated, optimal controls are developed and implemented for real-time<br />
cooperative control and no communication latencies exist between cars and infrastructure. To quantify the benefits of the proposed<br />
cooperative control algorithm, mobility and sustainability measures including travel time, stop delay, CO 2<br />
emissions and fuel consumptions<br />
were utilized. A hypothetical intersection was developed using a microscopic traffic simulation model, VISSIM, and multiple<br />
volume scenarios were generated through an experimental design. To establish baseline performance, the intersection control<br />
based on actuated control (AC) was used. It is noted that AC is the state of practice control method most commonly used in the traffic<br />
light control.<br />
The overall performances of the proposed algorithm compared to an actuated control (AC) are summarized in Table 1. The proposed<br />
approach reduced the total stop delay times by 99%. Total travel times and throughputs were also improved by 33% and 8%, respectively.<br />
Air quality and energy savings were also significant: 44% reduction of CO 2<br />
emissions and 44% reduction in fuel consumption.<br />
Measure Measure (Unit) Proposed AC Gain<br />
Mobility Average total stop delay time (Hour) 0.1 12.1 99%<br />
Measures<br />
Average total travel time (Hour) 25.1 37.2 33%<br />
Sustainability Carbon Dioxide (CO2) (ton) 263.7 471.0 44%<br />
Measures<br />
Fuel Consumption (Liter) 120.9 215.2 44%<br />
Table 1. Evaluation Results between the Proposed and Actuated Control<br />
CONCLUDING REMARKS<br />
Based on a simulation-based study at a hypothetical intersection, the potential improvements of the cooperative control over conventional<br />
actuated control were evaluated under varying traffic congestion conditions. The results showed that the cooperative control<br />
outperformed conventional actuated control.<br />
It is recommended several factors should be carefully considered and evaluated through physical and simulation test-beds before<br />
deploying the proposed cooperative control in the real world. These factors including system architecture (i.e., central, distributed or<br />
hybrid controls), protocols on vehicle-to-vehicle and/or vehicle-to-infrastructure communications, solution algorithm and computation<br />
power should be determined to ensure that the feasibility of the real-time implementation is guaranteed.<br />
REFERENCES<br />
IEEE. (2004, February). Cooperative Control School. IEEE Control Magazine, p. 104.<br />
Lee, J., & Park, B. (<strong>2012</strong>). Development and Evaluation of a Cooperative Vehicle Intersection Control Algorithm under the Connected<br />
Vehicles Environment. IEEE Transactions on Intelligent Transportation Systems,, 81-90.<br />
US Department of Transportation. (n.d.). Retrieved March 30, <strong>2012</strong>, from Connected Vehicle Technology Website: http://www.its.dot.<br />
gov/connected_vehicle/connected_vehicle.htm<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 17
WORKSHOP ON INTRODUCTION TO INSTITUTE FOR BASIC SCIENCE<br />
WORKSHOP TO INTRODUCE THE INSTITUTE FOR BASIC SCIENCE (IBS)<br />
AND ADVISORY COMMITTEE MEETING FOR VICE MINISTER CHANG-KYUNG KIM<br />
OF MEST IN BOSTON ON FEBRUARY 8-9, <strong>2012</strong><br />
Administrative Director Kyung-Taek Chung and his staff member of<br />
IBS introduced the newly established research institute that aims at<br />
leading the basic science research in the world. IBS is the first major<br />
establishment as part of the large-scale comprehensive International<br />
Science and Business Belt (ISBB) project in Korea. Audience was impressed<br />
about the opportunity and felt that IBS is destined to become<br />
a “research institute of scientists’ dream” where world-class scientists<br />
can undertake research with the utmost freedom and autonomy. As<br />
you can see in the photo, IBS provided a dinner to all participants at<br />
the Inn at Harvard.<br />
A workshop for introducing Institute for Basic Science (IBS, www.ibs.re.kr),<br />
Daejeon, Korea, was held at the Inn at Harvard on February 8-9, <strong>2012</strong>. Nearly<br />
100 young scientists and engineers were in attendance for the introduction<br />
of IBS event on the February 8 th , and 15 distinguished scientists and<br />
engineers attended the advisory committee meeting for IBS on February<br />
9 th . Both events started with a motivational speech by Vice Minister Chang-<br />
Kyung Kim of Ministry of Education, Science and Technology, wearing a<br />
red MIT alumnus shirt, who captivated the audience about the opportunity<br />
for basic research in Korea with his humor. During the Q&A session, he<br />
took off his jacket to show off his red shirt with a MIT logo saying it is too<br />
hot in the room. Young scholars were impressed with his straightforward<br />
answers to their pointed questions.<br />
Next day, 15 distinguished scholars were invited to give inputs to Dr. Chang-Kyung Kim and top officials of IBS. President Hosin<br />
Lee, Advisor Jim Gates, Editorial Board Hongkun Park, Former President Nakho Sung, Former President Kang-Won Wayne Lee,<br />
Executive Director Yongho Sohn, TG Director Eun-Suk Seo, HO Director Kyungjae Myung (NIH) and other distinguished scholars<br />
from Harvard took their time to help them start a world-class basic research institute with new perspectives. The meeting lasted<br />
nearly three hours and covered many different aspects of IBS from philosophy of research to very-detailed-practical operations.<br />
Each advisory committee member gave her/his advice on the operation of IBS and Vice Minister Kim took his time in responding<br />
to each piece of advice. All participants came away with the positive perspective for the new research institute that would lead the<br />
world with a great leadership.<br />
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<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>
MOU SIGNED WITH ADVANCED TECHNOLOGY CENTER ASSOCIATION (ATCA)<br />
MOU BETWEEN <strong>KSEA</strong> AND ATCA<br />
DURING A WORKSHOP AT SILICON VALLEY ON MARCH 5, <strong>2012</strong><br />
Advanced Technology Center Association (ATCA) (atca.or.kr) is an invitation-only association that consists of “World-Class” companies<br />
(typically small to medium sized) that strive for world’s largest market share for their products. More than 30 CEOs and<br />
Chief Technologists from ATCA members seeking recent technology trends and business opportunities gathered at KOTRA office<br />
in Silicon Valley for a workshop on March 5, <strong>2012</strong>.<br />
The workshop began with three technical presentations covering IT, Device Technology and<br />
Materials. Prof. Simon Shim from San Jose State University presented recent trends on computing<br />
technology with emphasis on storage technology and planning along with future strategies<br />
for business start-up and IP development. Then, Prof. Hanseup Kim (<strong>KSEA</strong> Membership Director)<br />
from University of Utah presented an overview of micro-devices and materials needs<br />
for energy and biological applications including optimization of energy harvesting. He also<br />
presented a world of biological system as fascinating electrical systems signals and chemical<br />
signals, where fluid control is critical to emulate.<br />
Finally, Prof. Yongho Sohn (<strong>KSEA</strong> Executive Director) from University of Central Florida presented<br />
a perspective on world’s energy production and recent research trends for coatings in<br />
advanced gas turbines and superlight-weight hierarchal hybrid composites.<br />
President Hosin Lee gave an introduction of <strong>KSEA</strong> and concluding remarks. The workshop<br />
concluded with a signing ceremony of MOU between <strong>KSEA</strong> and ATCA. Chapter President Jun<br />
Young Huh of <strong>KSEA</strong> Silicon Valley Chapter and his staff joined us for the MOU ceremony. The<br />
event was capped with a dinner hosted by ATCA. During a dinner time representatives from<br />
participating companies briefly introduced their product lines and future R&D interests.<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong><br />
19
KSTLC <strong>2012</strong><br />
MESSAGE FROM THE CONFERENCE CO-CHAIRS & WELCOMING RECEPTION<br />
SUMMARY OF KSTLC <strong>2012</strong><br />
“PIONEERING THE FUTURE”<br />
Conference Co-Chairs<br />
Hyunkyung Kathy Lee, DaEun Rachel Park, YeEun Sarah Rhee<br />
The 1 st <strong>Korean</strong> Student Technical and Leadership Conference (KSTLC) held in Chicago during March 16-18, <strong>2012</strong> was a great success<br />
with over a hundred students and young professionals from all across the US. All programs including the welcoming reception,<br />
keynote speaker presentations, career panels, technical poster session, advanced presentation workshop, and even the evening<br />
social events could not have been possible without the great leadership of Dr. Byoung-Do Kim (<strong>KSEA</strong> YG Director 1) and the many<br />
hours put in by our 25+ dedicated volunteer organizers.<br />
KSTLC <strong>2012</strong> rang its starting bell with an opening remark by <strong>KSEA</strong> President Hosin “David” Lee (University of Iowa). Along with<br />
his expression of <strong>KSEA</strong>’s devotion to the YG movement, our two distinguished keynote speakers, Dr. Chul Ahn (UT Southwestern)<br />
and Dr. Esther Yang (Abbott Lab), gave insightful presentations on how to construct successful lives as scientists and engineers and<br />
on the expanding roles of scientists and engineers in global economy. Beyond speaker presentations, our participants were privileged<br />
to attend special workshops on networking and presentation skills by Mr. Dan Conrod (Dale Carnegie) and Dr. Dan Moser<br />
(Northwestern University). Additionally, through the Career Development Workshop, the participants were able to attend a panel<br />
discussion consisting of distinguished members from academia, industry, national research, or medicine and pharmaceutics. The<br />
participants had opportunities to interact with the panels by asking questions and expressing their concerns on specific topics that<br />
are related to corresponding area of interest. Afterwards, the poster presentation session was held for about two hours and over<br />
sixty participants presented their research findings to the fellow peers at the conference.<br />
On behalf of the <strong>KSEA</strong>, 25 volunteer organizers, and over a hundred KSTLC participants, we would like to send our sincere appreciation<br />
to our our corporate sponsors of KEIT, KOSEN21, KWiSE, and LG Electronics as well as patrons of Chul Ahn, Hosin<br />
Lee, Hanseup Kim and Yongho Sohn for financial support of KSTLC <strong>2012</strong>.. Lastly, to all attendees, we would like to thank you for<br />
all the effort and active participation which allowed KSTLC <strong>2012</strong> to have a great start. Each individual’s presence was an asset to the<br />
conference in creating an exciting, nurturing, and diverse atmosphere among the most talented <strong>Korean</strong>-<strong>American</strong> future leaders<br />
in science and engineering field. We truly hope this conference was guidance in shaping you into the future pioneers of the world.<br />
Let us meet all again in KSTLC 2013.<br />
WELCOMING RECEPTION<br />
[Session Chairs: Tae Gyun Chung, Dongjun Kim]<br />
Undergraduate Students, University of Southern California<br />
The 1 st KSTLC welcomed its participants at the reception with a welcoming<br />
speech by <strong>KSEA</strong> <strong>40</strong> th President Hosin “David” Lee. The first official program of<br />
the conference started out with the speed networking session which provided<br />
quick greetings among participants in which they could share their name and<br />
short background. After the short introduction of YG directors and committee<br />
members, everyone moved onto the ice-breaking games. Grouping approximately<br />
twelve people per team, the setting endorsed building up close<br />
relationship among the team members. Even some of the panels joined the<br />
event and doubled the fun. This session was informal, but at the same time it<br />
was very engaging. And everyone just simply loved it!<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 21
KSTLC <strong>2012</strong><br />
PLENARY PRESENTATIONS & POSTER SESSION<br />
PLENARY PRESENTATIONS<br />
Hosin “David” Lee, President of <strong>KSEA</strong> and Professor of Civil and Environmental Engineering at University of Iowa<br />
At KSTLC <strong>2012</strong>, Dr. Lee gave an inspiring speech about his life time experience along with his association with <strong>KSEA</strong>.<br />
He also shared the activities of <strong>KSEA</strong> and its record breaking statistics on membership and funding. Dr. Lee’s sense<br />
of humor captured all the audiences’ attention and made them start this memorable event with a smile on their face.<br />
Chul Ahn, Professor of Clinical Science at UT Southwestern Medical School & Director of Biostatistics Core at Simmons<br />
Cancer Center<br />
At KSTLC <strong>2012</strong>, as a keynote speaker, Dr. Ahn gave a speech on how to construct a successful life. He described an individual’s<br />
life as connecting dots by referring to Steve Jobs. As if more dots depict more complex and detailed pictures<br />
in a dot-to-dot puzzle, the diverse experiences enrich the quality of lives and pave the way for the time that is to come.<br />
Se-Chan Jang, Team Lead, Office of R&D Program Management, KEIT<br />
Korea Evaluation Institute of Industrial Technology (KEIT) presented international research collaboration opportunities<br />
in various science and engineering fields. KEIT awards and manages more than $1.65B annually to the private and<br />
public sectors, focusing on fostering emerging technologies.<br />
Sang-Il Lee, Vice President of KEIT<br />
As a representative of KEIT, Mr. Lee gave a warm welcoming and congratulation on the first KSTLC, and expressed<br />
his pleasure of supporting its great start. This year, KEIT has made a generous donation to provide young students a<br />
unique atmosphere to enjoy meals with panels and other peers at a networking lunch and a dinner banquet.<br />
Esther Yang, Sr. R&D Director in Diagnostic Division at Abbott Lab<br />
At KSTLC <strong>2012</strong>, as a keynote speaker, Dr. Yang shared about the role of health-care careers in global economy. She<br />
pointed out that in rapidly growing world economy, the goal of science and engineering should be as followed: differentiated<br />
knowledge integrator, value creator, systems thinker, and servant leader. She also stressed out the importance<br />
of exceptional communication skills for the transfer of the usefulness and assessment of technology<br />
Sang Hee Yoo, President of <strong>Korean</strong>-<strong>American</strong> Women in Science and Engineering (KWiSE); Vertex Pharmaceuticals<br />
Dr. Yoo introduced the variety of opportunities available for our future female leaders in science and engineering field.<br />
KWiSE is active over the entire nation, seeking to promote the development of female <strong>Korean</strong>-<strong>American</strong> scientist and<br />
engineer community as a whole group by sponsoring conferences, including KSTLC.<br />
John Lee, YG Committee Chair of <strong>KSEA</strong><br />
John held a special report session on UKC <strong>2012</strong> and <strong>KSEA</strong>-YG activities. He encouraged the participants to apply for<br />
UKC <strong>2012</strong>, the largest <strong>KSEA</strong> annual conference, which will be held in L.A. in August 8th-11th, <strong>2012</strong>. Many YG activities<br />
including YGTLC, YGF and KSTLC were highlighted.<br />
POSTER SESSION<br />
[Session Chairs: Pilbum Kim, Kyungsoo Kim, Kyoungsun Rha]<br />
Ph.D. Candidate, UCLA & Ph.D. Student Penn State University & Undergraduate Student, University of Utah<br />
A great number of the first generation <strong>Korean</strong> students, due to the language barrier and<br />
the cultural differences, face the challenge of becoming active and extrovert. It is unfortunate<br />
that their wisdom, intelligence, and creativity remain in shade. KSTLC has been<br />
established with a mission to help those students pursue professional careers in the US.<br />
Along with many beneficial programs of KSTLC, the technical poster session provided<br />
participants with the opportunities to improve their presentation skills in an Englishspeaking<br />
professional setting. There were more than 60 posters from a variety of research disciplines. The presenters were passionate<br />
about their research projects and excited to share their hard-earned knowledge with others. Concerning the fact that most<br />
presenters were the first generation, despite the hardship in having to present in non-native language, the contents of the posters<br />
were very well delivered in general. It was truly inspiring to see many outstanding <strong>Korean</strong> students strive for their dreams, and it<br />
showed the bright future ahead for the <strong>Korean</strong> scientists and engineers working in the country.<br />
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<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>
KSTLC <strong>2012</strong><br />
SESSIONS AND WORKSHOPS<br />
DALE CARNEGIE INSTITUTE SPECIAL SEMINAR: CREATING CONNECTION<br />
[Conference Co-Chair & Session Chair: YeEun Sarah Rhee, Jungsook Yang]<br />
Undergraduate Student, University of Michigan & Software Engineer, Netapp<br />
After <strong>KSEA</strong> President Hosin “David” Lee opened up the first door of KSTLC, Mr. Dan Conrod took the<br />
lead and gave us a special privilege to learn the methods of communications. He discussed the importance<br />
of social networking and presented the ideas of the ‘good communication.’ As a program that started<br />
off the entire conference, it set a very welcoming and open environment. The speaker, Dan, had everyone<br />
to stand up and practice communication skills which encouraged the participants to actively engage<br />
themselves in conversations with brief self-introductions. Though “creating connection” was mainly about<br />
networking, it rather promoted a necessity<br />
of self-reflection. According to Dan,<br />
a successful networking requires confidence,<br />
patience, enthusiasm and perseverance. To build a great<br />
relationship with people, we need to be open and approachable<br />
to others first which requires the confidence and courage. Then<br />
the conversation needs to be followed by patience such as being<br />
a good listener and letting the opponent become a focus of the<br />
conversation. The participants discussed about these practical<br />
skills and values for the effective ways of communications, and<br />
tried to apply these at a personal level. This session was well suited<br />
for the purpose of the conference which promotes networking<br />
among <strong>Korean</strong>-<strong>American</strong> students on the paths to become the<br />
pioneers of the future.<br />
ADVANCED PROFESSIONAL PRESENTATION SKILLS<br />
[Session Chair: Yoomin Ahn, Wonjae Lee]<br />
R&D Chemist, BISCO, Inc & Ph.D. Student, University of Pennsylvania<br />
This was a unique session for KSTLC with the purpose of helping first generation <strong>Korean</strong> students improve<br />
their presentation skills. Our goal was to have a before and after presentation of students to show<br />
the improvement through a professional workshop in public speaking. Dr. Dan Moser worked with<br />
our two volunteers, Tae Gyu Kim and Youngbum Jun, in perfecting their speeches and powerpoints.<br />
The preparation for this session began a month before the conference. And throughout February, the<br />
volunteers sent Dr. Moser their original videos and slides, and received feedback from him. On the<br />
night before the presentation, the volunteers worked with Dr. Moser one-on-one for a couple of hours.<br />
On the day of the workshop, Dr. Moser started off the session with a short speech on the important<br />
factors in public speaking which was followed by the actual presentations. After showing the before<br />
videos, two volunteers stood up in front of a hundred students and performed the improved presentations. As a 1.5 generation<br />
student who came to the United States at the early ages, the only concern Tae Gyu had was a nervousness management when facing<br />
a huge crowd. On the other hand, Yongbum, who came to the U.S. in his mid-twenties, had a language barrier to overcome<br />
and was not confident about his English skills. When they walked up to the stage, however, it was evident that from a month-long<br />
interaction with Dr. Moser, they had gained enough courage and were more than ready for the presentation. Especially, the 1st<br />
generation student, Youngbum, showed a great improvement on public speaking and grabbed everyone’s attention with his sense<br />
of humor, despite his difficulties with the language.<br />
Overall, the lecture had entertaining elements along with useful presentation tips. The volunteers also gave great presentations<br />
that were comical as well. It was helpful to see that the presentation skills can be improved over a course of period. Moreover, the<br />
participants were able to learn the successful and effective skills for the professional presentation.<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong><br />
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KSTLC <strong>2012</strong><br />
SESSIONS AND WORKSHOPS<br />
CAREER DEVELOPMENT WORKSHOP<br />
[Session Chairs: JaiKyoung Jung, Wendy Shin, Chloe Sonya Kim, Chulwoo Park]<br />
Post-Doc; Virginia Tech, Software Product Manager; Caltech,<br />
Undergraduate Student; Northwestern University, Undergraduate Student; University of Utah<br />
I) Industry- Seung-Woo Choi, RCA Leader, GE Energy; Young Seok Lee, Research Scientist, Motorola; Chul Young Park, Lead Engineer,<br />
Boeing; Paul Park, Engineering Supervisor, Caterpilla Inc.; Sung Kwan Pyun, Lead Systems Engineer, GE Health Care - Surgery<br />
The panels briefly gave self-introductions, which were followed by answers to questions chosen<br />
from a survey conducted prior to the conference. Dr. Paul Park, helped distinguish the<br />
field of industry from academia and emphasized “creativity” and inspired participants with a<br />
quote, “Success is a combination of integrity and confidence”. Then, Dr. CY Park explained the<br />
two different tracks of industry, management and research fellow tracks, and provided tips on<br />
interviewing skills. He encouraged students to follow their passion. Dr. YS Lee described the<br />
team structure of his company and the hiring process. Dr. SW Choi gave talk on communication and presentation skills. Lastly,<br />
Mr. SK Pyun led a discussion on the visa support issues, which grasped the attention from the 1 st generation.<br />
II) Academia- Ken Choi, Assistant Professor of ECE, IIT; Youngjae Chun, Assistant Professor of IE and BE, U. of Pittsburgh; Hyunwoo<br />
Lee, Research Assistant Professor of Biology, U. of Illinois-Chicago; Yong Ho Sohn, Professor of MM and AE, U. of Central Florida<br />
The first panelist, Dr. Choi presented a brief overview on differences between industry and<br />
academia. He mentioned different research styles at industry, which helped him decide to<br />
devote his work to practical studies after he started his career as a professor. Then Dr. Chun<br />
shared his hardships of becoming a professor as a 1 st generation student in US. His life experience<br />
touched a lot of 1 st generation participant’s hearts. He also encouraged students to branch<br />
out the research topics while continuing the work that previous professor has achieved. Dr. Lee<br />
emphasized the importance of professional writing and grant proposal. He advised participants to not be afraid of the critics, but<br />
rather be open to the feedbacks. Lastly, Dr. Sohn gave tips on the grant proposal and the ethics future professors should pursue. He<br />
pointed out the significance of the relationship with senior professors and fund providers.<br />
III) National Research Lab- Seungbum Hong, Materials Scientist, Young Soo Park, Engineering Staff, Argonne National Lab<br />
With about 10 participants, we had a small group which actually allowed for a smooth,<br />
comfortable discussion session. The setting of the room was changed so that everyone<br />
would sit facing each other, instead of separating the panelists and the participants. It<br />
started with simple introduction for each panelist, followed by Dr. Park’s short powerpoint<br />
presentation about his research. Then it went straight into the question and answer portion<br />
of the discussion. With all participants very actively involved, many aspects of the career in<br />
the lab were covered, and a good number of the participants exchanged personal contact information with the panelists.<br />
IV) Medical and Pharmaceutics- Taeok Bae, Assistant Professor, Indiana University- School of Medicine; Hyunyoung Jeong,<br />
Assistant Professor of Pharmaceutics, U. of Illinois-Chicago<br />
A pre-survey was done to collect questions for the following criteria: entrance to the medical schools, M.D./Ph.D. program, research<br />
opportunities in health sciences, and panels’ backgrounds and experiences.<br />
Fortunately, we had current medical school students, which created a unique atmosphere<br />
for both participants and the panels to share their experiences freely. The admission process<br />
was the the most talked about since majority of participants were undergraduate<br />
students. The rest of topics were also covered based on the students’ voluntary questions<br />
which broadened their perspectives on careers in the health sciences field. Overall, this<br />
session was very successful in shaping future doctors, vets and pharmacists and encouraging<br />
them to interact and bond with the panels and other participants.<br />
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<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>
KSTLC <strong>2012</strong><br />
AWARDS<br />
AWARDS CEREMONY<br />
[Conference Co-Chairs: DaEun Rachel Park and YeEun Sarah Rhee]<br />
Undergraduate Students, Johns Hopkins University & University of Michigan<br />
Outstanding poster presentation awards were given out to nine participants, two in each science domain including biological<br />
and medical science (BM), chemical, civil, environmental and material engineering (CM), electrical and computer science engineering<br />
(ES), and mathematics, mechanical engineering and non-natural science (MN). Every poster presentation was evaluated<br />
by our critical reviewers consisting of eighteen panels and speakers from various fields. In addition, three undergraduate<br />
participants were awarded for the three best essays, and three more were honorably mentioned. To make this recognition more<br />
memorable, beautiful roses were also handed to female awardees.<br />
Technical Poster – Biological, Medical<br />
1 st Place ◆ Sa Do Kang, Duke University, "Developing Efficient Methods for Isolation of Endothelial Progenitor Cells"<br />
2 nd Place<br />
◆Ja Kyung Lee, U of Pennsylvania, "RP58 transcription factor inhibits oligodendrocyte differentiation"<br />
◆Bum Jun Kim, U of Utah, “Does ceramide contribute to vascular dysfunction in mice with type 1 diabetes”<br />
Technical Poster – Chemical, Civil, Environmental, Material<br />
1 st Place ◆ Woon-Hong Yeo, UIUC, "Multifunctional, skin-like electronics"<br />
2 nd Place ◆ Seung-Jin Lee, U.S. Environmental Protection Agency, "Biofuels: A Review of a Life Cycle Environmental Impacts"<br />
Technical Poster – Electrical, Computer Science<br />
1 st Place ◆ Jaeyoung Choi, UC Berkeley, "Semantic Computing and Privacy: A Case Study Using Inferred Geo-Location"<br />
2 nd Place ◆ Jaeeun Shim, Georgia Tech, "Biologically-Inspired Deceptive Behavior for a Robot"<br />
Technical Poster – Mechanical, Mathematics, Non-Natural<br />
1 st Place<br />
◆ Jun Suk Rho, UC Berkeley, "Spherical Hyperlens for Two-dimensional Sub-diffractional Imaging at Visible Frequencies"<br />
2 nd Place<br />
◆ Seul Ki Kang, Texas A&M University, "Multiscale simulations for Richard's equation in high-contrast media and<br />
applications"<br />
Essay Contest<br />
1 st Place ◆ Clara E. Park, University of Washington, "Network for Your Success"<br />
2 nd Place ◆ Haena Kim, University of British Columbia, "Questions"<br />
3 rd Place ◆ Soo Yeon Selene Kim, Princeton University, "Ms. Efficiency"<br />
Honoral<br />
Mention<br />
◆ Daniel Young Lee, Andrew Park, Yeo Ho (Patrick) Yoon<br />
Advisory Committee<br />
◆ Byoung-Do Kim ◆ Benjamin C. Lee ◆ Israel ‘Sun Min’ Jung<br />
(YG Director 1) (General Director) (YG Director 2)<br />
Organizer Recognition<br />
DaEun Park, Hyunkyung Lee, YeEun Rhee, JaiKyoung Jung, Pilbum Kim, Yoomin Ahn, Meeae Hong, Yumi Lim, HyounAe Min,<br />
Wendy Shin, Chulwoo Park, Chloe Sonya Kim, Kyungsoo Kim, Dongjun Kim, Kyoungsun Rha, Seung-Jun Kim, Wonjae Lee,<br />
Taewoo Ha, Hea Ryung Kim, Tae Gyun Chung, Youngbum Jun, John S. Lee, Jungsook Yang, John Cho, Steven Chong<br />
Sponsor Recognition<br />
KEIT (Korea Evaluation Institute of Industrial Technology), LG Electronics, KOSEN21(KISTI), KWiSE, Chul Ahn, Hosin ‘David’<br />
Lee, Hanseup Kim, Yongho Sohn<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong><br />
25
KSTLC <strong>2012</strong><br />
POST-KSTLC <strong>2012</strong> COMMENTS & TESTIMONIALS<br />
WHAT THE KSTLC <strong>2012</strong> PARTICIPANTS SAID<br />
It was a truly informative and enjoyable conference and also great to see so many awesome young <strong>Korean</strong> professionals<br />
in science and engineering! I was surprised to have so many outstanding leaders already well-established and stood up<br />
as leaders in their field as well from the panel discussion. I hope that we, as <strong>Korean</strong>-spirited professionals, can build our<br />
strong backgrounds here in the states in this way. Thank you KSTLC and <strong>KSEA</strong> for making this possible!<br />
- Claire Gayoung Jeong (Post-Doc, Duke University, Durham, NC)<br />
It was an awesome and inspiring event again!! <strong>KSEA</strong> events always give me motivation to work hard and study hard<br />
whenever I feel like to settle for the present. Big Thank you, Organizers!<br />
- Hangyeol Ryu (Senior Undergraduate, University of British Columbia, Port Moody, Canada)<br />
I was very honored to be at the very first KSTLC conference! I will for sure remember it forever! I got to meet a lot of<br />
<strong>Korean</strong> students studying abroad like me which was very encouraging and inspiring. I definitely would like to join any<br />
future event of <strong>KSEA</strong>! Good job organizers! I sincerely thank you!<br />
- YeEun Park (Mechanical Engineer - Manufacturing, Ford, Ann Arbor, MI)<br />
KSTLC <strong>2012</strong> was great experience in Chicago. It helped me meet lots of diverse people and inspired me to work harder<br />
for the future, especially in my studies. Thank you for an unforgettable memory!<br />
- Brian Keum (Senior Undergraduate, University of Michigan, Ann Arbor, MI)<br />
Before I attend KSTLC <strong>2012</strong>, I honestly had few expectations about it. I was excited about rather visiting Chicago than<br />
the event. However, I got so much fun and valuable memory after I met nice, handsome people and had awesome<br />
program at KSTLC. Everybody was so nice and fun and the program itself was very productive. I highly recommend<br />
people to participate this awesome event! Two thumbs up!<br />
-Seul Ki Kang (Ph.D. Candidate, Texas A&M University, College Station, TX)<br />
It was amazing experience and I learned a lot by meeting new people during the conference. The industry session was<br />
impressive and I gained practical advices. Thanks for this great opportunity!<br />
- Hyuk-Jin Park (Senior Undergraduate, USC, Los Angeles, CA)<br />
“BEING A STRANGER”<br />
[Yuna Shim]<br />
MS Candidate, University of Washington<br />
Walking into the hotel, waiting for registration, watching people talking to each other, having a strong feeling that everyone<br />
seems to know each other and realizing I know zero people here so there’s no room for me to join. This was not so<br />
pleasant experience when I first participated in YGTLC and this KSTLC was not much different. I barely knew anybody<br />
and felt intimidated again. However, I knew that this would turn out to be really great. YGTLC and KSTLC taught me<br />
that stepping out of my comfort zone and challenging myself to be a total stranger can make differences.<br />
Since KSTLC had the smaller number of participants and was designed for 1 st generation <strong>Korean</strong> students only with the poster<br />
presentation and essay contest, I was able to meet all participants in the same room and was able to talk to them while visiting their<br />
booths. I especially enjoyed the field-specific conversation with the people who have the same interest and future goals with me. This<br />
was the moment that “being a stranger” turns out really great, because I would never be able to meet and network with them if it<br />
were neither <strong>KSEA</strong> nor the conference.<br />
Sharing thoughts and hardships about studying in the US or about our future was another great feature of the conference as the majority<br />
of participants are the students who came to the US alone. I believe the first KSTLC brought different perspective in networking<br />
and building personal bonds depending on the language we use and the culture we grew up. This would be transferable to other<br />
events and might help young generations to better understand each other as <strong>Korean</strong>-<strong>American</strong>s. I really appreciate <strong>KSEA</strong> officers<br />
and KSTLC organizers’ work to put everything together and let me have an amazing experience.<br />
26<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>
KSTLC <strong>2012</strong><br />
TESTIMONIALS<br />
“PATH FINDER”<br />
[Youngbum Jun]<br />
Ph.D. Candidate, Drexel University<br />
As I continue my study at Drexel University as a fourth year Ph.D. student, I realize that the more I get into my own<br />
research field, the narrower my choice on my career gets; the choice between academic career and other options outside<br />
the academia. When I was in much need of guidance and mentorship, KSTLC <strong>2012</strong> was the perfect and fulfilling<br />
opportunity. The academic panel discussion provided participants with extremely useful information on academic<br />
career in the US. All the panelists were very enthusiastic about sharing their know-how’s in their career fields and personal<br />
stories of their success and failures. Through the discussion and Q&A’s, I was able to see the big picture of the academic career.<br />
“SUSPICION TO ADMIRATION”<br />
[Dongjun Kim]<br />
Undergraduate Student, University of Southern California<br />
Despite of my long concern about how I can network with unfamiliar people, the happy hour social enabled me to not<br />
only get to know others but also form an unbreakable, close friendship with them. Everyone in the conference shared<br />
the same hardship in their challenged journey for career in the US whether it’s due to the English as a second language,<br />
different culture, social custom, or academic difficulty. The shared trait of experience and culture was significant<br />
enough to catalyze the highly energized covalent bonds among participants and discover their new stability assisted by new friends.<br />
Moreover, extremely well-organized and brilliantly picked programs like Special Seminar on Networking & Communication by<br />
Dale Carnegie Institute was just perfect for the participants who all suffered from the difficulty of communication and networking<br />
in their 2 nd language. Particularly, Dr. Seungbum Hong, who works at the Argonne National Laboratory, deeply touched my heart<br />
with his infinite passion to help the young; in his national lab technical session, Dr. Hong asked for the phone numbers and e-mail<br />
addresses of every single participant and even took pictures of them so that he can not only help those desperate and hard-working<br />
students but also form a profound, long-term mentor-mentee relationship through which he could constantly support his mentees.<br />
Overall, I feel privileged to say that I leave with strong love toward my new friends, complete respect toward the mentors, and most<br />
importantly, full admiration of the extremely hard-working organizers behind the curtain.<br />
“OFF TO A GREAT START”<br />
[Seung-Jin Lee]<br />
Post-Doc, US Environmental Protection Agency<br />
Prior to attending the conference, I didn’t know what to expect as this was the first KSTLC and I only knew a handful<br />
of people. But once <strong>KSEA</strong> President Hosin Lee stepped onto the podium and delivered his opening speech, I knew we<br />
were all in for something special. As usual, his humor did not fail to amuse us all. And I agree with him on one point:<br />
my best decisions in life were marrying my wife and being a part of <strong>KSEA</strong>. Nothing in life is more valuable than health,<br />
family and the people you’re surrounded by. I believe <strong>KSEA</strong> has provided a big chunk of that value. All the panelists<br />
motivated me to work harder, and their invaluable words of advice were more than helpful in taking the next steps in my career.<br />
Being a 1 st or 1.5 th generation <strong>Korean</strong> in the US can be pretty tough. There are cultural differences and language barriers to adapt to,<br />
all of which can affect our experiences in school or workplace. Whether you’re here to start a business, get an education or simply<br />
turn your life around, life as a foreign minority can be quite challenging, especially when there’s a lack of guidance along the way.<br />
That’s why KSTLC felt very close to my heart. It was an event for people just like me who have had similar experiences and can<br />
share their stories of success and failure. As one of the oldest participants, I felt grateful that I was able to share my experiences with<br />
students and researchers in similar fields. However, in the end, I think I was the one most inspired. It was amazing to learn from all<br />
the hard-working young professionals around the country. They definitely made me proud to be <strong>Korean</strong>.<br />
Time flew by way too fast, and I only wish it had lasted longer. I’d like to thank <strong>KSEA</strong> President Lee, Dr. Byoung-Do Kim, and all<br />
the organizers for putting together a very rewarding conference. Thanks to all the sponsors as well. Our experiences would not<br />
have been so rewarding if not for all the hard work and time they invested. I look forward to being a part of KSTLC and <strong>KSEA</strong> for<br />
a long time coming, so please continue to organize KSTLC and build on its programs. And don’t forget, we are now one big family!<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong><br />
27
KSTLC <strong>2012</strong><br />
TESTIMONIALS<br />
“HELLO TO KSTLC”<br />
[John Cho]<br />
Cost Information Systems Coordinator, Caterpillar Inc.<br />
It was an absolute pleasure and honor to be your host in Chicago for KSTLC! I want to congratulate all the organizers<br />
for their hard work and successfully completing the first ever KSTLC! It was great to meet so many up and coming<br />
young professionals. This wonderful event reminded me to keep striving to challenge myself and to grow others to<br />
become the future leaders of tomorrow. I’m very proud of each and every one of our KSTLC members, and I’m excited<br />
to see what everyone will achieve in the upcoming years. I want to remind everyone that although KSTLC <strong>2012</strong> is over,<br />
this is only the beginning. Reach out and continue networking with your <strong>KSEA</strong> peers!<br />
“A BRIEF REFLECTION ON KSTLC CONFERENCE”<br />
[Daniel Young Lee]<br />
Undergraduate Student, Purdue University<br />
The day before the <strong>Korean</strong> Student Technical and Leadership Conference (KSTLC), I fretted about in my room and regretted<br />
my decision to participate in the conference. As one of the younger participants of the conference, I was afraid<br />
that I was neither technical nor a leader- a shameful contradiction to the qualities the conference convened to celebrate<br />
- and I increasingly doubted that my invitation was a mistake on the part of the admission committee. With no<br />
expectation from the conference; I only hoped to be spared of the embarrassment by my lack of expertise in any field.<br />
How wrong was I to expect nothing from the conference; I may have been the greatest beneficiary. My spirit lifted as I began to engage<br />
in conversations with other delegates and listened to the speeches from the seasoned professionals in variety of fields. I gained<br />
insights on the possibilities I had previously considered for myself, reversed my perceptions on the possibilities I had not wanted<br />
for myself, and learned possibilities I had not imagined were possible for myself. The fear I held before the conference quickly dissipated,<br />
and the energy of the conference, emanating from the enthusiasms of the conference organizers and the delegates themselves,<br />
enabled me to shift my focus from depressing thoughts on what I currently lacked to the immense possibilities what I could achieve.<br />
I return to Purdue University, where I am a sophomore undergraduate in mathematics, with a re-kindled optimism for my possible<br />
contributions to the society. And it is my hope that as I continue my studies in mathematics, I can one day provide the same inspiration<br />
to the younger generations of <strong>Korean</strong>-<strong>American</strong> students as the KSTLC delegates and speakers have done for me.<br />
“WHY AM I HERE AGAIN?”<br />
[Jeehong Peter Kim]<br />
First Year Medical Student, University of Pittsburgh<br />
Starting with the very first event of icebreaker to get to know each participant better, everyone in KSTLC spent the rest<br />
of their three days very productively. Every minute, we were learning, thinking, or laughing during workshops and<br />
various networking and social events. I met a lot of great people and became good friends with some of them including<br />
my roommates who I still keep in touch with. KSTLC also provided me with unique opportunities to meet other<br />
inspiring professionals such as Dr.Ahn Chul Woo, within the field of health care and connect with them.<br />
However, one of the biggest assets I earned during KSTLC would be encouragement and passion for my own career. I was about<br />
to finish my first year in medical school and was very exhausted from its demanding curriculum and highly competitive environment.<br />
I also believed I had some shortcomings in language skills as a first generation student, and was secretly struggling with ideas<br />
whether I could carry on my career successfully. However, after learning so many other fellow <strong>Korean</strong>s working hard and pushing<br />
the boundaries in the frontier of cutting edge science and technology, I find myself more inspired to enjoy what I chose to do and<br />
more confident that I can make the best out of myself. Now I am more motivated than before, and looking forward to finish strong<br />
the rest of my first year and looking forward to participating in UKC in <strong>2012</strong> after completing my summer research. I thank KSTLC<br />
for all the listed things, and all the other things I couldn’t list that are many. It was truly an amazing experience.<br />
28 <strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>
SPONSOR NEWS<br />
<strong>2012</strong> Ho-Am Prize Recipients<br />
☐ The Ho-Am Foundation (Chairman Hyun-Jae Lee, former Prime Minister) announced the <strong>2012</strong> Ho-Am Prize recipients<br />
on <strong>Apr</strong>il 3 rd , <strong>2012</strong>.<br />
This year’s recipients in each field are:<br />
◆ Prize in Science Prof. Minhyong Kim (Univ. of Oxford/POSTECH),<br />
◆ Prize in Engineering Prof. Taeghwan Hyeon (Seoul National Univ.),<br />
◆ Prize in Medicine Prof. Jae Ung Jung (Univ. of Southern California),<br />
◆ Prize in The Arts Composer Unsuk Chin (Seoul Philharmonic Orchestra),<br />
◆ Prize in Community Service Dr. Dong-han Lee (Chairman of Social Welfare Corporation Choon Kang)<br />
☐ The Ho-Am Prize Ceremony is scheduled to be held at 3:00 p.m. on June 1 st , <strong>2012</strong> at Ho-Am Art Hall. Each recipient will<br />
be awarded a diploma and a Ho-Am Prize medal with prize money of KRW 300 million. Prior to and after the ceremony, the<br />
recipients are scheduled to hold commemorative lectures in major universities, high schools and academies across the nation.<br />
<strong>2012</strong> HO-AM PRIZE RECIPIENTS<br />
Prize in Science<br />
Prof. Minhyong Kim<br />
Prize in Engineering<br />
Prof. Taeghwan Hyeon<br />
Prize in Medicine<br />
Prof. Jae Ung Jung<br />
Prize in The Arts<br />
Composer Unsuk Chin<br />
Prize in Community Service<br />
Dr. Dong-han Lee<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong><br />
29
EVENTS<br />
LOCAL CHAPTERS<br />
South Texas<br />
Spring Picnic (March 3, <strong>2012</strong>)<br />
Wisconsin<br />
<strong>KSEA</strong> President Cup Tennis Tournament (<strong>Apr</strong>il 14, <strong>2012</strong>)<br />
Alabama<br />
YG Career Development Seminar (January 13, <strong>2012</strong>)<br />
University of Southern California<br />
Rhythm and Hues Studio Tour (March 9, <strong>2012</strong>)<br />
Kentucky<br />
Kentucky Winter Conference (January 14, <strong>2012</strong>)<br />
Southern Virginia<br />
Tech Seminar with Prof. Philip Kim (March 16, <strong>2012</strong>)<br />
New England<br />
Technical Symposium and YG Forum (February 25, <strong>2012</strong>)<br />
30<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>
EVENTS<br />
AFFILIATED PROFESSIONAL SOCIETIES<br />
<strong>Korean</strong> Pathologists Association of North America (KOPANA)<br />
11 th Spring Seminar (March 15-17, <strong>2012</strong>)<br />
<strong>Korean</strong>-<strong>American</strong> Materials Society (KAMS)<br />
Annual Meeting (TMS <strong>2012</strong>) (March 11, <strong>2012</strong>)<br />
Association of <strong>Korean</strong> Physicists in America (AKPA)<br />
<strong>Korean</strong> Physics Symposium<br />
(March 1, <strong>2012</strong>)<br />
<strong>Korean</strong>-<strong>American</strong> Offshore Engineers Association (KOEA)<br />
& <strong>KSEA</strong> South TX Joint Technical Seminar<br />
(February 16, <strong>2012</strong>)<br />
<strong>Korean</strong> Transportation Association in America (KOTAA)<br />
23 rd KOTAA Annual Meeting (January 24, <strong>2012</strong>)<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 31
SPONSORS OF <strong>KSEA</strong>
<strong>Korean</strong>-<strong>American</strong> Scientists and Engineers Association<br />
1952 Gallows Road, Suite 300, Vienna, VA 22182<br />
Tel: 703-748-1221. Fax: 703-748-1331<br />
Email: sejong@ksea.org. Web: http://www.ksea.org<br />
Directors Committee (<strong>40</strong>th Administration)<br />
President: Hosin “David” Lee, Univ. of Iowa<br />
319-335-6818, ksea<strong>40</strong>p@gmail.com<br />
President-Elect: Hyung-Min Michael Chung, Calif. State Univ.<br />
562-985-7691, ksea<strong>40</strong>pe@gmail.com<br />
Vice President: Kookjoon Ahn, DOT<br />
916-227-9257, ksea<strong>40</strong>vp1@gmail.com<br />
Vice President: Hee-Koo Moon, Solar Turbines<br />
619-544-5226, ksea<strong>40</strong>vp2@gmail.com<br />
Executive Director: Yongho Sohn, Univ. of Central Florida<br />
<strong>40</strong>7-882-1181, ksea<strong>40</strong>ed@gmail.com<br />
Finance Director: Seri Park, Villanova University<br />
610-519-3307, ksea<strong>40</strong>fd@gmail.com<br />
General Director: Benjamin Lee, INVIA Medical Imaging Solutions<br />
734-678-1285, ksea<strong>40</strong>gd@gmail.com<br />
Technical Group Director: Eun-Suk Seo, Univ. of Maryland<br />
301-<strong>40</strong>5-4855, ksea<strong>40</strong>tgd@gmail.com<br />
IT Director: Sung Yi, Portland State Univ., ksea<strong>40</strong>itd@gmail.com<br />
Headquarter Operations Director: Kyungjae Myung, NIH<br />
301-451-8748, ksea<strong>40</strong>hod@gmail.com<br />
Membership Director: Youngsoo Park, Argonne National Lab<br />
630-252-5094, ksea<strong>40</strong>md1@gmail.com<br />
Membership Director: Hanseup Kim, Univ. of Utah<br />
801-587-9497, ksea<strong>40</strong>md2@gmail.com<br />
Membership Director: JungAh Jung, Millennium Pharmaceuticals<br />
973-752-5245, ksea<strong>40</strong>md3@gmail.com<br />
YG Director: Byungdo Kim, Univ. of Texas at Austin<br />
ksea<strong>40</strong>yd1@gmail.com<br />
YG Director: Israel (Sun Min) Jung, The Boeing Company<br />
425-263-2233, ksea<strong>40</strong>yd2@gmail.com<br />
Publications Director: Byungkyu Brian Park, Univ. of VA<br />
434-924-6347, ksea<strong>40</strong>pd1@gmail.com<br />
Publications Director: Hyunggun Kim, Univ. of Texas HSC at Houston,<br />
713-486-2342, ksea<strong>40</strong>pd3@gmail.com<br />
Publications Director: Jaehoon Yu, Univ. of Texas at Arlington<br />
817-272-2814, ksea<strong>40</strong>pd4@gmail.com<br />
Headquarters Staff<br />
IT Manager: Seung Seok Choi, 703-748-1221, it@ksea.org<br />
Finance Manager: Kelly Han, 703-748-1221,finance@ksea.org<br />
Admin Manager: Euna Yoon, 703-748-1221, admin@ksea.org<br />
Accounting Administrator: Yoon Hee Chang, 703-748-1221,<br />
database@ksea.org<br />
Auditors<br />
Gye Won Han, 858-784-7189, gyewon@scripps.edu<br />
Sam Ryu, 832-377-7267, sam.s.ryu@gmail.com<br />
Myung Jong Lee, 212-650-7260, mjlee999@yahoo.com<br />
Elected Councilors<br />
Group A: Physics<br />
Eun-Suk Seo, 301-<strong>40</strong>5-4855, ksea<strong>40</strong>tgd@gmail.com<br />
Group B: Chemistry<br />
Seogjoo Jang, 718-997-4110, seogjoo.jang@qc.cuny.edu<br />
Group C: Mathematics, Geology, Meteorology, Statistics, Others<br />
Yonil Park, 301-<strong>40</strong>2-1438, yonil.park@gmail.com<br />
Group D: Biology, Botany, Zoology, Biomedical Engineering,<br />
Genetic Engineering<br />
Jung Hyeob Roh, 713-500-6756, jung.h.roh@uth.tmc.edu<br />
Chul Hee Kang, 509-335-1<strong>40</strong>9, chkang@wsu.edu<br />
Group E: Agriculture, Ecology, Food, Nutrition<br />
Haejung An, 949-608-4<strong>40</strong>8, haejung.an@FDA.HHS.gov<br />
Group F: Medical Science, Pharmaceutical Science, Veterinary Medicine,<br />
Physical Education<br />
Kyoung-Jin Yoon, 515-294-1083, kyoon@iastate.edu<br />
Group G: Chemical Engineering, Textile Engineering, Nuclear<br />
Engineering, Petroleum Engineering, Applied Chemistry<br />
Inchan Kwon, 434-243-1822, ik4t@virginia.edu<br />
Group H: Mechanical Engineering, Aerospace Engineering, Naval<br />
Architecture<br />
Mun Y. Choi, 860-230-7003, choi@engr.uconn.edu<br />
Bongtae Han, 301-<strong>40</strong>5-5255, bthan@umd.edu<br />
Group I: Materials Science, Metallurgy, Mining Engineering<br />
Kyeong-Ook Lee, 630-252-9<strong>40</strong>3, klee@anl.gov<br />
Group J: Civil Engineering, Architecture, Environmental Engineering<br />
Jun-Seok Oh, 269-276-3216, junoh3@gmail.com<br />
Youngsoo (Richard) Kim, 919-515-7758, kim@ncsu.edu<br />
Group K: Electrical & Electronics Engineering, Communication Engineering<br />
Ki Wook Kim, 919-515-5229, kwk@ncsu.edu<br />
Taek Jin Kwon, 732-758-3242, taekjkwon@yahoo.com<br />
Group L: Computer Science, Systems Engineering<br />
Kyung Dong Ryu, 914-945-2502, kdryu2000@gmail.com<br />
Sam-Joo Doh, 781-565-5229, samjoodoh@yahoo.com<br />
Group M: Industrial Engineering and Mgmt Science<br />
Sunghoon Kim, 201-988-9094, stevekim.jsi@gmail.com<br />
Former President Councilors<br />
Jae Hoon Kim, The Boeing Company, 425-786-7723, jkim1@ieee.org<br />
Chin Ok Lee, Rockefeller University, 212-327-8617, leech@mail.rockefeller.edu<br />
Kang-Won Wayne Lee, Univ. of Rhode Island, <strong>40</strong>1-874-2695,<br />
kwaynel@gmail.com<br />
Chapter Presidents<br />
Central Penn (1) Jungwoo Ryoo, 814-949-5243, jryoo@psu.edu<br />
Georgia (3) Chulsung Kim, 678-<strong>40</strong>7-5776, ckim@ggc.usg.edu<br />
Indiana (4) Chan Kyoo Choi, choi@purdue.edu<br />
Michigan (6) Hahnsang Kim, 734-223-7284, hahnsang.kim@gmail.com<br />
Chicagoland (7) Duck Young Chung, 630-252-4907,<br />
dychung.ksea@gmail.com<br />
Minnesota (8) Yunje Oh, 952-835-6366, ohyunje@hotmail.com<br />
New England (9) Sangun Lee, 508-887-4564, sangun69@gmail.com<br />
New Jersey (10) Hong-Yong Kim, hongyong.kim@novartis.com<br />
NY Metro (11) Jun Ho Shin, 718-631-6255, jshin@qcc.cuny edu<br />
N. Carolina (12) Sung Woo Kim, 919-513-1494, swk.ncsu@gmail.com<br />
Ohio (14) Bomjun Kwon, 614-366-8377, bjkwon@gmail.com<br />
Seattle WA (15) Wookuen Shin, geoshin@gmail.com<br />
Philadelphia (16) Jin S. Kang, jinkang@drexel.edu<br />
St. Louis (17) Jayoung Choi, 310-562-7917, kseastl@gmail.com<br />
Southern CA (18) Chan Seung Park, 951-781-5771, cspark@cert.ucr.edu<br />
South Texas (19) Sukjoo Choi, 281-249-8732, sukjoo.choi@gmail.com<br />
Wash. Metro (21) June M Kwak, 301-<strong>40</strong>5-9726, jkwak@umd.edu<br />
Alabama (23) Dong Joo Daniel Kim, 334-844-4864, dkim@eng.auburn.edu<br />
Austin TX (24) Jinwoo Lee, 512-785-2098, jinwoo@mail.utexas.edu<br />
Silicon Valley (30) Jun Young Huh, heymosoo@yahoo.com<br />
Baltimore (31) Mihyun Bae, 443-804-7507, niceangel075@hotmail.com<br />
Tennessee (32) Thak Sang Byun, byunts@ornl.gov<br />
N. Texas (<strong>40</strong>) Jiyoung Kim, 972-883-6412, jiyoung.kim@utdallas.edu<br />
Central VA (41) Jungwook Jun, jungwook.jun@vdot.virginia.gov<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong> 55
Central IL (42) Seung-Yul Yun, 217-255-85<strong>40</strong>, Yes.Andrew@gmail.com<br />
Southern VA (49) Dong S. Ha, 5<strong>40</strong>-552-1965, ha@vt.edu<br />
Iowa City (52) Yang Oh Jin, yangoh.jin@gmail.com<br />
Utah (56) You Han Bae, 801-474-1945, you.bae@utah.edu<br />
Sacramento (58) Young Lee, 916-227-7645, ylee0617@hanmail.net<br />
San Diego (60) Yongkyoon In, 858-455-6655, yongkin@alum.mit.edu<br />
Oregon (62) Sung Yi, sungyi19@hanmail.net<br />
North Dakota (65) Chiwon W. Lee, 701-361-9411, chiwon.lee@ndsu.edu<br />
Central FL (67) Hyoungjin Cho, <strong>40</strong>7-927-4301, joehcho@gmail.com<br />
Tampa Bay (68) Myung Kim, mkkim@usf.edu<br />
Kentucky (903) Duk-Hyung Lee, 859-858-3511, duk.lee@asbury.edu<br />
<strong>KSEA</strong> Korea (905) Tammy Cho, 82-18-282-7995, btheb_02@naver.com<br />
Committee Chairs<br />
Contest Committee:<br />
Kookjoon Ahn, 916-227-8357, kookjoon_ahn@dot.ca.gov<br />
Election Committee:<br />
James Song, 301-602-2206, james.song.nih@gmail.com<br />
Fund Management Committee:<br />
Kang-Wook Lee, 914-945-3070, kangwook.lee.ibm@gmail.com<br />
History Committee:<br />
Yong Nak Lee, 847-577-5967, ynlee@htrdltd.com<br />
Honors and Awards Committee:<br />
Sung Kwon Kang, 914-945-3932, sungkang.ksea@gmail.com<br />
Long-range Planning Committee:<br />
Saeyoung Ahn, 301-646-6602, saeyounga@yahoo.com<br />
Nomination Committee:<br />
Jae Hoon Kim, 425-786-7723, jae.h.kim@boeing.com<br />
Rules Committee:<br />
Nak Ho Sung, 617-627-3447, nsung@tufts.edu<br />
Scholarship Committee:<br />
Seong Gon Kong, 215-204-7932, skong@temple.edu<br />
Young Generation Committee:<br />
John Hyung Lee, 310-280-8269, johnleelp@gmail.com<br />
Local Chapter Presidents Committee:<br />
Wookeun Shin, 206-714-4110, geoshin@gmail.com<br />
Affiliated Professional Society (APS) Presidents<br />
Association of <strong>Korean</strong> Neuroscientists (AKN)<br />
Jin Mo Chung, University of Texas, jmchung@utmb.edu<br />
Association of <strong>Korean</strong> Physicists in America (AKPA)<br />
Eun-Suk Seo, University of Maryland, seo@umd.edu<br />
Baltimore Life Scientists Association (BLSA)<br />
Woochang Hwang, Johns Hopkins University, whwang2@gmail.com<br />
<strong>Korean</strong> <strong>American</strong> Construction, Engineering, and Project Management<br />
Association (KACEPMA)<br />
Young Hoon Kwak, George Washington University, kwak@gwu.edu<br />
<strong>Korean</strong>-<strong>American</strong> Food Technologists Association (KAFTA)<br />
Youngmo Yoon, Sensient Flavors LLC, flavor331@yahoo.com<br />
<strong>Korean</strong>-<strong>American</strong> Intellectual Property Lawyers Association (KAIPLA)<br />
Joo Mee Kim, Rothwell, Figg, Ernst & Manbeck, P.C., jkim@rfem.com<br />
<strong>Korean</strong>-<strong>American</strong> Materials Society (KAMS)<br />
Jiyoung Kim, University of Texas at Dallas, jiyoung.kim@utdallas.edu<br />
<strong>Korean</strong>-<strong>American</strong> Mathematical Scientists Association (KAMSA)<br />
Hae Soo Oh, University of North Carolina at Charlotte, hso@uncc.edu<br />
<strong>Korean</strong>-<strong>American</strong> Society for Biomedical Informatics (KASBI)<br />
James S. Song, National Center for Biotechnology Information<br />
National Institutes of Health, james.Song@nih.gov<br />
<strong>Korean</strong> <strong>American</strong> Society for Biotech & Phamaceuticals (KASBP)<br />
Yong-Hae Han, Bristol-Myers Squibb, yong-hae.han@bms.com<br />
<strong>Korean</strong>-<strong>American</strong> Energy Exploration & Production Society (KEPS)<br />
Sam Jae Cho, Ryder Scott Company, chosj@blackmidas.com<br />
<strong>Korean</strong> Computer Scientists & Engineers Association in America (KOCSEA)<br />
Yoohwan Kim, University of Nevada, Las Vegas, yoohwan@cs.unlv.edu<br />
<strong>Korean</strong>-<strong>American</strong> Offshore Engineers Association (KOEA)<br />
Yong Lae Shim, ABS Technology, YShim@Eagle.org<br />
<strong>Korean</strong> Life Scientists at UCSF (KOLIS)<br />
Dae Hwi Park, University of California- San Francisco,<br />
Daehwi.park@ucsf.edu<br />
<strong>Korean</strong> Pathologists Association of North America (KOPANA)<br />
Eun Young Lee, University of Kentucky , eylee@uky.edu<br />
<strong>Korean</strong> Transportation Association in America (KOTAA)<br />
Alex Hak-Chul Shin, Louisiana State University, shin@lsu.edu<br />
<strong>Korean</strong>-<strong>American</strong> Society of Civil and Environmental Engineers (KSCEE)<br />
Myong Ho Steve Ro, Lee & Ro, Inc., steve-ro@lee-ro.com<br />
<strong>Korean</strong>-<strong>American</strong> Women in Science and Engineering (KWiSE)<br />
Sanghee Yoo, Vertex Pharmaceuticals, sanghee_yoo@yahoo.com<br />
NIH-<strong>Korean</strong> Scientists Association (NIH-KSA)<br />
Jung Hyung Park , National Institutes of Health, parkhy@mail.nih.gov<br />
New York <strong>Korean</strong> Biologists (NYKB)<br />
Sae Woong Park, Weill Cornell, sap2015@med.cornell.edu<br />
Research Triangle Park Bioscience and Biotechnology Meeting (RTP B&B)<br />
Hangsik Moon, Syngenta Biotechnology, Inc., hangsik.moon@syngenta.com<br />
San Diego <strong>Korean</strong> Biomedical Association (SDKoBA)<br />
Jongdae Lee, UCSD, j142lee@gmail.com<br />
The Society of <strong>Korean</strong> Statisticians in America (SKSA)<br />
Sin-Ho Jung, Duke University, jung0005@mc.duke.edu<br />
Ex-Presidents<br />
Kiuck Lee, Marquette Univ., 312-787-7060, kiucklee@aol.com<br />
Young Bae Kim, USC, 213-7<strong>40</strong>-2311<br />
Sang Il Choi, POSTECH, 919-357-7018, sangil@postech.ac.kr<br />
Kwang Bang Woo, Yonsei Univ., 82-2-2123-3555, kbwoo@yonsei.ac.kr<br />
Yong Nak Lee, HTRD, 847-577-5967,ynlee@htrdltd.com<br />
Jae Young Park, NC State Univ., 919-848-6110, JAEYPARK30@aol.com<br />
Chan-Mo Park, POSTECH, 82-11-521-8909, parkcm@postech.ac.kr<br />
Dong Han Kim, POSTECH, 82-54-279-2101, dhkim@postech.edu<br />
Ki-Hyon Kim, NC Central Univ., 919-530-6451, khk@nccu.edu<br />
Kwang Kuk Koh, Chrysan Ind., kwang@chrysanindustries.com<br />
Chin Ok Lee, Rockefeller Univ., 212-327-8617, leech@rockefeller.edu<br />
Chai Chin Suh, 610-678-0534, chaisuh@gmail.com<br />
Moo Young Han, Duke Univ., 919-660-2575, myhan@phy.duke.edu<br />
Kun Sup Hyun, Polymer Processing Institute, kshyun@polymers-ppi.org<br />
Hyo-Gun Kim, K-JIST, 703-663-8803, hkim@gist.ac.kr<br />
Moon Won Suh, NC State Univ., 919-515-6580, moon_suh@ncsu.edu<br />
Dewey Doo-Young Ryu, UC Davis, 530-752-8954, ddyryu@ucdavis.edu<br />
Saeyoung Ahn, Fuzbien Tech. Institute, saeyounga@yahoo.com<br />
Kyong Chul Chun, 301-598-3396, kcchun1@comcast.net<br />
Ki Dong Lee, Univ. of Illinois, Urbana-Champaign, kdlee@uiuc.edu<br />
Hong Taik (Thomas) Hahn, 310-825-2383, hahn@seas.ucla.edu<br />
Howard Ho Chung, Argonne National Lab., chung.ksea@gmail.com<br />
Nak Ho Sung, Tufts University, 617-627-3447, nsung@tufts.edu<br />
Chan I. Chung, Rensselaer Polytechnic Institute, chungc@rpi.edu<br />
Quiesup Kim, JPL/NASA, 818-354-8612, quiesup.kim@sbcglobal.net<br />
Sung Won Lee, Univ. of Maryland, 301-<strong>40</strong>5-1128, swlee@umd.edu<br />
Sung K. Kang, IBM T.J. Watson Research Ctr., sungkang.ksea@gmail.com<br />
Kang-Won Wayne Lee, Univ. of Rhode Island, kwaynel@gmail.com<br />
Kang-Wook Lee, IBM T.J. Watson Research Ctr., 914-945-3070,<br />
kangwook.lee.ibm@gmail.com<br />
Chueng-Ryong Ji, North Carolina State Univ., chueng.ji@gmail.com<br />
Jae Hoon Kim, The Boeing Company, 425-786-7723, jkim1@ieee.org<br />
Ex-Presidents (Deceased)<br />
Shoon Kyung Kim<br />
Inyong Ham<br />
Chong Wha Pyun<br />
Hogil Kim<br />
Je Hyun Kim<br />
Kyungsik Kang<br />
Soon Kyu Kim<br />
Kwang-Hae (Kane) Kim<br />
56<br />
<strong>KSEA</strong> LETTERS Vol. <strong>40</strong> No. 3 <strong>Apr</strong>il <strong>2012</strong>
www.kofst.or.kr<br />
KOFST will play a crucial role in leading<br />
the science and technology renaissance of Korea<br />
THE KOREAN FEDERATION OF SCIENCE AND TECHNOLOGY SOCIETIES<br />
KOFST is firmly committed to enriching and supporting science and<br />
technology societies; encouraging scientists to engage with society;<br />
protecting the rights and interests of scientists;<br />
and increasing public understanding of scientific discoveries<br />
and theories to reap even greater benefits for Korea.