Anticoagulation-related intracranial hemorrhage - Henry Ford Health ...

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Epidemiology 1-1 1.7% of the population is currently receiving OAC with vitamin K antagonists. (Schurgers, Blood 2004) 5–12% of ICH is related to OAC. (Flaherty&Broderick Neurology 2007) Rate of OAC-ICH is about 2–9 per 100,000 /y, an incidence 7- to 10- fold higher than in the untreated population(Steiner et al Stroke 2006) 5/9/2012 18
Epidemiology The incidence of anticoagulant-associated associated intracerebral hemorrhage quintupled in our population during the 1990s. The majority of this change can be explained by increasing warfarin use. Anticoagulant-associated associated intracerebral hemorrhage now occurs at a frequency comparable to subarachnoid hemorrhage. h (Flaherty&Broderick Neurology 2007) 5/9/2012 19
Page 1 and 2: Anticoagulation related Intracrania
Page 3 and 4: Objectives Clotting pathways refres
Page 5 and 6: 5/9/2012 5
Page 7 and 8: 5/9/2012 7 Hoffman 2003, 2005, J Th
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Page 15 and 16: So is anticoagulation a problem for
Page 17: Bleeding mechanical heart valves (1
Page 21 and 22: Flood is coming 5/9/2012 21
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Page 27 and 28: Is outcome any different between AA
Page 29 and 30: New Data 299 ICHs. Use of warfarin
Page 31 and 32: Reversal is indicated HOW???? 5/9/2
Page 33 and 34: AHA 2010 1. Patients with a severe
Page 35 and 36: Vitamin K slowly reverts INR to its
Page 37 and 38: Prothrombin Concentrate Complex PCC
Page 39 and 40: Comparison Blood type matching Thaw
Page 41 and 42: EBM Prothrombin Complex Concentrate
Page 43 and 44: INCH inclusion Spontaneous intracer
Page 45 and 46: Factor VII Still in use in many pla
Page 47 and 48: 5/9/2012 47
Page 49 and 50: October 4-7, 2012 Sheraton Denver D
Page 51 and 52: HFHS Anticoagulation Reversal Proto
Page 53 and 54: CoRICH data When looking at outcome
Page 55 and 56: Follow up INR 15-30 minutes after a
Page 57 and 58: Direct X inhibitors Dabigatran (200
Page 59 and 60: 5/9/2012 59
Page 61 and 62: The new arrivals Direct thrombin in
Page 63 and 64: A, Effect of dabigatran followed by
Page 65 and 66: Summary AA ICH is an increasing pro
Page 67 and 68: Henry Ford NeuroICU Team 04/05/2012
Page 69:
Thank you 04/05/2012 5/9/2012 69 69
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Anticoagulation-related intracranial hemorrhage - Henry Ford Health ...

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