Acute Kidney Injury in In Paediatrics

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Ways to Prevent Contrast-Induced Nephropathy • Adequate hydration is a well-established measure • Choice of fluid remains controversial: • Trials comparing bicarbonate vs saline have yielded conflicting results. • On currently available evidence, there is a strong suggestion that sodium bicarbonate may be superior to isotonic saline to decrease the risk of CIN. (P. Dennen et al, Crit Care Med 2010 Vol. 38, No. 1)
Ways to Prevent Contrast-Induced • N-Acetyl-Cysteine Nephropathy • is a free radical scavenger shown to decrease the risk of CIN compared to placebo • But there are conflicting results • Use low-volume, non-ionic, low-osmolar or isoosmolar contrast preparations • Prophylactic haemodialysis is not currently favoured. • Avoid concomitant nephrotoxic medications.
Page 1 and 2: Acute Kidney Injury In Paediatrics
Page 3 and 4: What is AKI? • A sudden deteriora
Page 5 and 6: Long Term Outcomes • At 3 to 5-yr
Page 7 and 8: RIFLE vs AKIN
Page 9 and 10: pRIFLE CLASS Change in eCCl Urine O
Page 11 and 12: Biomarkers • The pRIFLE, RIFLE an
Page 13 and 14: Biomarkers • The quest to find ea
Page 15 and 16: NGAL • Urine NGAL > 50ug/ml predi
Page 17 and 18: IL-18 • Induced in the proximal r
Page 19 and 20: Management • Prevention of AKI is
Page 21: Ways to Prevent Contrast-Induced Ne
Page 25 and 26: Common Nephrotoxins in ICU EXOGENOU
Page 27 and 28: Management General principles of
Page 29 and 30: Maintain Renal Perfusion Vasopresso
Page 31 and 32: Maintain Renal Perfusion • Renal
Page 33 and 34: Maintain Renal Perfusion Choice of
Page 35 and 36: Cumulative Fluid Overload • The p
Page 37 and 38: Nutritional Support • Nutrition i
Page 39 and 40: Renal Replacement Therapy • Curre
Page 41 and 42: Timing of RRT • In paediatrics, t
Page 43 and 44: Differences between adult and • P
Page 45 and 46: Differences between adult and • P
Page 47 and 48: With CRRT • We must continually w
Page 49 and 50: Conclusions • Management of AKI i
Page 51 and 52: Conclusion • However, paediatric

Acute Kidney Injury in In Paediatrics

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