Acute Kidney Injury in In Paediatrics
Acute Kidney Injury in In Paediatrics
Acute Kidney Injury in In Paediatrics
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Ma<strong>in</strong>ta<strong>in</strong> Renal Perfusion<br />
AVOID Dopam<strong>in</strong>e:<br />
• Low-dose dopam<strong>in</strong>e <strong>in</strong> children has not been effective at improv<strong>in</strong>g<br />
outcomes either.<br />
Filler G. Paediatr Drugs 2001; 3:783–792 .<br />
• May cause transient improvement of ur<strong>in</strong>e output, but<br />
• Does not decrease AKI <strong>in</strong>cidence, need for RRT or improve AKI outcomes.<br />
• Is associated with <strong>in</strong>creased myocardial oxygen demand.<br />
• Negative immunomodulatory effects<br />
• P. Dennen et al, Crit Care Med 2010 Vol. 38, No. 1<br />
• Adult studies of low/“renal”dose - dopam<strong>in</strong>e have failed to show benefit and<br />
actually may even be harmful<br />
Venkataraman R, Kellum JA:; Chest 2007; 131: 300–308 .<br />
Bellomo R, et al: Lancet 2000; 356: 2139–2143 .
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