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Radiation therapy for Graves’ ophthalmopathy: a systematic review and meta-analysis of randomized controlled trials
Table 3. Description of the design, aim, question, results and conclusion of the studies included in this meta-analysis
Author Year
Prummel et al.,
2004
Ng et al.,
2005
Prummel et al.,
1993
Marcocci et al.,
2001
Gorman et al.,
2001
Double-blind
randomized trial
Design /aim/
study question Results Conclusions/comments
To compared RT efficacy with sham
irradiation in mild ophthalmopathy
Double-blind
randomized trial
To assess the efficacy and safety
of combined orbital irradiation
and systemic steroids in the
management of moderate-tosevere
Graves’ ophthalmopathy
Double-blind
randomized trial
Randomized trial
To assess the efficacy and safety of
orbital radiotherapy combined with
either oral (prednisone; starting
dose, 100 mg/d; withdrawal after 5
months) or iv (methylprednisolone;
15 mg/kg for four cycles and then
7.5mg/kg for four cycles; each
cycle consisted of two infusions
on alternate days at 2-wk intervals)
glucocorticoids
Prospective, randomized, internally
controlled, double-blind clinical trial
To evaluate the efficacy of
radiotherapy for GO
RT was successful in 23 of 44 (52%) irradiated patients vs. 12 of
44 (27%) sham-irradiated patients at 12 months after treatment
(relative risk, 1.9; 95% CI, 1.1 - 3.4; P =0.02). was effective in
improving eye muscle motility and decreasing the severity of
diplopia. Quality of life improved similarly in both groups. In the
radiotherapy group there was less need for follow-up treatment;
66% vs. 84% of the patients needed further treatment (P=0.049)
Total eye score improved earlier in the SRT group, achieving
statistical significance (P