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Department of Pediatrics Biannual Report 2008-2009

Department of Pediatrics Biannual Report 2008-2009

Department of Pediatrics Biannual Report 2008-2009

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Upstate Golisano Children’s Hospital<br />

SUNY Upstate Medical University<br />

<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Bi-Annual <strong>Report</strong><br />

January 1, <strong>2008</strong> – December 31, <strong>2009</strong>


CONTENTS<br />

INTRODUCTION FROM THE CHAIR. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1<br />

DEPARTMENT LEADERSHIP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2<br />

PEDIATRICS BY THE NUMBERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3<br />

CRITICAL CARE AND INPATIENT PEDIATRICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />

Hospital Medicine:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />

RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />

SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />

EDUCATION PROGRAM IN GENERAL PEDIATRICS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />

Graduate Medical Education. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5<br />

Undergraduate Medical Education . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />

Administrative . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />

OVERVIEW. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />

RESIDENCY CURRICULUM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />

PEDIATRIC CLERKSHIP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6<br />

EDUCATION OUTCOMES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6<br />

EDUCATION PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7<br />

Book Chapters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7<br />

PUBLICATIONS WITH RESIDENTS, FELLOWS, OR STUDENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7<br />

PRESENTATIONS AT NATIONAL MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8<br />

PRESENTATIONS AT NATIONAL MEETINGS WITH RESIDENTS, FELLOWS AND STUDENTS . . . . . . . . . . . 8<br />

GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9<br />

PEDIATRIC EMERGENCY MEDICINE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />

HONORS, VISITING PROFESSORSHIPS, EDITORIAL DUTY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />

Editorial Boards/Reviewer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11<br />

GRANT ACTIVITY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />

SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />

PEDIATRIC ENDOCRINOLOGY, DIABETES & METABOLISM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />

AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />

RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13<br />

INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13<br />

GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13<br />

SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13<br />

GASTROENTEROLOGY & NUTRITION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14<br />

AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14<br />

RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14<br />

SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14<br />

GENERAL PEDIATRICS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15<br />

AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15<br />

RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17


Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />

Child Sex Abuse Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />

Foster Care . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />

PRESENTATIONS AT NATIONAL MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />

HONORS, VISITING PROFESSORSHIPS, EDITORIAL DUTY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />

INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18<br />

GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .19<br />

Blatt SD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19<br />

Botash AS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19<br />

SELECTED CLINICAL DATA (DIVISION TOTALS) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .19<br />

General <strong>Pediatrics</strong>, Adolescent, CARE, Enhance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19<br />

Upstate <strong>Pediatrics</strong> Outpatient. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19<br />

Inpatient encounters (General <strong>Pediatrics</strong> and Upstate <strong>Pediatrics</strong>) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19<br />

Newborn inpatient encounters (General <strong>Pediatrics</strong> and Upstate <strong>Pediatrics</strong>) . . . . . . . . . . . . . . . . . . . . . . . 19<br />

GENETICS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />

Adjunct Faculty: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />

AFFILIATED CLINICAL STAFF: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />

RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21<br />

INVITED WORKSHOPS AND CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22<br />

GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22<br />

SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22<br />

HEMATOLOGY & ONCOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />

AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />

AFFILIATED RESEARCH STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />

Children’s Oncology Group Participation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />

KNOT Center. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />

Neuro-Oncology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />

Hemophilia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />

New York State Designated . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />

Hemoglobinopathy Center . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />

Autologous Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />

Educational Specialist and Neuropsychology Service. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />

Pediatric Palliative Care. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />

RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />

Dr. William Kerr . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />

Dr. Jody Sima . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />

Dr. Richard Sills . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />

GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />

EDITORIAL SERVICE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />

SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />

INFECTIOUS DISEASES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />

FELLOWS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />

AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />

AFFILIATED RESEARCH STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />

RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />

Clinical Trials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27


HONORS, VISITING PROFESSORSHIPS, EDITORIAL DUTY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28<br />

INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28<br />

GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29<br />

Weiner LB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29<br />

Domachowske JB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30<br />

SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30<br />

NEPHROLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />

AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />

AFFILIATED RESEARCH STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />

RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />

Role <strong>of</strong> Local Complement Synthesis in the Kidney . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />

Development <strong>of</strong> Novel Inhibitors <strong>of</strong> Inflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />

HONORS, VISITING PROFESSORSHIPS, EDITORIAL DUTY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />

INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />

SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />

NEURODEVELOPMENTAL PEDIATRICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33<br />

AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33<br />

PROGRAMS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33<br />

RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34<br />

Original Scientific Articles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34<br />

Reviews . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34<br />

Reviews with American Academy <strong>of</strong> <strong>Pediatrics</strong> Council on Children with Disabilities (Dr. Liptak). . . . . . . . . . . 34<br />

Books and Book Chapters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34<br />

Other . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35<br />

INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36<br />

GRANTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36<br />

SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37<br />

Neurodevelopmental <strong>Pediatrics</strong> . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37<br />

Physical Disabilities (excluding spina bifida) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37<br />

Spina Bifida Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37<br />

NEUROLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />

AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />

RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />

PULMONOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39<br />

AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39<br />

CURRENT RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41<br />

HONORS, VISITING PROFESSORSHIPS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41<br />

INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .41<br />

GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43<br />

SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43<br />

RHEUMATOLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44


CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44<br />

EDITORIAL DUTY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44<br />

CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44<br />

PEDIATRIC SURGICAL SPECIALTIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />

PEDIATIC ANESTHESIOLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />

Full-Time: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />

Part-Time:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />

PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46<br />

PEDIATRIC CARDIOVASCULAR-THORACIC SURGERY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />

PEDIATRIC GENERAL SURGERY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />

PEDIATRIC NEUROSURGERY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />

Conditions Treated: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48<br />

Clinical Services Provided: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48<br />

PEDIATRIC OPHTHALMOLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />

PEDIATRIC ORTHOPEDIC SURGERY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />

PEDIATRIC OTOLARYNGOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />

PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />

AFFILIATED FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />

PEDIATRIC CARDIOLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />

NEONATALOGY: ST. JOSEPH’S HOSPITAL. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />

NEONATOLOGY: CROUSE HOSPITAL. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />

FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />

CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />

FACULTY RECOGNITION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />

AMERICAN PEDIATRIC SOCIETY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />

SOCIETY FOR PEDIATRIC RESEARCH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />

AMERICAN ACADEMY OF PEDIATRICS, SECTION ON ENDOCRINOLOGY. . . . . . . . . . . . . . . . . . . . 52<br />

AMERICAN BOARD OF PEDIATRICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />

THE HELFER SOCIETY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />

THE AMERICAN SOCIETY OF CLINICAL HYPNOSIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />

SIGMA XI SCIENTIFIC RESEARCH SOCIETY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />

BEST DOCTORS IN AMERICA. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52


INTRODUCTION FROM THE CHAIR<br />

Bi-Annual <strong>Report</strong> • 1<br />

I am happy to share with you our department report for <strong>2008</strong> and <strong>2009</strong>!<br />

This may have been the most important couple <strong>of</strong> years for our<br />

department since our first Chair, William Tomlinson Plant, published<br />

a study <strong>of</strong> childhood seizures in the inaugural edition <strong>of</strong> Archives <strong>of</strong><br />

<strong>Pediatrics</strong>, in 1884. <strong>2009</strong> was the year that we opened the Upstate<br />

Golisano Children’s Hospital, realizing a decades-long dream <strong>of</strong> the<br />

community and many <strong>of</strong> my predecessors. In the short time we have<br />

been open, the hospital has already garnered some national recognition<br />

for its architecture, and some <strong>of</strong> our patient care innovations have been<br />

the subject <strong>of</strong> presentations in national meetings.<br />

Although the hospital was only open for the last three months covered<br />

by this report, its impact can be seen in many places. Many <strong>of</strong> the new<br />

pediatricians and pediatric surgical specialists who have joined us in<br />

the past two years were attracted to Syracuse by the opportunities<br />

afforded by a state <strong>of</strong> the art facility. Our volumes <strong>of</strong> patient activity,<br />

both in the outpatient and the inpatient settings, have been increasing<br />

substantially. We have made a number <strong>of</strong> efforts to streamline our<br />

referral process, including opening new regional subspecialty satellite<br />

clinics, initiating a “one call” system for transfers and appointments<br />

(1-800-464-KIDS), improving the entirety <strong>of</strong> the family experience<br />

during the visit, and providing timely and complete reports to referring<br />

pr<strong>of</strong>essionals.<br />

One <strong>of</strong> our newest initiatives is a joint effort with the American Board<br />

<strong>of</strong> <strong>Pediatrics</strong>, which will permit us to <strong>of</strong>fer a project which will help<br />

both referring physicians and our subspecialty consultants evaluate<br />

each other’s roles in the consultation experience, insure the safety <strong>of</strong><br />

primary care/subspecialist “hand <strong>of</strong>fs”, and provide ABP Maintenance <strong>of</strong><br />

Certification (“MOC”) category 4 credit. As I am writing this letter, we<br />

are finalizing the operational details <strong>of</strong> this project, and will make these<br />

available on the Golisano Children’s Hospital website shortly.<br />

I hope that you will agree that the activity <strong>of</strong> our faculty and programs<br />

has grown in concert with our new hospital. Keep up with our<br />

programs through our newsletter (http://www.upstate.edu/gch/<br />

education/newsletters.php) or through our website (http://www.<br />

upstate.edu/gch/). Remember that you can also register to use our<br />

online clinical question system, ePED Direct, through our website.<br />

Thomas R. Welch, MD<br />

Pr<strong>of</strong>essor and Chair<br />

<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Upstate Medical University<br />

Medical Director<br />

Upstate Golisano Children’s Hospital


2 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

DEPARTMENT LEADERSHIP<br />

With the growth in department activity which has already occurred, and which is planned for the coming years, it<br />

has become critical to apportion leadership responsibilities in a meaningful way. We now have a group <strong>of</strong> vice chairs<br />

who have primary responsibilities for a variety <strong>of</strong> functions within the department. This group meets weekly, and<br />

together acts as a deliberative body to set policy and direction. Each <strong>of</strong> these individuals is also empowered to make<br />

independent decisions within his or her area <strong>of</strong> responsibility. Although I am always available to speak with referring<br />

physicians regarding hospital or department issues, these individuals may also be contacted directly in regard to<br />

matters within their respective purviews.<br />

Ann Botash, MD (botasha@upstate.edu) is Vice Chair for Educational Affairs, with ultimate responsibility for all<br />

aspects <strong>of</strong> education in the department: undergraduate, graduate, and continuing. The enormous growth in our<br />

education services is outlined in the education section <strong>of</strong> this report.<br />

Ann is a well-known figure in pediatrics nationally. She has received the Advocacy Award from the Ambulatory<br />

<strong>Pediatrics</strong> Association, and is very visible regionally and nationally in the area <strong>of</strong> child abuse.<br />

Scott Schurman, MD (schurmas@upstate.edu) continues to serve as our Vice Chair for Clinical Affairs. Scott also<br />

directs our highly-regarded and growing program in kidney diseases.<br />

In his Vice Chair role, Scott has ultimate responsibility for all inpatient and outpatient activity in the department. He<br />

has played an important role in our recent growth in faculty and programs, and is in charge <strong>of</strong> the development <strong>of</strong> our<br />

satellites.<br />

Leonard Weiner, MD (weinerl@upstate.edu) rounds out the department leadership team as Vice Chair for Academic<br />

Affairs. A former interim chair <strong>of</strong> our department, with a national reputation for clinical care and research in infectious<br />

diseases, Len is well suited for this role.<br />

In addition to responsibility for the department’s faculty promotion and tenure process, Len has overall responsibility<br />

for our research programs. We have made some steady strides in this area, as indicated by the individual division and<br />

section reports. With growth in faculty and programs, this will continue.<br />

The leadership team is supported by Leo Sawyer (sawyerl@upstate.edu), practice administrator, Cherlynn Clarry<br />

(clarryc@upstate.edu), department <strong>of</strong>fice manager, and Barbara Delaney (delaneyb@upstate.edu), assistant to the<br />

chair. In the past year, additional support positions have been created. Joy Tompkins, RN, MS, PNP has assumed the<br />

role <strong>of</strong> department research coordinator and provides invaluable support to our investigators. Bonnie Miner, MS, RN,<br />

CNS recently assumed the role <strong>of</strong> patient safety <strong>of</strong>ficer. She is leading a number <strong>of</strong> GCH safety initiatives, including<br />

our collaborative involvement with safety projects <strong>of</strong> the National Association <strong>of</strong> Children’s Hospitals and Related<br />

Institutions.


Bi-Annual <strong>Report</strong> • 3<br />

PEDIATRICS BY THE NUMBERS<br />

A few pertinent numbers provide a snapshot <strong>of</strong> our growth in child health care activity over the past two years. The<br />

Golisano Children’s Hospital did not open until September, <strong>2009</strong>, but in the remaining months <strong>of</strong> the year, our inpatient<br />

activity has accelerated significantly.<br />

Measure <strong>2008</strong> <strong>2009</strong> % change<br />

Inpatient discharges 3,713 3,884 + 4.6%<br />

Observation patients 595 671 + 12.8%<br />

Average length <strong>of</strong> stay 4.4 4.3 - 2.3%<br />

Pediatric ED visits 20,714 23,123 + 11.6%<br />

Pediatric outpatient visits 63,334 65,292 + 3%<br />

Surgical procedures 3,558 4,076 + 14.6%<br />

About 46.8% (1,477) <strong>of</strong> the pediatric inpatients in the Golisano Children’s Hospital in calendar year <strong>2009</strong> came from<br />

Onondaga County, and nearly 1.4% (43) were from outside New York State. Approximately 46% (1,460) <strong>of</strong> inpatients<br />

were under the age <strong>of</strong> five years and about half <strong>of</strong> admissions come through the Pediatric Emergency <strong>Department</strong>.<br />

Outpatient pediatric visits were drawn from an even wider geographic area throughout New York State, with nearly 30%<br />

(19,469) <strong>of</strong> children from outside Onondaga County. About 1% (529) <strong>of</strong> our outpatient visits were from outside New York State.


4 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

CRITICAL CARE AND INPATIENT PEDIATRICS<br />

FACULTY<br />

Critical Care:<br />

William P. Hannan, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Robert K. Kanter, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Division<br />

Director<br />

Kevin Ragosta, DO, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Neal A. Seidberg, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Jennifer Zuccaro, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Hospital Medicine:<br />

John Andrake, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Charles Bergstrom, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Elizabeth Jamme, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

James Listman, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

P. David Sadowitz, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Thomas Welch, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

CLINICAL OVERVIEW<br />

The Pediatric Critical Care service in the Golisano<br />

Children’s Hospital provides the only critical care for<br />

infants and children in a 15 county area <strong>of</strong> Central New<br />

York. The multidisciplinary medical and surgical Pediatric<br />

Intensive Care Unit includes 15 intensive care beds<br />

admitting 800 patients annually. The PICU serves the<br />

region’s Level 1 Trauma center. The Pediatric Interhospital<br />

Transport Service sends pediatric transport specialists to<br />

referring hospitals to provide care at the earliest possible<br />

time for critically ill infants and children throughout<br />

the region. We also coordinate the transition <strong>of</strong> care for<br />

children with special health care needs from intensive<br />

care to community based care, including formulation <strong>of</strong><br />

plans for emergency treatment <strong>of</strong> future unpreventable<br />

illnesses in this vulnerable population. Outpatient care<br />

is provided for selected technology assisted patients<br />

(Dr. Ragosta), in collaboration with the patient’s other<br />

subspecialists and primary care physicians. Finally, the<br />

Pediatric Critical Care service provides pediatric critical<br />

care education to residents in pediatrics and emergency<br />

medicine, nursing students, respiratory therapy students,<br />

and pharmacy students. In recent years many <strong>of</strong> our<br />

pediatric residents have gone on to training in critical care<br />

medicine at the finest fellowship programs after their<br />

residency in Syracuse.<br />

The inpatient (“hospitalist”) service provides<br />

comprehensive, coordinated inpatient care to children<br />

who are not on a subspecialty service or whose primary<br />

care provider does not serve inpatients. National trends<br />

in inpatient child health care over the past few years have<br />

been reflected in Syracuse as well, resulting in significant<br />

growth <strong>of</strong> this program.<br />

Outstanding care coordination, including active<br />

involvement <strong>of</strong> nurse practitioners and discharge<br />

planners, has resulted in severity adjusted length <strong>of</strong> stay<br />

for children at the Golisano Children’s Hospital being<br />

below national benchmarks.<br />

The growth in volume and complexity <strong>of</strong> this program has<br />

necessitated its planning to add additional faculty in 2010<br />

and become a separate division within the department.<br />

RESEARCH HIGHLIGHTS<br />

Dr Kanter’s health services research investigates the<br />

balance between pediatric acute care needs and existing<br />

regional hospital resources. In large public health<br />

emergencies, hospital resources would be overwhelmed<br />

if large numbers <strong>of</strong> children were involved. Quantitative<br />

modeling studies demonstrate that temporary<br />

mass critical care approaches would be essential<br />

to accommodate large surges <strong>of</strong> patients in sudden<br />

impact regional emergencies. Sustained mass critical<br />

care approaches would be necessary to accommodate<br />

pandemic surges (study in progress). A panel <strong>of</strong> experts<br />

demonstrated a method to develop pr<strong>of</strong>essional<br />

consensus regarding those hospital interventions that<br />

should be regarded as essential in mass critical care<br />

responses to a public health emergency. Evidence-based<br />

considerations for pediatric mass critical care in public<br />

health emergencies have been reviewed. A recently<br />

completed study found persistent changes in child<br />

mortality in the New Orleans region recovering from<br />

Hurricane Katrina. Persistent population displacement<br />

and post-disaster changes in demographics affect<br />

children’s needs for hospital services.<br />

SELECTED CLINICAL DATA<br />

Hospitalist service discharges <strong>2008</strong>: . . . . . . . . . . . . . . . 2,809<br />

Hospitalist service discharges <strong>2009</strong>: . . . . . . . . . . . . . . . 3,309<br />

Pediatric intensive care unit discharges <strong>2008</strong>: . . . . . . . . 209<br />

Pediatric intensive care unit discharges <strong>2009</strong>: . . . . . . . . . 266


Bi-Annual <strong>Report</strong> • 5<br />

EDUCATION PROGRAM IN GENERAL PEDIATRICS<br />

FACULTY<br />

Ann S. Botash, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Vice Chair for<br />

Educational Affairs<br />

Graduate Medical Education<br />

John Andrake, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Director <strong>of</strong> Residency Program<br />

Bradley Olson, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Associate Director <strong>of</strong> Residency<br />

Gloria Kennedy, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Associate Director <strong>of</strong> Residency<br />

Undergraduate Medical Education<br />

Charles Bergstrom, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Clerkship Director<br />

Robert Hingre, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Associate Clerkship Director<br />

Administrative<br />

James F. Peacock, MS, Education Program Administrator<br />

Patricia Mondore, MA, Residency Program Coordinator<br />

Carol Plumley, Clerkship Coordinator<br />

OVERVIEW<br />

For more than fifty years, the <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

has maintained a residency training program in<br />

general pediatrics that provides residents with a<br />

strong foundation in primary care pediatrics, acute<br />

care medicine and all subspecialties. Our collegial<br />

environment allows a “hands on” approach with a low<br />

faculty to resident ratio. Due to the large catchment<br />

area served by the department, residents directly care<br />

for patients with a vast array <strong>of</strong> medical problems,<br />

from common primary care issues to the most unique<br />

subspecialty conditions. Residents are actively involved<br />

in varied learning experiences such as resident run journal<br />

clubs, research and pathophysiology conferences, casebased<br />

ambulatory care and subspecialty conferences,<br />

daily rounds with faculty, weekly grand rounds, and<br />

regular discourse with visiting pr<strong>of</strong>essors. Our allencompassing<br />

curriculum has successfully prepared<br />

residents for fellowship training in subspecialties and<br />

careers in primary care pediatrics across the country. In<br />

<strong>2008</strong>, the residency received a full five-year accreditation<br />

from the ACGME with no citations.<br />

Our 6-week clerkship provides pediatric education to<br />

about 120 students every year. The students are exposed<br />

to extensive in-patient (3 weeks) and out-patient (3 weeks)<br />

experiences. They attend thirty core lectures given by<br />

the faculty and are required to study CLIPP (Computer<br />

Learning in Pediatric Project; www.clippcases.org) cases.<br />

A teaching attending is assigned to the students during<br />

their in-patient rotation.<br />

RESIDENCY CURRICULUM<br />

The broad-based curriculum enables residents to<br />

become competent in all areas <strong>of</strong> general pediatrics.<br />

Some <strong>of</strong> the highlights <strong>of</strong> the curriculum include:<br />

• Seminars - In 2007, the core curriculum for the<br />

residents was updated with some innovative<br />

changes. The faculty have translated the core<br />

curriculum to an on-line environment that is<br />

available to the residents anytime and anywhere.<br />

The material is contained within Blackboard and<br />

resident participation in the online curriculum is<br />

actively monitored. The first year residents have<br />

a separate case based series <strong>of</strong> seminars and the<br />

senior residents attend a more in depth seminar on<br />

the same topics later in the day. These interactive<br />

seminars reinforce and complement the on-line<br />

lectures and <strong>of</strong>fer and interactive approach to<br />

learning through cases. Residents complete quiz<br />

materials online that can be used for preparation<br />

for the board examination.<br />

• Primary care – The training in primary care takes<br />

advantage <strong>of</strong> the well-developed division <strong>of</strong> general<br />

pediatrics and takes place at the University Pediatric<br />

and Adolescent Center (UPAC). The residents<br />

participate in a continuity clinic experience one<br />

half day per week. In addition, there are six<br />

separate month-long block rotations at UPAC.<br />

This combination <strong>of</strong> experience provides residents<br />

with a greater continuity for health maintenance,<br />

chronic diseases and acute illnesses. In the second<br />

year, residents combine their UPAC experience<br />

with longitudinal training in the outpatient clinics<br />

<strong>of</strong> various subspecialties. An additional rotation in<br />

Adolescent Medicine rounds out their education<br />

in general pediatrics. Community practices are<br />

also available as sites for resident education, and<br />

nicely complement their training in the inner city,<br />

hospital-based UPAC.<br />

• Critical Care – The Golisano Children’s Hospital<br />

PICU is the setting for the training in Pediatric<br />

Critical Care Medicine. Residents provide direct<br />

patient care for the sickest children in Central<br />

New York, with a wide-range <strong>of</strong> acute conditions.<br />

Residents also provide concurrent care for<br />

patients admitted primarily for surgical conditions.<br />

Residents have exposure to Neonatal Intensive Care<br />

through two distinct NICU experiences, first at St.<br />

Joseph’s Hospital Health Center and subsequently<br />

at the tertiary care NICU at Crouse Hospital.<br />

• Emergency Medicine – Residents are the front line<br />

for children up to 18 years <strong>of</strong> age who come with<br />

medical or surgical emergencies to the area’s only<br />

Pediatric Emergency <strong>Department</strong>. More than 20,000<br />

annual visits are seen, and supervised by board<br />

certified Pediatric Emergency Medicine faculty.


6 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

• Developmental <strong>Pediatrics</strong> – This rotation takes<br />

advantage <strong>of</strong> some <strong>of</strong> the outstanding community<br />

resources in child development, as well as those<br />

at our Center for Neurodevelopmental <strong>Pediatrics</strong>.<br />

The Center is home to services for children with<br />

developmental and behavioral problems, including<br />

the autistic spectrum disorders, as well as those<br />

with complex medical conditions, such as spina<br />

bifida, cerebral palsy, and genetic disorders.<br />

• Inpatient – Dedicated hospitalists provide oversight<br />

and direct care for the inpatients at the Golisano<br />

Children’s Hospital. They also provide consultative<br />

care to other medical and surgical patients. A great<br />

deal <strong>of</strong> the education <strong>of</strong> residents and medical<br />

students is provided by these inpatient specialists.<br />

In addition, a separate attending, the Teaching<br />

Attending, provides hands-on and didactic teaching<br />

to complement the learning on the wards.<br />

• Pediatric surgery rotation – In <strong>2009</strong> our secondyear<br />

residents began taking a required onemonth<br />

rotation with the pediatric surgery team.<br />

This allows the pediatric residents to gain a<br />

better understanding <strong>of</strong> diagnosis, treatment<br />

and management <strong>of</strong> common pediatric surgical<br />

problems and allows them to teach the<br />

surgery team basic pediatric examination and<br />

communication skills.<br />

• Subspecialties – The curriculum continues to<br />

provide comprehensive training in the pediatric<br />

subspecialties. Clinical instruction is available in<br />

virtually all the major pediatric medical and surgical<br />

subspecialties. Residents have elective time that<br />

allows them to create additional experiences in<br />

focused areas <strong>of</strong> the subspecialties. In the third<br />

year, residents are able to spend a clinical rotation<br />

away from the medical center as an “away elective.”<br />

• Systems Based Care – A program <strong>of</strong> learning<br />

advocacy, established in 1995 as the Community<br />

Oriented Advocacy Training program, was one <strong>of</strong><br />

the first such advocacy training programs nationally.<br />

The curriculum now includes experiences in<br />

systems based care and educates residents on<br />

a wide range <strong>of</strong> advocacy skills and community<br />

related topics. Using a case based approach,<br />

residents identify a system issue affecting a patient<br />

and research community resources. Throughout<br />

this experience, the residents develop advocacy<br />

skills and then present their experience at an<br />

educational conference.<br />

• Teaching Skills for Housestaff – This monthly seminar<br />

series is in its 13th year and is designed to meet the<br />

needs <strong>of</strong> residents as teachers. The series addresses<br />

topics such as: delivering effective lectures, teaching<br />

at the bedside, providing feedback, evaluating<br />

students and serving as a role model.<br />

• Evidence Based Medicine – The housestaff present<br />

and participate in a series <strong>of</strong> workshops designed to<br />

analyze recent literature and demonstrate possible<br />

effects on practice. These workshops are held twice<br />

each month and utilize a curriculum in evidence<br />

based medicine.<br />

• Residents and students have the opportunity<br />

to participate in international health activities<br />

including electives in Central America such as the<br />

Rural Health, Adolescent Mentoring and Medical<br />

Spanish elective in El Salvador and the STI/HIV<br />

Education elective in Panama.<br />

• Many <strong>of</strong> our residents participate in active research<br />

with faculty. The underlined authors <strong>of</strong> the<br />

manuscripts in the sections below identify our<br />

residents or students.<br />

PEDIATRIC CLERKSHIP<br />

Medical students rotating through our pediatric clerkship<br />

are assigned for three weeks to an “outpatient program”<br />

at either on-site (general pediatrics and subspecialty<br />

clinics) or in the community. They are also assigned<br />

for three weeks to one <strong>of</strong> two inpatient services. A<br />

teaching attending is assigned to them during their<br />

in-patient rotation. Her or his role is to work closely<br />

with the students, mostly providing bed-side teaching<br />

(communicating with patients and families, taking medical<br />

histories, performing physical examinations, evaluation<br />

laboratory findings, interpreting x-rays, etc.)<br />

The students actively participate in patient care, morning<br />

report, teaching rounds, evidence based medicine<br />

conferences, adolescent conferences and on-line cases.<br />

They attend 30 core lectures given by the faculty and are<br />

required to study CLIPP (Computer Learning in Pediatric<br />

Project; www.clippcases.org) cases.<br />

EDUCATION OUTCOMES<br />

Graduates <strong>of</strong> the Residency program go on to careers in<br />

both primary care practice and in academic medicine, in<br />

the subspecialties and in general pediatrics. In the past<br />

five years, 62% <strong>of</strong> our residents have pursued academic<br />

fellowship programs. These have included: Hematology/<br />

Oncology, Endocrinology, Critical Care, Infectious<br />

Diseases, Gastroenterology, Pediatric Emergency<br />

Medicine, Neonatology, Allergy/Immunology and General<br />

Academic <strong>Pediatrics</strong>. In addition, 35% <strong>of</strong> our residents<br />

have joined primary care practices in the Syracuse area<br />

as well as various communities in New York State, North<br />

Carolina, California, Ohio, Louisiana, New Hampshire,<br />

Pennsylvania, and Washington. Another 2% have joined<br />

academic faculties directly upon completion <strong>of</strong> the<br />

residency. Nine percent have stayed on to become our<br />

chief residents. Of these, 100% entered fellowships upon<br />

completion <strong>of</strong> their chief year.<br />

In <strong>2008</strong>, 89% <strong>of</strong> our residents passed the American Board<br />

<strong>of</strong> <strong>Pediatrics</strong> Certifying Examination on the first attempt<br />

with a mean score well above the national average.<br />

On the NBME subject exam in pediatrics, our medical<br />

students’ scores for the years 2006-2007 average above<br />

the 50 th percentile nationally.


Bi-Annual <strong>Report</strong> • 7<br />

EDUCATION PUBLICATIONS<br />

Book Chapters<br />

Koszalka T, Olson B. Transforming a <strong>Pediatrics</strong> Lecture<br />

Series to Online Instruction. Handbook <strong>of</strong> research on<br />

distributed medical informatics and e-health. Hershey,<br />

PA. Medical Information Science Ref, Aug <strong>2008</strong>.<br />

PUBLICATIONS WITH RESIDENTS, FELLOWS,<br />

OR STUDENTS<br />

Anbar RD and Zoughbi GG. Relationship <strong>of</strong> headache<br />

associated stressors and hypnosis therapy outcome<br />

in children: a retrospective chart review. Am J <strong>of</strong> Clin<br />

Hypnosis. <strong>2008</strong>; 50:335-341<br />

Bennett N - E-Medicine: “HIV Disease” http://www.<br />

emedicine.com/MED/topic24.htm (Oct 22, <strong>2008</strong>)<br />

Bennett N, Domachowske D. Rocky Mountain Spotted<br />

Fever. Emedicine, 9/10/09<br />

Bennett, N – Emedicine<br />

Mononucleosis and Epstein-Barr Virus Infection (10/20/09)<br />

http://emedicine.medscape.com/article/963894-overview<br />

Nocardiosis and Gonorrhea.<br />

http://emedicine.medscape.com/article/966919-overview<br />

http://emedicine.medscape.com/article/964220-overview<br />

Bern RA, van Woensel JBM, Bos AP, Koski A, Farnand<br />

A, Domachowske JB, Rosenberg HF, Martin TR, and<br />

Matute-Bello G. Mechanical ventilation enhances lung<br />

inflammation and caspase activity in a model <strong>of</strong> mouse<br />

pneumovirus infection. AJP Lung <strong>2009</strong>; 296; L46-56.<br />

Dardas M, Abboud M, Salti I, et al. Thyroid cancer in<br />

Lebanese children and adolescents: a 15-year experience<br />

at a single institution. Pediatr Hematol Oncol. <strong>2009</strong> Sep<br />

26(6):439-47<br />

de Waal Malefyt D, Pecha M, Domachowske J. Poster,<br />

“Bacterial Meningitis in Children with Mondini Dysplasia”<br />

Poster, PAS, 5/09, Baltimore, MD<br />

Henderson JF, Anbar RD. Care for Amish and Mennonite<br />

children with cystic fibrosis: a case series. BMC <strong>Pediatrics</strong><br />

<strong>2009</strong>, 9:4.<br />

Kobayaa H, Souki RR, Trust S and Domachowske JB.<br />

Pastuerella multocida meningitis in newborns after<br />

incidental animal exposure. Pediatr Infect Dis J <strong>2009</strong>; in<br />

press<br />

Mallick D, Thapa R. An 11-year-old boy with dark skin,<br />

swallowing difficulty and absence <strong>of</strong> tears. Indian Journal<br />

<strong>of</strong> Dermatology, <strong>2009</strong>; 54(1)<br />

Mallick D, Thapa R. ‘Molar tooth’ sign in Joubert<br />

syndrome. Pediatr Radiol. 7/7/09.<br />

Maniscalco J, Dryer AL, Marks A, Yunghans M, Pierson<br />

SB, Sgarlat CM, Sveen AR, Blanch LE. Index <strong>of</strong> suspicion.<br />

Pediatr Rev. <strong>2008</strong> Sep;29(9):321-8.<br />

Moro M, Suryadevara M, Kiska D, Ridell S and Shaw<br />

J. Incidence <strong>of</strong> invasive community-onset (CO)<br />

Staphylococcus aureus infections in children in central<br />

New York - The Journal <strong>of</strong> <strong>Pediatrics</strong>. Accepted for<br />

publication. <strong>2009</strong>.<br />

Moro R, Contello K, Holz W, Weiner L, Shaw J.<br />

“Subcutaneous (SCIG) Versus Intravenous (IVIG)<br />

Immunoglobulin Replacement Therapy in a Pediatric<br />

Population with Primary Immunodeficiencies (PID)”<br />

Poster, PAS, 5/09, Baltimore, MD.<br />

Moro MR, Bonville CA, Suryadevara, M, Cummings E,<br />

Faddoul D, Kobayaa H., Branigan P, Domachowske JB.<br />

Clinical features, adenovirus types, and local production<br />

<strong>of</strong> inflammatory mediators in adenovirus infections.<br />

Pediatric Infectious Disease Journal. 28(5):376-380, May<br />

<strong>2009</strong>.<br />

Samkari A, Kiska D, Riddell et al. Dipylidium Caninum<br />

Mimicking Recurrent Enterobius Vermicularis (Pinworm)<br />

Infection. Clinical <strong>Pediatrics</strong>, In Press, <strong>2008</strong>.<br />

Samkari A, Sveen A. Pityriasis Rosea. Consultant for<br />

<strong>Pediatrics</strong>, February <strong>2008</strong><br />

Samkari A, Sveen A. Localized Schleroderma. Consult for<br />

Pediatricians, June <strong>2008</strong>:258-259.<br />

Samkari A. “Dipylidium caninum mimicking recurrent<br />

Enterobius vermicularis (pinworm) infection.” Poster<br />

presented at the Medical Society <strong>of</strong> the State New<br />

York (MSSNY) Resident and Fellow Research Poster<br />

Symposium. April 11, <strong>2008</strong>.<br />

Sgarlat C and Sveen A. Case presentation on<br />

hyperimmunoglobulin E syndrome. Pediatr in ev.<br />

<strong>2008</strong>;29:322-7<br />

Sgarlat CM, Sveen AR. Case Presentation. <strong>Pediatrics</strong> in<br />

Review. Sept <strong>2008</strong>. 324-327.<br />

Suryadevara M, Schurman S, Landas S, et al. BRIEF<br />

REPORT: Systemic Calciphylaxis. Pediatr Blood Cancer<br />

<strong>2008</strong>; 100:1-2.<br />

Tabarani CM, Bennett NJ, Kiska DL, Riddell SW, Botash AS<br />

and Domachowske JB. Empyema <strong>of</strong> pre-existing subdural<br />

hemorrhage caused by a rare Salmonella species after<br />

exposure to bearded dragons in a foster home. J Pediatr<br />

<strong>2009</strong>.<br />

Thapa R, Biswas B, Mallick D. Classic Hemorrhagic Disease<br />

<strong>of</strong> the Newborn Presenting with Bilateral Vitreous<br />

Hemorrhage. To The Editor. J <strong>of</strong> Emerg Med. <strong>2009</strong>.<br />

Thapa R, Ganguly D, Dhar S, Banerjee P. Short<br />

Communication: Pachyonychia congenital Type 1<br />

(Jadassohn-Lewandowky Type): <strong>Report</strong> <strong>of</strong> four cases.<br />

Indian Journal <strong>of</strong> Dermatology, <strong>2009</strong>; 54(2).<br />

Thapa R. Scientific Letters to the Editor: Discordance<br />

for Congenital Toxoplasmosis in Twins. Indian Journal <strong>of</strong><br />

<strong>Pediatrics</strong>, Vol 26, October, <strong>2009</strong>.Thapa R. Letter: Bilateral<br />

Subconjunctival Haemorrhage in Childhood Enteric Fever.<br />

Singapore Med J <strong>2009</strong> 50(10):1038.<br />

Thapa R, Ghosh A, Mallick D, Biswajit B. Letter: Lung<br />

Abscess Secondary to Non-Typhoidal Salmonellosis in an<br />

Immunocompetent Girl. Singapore Med J <strong>2009</strong> 50(10):1033-5.


8 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Thapa R, Ghosh A, Dhar S. Infantile giant congenital<br />

melanocytic nevus: report <strong>of</strong> three unusual cases. Int J<br />

<strong>of</strong> Derm, <strong>2009</strong>, 48, 1209-1212.<br />

Thapa R. Letter to the Editor. Moebius Syndrome with<br />

Atrial Septal Defect. Singapore Med J <strong>2009</strong>; 50(10):1.<br />

Thapa R, Mallick D, Biswas B, Ghosh A. Open and Closed<br />

Lip Schizencephaly in Seckel Syndrome: A Case <strong>Report</strong>.<br />

Journal <strong>of</strong> Child Neurology. <strong>2009</strong><br />

Thapa R, Bishwajit B, Debkrishna M et al.<br />

Childhood Plasmodium vivax Malaria With Severe<br />

Thrombocytopenia and Bleeding Manifestations. Pediatr<br />

Hematol Oncol, <strong>2009</strong>.<br />

Thapa R, Gosh A, Banerjee T. Childhood Plasmodium<br />

falciparum malaria complicated by spenic abscess.<br />

Emergency Medicine Australasia (<strong>2009</strong>) 21, 237-239.<br />

Thapa R, Ghosh A, Dhar S. Letter to Editors: Progressive<br />

hemifacial atrophy (Parry-Romberg syndrome ) with<br />

band-like alopecia. Indian Journal <strong>of</strong> <strong>Pediatrics</strong>. <strong>2009</strong>.<br />

Thapa R, Ghosh A, Mondol S et al. A 13-Year-old Boy With<br />

Extensive Bilateral Lung Infiltrates. J Pediatr Hematol<br />

Oncol. <strong>2009</strong>.<br />

Thapa R, Mallick D, Biswas B. Perinatal malaria and<br />

tuberculosis co-infection: A case report. . Int J <strong>of</strong><br />

Infectious Diseases (<strong>2009</strong>).<br />

Thapa R. Letter: Acute disseminated encephalomyelitis.<br />

Indian Journal <strong>of</strong> <strong>Pediatrics</strong>, Vol 26, Jan, <strong>2009</strong>.<br />

Thapa R, Chakrabartty S. Atyipcal Kawasaki disease with<br />

remarkable paucity <strong>of</strong> signs and symptoms. Rheumatol<br />

Int,, April <strong>2009</strong>.<br />

Thapa R, Mallick D, et al. Case <strong>Report</strong>: Childhood<br />

cutaneous polyarteritis nodosa: an unusual presentation.<br />

Rheumatol Int. June <strong>2009</strong>.<br />

Thapa R, Pal P, Mukhopadhyay M. To the Editor: Beta<br />

Thalassemia Major and Hodgkin Lymphoma. Pediatr<br />

Hematol ONcol, 31:6, June <strong>2009</strong>.<br />

Thapa R, Biswas B, et al. Pharyngeal-Cervical-Brachial<br />

Variant <strong>of</strong> Pediatric Guillain-Barre’ Syndrome With<br />

Antecedent Acute Hepatitis A Virus Infection. J <strong>of</strong> Child<br />

Neurol. July <strong>2009</strong>: 24(7).<br />

Thapa R, Mallick D, Biswas B, Chakrabartty. Transient<br />

unilateral oculomotor palsy and severe headach in<br />

childhood Kawasaki disease. Rheumatol Int, Oct 12, <strong>2009</strong>;<br />

1154-6.<br />

PRESENTATIONS AT NATIONAL MEETINGS<br />

Andrake J, Olsen BG, Peacock J, Harlan GA, Guralnick<br />

S, Blair RJ, Fahner J, Starr T, Perspectives on Curriculum<br />

Reform: Different Approaches to the Same Goal.<br />

Presented at the Annual Meeting <strong>of</strong> the Association <strong>of</strong><br />

Pediatric Program Directors,Baltimore, MDApril 28 – May<br />

2, <strong>2009</strong><br />

Andrake J, Sveen A.Building a Communication Skills<br />

Curriculum for the <strong>Pediatrics</strong> Clerkship. Presented at the<br />

Annual Meeting <strong>of</strong> COMSEP. Atlanta, GA; April 3-6, <strong>2008</strong><br />

PRESENTATIONS AT NATIONAL MEETINGS<br />

WITH RESIDENTS, FELLOWS AND STUDENTS<br />

Bennett N (et al) Poster Presentation: “The Effects <strong>of</strong><br />

Teaching a Novel Communication Skills Curriculum in<br />

<strong>Pediatrics</strong> on Medical Students’ Perceptions” at MSSNY<br />

(Medical Student Society <strong>of</strong> NY), Friday, May 1, <strong>2009</strong>.<br />

Bem RA, van Woensel JB, Bos AP, Koski A, Domachowske<br />

JB, Rosenberg HF, Martin TR, and Matute-Bello G.<br />

Mechanical ventilation enhances lung inflammation and<br />

cellular apoptosis in a model <strong>of</strong> mouse pneumovirus<br />

infection. American Thoracic Society Toronto Canada<br />

<strong>2008</strong>.<br />

Dawson E, Greenberg S, Mahar S, Olson B. Poster<br />

“The Predictive Value <strong>of</strong> Eosinophilia in Chronic<br />

Schistosomiasis and Strongyloidiasis: An Examination<br />

<strong>of</strong> the CDC Screening Guidelines for Newly Arriving<br />

Refugees”<br />

de Waal Malefyt S, Pecha M, Domachowske J. Poster,<br />

“Bacterial Meningitis in Children with Mondini Dysplasia”<br />

Poster, Baltimore, MD, PAS, 5/09<br />

El Feghaly R, McGann L, Domachowske J. et al – Poster,<br />

PAS, 5/09, Baltimore, MD. “A Decade <strong>of</strong> Pediatric<br />

Parainfluenza Virus Infections: Clinical Manifestations<br />

and Biomarkers <strong>of</strong> Disease Severity” et al – Poster, PAS,<br />

5/09, Baltimore, MD.<br />

El Feghaly R, McGann L, Domachowske J. et al – Poster,<br />

“A Decade <strong>of</strong> Pediatric Parainfluenza Virus Infections:<br />

Clinical Manifestations and Biomarkers <strong>of</strong> Disease<br />

Severity” et al – Poster, PAS, 5/09, Baltimore, MD.<br />

Moro R, Contello K, Holz W, Weiner L, Shaw J.<br />

“Subcutaneous (SCIG) Versus Intravenous (IVIG)<br />

Immunoglobulin Replacement Therapy in a Pediatric<br />

Population with Primary Immunodeficiencies (PID)”<br />

Poster, PAS, 5/09, Baltimore, MD.<br />

Pekarsky S, Botash A. Poster “Pediatric Patient Assent<br />

and Medical Provider Compliance with New York State<br />

Guidelines for HIV Post-Exposure Prophylaxis for Sexual<br />

Assault” PAS 5/09, Baltimore, MD<br />

Samkari A. “Dipylidium Caninum Mimicking Recurrent<br />

Enterobius Vermicularis (pinworm) Infection.” Poster<br />

presented at the Medical Society <strong>of</strong> the State New<br />

York (MSSNY) Resident and Fellow Research Poster<br />

Symposium. April 11, <strong>2008</strong>.


Bi-Annual <strong>Report</strong> • 9<br />

GRANTS AND CONTRACTS<br />

Botash AS: Child Abuse Medical Provider NYS Training<br />

Initiative: <strong>2008</strong>-2010 New York State <strong>Department</strong> <strong>of</strong><br />

Health, Rape Crisis Program Preventive Health and<br />

Health Services Block Grant from CDC, Rape Prevention<br />

Education. ~$160,000.<br />

Botash AS: Child Abuse Medical Provider Training and<br />

Network: <strong>2008</strong>-09, NYS Office <strong>of</strong> Children and Family<br />

Services pending legislative approval, $90,000 .<br />

Botash AS: Child Abuse Medical Provider Training and<br />

Network, Children’s Miracle Network Grant, <strong>2009</strong>.<br />

$30,000.<br />

Botash AS: Procedure Management Education (LEAPP).<br />

$8,400<br />

Botash AS: Friend In Deed Funding for Child Fatality<br />

Review Team: $2400<br />

Botash AS, Unger C, Ryan M.: Onondaga County Child<br />

Fatality Review Team: NYS OCFS <strong>2009</strong>- 2010. $ 52,000<br />

Botash AS: Assistance for Abused Children. St. Agatha<br />

Foundation. $25,000<br />

Botash AS, Bifano E: Empire Clinical Reseach Investigator<br />

Program, Post Graduate Medical Education research in<br />

Neonatology, September <strong>2008</strong> – August 2010, $120,000.<br />

Dosa NP: Parent Partners in Health Education. New York<br />

State Developmental Disabilities Planning Council: 2006-<br />

<strong>2009</strong>: $135,000


10 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

PEDIATRIC EMERGENCY MEDICINE<br />

Syracuse is fortunate to have a group <strong>of</strong> specialists in<br />

Pediatric Emergency Medicine. While these physicians<br />

have primary appointments in the <strong>Department</strong> <strong>of</strong><br />

Emergency Medicine, most have joint appointments in<br />

the <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong>.<br />

FACULTY<br />

Richard M. Cantor, MD FAAP/FACEP, Director <strong>of</strong> Pediatric<br />

Emergency Services/Medical Director, Central NY Poison<br />

Control Center, Associate Pr<strong>of</strong>essor <strong>of</strong> Emergency<br />

Medicine and <strong>Pediatrics</strong><br />

P. David Sadowitz, MD, Associate Pr<strong>of</strong>essor, Emergency<br />

Medicine and <strong>Pediatrics</strong><br />

James D’Agostino, MD, FAAP, Assistant Pr<strong>of</strong>essor,<br />

Emergency Medicine and <strong>Pediatrics</strong><br />

Jennifer E. Mackey, MD, FAAP, Assistant Pr<strong>of</strong>essor,<br />

Emergency Medicine and <strong>Pediatrics</strong><br />

Lisa Marie Keough, MD, Assistant Pr<strong>of</strong>essor, Emergency<br />

Medicine and <strong>Pediatrics</strong><br />

Alison McCrone MD, Assistant Pr<strong>of</strong>essor, Emergency<br />

Medicine and <strong>Pediatrics</strong><br />

CLINICAL OVERVIEW<br />

The Pediatric Emergency <strong>Department</strong> at University<br />

Hospital for the greater part <strong>of</strong> 25 years has provided<br />

24-hours a day, 7 days a week coverage for any and all<br />

pediatric emergencies. We service the entire Central<br />

New York region consisting <strong>of</strong> over 18 counties and over<br />

25 hospitals. We are the primary referral center for all<br />

pediatric emergencies, including major trauma, major<br />

medical emergencies, poisonings, and child abuse. All<br />

pediatric transports within our region are evaluated<br />

within our emergency department and disposition is<br />

arranged for daily. With the opening <strong>of</strong> the Golisano<br />

Children’s Hospital, the Pediatric Emergency <strong>Department</strong><br />

continues to play an expanded role in the delivery <strong>of</strong> subspecialty<br />

Pediatric Emergency Medical Services.<br />

The last few years have demonstrated a marked<br />

growth in both patient volume and diversity in our<br />

academic efforts. The faculty maintains a strong clinical<br />

relationship with all practitioners within the region,<br />

including family physicians and pediatricians alike. We<br />

maintain a strong educational presence in the region as<br />

evidenced by the annual Pediatric Emergency Medicine<br />

Teaching Day, which has been in place for the greater<br />

part <strong>of</strong> 10 years. In addition, under our directorship, PALS,<br />

APLS, and PEPP courses are <strong>of</strong>fered almost on a monthly<br />

basis. Target audiences include students, residents,<br />

paramedics, and private practitioners. Members <strong>of</strong><br />

the Pediatric Emergency Medicine faculty, specifically<br />

Drs. Cantor, Sadowitz, and D’Agostino, are nationally<br />

recognized figures in our field and are <strong>of</strong>ten invited to<br />

present to national and international audiences. This<br />

past year, our division was responsible for a reference<br />

text, “Neonatal Emergencies”, edited by Drs. Cantor and<br />

Sadowitz, and published by McGraw Hill.<br />

Within the Upstate Medical University College <strong>of</strong><br />

Medicine, the Pediatric Emergency <strong>Department</strong> <strong>of</strong>fers<br />

many educational opportunities. We are developing<br />

an educational model within the MedSTAR Simulation<br />

Center, addressing the needs <strong>of</strong> medical students and<br />

residents. In addition, we <strong>of</strong>fer a fourth year medical<br />

student elective in Pediatric Emergency Medicine.<br />

Lectures are given to residents within both the<br />

<strong>Department</strong>s <strong>of</strong> Emergency Medicine and <strong>Pediatrics</strong><br />

throughout the year. In addition, we maintain a strong<br />

affiliation with the family practice residency at St.<br />

Joseph’s Hospital, with their residents rotating through<br />

our Pediatric Emergency <strong>Department</strong> four days a week.<br />

Over the last five years, we have re-instituted our<br />

fellowship program in Pediatric Emergency Medicine,<br />

under the leadership <strong>of</strong> Dr. Richard Cantor. We accept<br />

one fellow per year, and at present will have three in<br />

place working within our division. These fellows are<br />

graduates <strong>of</strong> both pediatric residencies and emergency<br />

medicine residencies. The fellowship program in<br />

Pediatric Emergency Medicine at University Hospital is<br />

unique in the country in <strong>of</strong>fering positions to graduates <strong>of</strong><br />

emergency medicine residency programs. These are very<br />

competitive positions, and we are fortunate to have this<br />

<strong>of</strong>fering on a local basis.<br />

PUBLICATIONS<br />

Sadowitz PD, Souid A-K. Cancer and cancer related<br />

complications in children. Pediatric Emergency Medicine,<br />

<strong>2008</strong>. Ed. Baren, Brennan, Brown and Rothrock.<br />

Sadowitz PD, Souid A-K. Idiopathic thrombocytopenic<br />

purpura and other platelet disorders. Pediatric<br />

Emergency Medicine, <strong>2008</strong> Ed. Baren, Brennan, Brown and<br />

Rothrock<br />

Sadowitz PD: Neonatal Hematologic Emergencies, in<br />

Neonatal Emergency Medicine, Cantor and Sadowitz,<br />

McGraw-Hill, <strong>2009</strong><br />

Sadowitz PD: Neonatal Infectious Emergencies, in<br />

Neonatal Emergency Medicine, Cantor and Sadowitz,<br />

McGraw-Hill, <strong>2009</strong><br />

Cantor RM: Neonatal Emergencies, in Pediatric<br />

Emergency Medicine, Baren J. Elsevier, <strong>2008</strong>.<br />

Cantor RM: Aspirin and APAP Poisoning, in Pediatric<br />

Emergency Medicine, Baren J. Elsevier, <strong>2008</strong>.<br />

Cantor RM: Classic Pediatric Poisonings, in Pediatric<br />

Emergency Medicine, Baren J. Elsevier, <strong>2008</strong>.<br />

Cantor RM: Respiratory Distress in The Clinical Practice<br />

<strong>of</strong> Emergency Medicine, Wolfson A, Lippincott, Williams<br />

and Wilkins <strong>2009</strong><br />

Cantor RM: Upper Airway Emergencies, in Pediatric<br />

Emergency Medicine, 3rd Ed, McGraw-Hill <strong>2009</strong>


Bi-Annual <strong>Report</strong> • 11<br />

Cantor RM: Neonatal Abdominal Emergencies, in<br />

Neonatal Emergency Medicine, Cantor and Sadowitz,<br />

McGraw-Hill, <strong>2009</strong><br />

Cantor RM: Neonatal Neurological Emergencies, in<br />

Neonatal Emergency Medicine, Cantor and Sadowitz,<br />

McGraw-Hill, <strong>2009</strong><br />

D’Agostino J. Malrotation and Midgut Volvulus. In:<br />

Baren JM, et al., eds. Pediatric Emergency Medicine.<br />

Philadelphia, Saunders; <strong>2008</strong>, pp 630-633.<br />

Mackey JE Neonatal Respiratory Emergencies. in<br />

Neonatal Emergency Medicine, Cantor and Sadowitz,<br />

McGraw-Hill <strong>2009</strong><br />

PRESENTATIONS AT SCIENTIFIC MEETINGS<br />

Cantor RM. Pediatric Emergency Medicine Literature<br />

Review; Mistakes You Don’t Want to Make in Pediatric<br />

Patients. Presented at the American College <strong>of</strong><br />

Emergency Physicians Scientific Assembly, Chicago,<br />

Illinois. <strong>2008</strong><br />

Cantor RM. Pediatric Emergency Medicine Literature<br />

Review; Chief Complaints in Inafants Less Than 28<br />

Days <strong>of</strong> Age; Mistakes You Don’t Want to Make in<br />

Pediatric Patients. Presented at the American College<br />

<strong>of</strong> Emergency Physicians Scientific Assembly, Boston,<br />

Massachusetts. <strong>2009</strong><br />

Cantor RM. Emergency Medicine Grand Rounds.<br />

Presented at NYU Bellevue Medical Center <strong>Department</strong><br />

<strong>of</strong> Emergency Medicine, June, <strong>2008</strong><br />

Cantor RM. Keynote Speaker, St. Barnabus NJ Hospital<br />

Annual Emergency Medicine Teaching Day, <strong>2008</strong>, <strong>2009</strong>:<br />

Mistakes You Don’t Want To Make in Pediatric Emergency<br />

Patients, Short Hills, NJ<br />

Cantor RM. Keynote Speaker, Methodist Hospital Annual<br />

Pediatric Medicine Teaching Day, <strong>2008</strong>, <strong>2009</strong>: Lit Review,<br />

Toxicology, Mistakes, Miami, Florida<br />

Cantor RM. Speaker, NJ ACEP Annual Emergency<br />

Medicine Teaching Conference, <strong>2008</strong>, <strong>2009</strong>: Lit Review,<br />

Toxicology, Mistakes, Atlantic City, NJ<br />

Cantor RM. Invited Speaker, Stanford University Annual<br />

Emergency Medicine Teaching C<strong>of</strong>erence, <strong>2009</strong>: Lit<br />

Review, Toxicology, Mistakes, Maui, Hawaii<br />

Cantor RM. Visiting Pr<strong>of</strong>essor, <strong>Department</strong> <strong>of</strong> Emergency<br />

Medicine, University <strong>of</strong> Maryland, August, <strong>2009</strong>.<br />

Cantor RM. Visiting Pr<strong>of</strong>essor, <strong>Department</strong> <strong>of</strong> Emergency<br />

Medicine, University <strong>of</strong> Texas Southwestern, November,<br />

<strong>2009</strong>.<br />

HONORS, VISITING PROFESSORSHIPS,<br />

EDITORIAL DUTY<br />

Editorial Boards/Reviewer<br />

Cantor, R. Annals <strong>of</strong> Emergency Medicine. Pediatric<br />

Emergency Care, American Journal <strong>of</strong> Emergency<br />

Medicine, Micromedex Poisondex, Pediatric Emergency<br />

Medicine Abstracts, PRETx (Pediatric Research in<br />

Emergency Therapeutics).<br />

GRANT ACTIVITY<br />

Cantor RM. Development <strong>of</strong> a Child Life Specialist in the<br />

Pediatric Emergency <strong>Department</strong> (2005-8), Children’s<br />

Miracle Network, $40,000/year<br />

Sadowitz, PD. An Epidemiologic Study to Evaluate the<br />

Seasonality <strong>of</strong> Respiratory Syncytial Virus Associated<br />

Lower Respiratory Tract Infections or Apnea in Infants in<br />

the Emergency <strong>Department</strong>. $45,000 received to date<br />

9/1/06 – May 1, <strong>2008</strong><br />

SELECTED CLINICAL DATA<br />

Pediatric Emergency <strong>Department</strong> Visits, <strong>2008</strong>: . . . . . . 21,242<br />

Pediatric Emergency <strong>Department</strong> Visits, <strong>2009</strong>:. . . . . 21,338<br />

Percentage <strong>of</strong> patients admitted: . . . . . . . . . . . . . . . . . . . 10%<br />

Ambulances received per day: . . . . . . . . . . . . . . . . . . . . . 6-10<br />

Private patient referrals per day: . . . . . . . . . . . . . . . . . . . 10-15


12 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

PEDIATRIC ENDOCRINOLOGY, DIABETES & METABOLISM<br />

FACULTY<br />

Roberto Izquierdo, MD, Pr<strong>of</strong>essor <strong>of</strong> Medicine and<br />

<strong>Pediatrics</strong>; Section Head; Associate Medical Director,<br />

Joslin Diabetes Center Affiliate; Medical Director, Thyroid<br />

Cancer Center<br />

Lauren Lipeski, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Irene N. Sills, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>; Director,<br />

New York State Newborn Screening Program; Director,<br />

Pediatric Endocrine and Diabetes Fellowship<br />

Susan E. Stred, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>;<br />

Associate Medical Director, KNOT Program<br />

AFFILIATED CLINICAL STAFF<br />

Kathleen Bratt, PNP, CDE<br />

Sheri Hill, RN, Diabetes Educator<br />

Lynn Horowitch, PNP<br />

Joanne Kearns, RD, CDE<br />

Khuyet Le, PA<br />

Barbara Lindenmayer, PNP<br />

Andrea Gross, RN, Diabetes Educator<br />

CLINICAL OVERVIEW<br />

The Section <strong>of</strong> Pediatric Endocrinology, Diabetes and<br />

Metabolism provides care for children and adolescents<br />

with the full spectrum <strong>of</strong> disorders <strong>of</strong> the endocrine<br />

system. Staff endocrinologists and nurse practitioners<br />

evaluate and treat children with diabetes mellitus,<br />

short stature, thyroid disease, Turner syndrome,<br />

hypopituitarism, disorders <strong>of</strong> puberty, congenital<br />

adrenal hyperplasia, metabolic bone disorders, and<br />

other hormonal disorders. Our Center is one <strong>of</strong> the<br />

original referral sites for New York State’s Newborn<br />

Screening Program for congenital hypothyroidism<br />

and 21-hydroxylase congenital adrenal hyperplasia.<br />

We were recognized as an Endocrine Specialty Center<br />

for Congenital Hypothyroidism, Congenital Adrenal<br />

Hyperplasia, and Diabetes by the New York State<br />

<strong>Department</strong> <strong>of</strong> Health in 2004.<br />

Diabetes mellitus is treated by a comprehensive group<br />

<strong>of</strong> pr<strong>of</strong>essionals using the team model, under the<br />

direction <strong>of</strong> Dr. Izquierdo at the Joslin Diabetes Center<br />

at SUNY Upstate Medical University. The team includes<br />

nurse practitioners with a special interest in diabetes<br />

care, diabetes educators, including diabetes pump<br />

educators, dieticians, and an exercise physiologist. This<br />

multidisciplinary team provides care to children with<br />

type 1 and type 2 diabetes mellitus. On a consultative<br />

basis, we have support from adult and pediatric<br />

psychologists.<br />

Dr. Izquierdo and Kathleen Bratt direct the School<br />

Telemedicine Project, supported by a New York State<br />

Diabetes Center <strong>of</strong> Excellence Grant. This program<br />

provides diabetes care via telemedicine to students with<br />

diabetes in schools in our northern regions <strong>of</strong> New York.<br />

We are able provide pediatric DXA scanning and<br />

consultations on patients at risk for osteoporosis. In <strong>2008</strong>,<br />

Dr. Sills attained certification as a clinical Densitometrist<br />

by the International Society for Clinical Densitometry.<br />

Dr. Irene Sills is a member <strong>of</strong> the Harry Benjamin<br />

International Gender Dysphoria Association, Inc. and<br />

directs our program to treat children with gender<br />

dysphoria and adolescents with transsexualism.<br />

Dr. Stred supervises the endocrine portion <strong>of</strong> the KNOT<br />

(Kids Now Off Therapy) Program, the latter providing<br />

comprehensive care to cancer survivors. Although more<br />

than 70% <strong>of</strong> all children diagnosed with a malignancy<br />

during childhood now survive, 40-50% <strong>of</strong> those<br />

experience significant endocrine dysfunction as a result<br />

<strong>of</strong> their treatment.<br />

RESEARCH HIGHLIGHTS<br />

Dr. Izquierdo’s research interests lie in type 1 and 2<br />

diabetes mellitus, and thyroid nodular disease and<br />

cancer. He is the principal investigator for the Protégé<br />

Study, which is a multi-centered study that uses a<br />

monoclonal antibody to preserve beta-cell function in<br />

children and adolescents with type 1 diabetes mellitus.<br />

This improves glycemic control and prolongs the<br />

“honeymoon” phase <strong>of</strong> type 1 diabetes. He is also involve<br />

in the Diamyd clinical trial in which a GAD vaccine is<br />

administer to children early in the diagnoses <strong>of</strong> diabetes<br />

to preserve beta-cell function. Dr. Izquierdo continues as<br />

co-investigator <strong>of</strong> the TODAY study, a multicenter NIHsponsored<br />

trial to determine the best treatment options<br />

in children and adolescents with type 2 diabetes mellitus.<br />

Dr. Sills is interested in the natural history <strong>of</strong> type 1<br />

diabetes. She is our Center’s principal investigator for<br />

TrialNet, which aims at identifying individuals at high<br />

risk for development <strong>of</strong> type 1 diabetes. Identified high<br />

risk individuals are then eligible to participate in trials<br />

designed to delay or prevent the development <strong>of</strong> type 1<br />

diabetes mellitus.<br />

PUBLICATIONS<br />

Trief P.M., J. Sandberg, R.I. Izquierdo, P.C. Morin, S.<br />

Shea, R. Brittain, E.B. Feldhousen, R.S. Weinstock.<br />

Diabetes management assisted by telemedicine: patient<br />

perspectives. Telemedicine and e-Health 14(7):647-655,<br />

<strong>2008</strong>.<br />

Izquierdo R, Shankar R, Kort K, Khurana K. Ultrasound-<br />

Guided Fine-Needle Aspiration in the Management <strong>of</strong><br />

Thyroid Nodules in Children and Adolescents. Thyroid 19<br />

(7): 703-705, <strong>2009</strong><br />

Shea, S., R.S. Weinstock, J.A. Teresi, W. Palmas, J. Starren,<br />

J.J. Cimino, A.M. Lai, L. Field, P.C. Morin, R. Goland,


Bi-Annual <strong>Report</strong> • 13<br />

R.E. Izquierdo, S. Ebner, S. Silver, E. Petkova, J. Kong, J.P.<br />

Eimicke for the IDEATel Consortium. A randomized trial<br />

comparing telemedicine case management with usual<br />

care in older, ethnically diverse, medically underserved<br />

patients with diabetes mellitus: 5 year results <strong>of</strong> the<br />

IDEATel study. J Am Med Inform Assoc, 16: 446-456, <strong>2009</strong>.<br />

Sandberg J, Trief PM, Izquierdo R, Goland R, Morin PC,<br />

Palmas W, Larson CD, Shea S, Weinstock RS. A qualitative<br />

study <strong>of</strong> the experiences and satisfaction <strong>of</strong> direct<br />

telemedicine providers in diabetes case management.<br />

Telemedicine and e-Health <strong>2009</strong>: 15: 742-750.<br />

Izquierdo R, Morin PC, Bratt K, Moreau Z, Meyer S, Ploutz-<br />

Snyder R, Wade M, Weinstock RS. School Centered<br />

Telemedicine for Children with Type 1 Diabetes Mellitus. J<br />

Pediatr <strong>2009</strong>; 155:374-9.<br />

Shah SS, Faquin WC, Izquierdo R, Khurana KK. FNA<br />

<strong>of</strong> misclassified primary malignant neoplasms <strong>of</strong> the<br />

thyroid: Impact on clinical management. CytoJournal<br />

<strong>2009</strong>; vol 6, issue 1.<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS<br />

Izquierdo R, Weinstock RS, Morin P, Meyer S, Bratt<br />

K, Moreau Z, Ploutz-Snyder R. School Centered<br />

Telemedicine Study for Children with Diabetes. 68 th<br />

American Diabetes Association Scientific Sessions, June<br />

6-10, <strong>2008</strong>, San Francisco, CA.<br />

Izquierdo R, Barham K, Kort K, Khurana K, Hsu J, Numann<br />

P, Cico L. Intraoperative Use <strong>of</strong> Nck Sonography in the<br />

Management <strong>of</strong> Recurrent Thyroid Cancer. Endocrine<br />

Society’s 90 th Annual Meeting, June 16, <strong>2008</strong>, San<br />

Francisco, CA.<br />

INVITED WORKSHOPS, CME PRESENTATIONS<br />

Izquierdo, R. “Multiple Small Feedings <strong>of</strong> the Mind: New<br />

Directions in the Management <strong>of</strong> the Patient with Type<br />

1 Diabetes.” American College <strong>of</strong> Physicians NYACP<br />

Meeting. June 9, <strong>2009</strong>.<br />

Izquierdo, R. “Studies in Thyroid Cancer”. Endocrinology,<br />

Diabetes & Metabolism Journal Club. February 1, <strong>2008</strong>.<br />

Izquierdo, R. “Making Sense <strong>of</strong> Sensors”. School Nurse<br />

Teaching Day. September 13, <strong>2008</strong>.<br />

Izquierdo, R. “New Directions in the Management <strong>of</strong> the<br />

Patient with Type 1 Diabetes”. Medicine Grand Rounds,<br />

SUNY Upstate Medical University. February 19, <strong>2009</strong>.<br />

Izquierdo, R. “New Directions in the Management <strong>of</strong> the<br />

Patient with Type 1 Diabetes”. Pediatric Grand Rounds,<br />

SUNY Upstate Medical University. April 29, <strong>2009</strong>.<br />

Izquierdo, R. School Nurse Diabetes Teaching Day:<br />

“Insulin Pump Therapy”. Upstate Golisano Children’s<br />

Hospital at Upstate University Hospital. October 24,<br />

<strong>2009</strong>.<br />

Izquierdo, R. “Impact <strong>of</strong> Telemedicine on Medical<br />

Education”. Faculty Development Seminar. October 27,<br />

<strong>2009</strong>.<br />

Lipeski, L. Vitamin D Deficiency. Onondaga Pediatric<br />

Society Meeting. February 24, <strong>2009</strong>.<br />

Lipeski, L. Pediatric Obesity. Pediatric Grand Rounds.<br />

April 15, <strong>2009</strong>.<br />

Lipeski, L. Thyroid function testing. Endocrine<br />

Conference. October 8, <strong>2009</strong>.<br />

Sills, I. “Pediatric Endocrine Update” Annual Meeting <strong>of</strong><br />

New York State Nurse Practitioners, <strong>2008</strong>.<br />

Sills, I. “Gender Dysphoric Children and Transsexual<br />

Adolescents” Grand Rounds, Plattsburgh Hospital, <strong>2008</strong>.<br />

Sills, I. “Gender Dysphoric Children and Transsexual<br />

Adolescents”. American Academy <strong>of</strong> <strong>Pediatrics</strong> Meeting<br />

<strong>2009</strong>.<br />

Sills, I. “Transsexuality”. Psychiatry Grand Rounds <strong>2009</strong><br />

GRANTS AND CONTRACTS<br />

Sills, I. NIDDK: Diabetes TrialNet: Natural History<br />

Study <strong>of</strong> the Development <strong>of</strong> Type 1 Diabetes (Principal<br />

Investigator for our center). Funding accrual based.<br />

Izquierdo R. NIDDK: Trial for the Treatment <strong>of</strong> Type 2<br />

Diabetes in Children and Adolescents (co-investigator)<br />

Izquierdo R. A Phase 2/3, Randomized, Double-Blind,<br />

Multicenter, Multinational, 4-Arm, Controlled, Dose-<br />

Ranging Study to Evaluate Efficacy and Safety <strong>of</strong><br />

Teplizumab (MGA031), a Humanized, FcR Non-Binding,<br />

Anti-CD3 Monoclonal Antibody, in Children and Adults<br />

with Recent-Onset Type 1 Diabetes Mellitus. (Dr.<br />

Izquierdo, principal investigator for our center). Industrysponsored<br />

Trial (funding accrual based)<br />

Izquierdo R. NYS <strong>Department</strong> <strong>of</strong> Health School Centered<br />

Telemedicine Program for Children with Type 1 Diabetes<br />

Mellitus (Co-Investigator).<br />

Izquierdo R. Diamyd: A Phase III, 3- Arm, Randomized,<br />

Double-Blind, Placebo-Controlled, Multicenter Study<br />

to Investigate the Impact <strong>of</strong> Diamyd on the Progression<br />

<strong>of</strong> Diabetes in Newly Diagnosed with Type 1 Diabetes<br />

Mellitus. Industry-sponsored Trial (funding accrual<br />

based)<br />

SELECTED CLINICAL DATA<br />

Children in the diabetes mellitus program: .. . . . . . . . . 1000<br />

Children with new onset diabetes seen in <strong>2009</strong>: . . . . . . 100<br />

Children followed with congenital hypothyroidism: . . 100<br />

Children with diagnosed with congenital<br />

hypothyroidism in <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />

Children with congenital adrenal hyperplasia<br />

who are actively followed:. . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />

Children with septo-optic dysplasia<br />

who are actively followed:. . . . . . . . . . . . . . . . . . . . . . . . . . 30<br />

Endocrine component <strong>of</strong> KNOT Clinic: . . . . . . . . . . . . . . 80


14 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

GASTROENTEROLOGY & NUTRITION<br />

FACULTY<br />

Manoochehr Karjoo, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Section<br />

Chief<br />

Mirza Beg, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Christopher Justinich, MD, Clinical Associate Pr<strong>of</strong>essor<br />

AFFILIATED CLINICAL STAFF<br />

Shannon Kesselring, MSN, FNP<br />

CLINICAL OVERVIEW<br />

The Section <strong>of</strong> Pediatric Gastroenterology and Nutrition<br />

provides care for patients from birth to 21 years <strong>of</strong> age<br />

with all types <strong>of</strong> gastroenterological disorders. This<br />

includes neonates and infants with hyperbilirubinemia,<br />

and liver disease such as biliary atresia and all forms <strong>of</strong><br />

hepatitis. We <strong>of</strong>fer multi-modal therapy for children<br />

with a variety <strong>of</strong> functional intestinal disorders ranging<br />

from cyclic vomiting and chronic abdominal pain to<br />

constipation.<br />

Our division has a particular interest in the management<br />

<strong>of</strong> children with inflammatory bowel disease and<br />

the gastrointestinal manifestations <strong>of</strong> food allergy.<br />

Gastroesophageal reflux disease is an increasingly<br />

recognized entity in children from infancy through young<br />

adulthood. We <strong>of</strong>fer a broad range <strong>of</strong> diagnostic and<br />

therapeutic approaches for such disorders.<br />

The section works closely and collaboratively with a<br />

number <strong>of</strong> other programs, including pediatric surgery,<br />

ENT, general pediatrics, pulmonary, and endocrinology.<br />

We are particularly expert in the gastroenterological<br />

issues impacting children with developmental delays. We<br />

coordinate procedures with our pediatric surgeons, such<br />

as gastrostomy tube placement, esophageal dilatation<br />

and endoscopies.<br />

The gastroenterologists undertake a full array <strong>of</strong><br />

procedures including pH probe tests, Bravo pH<br />

monitoring, esophago-gastro-duodenoscopy with<br />

biopsy, esophageal dilatation, esophageal sclerotherapy<br />

and banding procedures for varices, rectal biopsy for<br />

evaluation <strong>of</strong> Hirshsprung’s disease, colonoscopy with<br />

biopsy and polypectomy, liver biopsy, breath hydrogen<br />

test for lactase and sucrase deficiency, esophageal<br />

and colon motility and esophageal impedance studies.<br />

Most procedures are done in the Pietrafesa Center for<br />

Children’s Surgery, while others are done in our clinic.<br />

Outpatient care is provided in the newly remodeled and<br />

expanded <strong>of</strong>fice located in the 725 Irving Avenue, Suite<br />

805, in Syracuse. For the past few years, a satellite clinic<br />

in Watertown, NY has been staffed by one <strong>of</strong> our parttime<br />

faculty, Dr. Justinich. With the recruitment <strong>of</strong> two<br />

new full-time gastroenterologists in 2010, our plan is to<br />

continue that service and add a satellite clinic in Utica, NY.<br />

The section continues to be very active in medical<br />

student and resident education. Many <strong>of</strong> our<br />

residency graduates have gone on to train in pediatric<br />

gastroenterology.<br />

RESEARCH HIGHLIGHTS<br />

The section currently is participating in a multi-center<br />

trial <strong>of</strong> treatment <strong>of</strong> eosinophilic esophagitis using an<br />

antagonist <strong>of</strong> IL5.<br />

We are also preparing to join a Phase 3, multi-center,<br />

double-blind randomized placebo controlled, parallelgroup,<br />

withdrawal study to evaluate the safety and<br />

efficacy <strong>of</strong> delayed release Rabeprazole in 1 to 11 month<br />

old pediatric subjects with symptomatic erosive<br />

gastroesophageal reflux disease.<br />

SELECTED CLINICAL DATA<br />

Outpatients seen in <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 5,243<br />

Outpatients seen in <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 5,300<br />

Endoscopies in <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 494<br />

Endoscopies in <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 544<br />

Colonoscopies in <strong>2008</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . . 249<br />

Colonoscopies in <strong>2009</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 276<br />

Ph probe studies in <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . 280<br />

Ph probe studies in <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . .240<br />

Bravo Ph Analysis in <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />

Bravo pH analysis in <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . 47


Bi-Annual <strong>Report</strong> • 15<br />

GENERAL PEDIATRICS<br />

FACULTY<br />

John Andrake, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Director, Pediatric Residency<br />

Joseph Bearman, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

Charles Bergstrom, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Director, Undergraduate Medical Education<br />

Steven Blatt, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Director, General <strong>Pediatrics</strong>, Associate Pr<strong>of</strong>essor Syracuse<br />

University College <strong>of</strong> Law (courtesy appointment)<br />

Ann Botash, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Vice Chair,<br />

Educational Affairs<br />

Robert Cavanaugh, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Section<br />

Head, Adolescent Medicine<br />

Katherine Chang, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

John Friedman, MD, Clinical Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong> and<br />

Psychiatry<br />

Paul Fuller, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Robert Hingre, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Elizabeth Jamme, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Toby Kressel, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

Ellen McHugh, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

Victoria Meguid, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Bradley Olson, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Associate Director, Pediatric Residency<br />

Alicia Pekarsky, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Ronald Saletsky, PhD, Associate Pr<strong>of</strong>essor <strong>of</strong> Psychiatry<br />

Ellen Schurman, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

Anne Sveen, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Howard Weinberger, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

AFFILIATED CLINICAL STAFF<br />

Wendy Broton, RN, FNP, Nurse Practitioner<br />

Karen Dygert MS, RN, PNP, PMHNP, Nurse Practitioner<br />

Susan Mahar, RN, PNP-BC Nurse Practitioner<br />

Nancy Mitchell, RN, PNP, Nurse Practitioner<br />

Terri Morse, RN-BC, FNP, Nurse Practitioner<br />

CLINICAL OVERVIEW<br />

The component programs <strong>of</strong> the Division <strong>of</strong> General<br />

<strong>Pediatrics</strong> encompass all <strong>of</strong> the inpatient and ambulatory<br />

clinical activities providing general pediatric and specialty<br />

program care to children and adolescents in a universitybased<br />

urban practice serving a diverse population. The<br />

Division has significant responsibilities for ambulatory<br />

and inpatient teaching <strong>of</strong> medical students and training <strong>of</strong><br />

pediatric residents.<br />

Clinical activity occurs in the term newborn nursery<br />

at Crouse Hospital, the inpatient pediatric units <strong>of</strong><br />

Golisano Children’s Hospital, and at University Pediatric<br />

and Adolescent Center located in University Health<br />

Care Center. A free-standing ambulatory care site <strong>of</strong><br />

Upstate Medical University, Upstate <strong>Pediatrics</strong>, a busy<br />

three-pediatrician practice, participates in departmental<br />

teaching and research activities. Medical students rotate<br />

through the <strong>of</strong>fice during their clerkship and residents<br />

can choose the <strong>of</strong>fice as an elective rotation. The <strong>of</strong>fice is<br />

also a study site for vaccine research.<br />

The Division provides a wide array <strong>of</strong> services to children,<br />

adolescents and families, including well child and<br />

adolescent care, acute episodic and chronic disease<br />

care, specialized care <strong>of</strong> abused and foster children,<br />

and a growing refugee population from Eastern Europe,<br />

Russia and Africa. An adolescent consultation practice is<br />

an active program in the Division. Academic generalists<br />

<strong>of</strong>ten consult and provide second opinions to family<br />

physicians in the central New York region. Faculty<br />

and resident physicians have established practices at<br />

University Pediatric and Adolescent Center with the<br />

goal <strong>of</strong> providing a stable medical home and continuity<br />

for children and adolescents with 24-hour availability.<br />

Inpatient care is provided under the supervision <strong>of</strong> the<br />

academic generalist faculty.<br />

Faculty have clinical expertise and research interests<br />

in child abuse, foster care, refugee health, substance<br />

abuse, childhood obesity and nutrition, lead poisoning,<br />

adolescent eating disorders and reproductive health,<br />

dermatology and medical education. The Medical Legal<br />

Partnership provides a unique opportunity for patients,<br />

families, and the medical staff to easily access legal<br />

services within our <strong>of</strong>fices.<br />

The Adolescent Medicine Program <strong>of</strong>fers primary and<br />

specialty care to patients 11 to 21 years <strong>of</strong> age. This is a<br />

state-<strong>of</strong>-the-art program in which the psychosocial as<br />

well as the physical needs <strong>of</strong> the adolescent patient are<br />

uniquely addressed. Our physicians have been at the<br />

forefront <strong>of</strong> adolescent preventive services for many<br />

years. They are particularly well qualified to screen<br />

adolescents in order to identify high-risk activities and<br />

behaviors and to <strong>of</strong>fer appropriate counseling. They are<br />

supported by a highly skilled “teen-friendly” nursing staff.<br />

The program welcomes referrals for second opinions or<br />

for consultations. Findings are promptly communicated


16 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

to referring physicians when applicable. A dietician who<br />

specializes in adolescent nutrition is available on site for<br />

consultation at the time <strong>of</strong> the visit.<br />

There is also a very close relationship with physicians<br />

in the <strong>Department</strong> <strong>of</strong> Psychiatry and a large referral<br />

network <strong>of</strong> other specialists at University Hospital and<br />

SUNY Upstate Medical University.<br />

Services include:<br />

• Behavioral evaluation and counseling<br />

• Comprehensive physicals and preventive exams<br />

• Contraceptive counseling<br />

• Gynecologic exams<br />

• Immunizations<br />

• Pregnancy testing and counseling<br />

• Risk-reduction assessment and counseling<br />

• Sports physicals as part <strong>of</strong> a comprehensive<br />

examination<br />

• Substance abuse evaluation and referral<br />

The CARE (Child Abuse Referral and Evaluation) team<br />

<strong>of</strong> pr<strong>of</strong>essionals includes a pediatrician, pediatric<br />

nurse practitioner, nurse and social worker who work<br />

together to provide child abuse medical evaluations.<br />

Team members include Ann Botash, MD, Alicia Pekarsky,<br />

MD, Nancy Mitchell, RN, CPNP, Anne Galloway, RN, and<br />

Elizabeth Kinsey, CSW.<br />

With over 10 years <strong>of</strong> experience, the program <strong>of</strong>fers<br />

comprehensive history and physical examinations,<br />

forensic evidence collection, photodocumentation and<br />

court-ready record documentation. Legal testimony<br />

and non-patient care case reviews are also available.<br />

Examinations are performed utilizing state-<strong>of</strong>–the-art<br />

colposcopic documentation <strong>of</strong> physical findings, and a<br />

variety <strong>of</strong> advanced patient coping techniques.<br />

Over 250 referrals per year come from several counties in<br />

Central and Upstate New York. Referral sources include<br />

child protective services, law enforcement agencies, rape<br />

crisis centers, teachers, parents and other physicians.<br />

These children are evaluated at 90 Presidential Plaza,<br />

University Pediatric and Adolescent Center as well as at a<br />

community <strong>of</strong>f-site location, 509 West Onondaga Street,<br />

the McMahon/Ryan Child Advocacy Site.<br />

The McMahon/Ryan Child Advocacy Site’s main goals are<br />

to provide a safe, child and family friendly environment<br />

for child abuse victims and their non-<strong>of</strong>fending family<br />

members and to reduce the trauma that abused children<br />

face during the investigative and treatment processes.<br />

The site’s focus is to support and enhance existing<br />

community agencies that work with child abuse. The<br />

staff at the McMahon/Ryan Child Advocacy Site is funded<br />

through a SUNY Research Foundation grant provided<br />

through CARE and other funding through a non-pr<strong>of</strong>it<br />

501-c donations. Children evaluated there have improved<br />

access to counseling services (Rape Crisis Center), law<br />

enforcement, and child protective investigators. (http://<br />

www.mcmahonryan.org)<br />

The CARE team <strong>of</strong>fers regular Child Abuse Licensing<br />

courses for physicians or other pr<strong>of</strong>essionals needing<br />

certification for licensing in New York State. Further<br />

information can be found at: http://www.upstate.edu/<br />

cme/licensing.shtml<br />

ENHANCE Services for Children in Foster Care has<br />

provided primary and comprehensive health care<br />

services to children in DSS custody since 1991. Consistent<br />

with the recommendations outlined in Fostering<br />

Health: Health Care for Children and Adolescents in<br />

Foster Care <strong>of</strong> the AAP Task Force on Health Care for<br />

Children in Foster Care, ENHANCE provides primary<br />

and comprehensive health care services, developmental<br />

testing and mental health services to the 500 children<br />

in DSS foster care. Medical care is provided by two<br />

pediatricians, Dr. Steven Blatt, Director and Dr. Victoria<br />

Meguid, Associate Director, two pediatric nurse<br />

practitioners, and two registered nurses. A nurse<br />

practitioner also performs developmental testing on<br />

young children in their home or day care setting. A child<br />

psychologist meets with older children and their foster<br />

parents to assess their need for mental health services.<br />

Annually, the 500 children in foster care are seen in more<br />

than 2400 ENHANCE visits.<br />

ENHANCE staff have also been active in policy issues.<br />

There are regular meetings with DSS administration,<br />

focusing on local policy and procedures. ENHANCE<br />

representatives participates on the New York State<br />

Permanent Judicial Commission on Justice for Children<br />

and the New York State, District II AAP Task Force on<br />

Health Care for Children in Foster Care. ENHANCE staff<br />

also meet with New York State foster care <strong>of</strong>ficials and<br />

have testified to legislative bodies.<br />

The Syracuse Medical-Legal Partnership (SMLP) is a<br />

Medical-Legal Partnership between the University<br />

Pediatric and Adolescent Center (UPAC) <strong>of</strong> University<br />

Hospital <strong>of</strong> SUNY Upstate Medical University and<br />

the Children’s Rights and Family Law Clinic (CRC) and<br />

Family Law and Social Policy Center (FLSPC) <strong>of</strong> Syracuse<br />

University College <strong>of</strong> Law. Through a triad approach,<br />

SMLP seeks to engage the disciplines <strong>of</strong> law and medicine<br />

to provide comprehensive advocacy to improve the<br />

overall health <strong>of</strong> low-income children and their families.<br />

SMLP helps improve health outcomes for low-income<br />

children and their families through collaborative<br />

advocacy and legal intervention. Cases handled through<br />

SMLP have included custody, adoption and child support;<br />

housing issues including landlord disputes, handicap<br />

access and utility disputes; education law including<br />

special education and unlawful exclusion from public<br />

schools; and other legal issues directly affecting child<br />

health. SMLP provides students, faculty and staff from<br />

both the <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong> and the College<br />

or Law with opportunities to learn about <strong>Pediatrics</strong><br />

and Legal Advocacy from experts in both disciplines.<br />

SMLP has been instrumental in educating state and<br />

national legislators about this new and growing national<br />

movement.<br />

The Pediatric International Health Clinic was started in


Bi-Annual <strong>Report</strong> • 17<br />

July 2005 in order to provide more specialized care to<br />

the more than 500 new immigrants arriving annually in<br />

Central New York. The care <strong>of</strong> such patients has become<br />

increasingly complex, requiring a degree <strong>of</strong> sophistication<br />

not allowed in a typical outpatient pediatric setting.<br />

Although they originate from all over the globe, this<br />

diverse refugee population most recently has come from<br />

the African continent. In addition to providing a much<br />

needed service to this medically diverse and fascinating<br />

population, this new service, directed by Dr. Bradley<br />

Olson, is a rich environment for housestaff education.<br />

RESEARCH HIGHLIGHTS<br />

Vaccines<br />

Faculty and staff at University Pediatric and Adolescent<br />

Center collaborate with the Division <strong>of</strong> Pediatric<br />

Infectious Disease on an ongoing basis with funded<br />

vaccine studies. Recent studies involve vaccines against<br />

meningococcus, pneumococcus, and influenzae.<br />

Child Sex Abuse Evaluation<br />

Dr. Ann Botash was one <strong>of</strong> the founders <strong>of</strong> the McMahon/<br />

Ryan Child Advocacy Center in 2002 and serves as<br />

medical director to the board <strong>of</strong> this non-pr<strong>of</strong>it<br />

organization. Dr. Botash is the primary investigator for a<br />

grant through the New York State Office <strong>of</strong> Children and<br />

Family Services, to fund the Advocacy site and is primary<br />

investigator <strong>of</strong> the New York State <strong>Department</strong> <strong>of</strong> Health<br />

grant to support the Child Abuse Medical Provider<br />

Program. This program began as a model network <strong>of</strong> child<br />

abuse medical providers with the creation <strong>of</strong> a training<br />

manual and now provides continuing education to child<br />

abuse medical pr<strong>of</strong>essionals throughout New York State.<br />

It is a resource for child abuse pr<strong>of</strong>essionals nationally as<br />

well as statewide.<br />

Foster Care<br />

Drs. Steven Blatt and Victoria Meguid have collaborated<br />

with researchers from Cornell University on the<br />

relationships between prenatal drug and alcohol use and<br />

subsequent involvement in the child protection system.<br />

The same faculty are also working with colleagues at the<br />

University <strong>of</strong> Rochester to examine the effectiveness<br />

<strong>of</strong> foster care clinics at both institutions in meeting the<br />

needs <strong>of</strong> children in foster care.<br />

PUBLICATIONS<br />

Cavanaugh RM. Managing the Transitions <strong>of</strong> Early<br />

Adolescence. Adolescent Health Update, American<br />

Academy <strong>of</strong> <strong>Pediatrics</strong> <strong>2008</strong>; 20(3): 1-8.<br />

Cavanaugh RM. Screening for Genitourinary<br />

Abnormalities in Adolescent Males. <strong>Pediatrics</strong> in Review<br />

<strong>2009</strong> 30: 431-438.<br />

Koszalka T, Olson B. Transforming a <strong>Pediatrics</strong> Lecture<br />

Series to Online Instruction. Handbook <strong>of</strong> research on<br />

distributed medical informatics and e-health. Hershey,<br />

PA. Medical Information Science Ref, Aug <strong>2008</strong>.<br />

PRESENTATIONS AT NATIONAL MEETINGS<br />

Blatt SD. Enhancing Services: Legal Aspects <strong>of</strong> Infant<br />

Attachment. CASA Conference: Healthy Beginnings:<br />

Creating Positive Attachments in Children. Painted Post,<br />

NY, April 3, <strong>2008</strong>.<br />

Blatt SD. Healthy Children in Foster Care: An Attainable<br />

Goal. Children in Foster Care: Development, Health and<br />

Well-Being. Westchester, NY, April 11, <strong>2008</strong>.<br />

Blatt SD. The Wonder Years: Children in Foster Care<br />

in the Courtroom. New York State Judicial Institute.<br />

Rye Brook, NY, (Presented at three different Judicial<br />

Institutes) June 24, July 8, August 26, <strong>2008</strong>.<br />

Blatt SD. Plenary: Opportunities and Challenges<br />

in Interdisciplinary Collaborative Education.<br />

Interdisciplinary Collaborative Education, Partnerships<br />

Between Law Schools and Health Pr<strong>of</strong>essions. Atlanta,<br />

GA. September 24, <strong>2009</strong>.<br />

Dawson E, Greenberg S, Olson B. The Predictive<br />

Value <strong>of</strong> Eosinophilia in Chronic Schistosomiasis and<br />

Strongyloidiasis: An Examination <strong>of</strong> the CDC Screening<br />

Guidelines for Newly Arriving Refugees. <strong>2009</strong> Pediatric<br />

Academic Society. Baltimore, MD. April 28-May 2, <strong>2009</strong>.<br />

Pekarsky AR, Cohen N, Singhi V and Botash, AS. Pediatric<br />

Patient Assent and Medical Provider Compliance with<br />

New York State Guidelines for HIV Post-exposure<br />

Prophylaxis for Sexual Assault. Poster presented at<br />

the Pediatric Academic Societies Meeting: May 3, <strong>2009</strong>:<br />

Baltimore, Maryland.<br />

HONORS, VISITING PROFESSORSHIPS,<br />

EDITORIAL DUTY<br />

Blatt SD: Member, New York State Permanent Judicial<br />

Committee on Justice for Children<br />

Blatt SD: New York State Children’s Cabinet Advisory<br />

Board Member (Appointed by the Governor)<br />

Blatt SD: National Center for Medical-Legal Partnership,<br />

Assistant National Medical Director<br />

Blatt SD: National Center for Medical-Legal Partnership,<br />

Medical Advisory Board Member<br />

Blatt SD: Peace Action <strong>of</strong> Central New York: Peace Award<br />

November 16, <strong>2008</strong><br />

Botash AS: Ray E. Helfer Society Vice President, 2007-<strong>2009</strong><br />

Botash AS: Ray E. Helfer Society President, <strong>2009</strong>-2010<br />

Cavanaugh RM: Executive Committee, American<br />

Academy <strong>of</strong> <strong>Pediatrics</strong> Section on Adolescent Health<br />

Cavanaugh RM: Program Chair, American Academy <strong>of</strong><br />

<strong>Pediatrics</strong>, Section on Adolescent Health<br />

Cavanaugh RM: Editorial Board, American Academy <strong>of</strong><br />

<strong>Pediatrics</strong> Adolescent Health Update<br />

Friedman J: Island Peer Review Organization, Vice<br />

President<br />

Meguid V: National Committee-AAMC Group on Women<br />

in Medicine and Science.


18 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

INVITED WORKSHOPS, CME PRESENTATIONS<br />

Andrake JS, Olson B, Peacock J, et al. Perspectives on<br />

Curriculum Reform: Different Approaches to the Same<br />

Goal. Presented at the Annual Meeting <strong>of</strong> the Association<br />

<strong>of</strong> Pediatric Program Directors. Baltimore, MD, April 28-<br />

May 2, <strong>2009</strong>.<br />

Andrake SJ, Sveen A. Building a Communication Skills<br />

Curriculum for the <strong>Pediatrics</strong> Clerkship. Presented at the<br />

Annual Meeting <strong>of</strong> COMSEP. Atlanta, GA. April 3-6, <strong>2008</strong><br />

Blatt SD, Galowitz P, Retkin R, Tames P. Hot Topics in<br />

Medical-Legal Partnerships. American Bar Association<br />

& National Legal Aid Defender Association Equal Justice<br />

Conference. Orlando, FL, May 14, <strong>2009</strong>.<br />

Blatt SD, Lawry K, Leon J, Ryan A. Do MLP’s Need<br />

Institutional Review Board Approval? What? Why? How?<br />

Medical-Legal Partnership National Summit, Cleveland,<br />

OH, March 27, <strong>2009</strong>.<br />

Blatt SD, Norwood M, Cumbie Reckess S, White<br />

McCormick H, Melendez S. Fostering the Next<br />

Generation <strong>of</strong> Pr<strong>of</strong>essionals: Engaging Educational<br />

Institutions as Partners. Medical-Legal Partnerships.<br />

Medical-Legal Partnership National Summit, Cleveland,<br />

OH, March 26, <strong>2009</strong>.<br />

Blatt SD, Melendez SM, Ramsey SH, Broton W, Krishna<br />

S, Gresens L. Unmet Legal Needs in a Clinic Population.<br />

Medical-Legal Partnership National Summit. Kansas City,<br />

Mo, March 12, <strong>2008</strong>.<br />

Blatt SD, Morton S, Tichner J. Ethics at 40,000 Feet: Big<br />

Picture Ethical Dimensions <strong>of</strong> MLP Practice. Medical-Legal<br />

Partnership National Summit, Cleveland, OH, March 27,<br />

<strong>2009</strong>.<br />

Blatt SD, Seagriff P, Heer T, Gambino J. Meeting the<br />

Medical and Dental Needs <strong>of</strong> Children in Foster Care.<br />

Children in Foster Care: Development, Health and Well-<br />

Being. Westchester, NY, April 11, <strong>2008</strong>.<br />

Blatt SD, Tames P, Zolezzi-Wyndham V. Training and<br />

Education Working Group. Medical-Legal Partnership<br />

National Summit, Cleveland, OH, March 27, <strong>2009</strong>.<br />

Blatt SD, Tichner J, Morton S. “It’s None <strong>of</strong> Your<br />

Business!” Doctors, Lawyers and Confidentiality.<br />

Medical-Legal Partnership National Summit. Kansas City,<br />

Mo, March 12, <strong>2008</strong>.<br />

Botash AS. Sexually Transmitted Infections in Sexual<br />

abuse and Assault: A Bug’s Life in Perspective. PREP:<br />

CAP: An Intensive Review and Update in Child Abuse<br />

<strong>Pediatrics</strong>, Portland, Oregon, July 22-25 <strong>2009</strong>.<br />

Botash AS. Head to Toe and Other Body Parts: The Male<br />

Genital Examination. PREP: CAP: An Intensive Review and<br />

Update in Child Abuse <strong>Pediatrics</strong>, Portland, Oregon, July<br />

22-25 <strong>2009</strong>.<br />

Botash AS, DeJong A. Sexually Transmitted Infections<br />

in Children and Adolescents. PREP: CAP: An Intensive<br />

Review and Update in Child Abuse <strong>Pediatrics</strong>, Portland,<br />

Oregon, July 22-25 <strong>2009</strong>.<br />

Botash AS, Kaplan R, Levit C. Basic Medical Training<br />

Academy in Child Abuse (on the topics <strong>of</strong> Fractures, STI’s,<br />

and Child Sexual Abuse), National Children’s Alliance<br />

Funded Conference. Burlington, VT. October 20. <strong>2008</strong><br />

Brandfield J, Melendez S, Blatt SD. Training and<br />

Education: Tips on how to Develop and Present<br />

Educational Programs to Pr<strong>of</strong>essionals in other<br />

Disciplines. Medical-Legal Partnerships: NY<br />

Pr<strong>of</strong>essionals Working Together to Improve Health Care.<br />

Syracuse, NY. June 5, <strong>2009</strong>.<br />

Retkin R, Blatt SD, White McCormick H, Palumbo CM,<br />

Aerni JM, Branchfield J. Bringing the Law Office into the<br />

Healthcare Setting: Creating a Medical-Legal Partnership.<br />

New York State Bar Association <strong>2008</strong> Partnership<br />

Conference. Albany, NY, September 24, <strong>2008</strong>.<br />

Roswig BB, Tobin Tyler L, Tames P, Blatt SD. Lighting<br />

the Way: How Medical and Legal Pr<strong>of</strong>essionals Use<br />

Community Projects to Bring Services to Clients<br />

and Greater Communication to Their Pr<strong>of</strong>essional<br />

Partnerships. American Bar Association & National Legal<br />

Aid Defender Association Equal Justice Conference.<br />

Orlando, FL. May 15, <strong>2009</strong>.<br />

Tames P, Blatt SD, Riseberg R. Training & Evaluation.<br />

Medical-Legal Partnership National Summit. Kansas City,<br />

Mo, March 12, <strong>2008</strong>.


Bi-Annual <strong>Report</strong> • 19<br />

GRANTS AND CONTRACTS<br />

Blatt SD<br />

Syracuse Medical Legal Partnership for Children, The<br />

John Ben Snow Foundation, 7/09: $10,000<br />

Regional Lead Poisoning Resource Center, NY State<br />

Health <strong>Department</strong> in the amount <strong>of</strong> $200,000 per year<br />

for five years.<br />

Botash AS<br />

Rape Crisis Program (CHAMP), <strong>2009</strong>, NYS DOH: $36,000<br />

Rape Crisis Program for CHAMP, <strong>2008</strong>, NYS DOH: $75,000<br />

PI: <strong>2009</strong>-2010, NYS Office <strong>of</strong> Children and Family Services<br />

CHAMP Initiative, through a grant from Senator Valesky’s<br />

<strong>of</strong>fice ($65,0000) and from Sen. Aubertine’s Office<br />

($30,000)<br />

PI: 2007- <strong>2008</strong>, NYS Office <strong>of</strong> Children and Family Services<br />

Child Abuse Medical Provider Initiative: $500,000<br />

PI: Child Fatality Review Team, NYS OCFS, 2010-<strong>2009</strong>:<br />

$52,000<br />

PI: Child Fatality Review Team, NYS OCFS, <strong>2009</strong>-2010:<br />

$52,000<br />

PI, with grant assistance from Catherine Unger and<br />

Martha Ryan for Child Fatality Review Team, 2007-<strong>2009</strong>,<br />

NYS OCFS: $ 88,224<br />

<strong>2009</strong>: Friend in Deed Foundation for Child Fatality Review<br />

Team: $2,400<br />

<strong>2009</strong>: St. Agatha’s Foundation for CARE program: $25,000<br />

<strong>2009</strong>: CHAMP medical education grant: $30,000<br />

<strong>2009</strong>: Golisano Children’s Hospital education grant for<br />

Procedure Management (LEAPP) project: $8400<br />

SELECTED CLINICAL DATA (DIVISION TOTALS)<br />

General <strong>Pediatrics</strong>, Adolescent, CARE, Enhance<br />

<strong>2008</strong>: . . . . . . . . . 23,632<br />

<strong>2009</strong>: . . . . . . . . . 23,766<br />

Upstate <strong>Pediatrics</strong> Outpatient<br />

<strong>2008</strong>: . . . . . . . . . 13,611<br />

<strong>2009</strong>: . . . . . . . . . 13,336<br />

Inpatient encounters (General <strong>Pediatrics</strong> and<br />

Upstate <strong>Pediatrics</strong>)<br />

<strong>2008</strong>: . . . . . . . . . 1,043<br />

<strong>2009</strong>: . . . . . . . . . 833<br />

Newborn inpatient encounters (General<br />

<strong>Pediatrics</strong> and Upstate <strong>Pediatrics</strong>)<br />

<strong>2009</strong>: . . . . . . . . . 1,172<br />

<strong>2009</strong>: . . . . . . . . . 1,397


20 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

GENETICS<br />

FACULTY<br />

Robert Roger Lebel, MD, FACMG, Chief, Section Medical<br />

Genetics, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Internal Medicine, Ob/<br />

Gyn & Pathology, Lecturer in Bioethics & Humanities<br />

Joan Pellegrino, MD, FAAP, FACMG, Associate Pr<strong>of</strong>essor<br />

<strong>of</strong> <strong>Pediatrics</strong><br />

Adjunct Faculty:<br />

Constance Stein, PhD, Director Cytogenetics Laboratory;<br />

Pr<strong>of</strong>essor, Pathology<br />

Antony Shrimpton, PhD, Director, Molecular Diagnostic<br />

Laboratory; Associate Pr<strong>of</strong>essor, Pathology<br />

AFFILIATED CLINICAL STAFF:<br />

Bonnie R. Braddock, MPH, CGC, Senior Certified Genetic<br />

Counselor<br />

Ryan T. Miller, MS, CGC, Certified Genetic Counselor<br />

CLINICAL OVERVIEW<br />

The section <strong>of</strong> Medical Genetics provides high quality<br />

and comprehensive clinical genetics services, including<br />

screening, diagnosis, treatment, counseling and<br />

preventive services to the 11 counties defined as Health<br />

Services Area 3 (HSA3) and to several other surrounding<br />

counties. Medical Genetics provides genetic evaluation<br />

and genetic counseling services for a wide range <strong>of</strong><br />

neonatal, pediatric and adult onset indications. The<br />

Medical Genetics staff <strong>of</strong> clinical geneticists and genetic<br />

counselors work in a team approach to providing<br />

services. The program includes general genetic<br />

evaluation clinics, Inherited Metabolic Disease Specialty<br />

Center (IMD), inpatient genetic evaluation consultations,<br />

cancer and general genetic counseling, and genetic<br />

counseling within various specialty clinics at Upstate,<br />

including in conjunction with the Multidisciplinary Breast<br />

Cancer Program, the cystic fibrosis newborn screening<br />

program and crani<strong>of</strong>acial clinic. Medical Genetics also<br />

provides outreach genetic evaluation services at satellite<br />

clinics in Watertown and Binghamton.<br />

Medical Genetics is staffed by clinical geneticists, Robert<br />

Roger Lebel, MD, FACMG, and Joan Pellegrino, MD,<br />

FAAP, FACMG, and two full time board certified genetic<br />

counselors, Bonnie R. Braddock, MPH, CGC, and Ryan<br />

T. Miller, MS, CGC. Dr. Lebel arrived as new section<br />

chief in July <strong>2008</strong>, and has interacted extensively with<br />

the extended <strong>Pediatrics</strong> department as well as other<br />

sectors <strong>of</strong> the medical university. As such, he supervises<br />

the activities <strong>of</strong> the genetic counselors and administers<br />

the section. He has seen over 700 new patients since<br />

arriving, and has had the opportunity to make diagnoses<br />

<strong>of</strong> a number <strong>of</strong> very rare syndromes, and also to lead<br />

the group in proposing a syndrome “new” to the medical<br />

literature. The lengthy waiting list which had grown<br />

during the interim has been reduced to manageable<br />

length and the satellite clinics in Watertown and<br />

Binghamton were re-established after Dr. Lebel arrived.<br />

Dr. Joan Pellegrino manages the Inherited Metabolic<br />

Diseases Specialty Center (IMD), which has continued<br />

to grow. The center is staffed by a dedicated nurse<br />

practitioner, registered nurse, dietician, social worker,<br />

genetic counselor and geneticist. The IMD evaluates<br />

infants with abnormal newborn screens or suspected<br />

metabolic disorders and manages those individuals<br />

with a known inborn error <strong>of</strong> metabolism. In <strong>2008</strong>, 144<br />

patients were seen and, in <strong>2009</strong>, 179 patients have been<br />

seen. The Center has also had an increase in the number<br />

<strong>of</strong> abnormal newborn screening patients sent in for<br />

evaluation. In the year <strong>2009</strong> alone, 9 newborns with PKU<br />

were identified and treated. The IMD is actively involved<br />

with the other Metabolic centers in the state.<br />

Ryan T. Miller, MS, CGC, works closely with Dr. Pellegrino<br />

in the IMD. He also works closely with the Crani<strong>of</strong>acial<br />

Clinic and the Pediatric Pulmonary section providing<br />

genetic counseling input at their locations.<br />

Bonnie R. Braddock, MPH, CGC, provides genetic<br />

counseling for the inherited cancer risk services, which<br />

has continued to grow over the last several years. In <strong>2008</strong><br />

and <strong>2009</strong>, a total <strong>of</strong> 386 patients were seen for cancer<br />

genetic counseling.<br />

Medical Genetics coordinates the monthly Genetics<br />

Pr<strong>of</strong>essional Review Group meeting at Upstate.<br />

Attendees include a range <strong>of</strong> clinical- and research-based<br />

genetics pr<strong>of</strong>essionals and students throughout various<br />

departments at Upstate. The goals <strong>of</strong> the meetings are to<br />

foster collaboration <strong>of</strong> cases and research opportunities<br />

and to provide in-house educational opportunities.<br />

RESEARCH HIGHLIGHTS<br />

The IMD participates with the Lysosomal Storage<br />

Registry sponsored by Genzyme and has IRB approval to<br />

participate in studies on Gaucher, Fabry, Pompe and MPS1<br />

diseases. Patients are enrolled into long term follow-up<br />

studies after being identified on newborn screen to have<br />

an increased risk for Krabbe disease.<br />

Dr. Lebel’s research interests include syndrome<br />

identification and ethical issues in genetics. Dr. Stein’s<br />

research interests include investigation <strong>of</strong> chromosomal<br />

fragile sites, cytogenetic and molecular characterization<br />

<strong>of</strong> malignant tumors, chromosome imprinting. Dr.<br />

Shrimpton has research interest in sequencing<br />

Neuroserpin in patients with autism.


Bi-Annual <strong>Report</strong> • 21<br />

PUBLICATIONS<br />

Vajpayee N, Stein CK, Poiesz B, Hutchison R. Case <strong>of</strong><br />

the Quarter - February <strong>2008</strong>: Extramedullary Blast<br />

Transformation <strong>of</strong> CML at Initial Presentation. www.<br />

socforheme.org/case-feb-08.htm. <strong>2008</strong>.<br />

Narendra S, Tull J, Muscolino D, Stein CK, Zhang<br />

S. Detection <strong>of</strong> DDIT3(CHOP) Gene Break-Apart by<br />

Fluorescence in Situ Hybridization (FISH) in Formalin Fixed<br />

Paraffin Embedded Myxoid/Round Cell Liposarcoma.<br />

Abstract, presented at a meeting, <strong>2008</strong>.<br />

Riccardi GF, Stein CK, de la Roza G, Damron TA. Newly<br />

described translocation, t(18;19)(q23;q13.3) in abdominal<br />

wall s<strong>of</strong>t tissue tumor resembling Ewing sarcoma/<br />

Peripheral Neuroectodermal Tumor. (accepted pending<br />

modification by Cancer Genetics and Cytogenetics).<br />

Lebel RR, Spranger JW. Chance favors the prepared<br />

mind: A brief moral biography <strong>of</strong> Gregor Johann Mendel<br />

(7/22/1822-1/6/1884). Proc Greenwood Genet Center 27:3-<br />

5, <strong>2008</strong>.<br />

Lebel RR, Logrieco GP. First report <strong>of</strong> Majewski-type<br />

short limbed polydactyly. Proc Greenwood Genet<br />

Center 27:6-7, <strong>2008</strong>.<br />

Stallworth LJ, Avery J, DuPont BR, Lebel RR. Partial<br />

trisomy 2p and partial monosomy 9p in a fetus with<br />

anencephaly, polydactyly, and other abnormalities. Proc<br />

Greenwood Genet Center 27:18-21, <strong>2008</strong>.<br />

Lebel RR, Collins JS, Avery JM, Logrieco GP, Broome PJ.<br />

Perinatal autopsy: prenatal growth in trisomy 21. Proc<br />

Greenwood Genet Center 27:22-24, <strong>2008</strong>.<br />

Lebel RR, Jones JR, Pridgen C, Gregg AR, Avery JM,<br />

Broome PJ, Friez MJ. Monosomy X proven (confirming<br />

clinical suspicion) in a fetus from which cells failed to<br />

grow in tissue culture: novel application <strong>of</strong> “multiplex<br />

ligation-dependent probe amplification” (MLPA), Proc<br />

Greenwood Genet Center 27:42-44, <strong>2008</strong>.<br />

Lebel RR, Avery JM, Broome PJ, Gregg AR, Alan C,<br />

Mostafa M. Fetal peritonitis due to appendiceal rupture:<br />

a rare complication <strong>of</strong> hydrops. Fetal Pediatr Pathol<br />

27(3):121-125, <strong>2008</strong>.<br />

Lebel RR. The Language <strong>of</strong> God (Collins). Proc<br />

Greenwood Genet Center 27:45-47, <strong>2008</strong>.<br />

Gopaluni S, Perzova R, Abbott L, Farah R, Shrimpton<br />

A, Hutchison R, Poiesz BJ. CD8+ Cutaneous T-cell<br />

lymphoma successfully treated with Bexarotene: a case<br />

report and review <strong>of</strong> the literature. American Journal <strong>of</strong><br />

Hematology. 83(9):744-6, <strong>2008</strong>.<br />

Mehra A, Tull J, Shrimpton AE, dela Rosa G, Valente A,<br />

Zhang S. Detection <strong>of</strong> FKHR (FOX01) gene break-apart<br />

by Fluorescence in situ hybridization (FISH) in formalin<br />

fixed paraffin embedded Alveolar Rhabdomyosarcomas.<br />

Diagnostic Molecular Pathology, 17(1): 14-20, <strong>2008</strong>.<br />

Shrimpton AE, Levinsohn EM. HOXD10 and congenital<br />

vertical talus. Chapter 71 “Inborn errors <strong>of</strong> development”<br />

Second Edition. Ed Epstein CJ, Erickson RP, Wynshaw-<br />

Boris A. Oxford University Press NY, <strong>2008</strong>, pp 682-688.<br />

Lebel RR, Avery JM, Broome PJ, Collins JS. Prenatal<br />

diagnostic accuracy in South Carolina, demonstrated by<br />

autopsy. Fetal Pediatr Pathol 28(6):253-261, <strong>2009</strong>.<br />

Barker SD, Bale S, Buller A, Das S, Friedman K, Godwin AK,<br />

Grody W, Highsmith E, Kant J, Lyon E, Mao R, Monaghan<br />

KG, Payne DA, Pratt VM, Roa B, Schrijver I, Shrimpton AE*,<br />

Hoopes RR*, Knohl SJ, Hueber P, Scheinman SJ. OCRL1<br />

Mutations in Dent 2 Patients Suggest a Mechanism for<br />

Phenotypic Variability. Nephron Physiology 112:27-36, <strong>2009</strong>.<br />

Shrimpton A, Kessler J, Bassuk AG. Variability <strong>of</strong> Epilepsy,<br />

Autism, Brachydactyly, and Other Clinical Features in<br />

Familial and Sporadic 2q37.3 Deletion. J Ped Neurol. 7:1-5,<br />

<strong>2009</strong>.<br />

Shrimpton AE, Spector E, Telatar M, Weck K, Zehnbauer<br />

B, Booker J, Kalmanet LV, al. Development and<br />

characterization <strong>of</strong> reference materials for MTHFR,<br />

SERPINA1, RET, BRCA1, and BRCA2 genetic testing<br />

Accepted The Journal <strong>of</strong> Molecular Diagnostics. #JMD09-<br />

0078 accepted.<br />

Duffner PK, Caggana M, Orsini JJ, Wegner DA, Patterson<br />

MC, Crosley CJ, Kurtzberg J, Arnold, GL, Escolar ML,<br />

Adams DJ, Andriola MR, Aron AM, Ciafaloni E, Djukie A,<br />

Erbe RW, Galvin-Parton P, Helton LE, Kolodny EH, Kos<strong>of</strong>sky<br />

BE, Kronn DF, Kwon JM, Levy PA, Miller-Horn J, Naidich TP,<br />

Pellegrino JE, Provenzale JM, Rothman SJ, Wasserstein MP,<br />

Newborn Screening <strong>of</strong> Krabbe Disease: the New York State<br />

Model. Pediatr Neurol 40:245-252, <strong>2009</strong>.<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS<br />

Lebel R, Seaver L, Gregg A, Edwards J, Salley M, Avery<br />

J, Broome P, Stevenson R. Prenatal phenotypic variation<br />

in Ellis-van Creveld syndrome. Am J Hum Genet<br />

83:(Suppl):161, Abstract #692, <strong>2008</strong>.<br />

Miller RT, Barkan HI, Lebel RR. MECP2 duplication found<br />

by microarray study in a man with developmental<br />

regression. Genet Med 11 (Suppl.):151, Abstract #216, <strong>2009</strong>.<br />

Lebel RR, Miller, RT, Havernick NJ, Dosa NP, Braddock<br />

BR, Smith FC, Shprintzen RJ. Cardio-renal-epilepsydigital-oculo<br />

(CREDO) syndrome: a “new” syndrome <strong>of</strong><br />

developmental-delays and multiple-malformations. Am<br />

J Hum Genet 85(Suppl):206, Abstract #2600, <strong>2009</strong>.<br />

Arnold GL, Galvin-Parton PA, Erbe R, DeVincentis E,<br />

Kronn D, M<strong>of</strong>idi S, Wasserstein M, Pellegrino JE, Levy PA,<br />

Adams DJ, Saavedra-Matiz CA, Nichols TJ. Genotype-<br />

Metabolite Correlations and Outcome in MCAD<br />

Deficiency Diagnosed by Newborn Screening in New<br />

York State. Abstract 137, Platform presentation, Society<br />

<strong>of</strong> Inherited Metabolis Diseases meeting, San Diego, CA,<br />

September <strong>2009</strong>


22 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

INVITED WORKSHOPS AND CME<br />

PRESENTATIONS<br />

Braddock B. Invited Lecture, “Hereditary Risk for Colon<br />

Cancer”, Healthlink Program, March, <strong>2008</strong>.<br />

Braddock B. Invited Lecture, “Genetic Counseling”,<br />

Genetics, Disability and the Law, March 23, <strong>2008</strong>.<br />

Braddock B. Invited Lecture, “Genetic Counseling and<br />

Testing for Inherited Colon Cancer Syndromes”, VA<br />

Hospital Gastroenterology Dept, September, <strong>2009</strong>.<br />

Braddock B. Invited Lecture, “Genetic Testing for<br />

Hereditary Risk to Cancer”, Hematology Oncology<br />

Associates <strong>of</strong> Central New York, October, <strong>2008</strong>.<br />

Lebel R. Invited Lecture, Grand Rounds, Dept <strong>Pediatrics</strong>,<br />

SUNY Upstate Med Univ (9/17/08, 3/18/09, 11/18/09).<br />

Lebel R. Invited Lecture, Grand Rounds, Dept Int Med,<br />

SUNY Upstate Med Univ (8/28/08, 4/30/09)<br />

Lebel R. Invited Lecture, Grand Rounds, Dept Obstet/<br />

Gynecol, SUNY Upstate Med Univ (10/10/08, 2/6/09, 11/13/09)<br />

Lebel R. Invited Lecture, Grand Rounds, Dept Pathology,<br />

SUNY Upstate Med Univ (11/19/08)<br />

Lebel R. Invited Lecture, Grand Rounds, Dept Bioethics &<br />

Humanities, SUNY Upstate Med Univ (12/12/08)<br />

Lebel R. Invited Lecture, Onondaga County <strong>Pediatrics</strong><br />

Society (11/18/08)<br />

Lebel R. Invited Lecture, Central New York Medical<br />

Academy (2/12/09)<br />

Lebel R. Invited Lecture, St. Olaf College, Northfield, MN,<br />

Scientific Day (5/1/09)<br />

Lebel R. Invited Lecture, Central New York<br />

Cytogeneticists’ Seminar (9/12/09)<br />

Lebel R. Invited Lecture, Regional seminar for Lutheran<br />

Pastors (10/7/09, 12/2/09)<br />

Lebel R. Invited Lecture, Onondaga Community College<br />

Special Education Class (11/9/09)<br />

Lebel R. Invited Lecture, Cato-Meridian High School<br />

Biology Classes (11/30/09)<br />

Miller R. Invited Lecture, Grand Rounds, <strong>Pediatrics</strong>,<br />

Chromosomal Microarray: New Diagnostic Frontier<br />

(5/27/09)<br />

Pellegrino J. Invited Lecture, Annual Pediatric Teaching<br />

Day, Newborn Screening: It’s not just PKU anymore,<br />

OnCenter Syracuse NY 6/4/08.<br />

Pellegrino J. Invited Lecture, Brighton Hills Pediatric<br />

Group, Update on Newborn Screening. Syracuse NY<br />

10/9/09<br />

Pellegrino J. Invited Lecture, Children at Risk Nursing<br />

Conference, Update on Newborn Screening, Syracuse NY<br />

11/19/08<br />

GRANTS AND CONTRACTS<br />

New York State <strong>Department</strong> <strong>of</strong> Health Genetic Services<br />

Program grant, in the amount <strong>of</strong> $140,858 annually from<br />

January 1, <strong>2009</strong> through December 31, 2013.<br />

CNY Children’s Miracle Network Patient Supplies for<br />

Metabolic Clinic, $4660, awarded in 2006.<br />

SELECTED CLINICAL DATA<br />

<strong>2008</strong> total number <strong>of</strong> patients<br />

seen by Medical Genetics: . . . . . . . . . . . . . . . . . . . . . . . . . 865<br />

<strong>2009</strong> total number <strong>of</strong> patients<br />

seen by Medical Genetics: . . . . . . . . . . . . . . . . . . . . . . . . . 1,019


Bi-Annual <strong>Report</strong> • 23<br />

HEMATOLOGY & ONCOLOGY<br />

FACULTY<br />

Richard H. Sills, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Division<br />

Director<br />

Irene Cherrick, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Gloria Kennedy, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Trisha Tavares, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Jody Sima, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Karol Kerr, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

William Kerr, Ph.D., Murphy Family Pr<strong>of</strong>essor <strong>of</strong><br />

Children’s Oncology Research<br />

AFFILIATED CLINICAL STAFF<br />

Diane Groth, R.N., C.P.N.P., Pediatric Nurse Practitioner<br />

Susan Shaw, M.S.N, P.N.P., A.N.P., Pediatric and Adult<br />

Nurse Practitioner<br />

Karen Leshko, L.M.S.W., Licensed Medical Social Worker<br />

Brittany Metcalf, C.C.L.S., Certified Childlife Specialist<br />

Ruth McKay, M.A., L.M.F.T., Licensed Family Medical<br />

Therapist<br />

Kristi Scully, M.S. Ed., Education Specialist<br />

AFFILIATED RESEARCH STAFF<br />

Michelle Cavallerano, C.C.R.P., Clinical Research<br />

Associate<br />

Gayle Froio, M.T., Clinical Research Associate<br />

CLINICAL OVERVIEW<br />

The Division <strong>of</strong> Hematology/Oncology cares for infants,<br />

children and adolescents with the full spectrum <strong>of</strong><br />

hematologic and malignant disorders. The clinical<br />

activity <strong>of</strong> the section is based in the Waters Center for<br />

Children’s Cancer and Blood Disorders (CCCBD). Serving<br />

a 21 country area in New York and Northern Pennsylvania,<br />

we are the sole regional provider for the specialty. The<br />

division also provides the primary source <strong>of</strong> patients for<br />

the 11G Pediatric Hematology/ Oncology Inpatient unit in<br />

the new Golisano Children’s Hospital.<br />

The Center employs five full-time and one part-time<br />

physician. We currently have two nurse practitioners;<br />

Diane Groth provides a primary role in caring for children<br />

with bleeding disorders, as well as, children with<br />

malignancies. Susan Shaw provides care part-time to<br />

children and young adults who were previously treated<br />

for a malignancy but are now considered long-term<br />

survivors. William Kerr, Ph.D., provides the basic science<br />

research component to the division.<br />

At the present time, the division has 5.7 registered nurses,<br />

3.5 <strong>of</strong>fice personnel, a social worker, family therapist,<br />

educational specialist, two clinical research associates, a<br />

research technician and a post doctoral student.<br />

The division cares for over 50 newly diagnosed children<br />

with cancer annually and more than 70 children on active<br />

chemotherapy programs. The division also provides care<br />

to children with a wide variety <strong>of</strong> hematologic disorders<br />

on an ongoing basis as well as providing consultative<br />

services for regional primary care providers who need<br />

assistance caring for children with potential hematologic<br />

or oncologic diagnoses.<br />

Children’s Oncology Group Participation<br />

The division continues to function as a full member <strong>of</strong><br />

the Children’s Oncology Group under the leadership <strong>of</strong><br />

Dr. Irene Cherrick. All <strong>of</strong> COG’s research protocols are<br />

available to our patients and we have been very effective<br />

at entering the great majority <strong>of</strong> newly diagnosed patients<br />

onto research protocols.<br />

KNOT Center<br />

This is our program <strong>of</strong> long-term follow up for late<br />

effects which was one <strong>of</strong> the first <strong>of</strong> its kind in the nation.<br />

The program follows more than 500 patients. Susan<br />

Shaw, RN, PNP provides the primary clinical services<br />

under the supervision <strong>of</strong> Dr. Jody Sima. Dr. Sima’s prime<br />

research interest has been late effects, providing a<br />

research component to this clinical service. Dr. Sima has<br />

begun to better organize our databases on late effects<br />

and has been able to publish her initial studies looking<br />

at primary care providers and their understanding<br />

(or relative lack <strong>of</strong> understanding) <strong>of</strong> readily available<br />

resources concerning late effects <strong>of</strong> the malignancies and<br />

their treatment.<br />

Ms. Shaw has a national reputation for her work and is a<br />

frequently invited speaker. She is on the COG late effects<br />

committee. Patients usually enter the KNOT program<br />

when they are five years from diagnosis and at low risk<br />

for relapse. Specific protocols are followed to assure that<br />

the longer term effects <strong>of</strong> chemotherapy, radiation and<br />

surgery are recognized and managed appropriately.<br />

Neuro-Oncology<br />

This multidisciplinary neuro-oncology program is now<br />

directed by Dr. Gloria Kennedy with the assistance <strong>of</strong><br />

Dr. Trisha Tavares. The program is held in the CCCBD on<br />

a monthly basis and is regularly attended by pediatric<br />

neurology, radiation oncology and an educational<br />

specialist. The visits focus not only on the medical care<br />

and management <strong>of</strong> long term complications but also<br />

focus on the psychosocial and educational needs <strong>of</strong> these<br />

children. It is a true multi-disciplinary program which<br />

makes it much simpler for patients and their families;<br />

they are able to see all their neuron-oncology providers<br />

at a single visit.


24 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Hemophilia<br />

Diane Groth, RN, PNP and Dr. Kennedy coordinate the<br />

federally funded hemophilia program. More than fifty<br />

patients with hemophilia and more than 220 with other<br />

coagulopathies receive consistent, comprehensive care<br />

through this program. Camp High Hopes, co-founded and<br />

operated by Ms. Groth, provides a wonderful week-long<br />

camp experience for boys with hemophilia. It is open to<br />

boys from the entire upstate region and is unique for this<br />

area.<br />

New York State Designated<br />

Hemoglobinopathy Center<br />

This program is directed by Dr. Richard Sills. Its primary<br />

role is to provide the focus <strong>of</strong> care for children with<br />

hemoglobinopathies; most <strong>of</strong> these children are<br />

identified by the New York State Newborn Screening<br />

Program and referred to us directly as the regional<br />

center. Smaller numbers <strong>of</strong> children are referred<br />

when they move into the area. We currently care for<br />

approximately 100 children with sickle cell disease.<br />

We also provide service to children with other<br />

hemoglobinopathies such as thalassemia and hemoglobin<br />

C or E disorders. In addition we provide genetic<br />

counseling to families identified as having infants with<br />

hemoglobinopathy traits identified by newborn screening<br />

or referred by outside physicians.<br />

Autologous Stem Cell Transplantation<br />

The pediatric stem cell transplant program continues to<br />

develop and serve the needs <strong>of</strong> patients with a variety <strong>of</strong><br />

solid tumors, particularly those with neuroblastoma and<br />

brain tumors. We are an approved autologous transplant<br />

center for COG studies.<br />

Educational Specialist and Neuropsychology<br />

Service<br />

This is an area <strong>of</strong> innovation in our division. Kristi Scully<br />

has taken over the role since Nan Songer’s death. This<br />

was a difficult time for the division, but Ms. Scully is<br />

doing a remarkable job. Ms. Scully’s role is to coordinate<br />

tutoring, school re-entry, assessing and guaranteeing<br />

adaptation <strong>of</strong> the educational system to the unique needs<br />

<strong>of</strong> our children, the monitoring <strong>of</strong> school performance<br />

and active participation in the educational planning for<br />

children with neurocognitive deficits. Close collaboration<br />

with the regional school districts and the use <strong>of</strong> school<br />

visits is integral to the success <strong>of</strong> this program. She also<br />

coordinates our “When Cancer Enters the Classroom”<br />

program for school nurses and teachers in our region to<br />

learn more about working with our children. Brian Rieger,<br />

PhD, a neuropsychologist in the <strong>Department</strong> <strong>of</strong> Physical<br />

Medicine and Rehabilitation, is a close collaborator with<br />

the service and supervises all <strong>of</strong> the neuropsychological<br />

testing. Participation <strong>of</strong> PhD students from the School<br />

<strong>of</strong> Education at Syracuse University has been funded by<br />

the CCCBD and has been an integral part <strong>of</strong> an innovative<br />

research program.<br />

Pediatric Palliative Care<br />

Dr. Irene Cherrick has very successfully expanded the<br />

palliative care program which is becoming a separate<br />

program as much <strong>of</strong> its activity has moved beyond<br />

pediatric hematology and oncology. It has been very<br />

successful. It fills a tremendous void by organizing and<br />

providing support for children who are still receiving<br />

some therapy to improve their quality <strong>of</strong> survival in<br />

spite <strong>of</strong> an inability to cure their disease. The traditional<br />

hospice program manages patients only after therapies,<br />

such as chemotherapy, are no longer being used. Dr.<br />

Cherrick’s program has expanded beyond the population<br />

<strong>of</strong> children with hematologic and oncologic diagnoses<br />

and now includes all children in our region whose<br />

insurance qualifies them for this support.<br />

RESEARCH HIGHLIGHTS<br />

Dr. William Kerr<br />

An important area <strong>of</strong> investigation for Dr. Kerr’s lab is the<br />

role that SHIP plays in stem cell biology, both pluripotent<br />

stem (PS) cells and hematopoietic stem cells (HSC). In<br />

2001 we identified a stem cell specific is<strong>of</strong>orm <strong>of</strong> SHIP,<br />

s-SHIP, that is expressed by PS cells and HSC. s-SHIP<br />

associates with Grb2 and is constitutively recruited<br />

to the plasma membrane to receptor components<br />

like gp130. Thus, we propose that s-SHIP sets signaling<br />

thresholds for PS cell populations. We also found that<br />

SHIP expression is required to sustain their multi-lineage<br />

repopulating capacity. We have recently demonstrated<br />

that SHIP is required for the normal function <strong>of</strong> the BM<br />

niche that supports HSC. Future studies will define the<br />

cell types and signaling pathways that SHIP influences<br />

which are required for niche function. We have recently<br />

developed SHIP1 inhibitors that our research suggests<br />

might be used to mobilize HSC for transplant purposes<br />

and to improve blood cell recovery in myelosuppressed<br />

patients. Applications <strong>of</strong> SHIP1 inhibition that we will be<br />

examining in the near future.<br />

We find that SHIP is critical to maintaining a diverse<br />

repertoire <strong>of</strong> activating and inhibitory receptors in<br />

mature Natural Killer (NK) cells. The NK repertoire<br />

disruption that occurs in<br />

SHIP -/- mice has pr<strong>of</strong>ound functional consequences<br />

and disables rejection <strong>of</strong> allogeneic bone marrow<br />

(BM) grafts. Surprisingly, SHIP-deficiency also appears<br />

to abrogate graft-versus-host-disease (GVHD) - the<br />

major cause <strong>of</strong> treatment-related mortality in human<br />

allogeneic BM transplantation. This appears to be due<br />

to a dramatic expansion <strong>of</strong> a myeloid and T lymphoid<br />

immunoregulatory cells in SHIP -/- hosts that suppress<br />

allogeneic T cell responses that mediate GvHD or organ<br />

graft rejection. We have recently developed chemicals<br />

inhibitors <strong>of</strong> SHIP1 that might be used to increase both the<br />

efficacy and utility <strong>of</strong> allogeneic BM transplantation in<br />

cancer and genetic diseases. SHIP1/2 inhibitors might also<br />

find utility in prevention <strong>of</strong> solid organ rejection and in<br />

the treatment <strong>of</strong> malignancy - two possibilities we will be<br />

examining in the future.


Bi-Annual <strong>Report</strong> • 25<br />

Dr. Jody Sima<br />

Dr. Sima has effectively examined the current<br />

understanding <strong>of</strong> late effects <strong>of</strong> childhood cancer by<br />

primary care providers. As these children age out <strong>of</strong><br />

pediatrics and begin to <strong>of</strong>ten be followed by primary<br />

care providers, it is essential to improve the ability <strong>of</strong><br />

these providers to understand and recognize potential<br />

complications.<br />

Dr. Richard Sills<br />

Dr. Sills is trying to re-establish the planned regional<br />

consortium involving Rochester, Buffalo and Syracuse for<br />

a research basis into children with sickle cell disease.<br />

PUBLICATIONS<br />

Collazo, M.C., Wood, D., Paraiso, K.H.T., Lund, E.,<br />

Engelman, R.W., Le, C.T., Stauch, D., Kotsch, K. and Kerr,<br />

W.G. SHIP limits immunoregulatory capacity in the T cell<br />

compartment. Blood 113: 2934-44 (<strong>2009</strong>). [featured on<br />

cover]<br />

Hazen, A.L, Smith, M.J., Desponts, C., Winter, O., Moser,<br />

K., and Kerr, W.G. SHIP is required for a functional<br />

hematopoietic stem cell niche. Blood 113: 2924-33 (<strong>2009</strong>).<br />

HYD1-induced increase in reactive oxygen species leads to<br />

autophagy and necrotic cell death in multiple myeloma<br />

cells. Nair R.R., Emmons M.F., Cress A.E., Argilagos R.F.,<br />

Lam K., Kerr W.G., Wang H.G., Dalton W.S., Hazlehurst L.A.<br />

Mol. Cancer Ther. 8:2441-51 (<strong>2009</strong>).<br />

Kanwar VS, Sills RH. Hereditary disorders <strong>of</strong> red cell<br />

permeability. Emedicine <strong>2008</strong>. Available from URL: http://<br />

emedicine.medscape.com/article/955921-overview<br />

Sills RH, Meck M. Hereditary elliptocytosis and related<br />

disorders. Emedicine <strong>2008</strong>. Available from URL: http://<br />

emedicine.medscape.com/article/955827-overview<br />

Cerone JB, Kanwar VS, Sills RH. Consumption<br />

coagulopathy. Emedicine <strong>2009</strong>. Available from URL: http://<br />

emedicine.medscape.com/article/955059-overview<br />

Kanwar VS, Sills RH. Lymphadenopathy. Emedicine, <strong>2009</strong>.<br />

Available from URL: http://emedicine.medscape.com/<br />

article/956340-overview<br />

Kanwar VS, Sills RH. Splenomegaly. Emedicine, <strong>2009</strong>.<br />

Available from URL: http://emedicine.medscape.com/<br />

article/958739-overview<br />

Shaw S.(<strong>2009</strong>). Endocrine Late Effects in Survivors <strong>of</strong><br />

Pediatric Brain Tumors. Journal <strong>of</strong> Pediatric Oncology<br />

Nursing 26(5):295-302.<br />

Landier, W., Kinahan, K., Shaw, S., Bhatia, S.(<strong>2009</strong>).<br />

Screening for Late Effects in Brain Tumor Survivors. In S.<br />

Goldman and C. Turner (Eds.), Late Effects <strong>of</strong> Treatment<br />

for Brain Tumors (Chapter 26, pp.389-409). New York:<br />

Springer.<br />

GRANTS AND CONTRACTS<br />

COG – Irene Cherrick, PI<br />

Novartis Exjade Study – Richard Sills, PI<br />

NIH – William Kerr<br />

2002-2011 RO1 HL72523: Role <strong>of</strong> SHIP in NK Cell Biology (PI)<br />

<strong>2008</strong>-2012 R01HL085580: SHIP and Immunoregulatory Cell<br />

Function (PI)<br />

2007-2010 R21CA118632: Defining the Multiple Myeloma<br />

Kinome (PI)<br />

2007-2010 R21CA25398: The Kinomes <strong>of</strong> Non-Hodgkin<br />

Lymphoma (PI)<br />

EDITORIAL SERVICE<br />

Dr. Sills serves as a consulting editor <strong>of</strong> PREP 2001-present<br />

and continues to be a question writer for PREP.<br />

SELECTED CLINICAL DATA<br />

Outpatient visits: <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . 4,608<br />

<strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 5,261<br />

Inpatient Visits: <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 2,718<br />

<strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 3,291


26 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

INFECTIOUS DISEASES<br />

FACULTY<br />

Leonard B. Weiner, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Pathology<br />

and Family Medicine, Director, Division <strong>of</strong> Infectious<br />

Disease and Immunology<br />

Joseph B. Domachowske, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Microbiology and Immunology<br />

Jana Shaw, MD, MPH, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Jeffrey D. Snedeker, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

John A. Bradshaw, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

FELLOWS<br />

Nicholas Bennett MD, PhD, MB/BChir<br />

Manika Suryadevara, MD<br />

AFFILIATED CLINICAL STAFF<br />

Kathie Contello, RN, MS, CPNP<br />

M. Christine Crandall, RN, MS, PNP<br />

Wendy Holz, RN, MS, PNP<br />

AFFILIATED RESEARCH STAFF<br />

Cynthia Bonville, MS, Senior Research Support<br />

Technologist<br />

Lisa Susko RN, Study Coordinator<br />

Christy Tabarani, MD, Research Assistant<br />

Joy M. Tompkins, RN, MS, PNP, Administrator<br />

CLINICAL OVERVIEW<br />

The Division <strong>of</strong> Infectious Diseases provides care for<br />

infants, children and adolescents with severe or unusual<br />

infections and immune deficiency syndromes, including<br />

HIV. Infectious disease specialists evaluate and treat<br />

children with recurrent infections, persistent or periodic<br />

fever syndromes, unusual or severe bacterial, viral,<br />

fungal and parasitic diseases, and innate or acquired<br />

immune deficiency syndromes. As a designated New York<br />

State <strong>Department</strong> <strong>of</strong> Health Pediatric AIDS Center <strong>of</strong><br />

Excellence, we provide medical care for pediatric patients<br />

infected with, or exposed to human immunodeficiency<br />

virus. Our outpatient care is provided in the Pediatric<br />

and Adolescent Infectious Disease and Immunology<br />

Center in the pediatric subspecialty outpatient setting<br />

located in the Golisano Children’s Hospital. Patients<br />

referred by their primary care physicians for infectious<br />

disease immunologic diagnostic evaluations or who need<br />

intravenous antibiotics and immunoglobulin infusions<br />

are administered in this Center. Follow-up evaluations<br />

on recently hospitalized patients also take place in this<br />

setting.<br />

Hospitalized patients are evaluated upon the request<br />

<strong>of</strong> their primary care physician at University, Crouse<br />

and Saint Joseph’s Hospitals. Our infectious disease<br />

specialists work closely with the primary care<br />

pediatricians and family physicians, surgical specialist,<br />

intensivists, hospitalists, and neonatologists to direct the<br />

diagnostic and therapeutic evaluations <strong>of</strong> patients with<br />

infectious disease and/or immunologic problems.<br />

The activities <strong>of</strong> the Division <strong>of</strong> Infectious Disease include<br />

the only Pediatric Designated AIDS Center in the region.<br />

This program has also received a Center <strong>of</strong> Excellence<br />

designation and grant from the New York State<br />

<strong>Department</strong> <strong>of</strong> Health.<br />

The Pediatric Infectious Disease Division has an<br />

accredited fellowship program that accommodates one<br />

post graduate resident a year. The focus <strong>of</strong> this specialty<br />

education is on clinical care and research.<br />

RESEARCH HIGHLIGHTS<br />

Clinical Trials<br />

A major effort <strong>of</strong> the infectious disease physicians is the<br />

participation in multi-center, national and international<br />

clinical trials to evaluate the safety and efficacy <strong>of</strong> new<br />

pharmacologic agents and vaccines related to the care<br />

<strong>of</strong> children and adolescents. Specifically, Dr. Weiner<br />

currently supervises protocols to evaluate novel antiviral<br />

therapies and multiple clinical vaccine trials.<br />

Studies involving newer meningococcal, pneumococcal,<br />

influenza, DTAP/Hib/IPV and MMRV vaccines are currently<br />

underway. Vaccine trials usually take place at University<br />

Pediatric and Adolescent Center or Upstate <strong>Pediatrics</strong>.<br />

Dr. Domachowske’s clinical research interests focus on<br />

the epidemiology and clinical manifestations <strong>of</strong> lower<br />

respiratory tract viral infections. He has paralleled these<br />

interests with an extensive laboratory program involving<br />

the study <strong>of</strong> severe respiratory virus infection utilizing<br />

animal models. Severe viral bronchiolitis and pneumonia<br />

depend on both active viral replication, and on the<br />

host cell immune responses to that infection. Studies<br />

to elucidate these host responses and to determine<br />

the clinical effects <strong>of</strong> inhibiting these responses have<br />

revealed that combination therapy with antiviral<br />

compounds and specific immunomodulatory agents <strong>of</strong>fer<br />

dramatic clinical benefits. Dr. Domachowske’s clinical<br />

and epidemiologic trials include four RSV-prevention<br />

protocols, two RSV/parainfluenza vaccine trials, and a<br />

large scale pediatric influenza vaccine trial.<br />

Dr. Shaw’s clinical research interests focus on<br />

epidemiology and severity <strong>of</strong> S. aureus infection<br />

among healthy children. Current research focuses on<br />

establishing the role <strong>of</strong> S. aureus virulence factors among<br />

seriously ill children and the importance <strong>of</strong> S. aureus<br />

colonization among children with cystic fibrosis.


Bi-Annual <strong>Report</strong> • 27<br />

Dr. Shaw has also been interested in a quality <strong>of</strong> life and<br />

clinical outcomes among immuncompromised patients<br />

receiving immunoglobulin replacement therapy. She has<br />

been mentoring and supervising medical students and<br />

fellows engaged in her research.<br />

PUBLICATIONS<br />

Samkari A, Kiska DL, Riddell SW, Wilson K, Weiner LB,<br />

and Domachowske JB. Dipylidium Caninum Mimicking<br />

Recurrent Enterobius Vermicularis (Pinworm) Infection.<br />

Clin Pediatr, <strong>2008</strong>;47:397-99.<br />

Krilov, LR, Weiner LB, Yogev R, Fergie J, Katz<br />

BZ, Henrickson KJ, Welliver RC, The <strong>2009</strong> COID<br />

Recommendations for RSV Prophylaxis: Issues <strong>of</strong><br />

Efficacy, Cost and Evidence-Based Medicine. <strong>Pediatrics</strong>,<br />

<strong>2009</strong>;124:1682-1684.<br />

Rosenberg HF and Domachowske JB. Respiratory viruses<br />

and eosinophils: exploring the connections Antiviral Res<br />

<strong>2009</strong>; 83:1-9.<br />

Tabarani C and Domachowske JB. Influenza vaccine in<br />

health care workers. Pediatr Annals <strong>2009</strong>; 38:661-6.<br />

Arguedas A, Cespedes J, Botet FA, Blumer J, Yogev R,<br />

Gesser R, Wang J, West J, Snyder T, Wimmer W; Protocol<br />

036 Study Group. Safety and tolerability <strong>of</strong> ertapenem<br />

versus ceftriaxone in a double-blind study performed<br />

in children with complicated urinary tract infection,<br />

community-acquired pneumonia or skin and s<strong>of</strong>ttissue<br />

infection. Int J Antimicrob Agents. <strong>2009</strong>;33:163-7.<br />

(Domachowske)<br />

Percopo CM, Phipps S, Foster PS, Domachowske JB, and<br />

Rosenberg HF. Pulmonary eosinophils and their role in<br />

immunopathologic responses to formalin-inactivated<br />

pneumonia virus <strong>of</strong> mice. J Immunol <strong>2009</strong>; 183:604-12.<br />

Kobayaa H, Souki RR, Trust S and Domachowske JB.<br />

Pastuerella multocida meningitis in newborns<br />

after incidental animal exposure. Pediatr Infect Dis J<br />

<strong>2009</strong>; 28:928-9.<br />

Bonville CA, Percopo CM, Dyer KD, Gao JL, Prussin<br />

C, Foster B, Rosenberg HF and Domachowske JB.<br />

Interferon-gamma coordinates CCL3-mediated<br />

neutrophil recruitment in vivo. BMC Immunology<br />

<strong>2009</strong>;10:14.<br />

Moro MR, Bonville CA, Suryadevara, M, Cummings<br />

E, Faddoul D, Branigan P, Domachowske JB. Clinical<br />

features, adenovirus types, and local production <strong>of</strong><br />

inflammatory mediators in adenovirus infections. Pediatr<br />

Infect Dis J <strong>2009</strong>; 28:376-80.<br />

Rosenberg HF, Dyer KD, and Domachowske JB.<br />

Eosinophils and their interactions with respiratory virus<br />

pathogens. Immunologic Res. <strong>2009</strong>; 43:128-37.<br />

Bern RA, van Woensel JBM, Bos AP, Koski A, Farnand<br />

A, Domachowske JB, Rosenberg HF, Martin TR, and<br />

Matute-Bello G. Mechanical ventilation enhances lung<br />

inflammation and caspase activity in a model <strong>of</strong> mouse<br />

pneumovirus infection. AJP Lung <strong>2009</strong>;296;L46-56.<br />

Rosenberg HF and Domachowske JB. Pneumonia virus <strong>of</strong><br />

mice: Severe respiratory virus infection in a natural host.<br />

Immunol Lett. <strong>2008</strong>; 118:6-12.<br />

Samkari A, Kiska DL, Riddell SW, Wilson KW, and<br />

Domachowske JB. Dipylidium canium infestation<br />

masquerading as treatment-resistant pinworms. Clin<br />

Pediatr. <strong>2008</strong>;47:397-99.<br />

Eick A, Karron R, Shaw J, Thumar B, Reid R, Santosham<br />

M, O’Brien KL. The role <strong>of</strong> neutralizing antibodies in<br />

protection <strong>of</strong> American Indian infants against respiratory<br />

syncytial virus disease.Pediatr Infect Dis J. <strong>2008</strong><br />

Mar;27(3):207-12.<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS<br />

Moro MR, Contello K, Holz W, Weiner LB, Shaw<br />

J. Subcutaneous (SCIG) versus Intravenous (IVIG)<br />

Immunoglobulin Replacement Therapy in a Pediatric<br />

Population with Primary Immunodeficiencies (PID).<br />

Pediatric Academic Societies, Baltimore MD, May <strong>2009</strong>.<br />

El Feghaly RE, McGann L, Bonville CA, Rosenberg HF, and<br />

Domachowske JB.<br />

A Decade <strong>of</strong> Pediatric Parainfluenza Virus Infections:<br />

Clinical Manifestations and Biomarkers <strong>of</strong> Disease<br />

Severity. Pediatric Academic Societies Baltimore MD May<br />

<strong>2009</strong>.<br />

deWaal Malefyt SK, Pecha MM, and Domachowske JB.<br />

Bacterial meningitis in children with Mondini dysplasia.<br />

Pediatric Academic Societies Baltimore MD May <strong>2009</strong>.<br />

Gilroy SA, Martin D, Stahl R, Domachowske JB, Weiner<br />

LB, Johnson H, Costello K, Dadey J, Gross S, Bode M,<br />

Fuller P, Agnew M, Smith F, Susman R, Barrington K, and<br />

Johnson L. RSV Infection in a neonatal ICU: <strong>Report</strong> <strong>of</strong><br />

prevention strategies to control an outbreak. Society for<br />

Healthcare Epidemiology <strong>of</strong> America. San Diego CA <strong>2009</strong><br />

Gilroy SA, Martin D, Stahl R, Domachowske JB, Allen R,<br />

Johnson H, Costello K, Bode, M, Treatmen S, Sikora R,<br />

Hall E, Fuller P, LeRoy S, Steinman R Kosinsky M, Agnew M,<br />

Shaw J, Smith F, Susman R, Barrington K, Cook B, Johnson<br />

L, Watkins J, Richey D, Morrow C. Mumps exposure in<br />

a neonatal intensive care unit: <strong>Report</strong> <strong>of</strong> prevention<br />

strategies implemented to control an outbreak. Society<br />

for Healthcare Epidemiology <strong>of</strong> America. San Diego CA<br />

<strong>2009</strong><br />

Bonville CA, Rosenberg HF, and Domachowske JB.<br />

Newborn inflammatory responses to severe viral<br />

bronchiolitis. Infectious Disease Society <strong>of</strong> America.<br />

Washington, DC October, <strong>2008</strong><br />

Bonville CA, Moro RM, and Domachowske JB. A decade<br />

<strong>of</strong> pediatric adenovirus infection in Upstate New York:<br />

Clinical features and adenovirus types. Infectious Disease<br />

Society <strong>of</strong> America. Washington, DC October, <strong>2008</strong><br />

Cummings E, Suryadevara M, Bonville CA, Bartholoma<br />

N, Riddell S, Kiska D, and Domachowske JB. Viral coinfection<br />

is common in RSV-infected hospitalized<br />

children. Infectious Disease Society <strong>of</strong> America.<br />

Washington, DC October, <strong>2008</strong>


28 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Moro RM and Domachowske JB. Tracking curbside<br />

questions posed to a pediatric infectious disease service<br />

2007 compared to 1990. Pediatric Academic Societies,<br />

Honolulu HI, May <strong>2008</strong>.<br />

Moro MR, Bonville CA, Suryadevara M, Cummings E,<br />

Faddoul D, Kobayaa H, Branigan PJ and Domachowske<br />

JB. Adenovirus Infection Induces a Series <strong>of</strong> Pro-<br />

Inflammatory Mediators, but only Interleukin-1a and<br />

Interleukin-8 Correlate with Illness Severity. Pediatric<br />

Academic Societies, Honolulu HI, May <strong>2008</strong>.<br />

Bem RA, van Woensel JB, Bos AP, Koski A, Domachowske<br />

JB, Rosenberg HF, Martin TR, and Matute-Bello G.<br />

Mechanical ventilation enhances lung inflammation and<br />

cellular apoptosis in a model <strong>of</strong> mouse pneumovirus<br />

infection. American Thoracic Society Toronto Canada<br />

<strong>2008</strong>.<br />

Moro MR, Contello K, Holz W, Weiner LB, Shaw<br />

J. Subcutaneous (SCIG) versus Intravenous (IVIG)<br />

Immunoglobulin Replacement Therapy in a Pediatric<br />

Population with Primary Immunodeficiencies (PID).<br />

Pediatric Academic Societies, Baltimore MD, May <strong>2009</strong>.<br />

Gilroy SA, Martin D, Stahl R, Domachowske JB, Allen R,<br />

Johnson H, Costello K, Bode, M, Treatmen S, Sikora R,<br />

Hall E, Fuller P, LeRoy S, Steinman R Kosinsky M, Agnew<br />

M, Shaw J, et al. Mumps exposure in a neonatal intensive<br />

care unit: <strong>Report</strong> <strong>of</strong> prevention strategies implemented<br />

to control an outbreak. Society for Healthcare<br />

Epidemiology <strong>of</strong> America. San Diego CA <strong>2009</strong><br />

Suryadevara M, Moro MR, Rosenbaum P, Kiska D, Ridell<br />

S, Shaw J. Invasive community-acquired methicillinresistant<br />

Staphylococcus aureus infections in children in<br />

upstate New York. Pediatric Academic Societies, Honolulu<br />

HI, May <strong>2008</strong>.<br />

HONORS, VISITING PROFESSORSHIPS,<br />

EDITORIAL DUTY<br />

Joseph Domachowske, MD<br />

Leonard Tow Humanism in Medicine Award<br />

<strong>2009</strong><br />

Editor, Clinical Microbiology Reviews<br />

2002-2007, 2007-2012<br />

Managing Editor, <strong>Pediatrics</strong> e-medicine<br />

Infectious Diseases Section www.emedicine.com<br />

1999-present<br />

INVITED WORKSHOPS, CME PRESENTATIONS<br />

Domachowske JB: Immunization Advocacy. American<br />

Academy <strong>of</strong> <strong>Pediatrics</strong> Vaccine Summitt. Canandaguia NY<br />

May <strong>2009</strong><br />

Domachowske JB: Global health: the Central America<br />

perspective. High school advocacy group, Young Life Feb<br />

10, <strong>2009</strong>.<br />

Domachowske JB: Mucosal delivery <strong>of</strong> vaccines for<br />

respiratory tract infections. Albany Pediatric Society. Jan<br />

13, <strong>2009</strong>.<br />

Domachowske JB: Vaccines: The accused. Pediatric<br />

Grand Rounds Syracuse, NY Jan 7, <strong>2009</strong><br />

Domachowske JB: Measles and mumps in <strong>2008</strong>. Children<br />

at Risk Conference. Liverpool NY Nov 19 , <strong>2008</strong>.<br />

Domachowske JB: Invasive fungal infections in children.<br />

Diagnosis and treatment. Resident education seminar.<br />

Syracuse, NY Nov 13, <strong>2008</strong><br />

Domachowske JB: Maintaining public confidence in<br />

vaccines. American Academy <strong>of</strong> <strong>Pediatrics</strong> Vaccine<br />

Summitt. New Palz NY Nov 8, <strong>2008</strong><br />

Domachowske JB: Immune deficiencies and<br />

immunoglobulin replacement. Family advocacy group.<br />

Nov 5 th <strong>2008</strong> Syracuse NY<br />

Domachowske JB: The quest for an RSV vaccine. Pediatric<br />

Grand Rounds Duke University November 4, <strong>2009</strong><br />

Domachowske JB: <strong>2008</strong> Pr<strong>of</strong>essional Immunization<br />

Seminar: The Future is Now. Erie County <strong>Department</strong> <strong>of</strong><br />

Health, Erie PA. September <strong>2008</strong><br />

Domachowske JB: <strong>2008</strong> Immunization Update. Nursing<br />

conference. Canastota, NY March <strong>2008</strong>.<br />

Domachowske JB: Adolescent Immunization: A new<br />

focus on the next generation. Satellite symposium during<br />

the National Immunization Conference. Atlanta, GA<br />

March <strong>2008</strong>.<br />

Domachowske JB: How protected are we? Outbreaks <strong>of</strong><br />

vaccine preventable infections. Why? How? APIC Chapter<br />

Heart <strong>of</strong> New York’s Don’t gamble with infection control.<br />

Oneida, NY. March <strong>2008</strong>.<br />

Domachowske JB: Travel advice for college students:<br />

vaccines, food, water, and malaria. Syracuse University<br />

Teaching Day, Syracuse, NY January <strong>2008</strong><br />

Weiner LB: Invited Speaker – Albany County Medical<br />

Society, Albany, NY, “Influenza Vaccine Update <strong>2008</strong>”, May<br />

14, <strong>2008</strong>.<br />

Weiner LB: Invited Participant – New York City,<br />

Meningococcal Vaccine Advisory Committee, August 6,<br />

<strong>2008</strong>.<br />

Weiner LB: Invited Speaker – Monroe County Medical<br />

Society, Rochester, NY, “New Approaches to Pertussis<br />

Prevention”, August 14, <strong>2008</strong>.<br />

Weiner LB: Invited Speaker – New York State <strong>Department</strong><br />

<strong>of</strong> Health, Immunization Conference, Syracuse, NY,<br />

September 12, <strong>2008</strong>.<br />

Weiner LB: Pediatric Grand Rounds, “Influenza<br />

Immunization – Today and in the Future”, SUNY Upstate<br />

Medical University, Syracuse, NY, December 10, <strong>2008</strong>.<br />

Weiner LB: Invited Speaker – Sullivan County Medical<br />

Society, NYSDOH/MSSNY, “Immunization Update for<br />

Health Care Pr<strong>of</strong>essionals-<strong>2009</strong>”, Rock Hill, NY, December<br />

17, <strong>2008</strong>.<br />

Weiner LB: Invited Speaker – “Pediatric Respiratory Viral<br />

Infections”, Saratoga Springs, NY, February 4, <strong>2009</strong>.<br />

Weiner LB: Invited Speaker – Ulster County Medical


Bi-Annual <strong>Report</strong> • 29<br />

Society, NYSDOH/MSSNY, “Immunization Update for<br />

Health Care Pr<strong>of</strong>essionals-<strong>2009</strong>”, Woodstock, NY, April 7,<br />

<strong>2009</strong>.<br />

Weiner LB: Invited Speaker – Medical Grand Rounds, Our<br />

Lady <strong>of</strong> Lourdes Memorial Hospital, “New Considerations<br />

for Adult Immunization”, Binghamton, NY, April 23, <strong>2009</strong>.<br />

Weiner LB: Invited Speaker - Orange County Medical<br />

Society, NYSDOH/MSSNY, “Immunization Update for<br />

Health Care Pr<strong>of</strong>essionals-<strong>2009</strong>”, Newburgh, NY, May 12,<br />

<strong>2009</strong>.<br />

Weiner LB: Invited Speaker – Pediatric Associates,<br />

“Update – Rotavirus Vaccines”, Camillus, NY, May 20, <strong>2009</strong>.<br />

Weiner LB: Invited Speaker – Immunization Summit<br />

<strong>2009</strong>, “Immunization Safety & Breaking Communication<br />

Barriers”, Albany, NY, June 30, <strong>2009</strong>.<br />

Weiner LB: Invited Speaker – Northeast <strong>Pediatrics</strong> ,<br />

“Update on Prevention <strong>of</strong> Rotavirus Disease”, Ithaca, NY,<br />

September 30, <strong>2009</strong>.<br />

Weiner LB: Participant – Scientific Advisory Board<br />

Meeting, “Epidemiology <strong>of</strong> RSV Disease”, Washington, DC,<br />

October 1-2, <strong>2009</strong>.<br />

Weiner LB: Invited Speaker – Broome County Pediatric<br />

Society, “Update on RSV & Influenza”, Binghamton, NY,<br />

October 21, <strong>2009</strong>.<br />

Weiner LB: Invited Speaker – Arnot Ogden Hospital,<br />

NYSDOH/MSSNY, “A 2010 Clinician’s Guide to Influenza<br />

and Vaccination Protocols”, Ogdensburg, NY, October 27,<br />

<strong>2009</strong>.<br />

Weiner LB: Invited Speaker – American Academy <strong>of</strong><br />

<strong>Pediatrics</strong>/NYSDOH Vaccine Summit, “Emerging Vaccines<br />

in the Research Pipeline”, Mohonk, NY, November 6-8,<br />

<strong>2009</strong>.<br />

Weiner LB: Invited Speaker – SUNY Upstate Medical<br />

University, <strong>Department</strong> <strong>of</strong> Medicine, NYSDOH/MSSNY,<br />

“A 2010 Clinician’s Guide to Influenza and Vaccination<br />

Protocols”, Syracuse, NY, November 23, <strong>2009</strong>.<br />

GRANTS AND CONTRACTS<br />

Weiner LB<br />

2005-<strong>2009</strong> Comparative Immunogenicity <strong>of</strong><br />

Different Multivalent Component<br />

Pertussis Vaccine Formulations Based<br />

on a 5-component Acellular Pertussis in<br />

Infants and Toddlers, M5A10: Principal<br />

Investigator<br />

2006-<strong>2008</strong> Phase III Study for the Immunogenicity<br />

and Consistency Evaluation <strong>of</strong> 3 Hib-<br />

MenCY-TT Vaccine Lots and Evaluation<br />

<strong>of</strong> Safety and Immunogenicity <strong>of</strong> GSK<br />

Biologicals’ Haemophilus Influenzae Type<br />

B and Neisseria Meningitidis Serogroups<br />

C & Y-tetanus T, Hib 009/010: Principal<br />

Investigator<br />

2006-<strong>2008</strong> A phase III, single-blind, Randomized,<br />

Controlled, Multinational Study for the<br />

Evaluation <strong>of</strong> Safety <strong>of</strong> GSK Biologicals’<br />

Haemophilus Influenzae Type B and<br />

Neisseria Meningitidis Serogroups<br />

C and Y-Tetanus Toxoid Conjugate<br />

Vaccine Combined, Hib 011/012: Principal<br />

Investigator<br />

2007-<strong>2008</strong> Wyeth Pharmaceuticals: Trial<br />

Evaluating the Safety, Tolerability,<br />

and Immunogenicity <strong>of</strong> Three Lots <strong>of</strong><br />

13-valent Pneumococcal Conjugate<br />

Vaccine in Healthy Infants, 6096A1-3005:<br />

Principal Investigator<br />

2007-<strong>2009</strong> GlaxoSmithKline: A Phase II Randomized,<br />

Observer Blind, Multicenter Study <strong>of</strong><br />

GlaxoSmithKline Biologicals’ Combined<br />

Measles-Mumps-Rubella-Varicella<br />

Vaccine (MMRV) Versus ProQuad,<br />

According to a One Dose Schedule,<br />

both Administered Subcutaneously<br />

at 12-14 months, MMRV-054: Principal<br />

Investigator<br />

<strong>2009</strong>-2010 Merck and Company: Safety, Tolerability<br />

and Immunogenicity <strong>of</strong> VARIVAX<br />

(2007 Commercial VZV Bulk Process)<br />

Administered Concomitantly with MMRII<br />

in Healthy Children 12-23 Months <strong>of</strong> Age,<br />

V210-057: Principal Investigator<br />

<strong>2008</strong>-2010 Novartis: A Phase I, Open Label,<br />

Randomized Multi-Center Study to<br />

Evaluate the Safety and Immunogenicity<br />

<strong>of</strong> ProQuad Vaccine When Administered<br />

Concomitantly with Novartis<br />

Meningococcal ACWY Conjugate Vaccine<br />

to Healthy Toddlers, Protocol # V59P21:<br />

Principal Investigator<br />

<strong>2008</strong>-2010 Novartis: A Phase 3b, Open-Label,<br />

Randomized, Parallel-Group,<br />

MultiCenter Study to Evaluate the Safety<br />

<strong>of</strong> Novartis MenACWY Conjugate Vaccine<br />

when Administered with Routine Infant<br />

Vaccinations to Healthy Infants, V59P23:<br />

Principal Investigator<br />

<strong>2008</strong>-<strong>2009</strong> Tibotec: A Phase II, Open-Label Trial<br />

to Evaluate the Safety, Tolerability<br />

and Antiviral Activity <strong>of</strong> TMC125 in<br />

Antiretroviral Experienced HIV-1 Infected<br />

Children and Adolescents, TMC125-<br />

TiDP35-C213: Principal Investigator<br />

2006-<strong>2009</strong> San<strong>of</strong>i Pasteur: An Immunogenicity,<br />

Safety, and Non-Interference Evaluation<br />

<strong>of</strong> Pediatric Vaccines Administered<br />

Concomitantly with Menactra ®<br />

(Meningococcal [Groups A, C, Y and<br />

W-135] Polysaccharide Diphtheria Toxoid<br />

Conjugate Vaccine) to Healthy Toddlers:<br />

MTA37: Principal Investigator


30 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

2006-<strong>2008</strong> An Immunogenicity and Safety<br />

Evaluation <strong>of</strong> Two Doses <strong>of</strong> Menactra®<br />

(Meningococcal [Groups A,C,Y and<br />

W-135] Polysaccharide Diphtheria Toxoid<br />

Conjugate Vaccine) Given to Healthy<br />

Subjects at 9 and 12 Months <strong>of</strong> Age<br />

(MTA44): Principal Investigator<br />

2006-<strong>2008</strong> Immunogenicity and Safety <strong>of</strong><br />

Meningococcal (Serogroups A,C,Y, and<br />

W-135) Polysaccharide Diphtheria Toxoid<br />

Conjugate Vaccine (Menactra) in Children<br />

Aged 4 to 6 Years in the US when<br />

Administered Concomitantly with a Fifth<br />

Dose Diphtheria and Tetanus Toxoids and<br />

Acellular Pertussis Vaccine Adsorbed,<br />

MTA 43: Principal Investigator<br />

2004-2010 New York State, <strong>Department</strong> <strong>of</strong> Health,<br />

AIDS Institute – Center <strong>of</strong> Excellence,<br />

Pediatric HIV Care.<br />

A Double Blind, Placebo-Controlled,<br />

Virologic Efficacy Trial <strong>of</strong> Pleconaril<br />

(VP63843) in the Treatment <strong>of</strong> Neonates<br />

with Enteroviral Sepsis Syndrome, NIH/<br />

NIAID/CASG 106<br />

A Phase III, Randomized, Placebo-<br />

Controlled, Blinded Investigation<br />

<strong>of</strong> Six Weeks Vs. Six Months Of Oral<br />

Valganciclovir Therapy In Infants<br />

With Symptomatic Congenital<br />

Cytomegalovirus Infection (NIH/NIAID/<br />

CASG 112) Protocol Number: 06-0046:<br />

Principal Investigator<br />

<strong>2008</strong>- A Phamacokinetic/Pharmacodynamic and<br />

Safety Evaluation <strong>of</strong> Oseltamivir (Tamiflu)<br />

for the Treatment <strong>of</strong> Children less<br />

than 24 Months <strong>of</strong> Age with Confirmed<br />

Influenza Infection (NIH/NIAID/CASG 114,<br />

Protocol# 06-0059): Principal Investigator<br />

<strong>2009</strong>- A Pharmacokinetic/Pharmacodynamic<br />

And Safety Evaluation Of Investigational<br />

Intravenous Peramivir In Children With<br />

Influenza Disease NIH/NIAID/CASG 117:<br />

Principal Investigator<br />

Domachowske JB<br />

<strong>2009</strong> GlaxoSmithKline<br />

Phase 3, observer-blind, randomized<br />

study to evaluate the immunogenicity<br />

and safety <strong>of</strong> FluLaval TF (GSK<br />

Biologicals) compared with Fluzone<br />

(San<strong>of</strong>i –Pasteur,Inc) administered<br />

intramuscularly in children 3 to 17 years<br />

<strong>of</strong> age in the US. Role: PI<br />

<strong>2009</strong>-2011 National Institutes <strong>of</strong> Health, NIAID. The<br />

Innate Immune Shield: Lactobacillus<br />

species promote resistance to the lethal<br />

sequelae <strong>of</strong> respiratory virus infection.<br />

Role: Collaborator<br />

<strong>2009</strong>- Medimmune Research Grant<br />

Respiratory events among premature<br />

infants (32-36 week GA): Outcomes and<br />

risk tracking study Role: PI<br />

<strong>2009</strong>- Medimmune Research Grant<br />

A Phase 1/2a, Randomized, Double-Blind,<br />

Placebo-Controlled Study to Evaluate<br />

the Safety, Tolerability, Immunogenicity,<br />

and Viral Shedding <strong>of</strong> MEDI-559, a Live<br />

Attenuated Intranasal Vaccine Against<br />

Respiratory Syncytial Virus in Healthy 1 to<br />


Bi-Annual <strong>Report</strong> • 31<br />

NEPHROLOGY<br />

FACULTY<br />

James Listman, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Scott Schurman, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Section Head<br />

Thomas Welch, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Chairman,<br />

<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

AFFILIATED CLINICAL STAFF<br />

Susan Sheffield, PNP, Nurse Practitioner and Coordinator<br />

Voiding Improvement Program<br />

Vickie Keeler, RN, BSN, MA<br />

AFFILIATED RESEARCH STAFF<br />

Lisa W. Blystone, MS, Instructional Support Specialist<br />

JoAnne E. Race, MS, Instructional Support Specialist<br />

CLINICAL OVERVIEW<br />

The Section <strong>of</strong> Nephrology provides inpatient<br />

consultation and acute dialysis care, including peritoneal<br />

dialysis, hemodialysis, and hem<strong>of</strong>iltration at the Upstate<br />

Golisano Children’s Hospital. Outpatient dialysis care,<br />

both peritoneal dialysis and hemodialysis, is provided<br />

at the University Dialysis Center in Syracuse. Other<br />

outpatient services are provided at our primary site in<br />

Syracuse, 725 Irving Ave., Suite 401, and satellite facilities<br />

in Watertown (Dr. Listman), Utica (Dr. Schurman), and<br />

Binghamton (Dr. Welch).<br />

The section evaluates and treats infants, children, and<br />

adolescents with the full spectrum <strong>of</strong> disorders <strong>of</strong> the<br />

urinary tract. This activity includes bread and butter<br />

nephrology, disorders such as nephrotic syndrome,<br />

glomerulonephritis, and all stages <strong>of</strong> chronic renal<br />

insufficiency. However, the section’s activity has few<br />

limits. We have an established expertise in the diagnosis<br />

and treatment <strong>of</strong> children with hypertension, including<br />

24 hour ambulatory blood pressure monitoring. We<br />

care for patients with mineral metabolism disorders<br />

and metabolic bone disease, including inherited and<br />

acquired forms <strong>of</strong> rickets, osteogenesis imperfecta, and<br />

osteoporosis. Metabolic evaluations <strong>of</strong> children with<br />

urolithiasis are performed, stressing dietary measures<br />

that can minimize risk <strong>of</strong> recurrence.<br />

The section provides coordinated care to infants and<br />

children with simple and complex urologic abnormalities,<br />

including prenatal visits. Patients with congenital or<br />

other hydronephrosis and vesicoureteral reflux are<br />

evaluated and followed. When necessary, urologic<br />

intervention is accessed.<br />

In addition, the section has attempted to address the<br />

growing number <strong>of</strong> children with voiding dysfunction,<br />

particularly children with associated daytime urinary<br />

urgency/incontinence and recurrent urinary tract<br />

infections. This effort, the “Voiding Improvement<br />

Program” (VIP) is coordinated by our pediatric nurse<br />

practitioner and nephrology nurse specialist, Susan<br />

Sheffield and Vickie Keeler. A multimodal approach to<br />

treatment is employed, including dietary, behavioral<br />

modification, and medication therapy.<br />

RESEARCH HIGHLIGHTS<br />

Role <strong>of</strong> Local Complement Synthesis in the<br />

Kidney<br />

Dr. Welch’s laboratory has continued its study <strong>of</strong><br />

novel roles for the human complement system in<br />

progressive renal disease. The role <strong>of</strong> activation and<br />

deposition <strong>of</strong> serum complement in the glomerulus<br />

as a major mediator <strong>of</strong> glomerulonephritis has long<br />

been established. We were the first laboratory to<br />

demonstrate that the human kidney itself could be a<br />

source <strong>of</strong> a number <strong>of</strong> complement components and<br />

that activation <strong>of</strong> these components in the peritubular<br />

interstitium was a major mediator <strong>of</strong> progressive renal<br />

damage.<br />

Over the past few years, we have developed a murine<br />

model <strong>of</strong> chronic immune complex glomerulonephritis<br />

and have used animals lacking various complement<br />

components as a mechanism for dissecting the specific<br />

role <strong>of</strong> complement in this process. We have further<br />

demonstrated that expression <strong>of</strong> the third component<br />

<strong>of</strong> complement, C3, is differentially regulated in the<br />

kidney and the liver. This has opened the possibility<br />

<strong>of</strong> specifically targeting renal complement expression<br />

without interfering with the important role <strong>of</strong> the<br />

complement cascade in the systemic immune response.<br />

We are now using the technique <strong>of</strong> gene expression<br />

analysis through microarray in order to examine<br />

differences in gene expression pr<strong>of</strong>iles between wild<br />

type animals and those lacking specific complement<br />

components. This is permitting us to understand<br />

the downstream molecular mechanisms by which<br />

peritubular complement activation induces renal<br />

damage.<br />

Finally, we have very recently been investigating ways in<br />

which progressive interstitial scarring can be attenuated.<br />

We have now shown in our murine model that<br />

angiotensin converting enzymes (ACE) inhibitors have a<br />

very important effect in attenuating interstitial injury in<br />

this model. Examining this effect in various complement<br />

deficient animals suggests preliminarily that this effect is<br />

mediated by a non-complement-dependent mechanism.<br />

Further examination <strong>of</strong> microarray data will allow us to<br />

explore more deeply the interplay between the many<br />

inflammatory cascades participating in renal damage.<br />

The ultimate goal <strong>of</strong> this would be to identify important<br />

pathways to target pharmacologically.


32 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Development <strong>of</strong> Novel Inhibitors <strong>of</strong><br />

Inflammation<br />

The major goal <strong>of</strong> Dr. Listman’s laboratory is to define<br />

small molecules that will specifically inhibit transcritpion<br />

<strong>of</strong> the IL-1b gene. IL-1b is a potent cytokine with diverse<br />

roles in inflammation including induction <strong>of</strong> the acute<br />

phase response, activation <strong>of</strong> the cellular components<br />

<strong>of</strong> acquired immunity, and promotion <strong>of</strong> chronic<br />

inflammation. Thus, inhibiting IL-1b expression (and<br />

other similarly regulated cytokines like TNFa) has major<br />

therapeutic potential for the treatment <strong>of</strong> a variety <strong>of</strong><br />

disease states including sepsis, arthritis, autoimmune<br />

diseases and transplant rejection among others.<br />

To accomplish our goal, the laboratory is investigating the<br />

structural/functional interactions <strong>of</strong> several transcription<br />

factors that regulate the IL-1b gene. These include Spi-1<br />

and C/EBPb, which are endogenous regulators <strong>of</strong> the<br />

IL-1b promoter, and the exogenous regulator Immediate-<br />

Early 2 (IE2) protein <strong>of</strong> Cytomegalovirus (CMV). The IE2<br />

protein provides a powerful tool for our task because<br />

it is a potent regulator <strong>of</strong> numerous host genes besides<br />

IL-1b, including TNFa, IL-8 and IL-2. Our laboratory<br />

is investigating the structural interactions that allow<br />

IE2 to participate with Spi-1 and C/EBPb to induce IL-1b<br />

expression. By narrowing down the peptide or, better<br />

yet, amino acid interactions between these molecules<br />

we hope to devise mimetic peptides would lack the<br />

major functional components <strong>of</strong> the parent molecule,<br />

but retain ability to bind to ligand, thus, interfering<br />

with the normal productive interactions that permit<br />

gene transcription. This goal is achieved by utilizing a<br />

combination <strong>of</strong> functional and biochemical techniques<br />

including recombinant DNA technology, gene reporter<br />

assays, and NMR spectroscopy, among others.<br />

Thus far, we identified a 14-residue fragment <strong>of</strong> the IE2<br />

molecule can function in a dominant negative manner to<br />

inhibit IL-1b promoter activity in heterologous systems.<br />

We are currently performing confirmatory analyses in<br />

CMV infected monocytic cell lines and in LPS activated<br />

monocytes to determine the effectiveness <strong>of</strong> this<br />

technology.<br />

PUBLICATIONS<br />

Listman JA, Race JE, Walker-Kopp N, Unlu S, Auron PE.<br />

Molecular Immunology 45(9), 2667, <strong>2008</strong>.<br />

Listman JA, Schurman SJ. Vasculitis. In: Kiessling,<br />

S. G., Goebel, J., and Somers, M. J. G. (eds). Pediatric<br />

Nephrology in the ICU, Springer, <strong>2008</strong>.<br />

Welch TR, Blystone LW. Immune complex<br />

glomerulonephritis following bone marrow<br />

transplantation in C3 deficient mice. PLoS ONE, Oct<br />

6;3(10):e3334, <strong>2008</strong>.<br />

Schurman SJ, Welch TR. Treatment <strong>of</strong> severe<br />

gentamicin overdose in a child with hemodialysis.<br />

Pediatr Nephrol, 26:211-213, <strong>2009</strong>.<br />

Welch TR, Berman D, Clement K. Wilderness first aid: Is<br />

there an industry standard? Wilderness Environ Med,<br />

20:113-117, <strong>2009</strong>.<br />

Welch TR, Blystone, LW. Renal disease associated with<br />

inherited disorders <strong>of</strong> the complement system. Pediatr<br />

Nephrol, 24:1439-1444, <strong>2009</strong>.<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS<br />

Welch TR, Miner B, Page N, Nimeh J. Implementation<br />

<strong>of</strong> ‘Patient Safety Rounds’ in Pediatric Inpatient Units,<br />

Pediatric Academic Socieities Annual Meeting, Baltimore,<br />

MD, <strong>2009</strong>.<br />

Welch TR, Blystone L, Gentile K, Middleton F. ACE<br />

Inhibition Attenuates Interstitial Injury in a Murine Model<br />

<strong>of</strong> Chronic Immune Complex Glomerulonephritis.<br />

Pediatric Academic Socieities Annual Meeting, Baltimore,<br />

MD, <strong>2009</strong>.<br />

HONORS, VISITING PROFESSORSHIPS,<br />

EDITORIAL DUTY<br />

Welch TR: Associate editor, the Journal <strong>of</strong> <strong>Pediatrics</strong><br />

Welch TR: Visiting Pr<strong>of</strong>essor, Columbia University,<br />

<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong>, New York, NY, September,<br />

<strong>2008</strong>.<br />

INVITED WORKSHOPS, CME PRESENTATIONS<br />

Welch TR. Manuscript Preparation for Peer Reviewed<br />

Publication workshop, Southern Society for Pediatric<br />

Research Annual Meeting, Atlanta, GA, February, <strong>2008</strong>.<br />

Welch TR. Manuscript Preparation for Peer Reviewed<br />

Publication workshop, Southern Society for Pediatric<br />

Research Annual Meeting, New Orleans, LA, February,<br />

<strong>2009</strong>.<br />

Welch TR. Ethical Issues in Manuscript Preparation<br />

and Publishing – A Round-Table Discussion. Pediatric<br />

Academic Socieities Annual Meeting, Baltimore, MD, <strong>2009</strong>.<br />

Welch TR. What are These Mysterious Things Called<br />

RVU’s? Pediatric Academic Socieities Annual Meeting,<br />

Baltimore, MD, <strong>2009</strong>.<br />

SELECTED CLINICAL DATA<br />

Outpatient visits, <strong>2008</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . 2,704<br />

Outpatient visits, <strong>2009</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . 2,653<br />

Inpatient visits, <strong>2008</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 648<br />

Inpatient visits, <strong>2009</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 564<br />

Inpatient dialysis procedures, <strong>2008</strong>:. . . . . . . . . . . . . . . . . . 128<br />

Inpatient dialysis procedures, <strong>2009</strong>:. . . . . . . . . . . . . . . . . . . 79<br />

Kidney transplants, <strong>2008</strong>-<strong>2009</strong>:. . . . . . . . . . . . . . . . . . . . . . . . 9


Bi-Annual <strong>Report</strong> • 33<br />

NEURODEVELOPMENTAL PEDIATRICS<br />

FACULTY<br />

Nienke Dosa, MD, MPH, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Gregory Liptak, MD, MPH, Upstate Foundation Pr<strong>of</strong>essor<br />

<strong>of</strong> Development, Division Director<br />

Louis Pellegrino, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Carol Grant, PhD, Clinical Assistant Pr<strong>of</strong>essor<br />

Henry Roane, PhD, Associate Pr<strong>of</strong>essor, Psychiatry and<br />

Behavioral Sciences, <strong>Pediatrics</strong><br />

Terry Hargrave, MD, MPH, Assistant Pr<strong>of</strong>essor, Psychiatry<br />

and Behavioral Sciences, <strong>Pediatrics</strong><br />

AFFILIATED CLINICAL STAFF<br />

Susan Delaney, FNP<br />

Mary MacBlane, RNC, PNP<br />

CLINICAL OVERVIEW<br />

The Center for Development, Behavior and Genetics<br />

provides evaluation, treatment, and management services<br />

for children and adolescents with developmental delays<br />

and disabilities. Outpatient clinical services are located<br />

in the Physician Office Building, Suite 112. These include<br />

interdisciplinary programs in Autism Spectrum Disorders,<br />

Child Development, Clinical Genetics, Inherited<br />

Metabolic Diseases (accredited by New York State),<br />

Physical Disabilities, and Spina Bifida. Dr. Nienke Dosa<br />

focuses on the care <strong>of</strong> children with physical disabilities,<br />

Dr. Louis Pellegrino focuses on children with cognitive<br />

challenges, while Dr. Liptak provides care for children<br />

with cognitive disorders and physical disabilities. Genetic<br />

services are also provided under the umbrella <strong>of</strong> this<br />

program, and are described separately in the “Genetics”<br />

section.<br />

Dr. Dosa directs the Physical Disabilities Program for<br />

children with cerebral palsy and those who other<br />

physical disabilities. She also directs the Spina Bifida<br />

Clinic. Dr. Pellegrino directs the Autism Spectrum<br />

Program and the Child Development Program, which<br />

includes children with developmental delays from other<br />

causes.<br />

In addition, the Center is staffed by two nurse<br />

practitioners, Mary MacBlane, RNC, PNP, and Susan<br />

Delaney, FNP; they provides care for patients with<br />

metabolic disorders (MM) and developmental disabilities<br />

(both). The Center also has pr<strong>of</strong>essionals in pediatric<br />

nursing, nutrition, occupational therapy, and social<br />

work. Pediatric specialists in orthopaedics, psychiatry,<br />

neurosurgery, and urology provide on-site consultation.<br />

Most recently, the team has been joined by Drs.<br />

Henry Roane and Terry Hargrave, faculty with joint<br />

appointments in <strong>Pediatrics</strong> and Psychiatry.<br />

PROGRAMS<br />

The Child Development Program <strong>of</strong>fers diagnostic,<br />

management and counseling services to the families<br />

<strong>of</strong> children with a variety <strong>of</strong> neurodevelopmental<br />

concerns, including the autistic spectrum disorders,<br />

cognitive and learning disabilities, speech and language<br />

disorders, attention deficit hyperactivity disorder, motor<br />

coordination disorders, and Down syndrome. Children<br />

from birth through the teenage years are served through<br />

the program. Diagnostic evaluations are provided<br />

by Drs. Liptak and Lou Pellegrino, both <strong>of</strong> whom are<br />

certified in general pediatrics and neurodevelopmental<br />

pediatrics. Special, standardized testing is employed in<br />

the assessment <strong>of</strong> children on the autistic spectrum. The<br />

physicians, with the support <strong>of</strong> Mary MacBlane and Susan<br />

Delaney, also provide ongoing support and management<br />

<strong>of</strong> children with a variety <strong>of</strong> neurodevelopmental<br />

disorders, including targeted medication management<br />

when appropriate. Amy Beale, a social worker at Upstate<br />

Medical University’s Psychiatry <strong>Department</strong>, provide<br />

behavioral assessment, counseling services and support<br />

for the development <strong>of</strong> social-adaptive skills, targeting<br />

children less than 6 years <strong>of</strong> age.<br />

The Physical Disability Program provides specialty care to<br />

children who are multiply disabled by conditions such as<br />

cerebral palsy, vision impairment/blindness, and genetic<br />

disorders. The focus is on habilitation. Some children<br />

may be referred for a single visit, such as spasticity<br />

evaluation and management, including injections with<br />

botulinum toxin (Botox), while other children may<br />

receive ongoing care for complex medical problems.<br />

The program <strong>of</strong>fers a multidisciplinary approach and<br />

addresses both medical and behavioral/developmental<br />

issues. It helps to establish a diagnosis and to develop<br />

a care plan. The Physical Disability Program <strong>of</strong>fers an<br />

interdisciplinary approach and collaboration with other<br />

pediatric specialists and surgeons. The program is staffed<br />

by Dr. Dosa who is board-certified in pediatrics and in<br />

neurodevelopmental disabilities, and pr<strong>of</strong>essionals in<br />

occupational therapy, physical therapy, nutrition, and<br />

specialty nursing.<br />

The Spina Bifida Center <strong>of</strong> Central New York provides<br />

comprehensive specialty care to children and<br />

adolescents with spina bifida. The center is staffed by<br />

Dr. Dosa who is board-certified in pediatrics and in<br />

neurodevelopmental disabilities, and pr<strong>of</strong>essionals in<br />

physiatry, occupational therapy, physical therapy, social<br />

work, nutrition, and specialty nursing. Our focus is on<br />

wellness and the prevention <strong>of</strong> secondary conditions.<br />

The Spina Bifida program schedules screening studies<br />

as needed and coordinate care with surgical subspecialists<br />

in neurosurgery, orthopaedics and urology.<br />

It also collaborates with specialists in wound care and<br />

facilitates the ordering <strong>of</strong> adaptive equipment. It <strong>of</strong>fers a<br />

multidisciplinary approach and address both medical and<br />

behavioral/developmental issues. In collaboration with


34 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

faculty from SUNY Cortland, Dr. Dosa has developed a<br />

Group Visit Model for individuals with spina bifida.<br />

In collaboration with faculty in adapted physical<br />

education from SUNY Cortland, Dr. Dosa has developed<br />

a Group Visit Model for individuals with spina bifida,<br />

cerebral palsy, and other motor disabilities. Group<br />

Visits focus on adapted sports and physical activity for<br />

the entire family. Group Visits take place at a state-<strong>of</strong>the-art<br />

gym and pool facility at the Institute for Human<br />

Performance on the SUNY Upstate campus.<br />

RESEARCH HIGHLIGHTS<br />

Dr. Dosa’s work is focused on improving communitybased<br />

health services for children and adolescents with<br />

disabilities and complex medical conditions, especially<br />

as they transition from adolescence to adulthood. She<br />

heads the New York State Institute for Health Transition<br />

Training (www.HealthyTransitionsNY.org) and coordinates<br />

the Parent Partners in Health Education home visit<br />

program for residents in pediatrics, psychiatry and<br />

family medicine. She is collaborating with the Family<br />

Medicine <strong>Department</strong> on a funded grant entitled, “Center<br />

for Excellence in Primary Care,” whose purpose is to<br />

increase the knowledge <strong>of</strong> primary care providers in<br />

areas <strong>of</strong> developmental pediatrics. She is part <strong>of</strong> a multiinstitutional<br />

study, funded by the NIH, to evaluate the<br />

safety and efficacy <strong>of</strong> oral Bacl<strong>of</strong>en in children who have<br />

cerebral palsy.<br />

Dr. Liptak is interested in researching the health services<br />

received by children who have special needs. He<br />

completed a project that examined the use <strong>of</strong> group<br />

visits in children with vision impairments to evaluate its<br />

feasibility as a model <strong>of</strong> care. He currently is analyzing<br />

data from the National Longitudinal Transition Study-2<br />

to evaluate the transitions <strong>of</strong> adolescents who have<br />

spina bifida as well as those who have autism. He is<br />

working on the clinical trial <strong>of</strong> Bacl<strong>of</strong>en with Dr. Dosa, and<br />

serves as an epidemiological consultant to NASPGHAN<br />

(North American Society for Pediatric Gastroenterology<br />

Hepatology and Nutrition).<br />

PUBLICATIONS<br />

Original Scientific Articles<br />

Liptak GS, Benzoni LB, Mruzek DW, Nolan KW, Thingvoll<br />

MA, Wade CM, Fryer GE. Disparities in diagnosis and<br />

utilization <strong>of</strong> health services for children with autism:<br />

Data from the National Survey <strong>of</strong> Children’s Health.<br />

Journal <strong>of</strong> Developmental and Behavioral <strong>Pediatrics</strong>. <strong>2008</strong><br />

Jun;29(3):152-60.<br />

Dosa NP, Foley JT, Eckrich M, Woodall-Ruff D, Liptak GS.<br />

Obesity across the lifespan among persons with spina<br />

bifida. Disabil Rehabil. <strong>2008</strong> Nov 26:1-7.<br />

Reviews<br />

Liptak GS. Health and well being <strong>of</strong> adults with cerebral<br />

palsy. Current Opinion in Neurology. <strong>2008</strong>;21:136–142.<br />

Pierce K, Glatt SJ, Liptak GS, McIntyre LL. The power<br />

and promise <strong>of</strong> identifying autism early: insights from<br />

the search for clinical and biological markers. Ann Clin<br />

Psychiatry. <strong>2009</strong> Jul-Sep;21(3):132-47.<br />

Vandenplas Y, Rudolph CD, Di Lorenzo C, Hassall<br />

E, Liptak GS, Mazur M, Sondheimer J, Staiano A,<br />

Thomson M, Veereman-Wauters G, Wenzl TG. Pediatric<br />

Gastroesophageal Reflux Clinical Practice Guidelines:<br />

Joint Recommendations <strong>of</strong> the North American Society<br />

for Pediatric Gastroenterology, Hepatology, and Nutrition<br />

(NASPGHAN) and the European Society for Pediatric<br />

Gastroenterology, Hepatology, and Nutrition (ESPGHAN).<br />

Journal <strong>of</strong> Pediatric Gastroenterology and Nutrition,<br />

<strong>2009</strong>;49:498–547.<br />

Dosa NP, Mukherjee S, Tovar-Spinoza Z. Spina Bifida and<br />

Neural Tube Defects. BMJ Point <strong>of</strong> Care, November <strong>2009</strong>.<br />

Reviews with American Academy <strong>of</strong> <strong>Pediatrics</strong><br />

Council on Children with Disabilities (Dr. Liptak)<br />

Murphy NA, Carbone PS; American Academy <strong>of</strong> <strong>Pediatrics</strong><br />

Council on Children With Disabilities. Promoting the<br />

participation <strong>of</strong> children with disabilities in sports,<br />

recreation, and physical activities. <strong>Pediatrics</strong>. <strong>2008</strong><br />

May;121(5):1057-61.<br />

Desch LW, Gaebler-Spira D; Council on Children With<br />

Disabilities. Prescribing assistive-technology systems:<br />

focus on children with impaired communication.<br />

<strong>Pediatrics</strong>. <strong>2008</strong> Jun;121(6):1271-80.<br />

Council on Children With Disabilities. From the American<br />

Academy <strong>of</strong> <strong>Pediatrics</strong>: Policy statements--Supplemental<br />

Security Income (SSI) for children and youth with<br />

disabilities. <strong>Pediatrics</strong>. <strong>2009</strong> Dec;124(6):1702-8.<br />

Books and Book Chapters<br />

Dosa NP, Liptak GS. School Related Issues for Children<br />

with Special Needs. In: McInerny TK, Adam HM, Campbell<br />

D, Kamat DK, Kelleher KJ, Eds. American Academy <strong>of</strong><br />

<strong>Pediatrics</strong> Textbook <strong>of</strong> Pediatric Care. Elk Grove Village,<br />

IL. American Academy <strong>of</strong> <strong>Pediatrics</strong>; <strong>2009</strong>, pp. 588-592 .<br />

Liptak GS. Diaper rash. In: McInerny TK, Adam HM,<br />

Campbell D, Kamat DK, Kelleher KJ, Eds. American<br />

Academy <strong>of</strong> <strong>Pediatrics</strong> Textbook <strong>of</strong> Pediatric Care. Elk<br />

Grove Village, IL. American Academy <strong>of</strong> <strong>Pediatrics</strong>; <strong>2009</strong>,<br />

pp. 2010-2016.<br />

Liptak GS. Spina bifida. In: McInerny TK, Adam HM,<br />

Campbell D, Kamat DK, Kelleher KJ, Eds. American<br />

Academy <strong>of</strong> <strong>Pediatrics</strong> Textbook <strong>of</strong> Pediatric Care . Elk<br />

Grove Village, IL. American Academy <strong>of</strong> <strong>Pediatrics</strong>; <strong>2009</strong>,<br />

pp2537-2545.<br />

Liptak GS. Cerebral palsy. In: McInerny TK, Adam HM,<br />

Campbell D, Kamat DK, Kelleher KJ, Eds. American<br />

Academy <strong>of</strong> <strong>Pediatrics</strong> Textbook <strong>of</strong> Pediatric Care . Elk<br />

Grove Village, IL. American Academy <strong>of</strong> <strong>Pediatrics</strong>; <strong>2009</strong>,<br />

pp 1903-1910.<br />

Liptak GS. Chromosomal abnormalities. In Beers MH.<br />

Ed. The Merck Manual <strong>of</strong> Medical Information: Second<br />

Home Edition. Whitehouse Station, NJ: Merck Research


Bi-Annual <strong>Report</strong> • 35<br />

Laboratories, <strong>2009</strong>, http://www.merck.com/mmpe/sec19/<br />

ch294/ch294a.html.<br />

Osterlund CA, Dosa NP, Arnott-Smith CA. Mother knows<br />

best: What role do patients with chronic conditions<br />

and parents play in the management <strong>of</strong> their medical<br />

information? In The Informatics <strong>of</strong> Diabetes: A Research<br />

Agenda for the Socially and Institutionally Sensitive<br />

Use <strong>of</strong> Information Technology to Improve Healthcare,<br />

Barbara M. Hayes and William Aspray, editors. MIT Press,<br />

<strong>2009</strong>.<br />

Other<br />

Educational DVDs<br />

Dosa NP, Judd-Litera K, Nellis J, LaMacchia S, LaValley<br />

R. Special Needs Advocacy Partners: (a) Preparing Your<br />

Child For Surgery (b) What We Can Do To Make Your<br />

Hospital Stay Better. Instructional DVD, published<br />

August <strong>2009</strong> in collaboration with Child Life Service at<br />

Golisano Childrens Hospital at SUNY Upstate Medical<br />

University with grant support from the New York State<br />

Developmental Disabilities Planning Council.<br />

Cleary D and Dosa NP. Collaboration for Orientation and<br />

Mobility at the Elementary School Level. Instructional<br />

DVD, published May <strong>2009</strong> in collaboration with Syracuse<br />

City School District and Syracuse University School <strong>of</strong><br />

Education. Distributed state-wide to teachers for visually<br />

impaired children with grant support from the New York<br />

State Developmental Disabilities Planning Council.<br />

Cleary D, Dosa NP, Foley JT, Lieberman L. Liptak GS,<br />

MacBlane M, Welch T. (A SUNY Upstate-SUNY Cortland-<br />

SUNY Brockport collaboration) Sport Opportunities<br />

and Activities for Children with Visual Impairments.<br />

Instructional DVD, published October <strong>2008</strong> and on the<br />

internet at http://www.campabilitiesbrockport.org/Camp-<br />

Video.html. DVD distributed state-wide to adaptive<br />

physical education instructors with grant support from<br />

Children’s Miracle Network.<br />

Liptak GS. Medical home optimizes care for children with<br />

cerebral palsy. AAP News <strong>2009</strong>(September):15.<br />

Liptak GS. Reviewer and Contributor to Shelov SP. Ed.<br />

Caring for Your Baby And Young Child: Birth To Age 5.<br />

American Academy <strong>of</strong> <strong>Pediatrics</strong>, Bantam Books. <strong>2009</strong>.<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS<br />

Liptak GS, Foley JT, Dosa NP, Cleary D, Welch TR,<br />

Columna L. A group visit model program for children<br />

who are blind/visually impaired. Poster presented at the<br />

Association for Education and Rehabilitation <strong>of</strong> the Blind<br />

and Visually Impaired (AER) International Meeting July 22-<br />

27, <strong>2008</strong>, Chicago.<br />

Liptak GS, Worley G. The year’s top ten articles on<br />

developmental disabilities. Instructional Course<br />

presented at the American Academy <strong>of</strong> Cerebral Palsy<br />

and Developmental Medicine annual meeting, Atlanta,<br />

GA, September 19, <strong>2008</strong>.<br />

Liptak GS. Complications <strong>of</strong> botulinum toxin. Invited<br />

Presidential Guest Speaker. Presented at the American<br />

Academy <strong>of</strong> Cerebral Palsy and Developmental Medicine<br />

annual meeting, Atlanta, GA, September 20, <strong>2008</strong>.<br />

Liptak GS, Murphy N. Controversies and Challenges<br />

for Children and Youth with Disabilities: The Ashley<br />

Treatment: A Cry for Help. Presented at the American<br />

Academy <strong>of</strong> <strong>Pediatrics</strong> National Conference and<br />

Exposition. Boston, MA, October 11, <strong>2008</strong>.<br />

Liptak GS, Foley JT, Dosa NP, Cleary D, Welch TR,<br />

Columna L. Group Visits Model: A Collaborative<br />

Perspective in Adapted Physical Education. Research<br />

Consortium presentation at the <strong>2009</strong> AAHPERD National<br />

Convention in Tampa, Florida; April 1, <strong>2009</strong>.<br />

Dosa NP, Osterlund C, Tamburo J, Morley C, Beatty P,<br />

Epling J, Liptak GS. Curriculum and Interactive Tools<br />

to Facilitate Health Care Transition <strong>of</strong> Youth with<br />

Developmental Disabilities. Poster presented at the Spina<br />

Bifida World Congress, Orlando, Florida, March 16-19,<br />

<strong>2009</strong>.<br />

MacBlane ME, Garver K, Hodge J, Mahunik A, Davis T,<br />

Columna L, Foley J, Dosa NP, Liptak GS. A Group Visit<br />

Model Program for Children with Spina Bifida. Poster<br />

presented at the Spina Bifida World Congress, Orlando,<br />

Florida, March 16-19, <strong>2009</strong>.<br />

Liptak GS, Kennedy JA, Dosa NP. Youth with Spina Bifida<br />

and Transitions: Using the WHO ICF Model in a Nationally<br />

Representative Sample. Poster presented at the Spina<br />

Bifida World Congress, Orlando, Florida, March 16-19,<br />

<strong>2009</strong>. Platform presentation at the American Academy<br />

<strong>of</strong> Cerebral Palsy and Developmental Medicine annual<br />

meeting, Scottsdale, Arizona, September 24, <strong>2009</strong>.<br />

Liptak GS. Disease Management and 10 Simple Rules for<br />

the 21st Century Health Care System. Presented at the<br />

Spina Bifida World Congress, Orlando, Florida, March 16,<br />

<strong>2009</strong>.<br />

Liptak GS. Health care and spina bifida: the canary in the<br />

coal mine. Keynote address. Presented at the Spina Bifida<br />

World Congress, Orlando, Florida, March 18, <strong>2009</strong>.<br />

Liptak GS, Kennedy JA, Dosa NP. Youth with Autism and<br />

Transitions: Using the WHO ICF Model in a Nationally<br />

Representative Sample. Platform presentation at the<br />

American Academy <strong>of</strong> Cerebral Palsy and Developmental<br />

Medicine annual meeting, Scottsdale, Arizona, September<br />

24, <strong>2009</strong>.<br />

Liptak GS, Worley G. The year’s top ten articles on<br />

developmental disabilities. Instructional Course<br />

presented at the American Academy <strong>of</strong> Cerebral Palsy<br />

and Developmental Medicine annual meeting, Scottsdale,<br />

AZ, September 24, <strong>2009</strong>.<br />

Liptak GS, O’Donnell M. To screen or not to screen for<br />

autism. Plenary presentation at the American Academy<br />

<strong>of</strong> Cerebral Palsy and Developmental Medicine annual<br />

meeting, Scottsdale, AZ, September 25, <strong>2009</strong>.<br />

Liptak GS, Myers SM. Beyond Developmental Screening:<br />

Office Management <strong>of</strong> the Child with a Developmental<br />

Disability in the Primary Care Medical Home. Presented<br />

at the National Conference and Exhibition, American


36 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Academy <strong>of</strong> <strong>Pediatrics</strong>, Washington, DC, October 17 and<br />

18, <strong>2009</strong>.<br />

Dosa NP, Slaski P, James L. HealthyTransitionsNY.org<br />

curriculum and toolkit, Instructional Course, American<br />

Academy <strong>of</strong> Cerebral Palsy and Developmental Medicine,<br />

Phoenix Arizona, September 24, <strong>2009</strong>.<br />

Dosa NP, Webb T, Walters C,Worley G, Nolan K,<br />

Armstrong J, Boerger P, Hulse C, Dias M, Olson A, Liptak<br />

GS. Assessment <strong>of</strong> Spina Bifida Care for Adolescents:<br />

A Quality Improvement Tool for Spina Bifida Centers.<br />

Spina Bifida World Congress, abstracts with programs,<br />

Orlando, Florida, March 16-19, <strong>2009</strong>.<br />

Dosa NP, Transition and Adult Health Care, plenary panel,<br />

Spina Bifida World Congress, Orlando, Florida, March 17,<br />

<strong>2009</strong>.<br />

Morley C, Dosa NP, Jain S, Kelly B, Jurczyck I, Reiss J,<br />

Winslow M, Boyd D, Tamburo J, Transition Planning<br />

and Management Continuity <strong>of</strong> Care for Youth with<br />

Developmental Disabilities. Panel discussion, 35th<br />

Annual Predoctoral Education Conference, Society <strong>of</strong><br />

Teachers <strong>of</strong> Family Medicine, Savannah, Ga, January 23,<br />

<strong>2009</strong>.<br />

INVITED WORKSHOPS, CME PRESENTATIONS<br />

Pellegrino L. Sensory Integration Dysfunction. <strong>2009</strong><br />

Menichello Teaching Day, Wilson Hospital, Johnson City,<br />

New York (Regional Conference), May <strong>2009</strong><br />

Dosa NP and Columna L. Promoting Physical Activity for<br />

Children with Vision Impairment/Blindness. Onondaga-<br />

Cortland-Madison BOCES annual conference for<br />

Teachers for the Visually Impaired. Syracuse, NY. April 2,<br />

<strong>2008</strong>.<br />

Pellegrino L, Liptak GS, McIntyre LL, Magyar CI.<br />

Understanding Individuals With Asperger’s Syndrome<br />

or High Functioning Autism in New York. Syracuse, NY,<br />

December 10, <strong>2008</strong>. Sponsored by Lorman Education<br />

Services.<br />

Dosa NP and Columna L. Promoting Physical Activity for<br />

Children with Vision Impairment/Blindness. Onondaga-<br />

Cortland-Madison BOCES annual conference for<br />

Teachers for the Visually Impaired. Syracuse, NY. April 2,<br />

<strong>2008</strong>.<br />

Dosa NP and Epling J. Making Health Transitions Caring<br />

for Young Adults with Disabilities. 37th Annual Family<br />

Medicine Refresher Course. SUNY Upstate <strong>Department</strong><br />

<strong>of</strong> Family Medicine, Syracuse, NY, March 29, <strong>2008</strong>.<br />

Pellegrino L. Autism Spectrum Disorders: What We Think<br />

We Know. <strong>2008</strong> Menichello Teaching Day, Wilson Hospital,<br />

Johnson City, New York (Regional Conference), May <strong>2008</strong><br />

GRANTS<br />

NICHD/NIH Contract No. HHSN267200603421C. (Janice<br />

Brunstrum, MD, PI [St. Louis University]) 9/1/<strong>2009</strong> -<br />

8/31/2010. Bacl<strong>of</strong>en for spasticity [Clinical trial]. ($36,000<br />

plus enrollment).<br />

Competency in Transition for Physicians in Training, New<br />

York-Mid Atlantic Consortium for Genetic and Newborn<br />

Screening Services Grant. Robert Ostrander MD, Kim<br />

Garver MSW, Nienke Dosa MD, MPH 32,000 (2010).<br />

Fit Families Group Visits: Physical Activity and Medical<br />

Services for Hispanic and Caucasian Children with<br />

Spina Bifida and their Families, Christopher and Dana<br />

Reeve Foundation Quality <strong>of</strong> Life Award, Co-Principal<br />

Investigator with Luis Columna, PhD <strong>Department</strong> <strong>of</strong><br />

Adapted Physical Education, SUNY Cortland, $6000<br />

(<strong>2009</strong>).<br />

Center for Excellence in Primary Care (HRSA AAU Grant<br />

Award Number 2 D54HP05462-04-00). September<br />

<strong>2008</strong>-August 2011. ($858,000) 0.10 FTE.<br />

Parent Partners in Health Education. (Principal<br />

Investigator, 0.1 FTE) New York State Developmental<br />

Disabilities Planning Council: 2006-<strong>2009</strong>: $135,000.<br />

New York State Institute for Health Transition Training<br />

for Youth with developmental Disabilities, (Principal<br />

Investigator, 0.2 FTE) New York State Developmental<br />

Disabilities Planning Council: 2006-2010: $580,000.<br />

Group Visits for Children with Spina Bifida. American<br />

Legion Auxiliary (in collaboration with SUNY Cortland<br />

Adapted Physical Education <strong>Department</strong>), <strong>2008</strong>: $2,500.<br />

Usability Testing <strong>of</strong> Healthy Transitions Network<br />

s<strong>of</strong>tware via Model High School Transition Programs.<br />

Maternal Child Health Bureau/New York State<br />

<strong>Department</strong> <strong>of</strong> Health: Integrated Community Systems<br />

Grant (Principal Investigator). June <strong>2008</strong>-April <strong>2009</strong>.<br />

$15,700.<br />

State-wide distribution <strong>of</strong> instructional DVD to adaptive<br />

physical education teachers: “Sport Opportunities and<br />

Activities for Children with Visual Impairments.” Central<br />

New York Golisano/Children’s Miracle Network Project<br />

Grant (Dosa NP, in collaboration with John Foley PhD,<br />

Deborah Cleary TVI, Lauren Lieberman PhD, Terry Welch<br />

PhD, Mary MacBlane PNP, and Gregory Liptak MD, MPH):<br />

February <strong>2008</strong> $4,000<br />

Trajectory <strong>of</strong> Transition for Adolescents and Young<br />

Adults with Spina Bifida, a multi-center longitudinal study<br />

<strong>of</strong> medical and social outcomes among youths with spina<br />

bifida. (In collaboration with Kimberlee Garver CSW,<br />

Mary MacBlane PNP, and Judy Hodge RN), Spina Bifida<br />

Association <strong>of</strong> America, local co- investigator, 2007-2010<br />

($1,500).<br />

A Six-Month, Multi-Center, Open-Label Study to Assess<br />

the Safety and Efficacy <strong>of</strong> Oral Glycopyrrolate Liquid for<br />

the Treatment <strong>of</strong> Pathologic (Chronic Moderate to Severe)<br />

Drooling in Pediatric Patients 3 to 16 Years <strong>of</strong> Age with<br />

Cerebral Palsy or other Neurologic Conditions, Protocol<br />

No. Sc-06-01: IND #61,716, Sciele Pharmaceuticals.


Bi-Annual <strong>Report</strong> • 37<br />

(Principal Investigator, SUNY Upstate Medical University)<br />

June 2007-February <strong>2008</strong>. (per enrollment).<br />

New York State <strong>Department</strong> <strong>of</strong> Health Youth Advisory<br />

Council Collaboration: Usability Testing for Healthy<br />

Transitions Network s<strong>of</strong>tware. Maternal Child Health<br />

Bureau/New York State <strong>Department</strong> <strong>of</strong> Health: Integrated<br />

Community Systems Grant (Principal Investigator).<br />

August 2007-April <strong>2008</strong>. $9,600.<br />

NICHD/NIH Contract No. HHSN267200603421C. (Janice<br />

Brunstrum, MD, PI [St. Louis University]) 9/1/<strong>2009</strong> -<br />

8/31/2010. Bacl<strong>of</strong>en for spasticity [Clinical trial]. ($36,000<br />

plus enrollment).<br />

SELECTED CLINICAL DATA<br />

Neurodevelopmental <strong>Pediatrics</strong><br />

Outpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,356<br />

Outpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,474<br />

Inpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16<br />

Inpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6<br />

Physical Disabilities (excluding spina bifida)<br />

Outpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210<br />

Outpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263<br />

Inpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35<br />

Inpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15<br />

Spina Bifida Program<br />

Outpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . 254<br />

Outpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243<br />

Inpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />

Inpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15


38 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

NEUROLOGY<br />

Child neurology services are provided through the<br />

Section <strong>of</strong> Child Neurology <strong>of</strong> the <strong>Department</strong> <strong>of</strong><br />

Neurology. These faculty have joint appointments in the<br />

<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong>.<br />

FACULTY<br />

Carl J. Crosley, MD, Pr<strong>of</strong>essor <strong>of</strong> Neurology and<br />

<strong>Pediatrics</strong>, Director<br />

Nancy Havernick, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Neurology and Psychiatry<br />

Melissa Ko, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> Neurology<br />

Malavalli Seetharam, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Neurology<br />

AFFILIATED CLINICAL STAFF<br />

Leigh B. Wilson, MSN, PNP, Pediatric Nurse Practitioner<br />

Mary MacBlane, MS, RN, PNP<br />

CLINICAL OVERVIEW<br />

The Section <strong>of</strong> Child Neurology provides diagnosis,<br />

treatment, and management for children and<br />

adolescents with neurodevelopmental and neurologic<br />

disorders. The outpatient <strong>of</strong>fices are located in the<br />

University Health Care Center, 90 Presidential Plaza,<br />

Syracuse, NY 13202. Extensive services are in particular<br />

available for children with epilepsy, headaches, cerebral<br />

palsy, muscular dystrophy, neur<strong>of</strong>ibromatosis. The<br />

neurodevelopmental conditions <strong>of</strong> developmental delay,<br />

attention deficit disorder and autism also receive full<br />

attention.<br />

Children with epilepsy are reviewed as appropriate with<br />

the additional input and services <strong>of</strong> the epilepsy team <strong>of</strong><br />

the <strong>Department</strong> <strong>of</strong> Neurology and have the full services<br />

<strong>of</strong> the <strong>Department</strong> <strong>of</strong> Clinical Neurophysiology available<br />

to them including, electroencephalography, long-term<br />

video electroencephalographic monitoring, ambulatory<br />

electroencephalograms, and epilepsy surgery.<br />

Children with muscular dystrophies are eligible for<br />

care under the auspices <strong>of</strong> the Muscular Dystrophy<br />

Association weekly clinic centrally located in Syracuse<br />

with continuing care available in Utica and Watertown<br />

New York.<br />

In collaboration with Dr. Gloria Kennedy children with<br />

brain tumors and other tumors <strong>of</strong> the central nervous<br />

system are cared for at the monthly Pediatric Brain<br />

Tumor Clinic at University Hospital.<br />

Dr. Crosley is Medical Director at Enable in Syracuse<br />

where children with developmental disabilities<br />

including cerebral palsy and pervasive developmental<br />

disorders are provided the locally unique mix <strong>of</strong><br />

ongoing multidisciplinary therapies including physical<br />

occupational and speech therapy as well as on site<br />

aquatherapy, and individual and group behavioral<br />

therapies.<br />

RESEARCH HIGHLIGHTS<br />

The section is currently participating in sponsored<br />

clinical trials investigating the efficacy and safety <strong>of</strong><br />

two anti-epileptic drugs in infants and toddlers and in a<br />

sponsored clinical trial studying the efficacy and safety <strong>of</strong><br />

a particular triptan in adolescents with migraine.<br />

PUBLICATIONS<br />

Ko MW, Tamhankar MA, Volpe NJ, Porter D, McGrath C,<br />

Galetta SL: Acute promyelocytic leukemic involvement<br />

<strong>of</strong> the optic nerves following mitoxantrone treatment for<br />

multiple sclerosis. J Neurol Sci, 273(1-2):144-7, <strong>2008</strong>.<br />

Ko MW, Dalmau J, Galetta SL: Neuro-ophthalmologic<br />

manifestations <strong>of</strong> paraneoplastic syndromes. J<br />

Neuroophthalmol, 28(1):58-68, <strong>2008</strong>.<br />

Duffner PK, Caggana M, Orsini JJ, Wenger DA, Patterson<br />

MC, Crosley CJ, et al: Newborn screening for Krabbe<br />

disease: the New York State model. Pediatr Neurol<br />

40(4):245-52, <strong>2009</strong>.<br />

Ko MW, Turkeltaub PE, Lee EB, Gonatas NK, Volpe NJ,<br />

Moster ML, Galetta SL: Primary diffuse leptomeningeal<br />

gliomatosis mimicking a chronic inflammatory meningitis.<br />

J Neurol Sci, 278(1-2):127-31, <strong>2009</strong>.


Bi-Annual <strong>Report</strong> • 39<br />

PULMONOLOGY<br />

FACULTY<br />

Ran D. Anbar, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong> and Medicine,<br />

Division Director<br />

Robert V. Hingre, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Lawrence E. Kurlandsky, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

Kevin G. Ragosta, DO, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Zafer N. Soultan, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

AFFILIATED CLINICAL STAFF<br />

Susan Delaney, NP, Nurse Practitioner, High Technology<br />

Program<br />

Mary Foster, NP, Nurse Practitioner, Cystic Fibrosis<br />

Center Coordinator<br />

Margaret O’Shea, NP, Nurse Practitioner, Hypnosis<br />

Program<br />

CLINICAL OVERVIEW<br />

The Division <strong>of</strong> Pulmonology provides care for children<br />

and adolescents with lung and airway diseases. Major<br />

clinical activities <strong>of</strong> the Division include care <strong>of</strong> patients<br />

with asthma, allergies, cystic fibrosis, bronchopulmonary<br />

dysplasia, sleep disorders, and children who require<br />

assistance from technology, such as patients with<br />

tracheostomies, some <strong>of</strong> whom are ventilator<br />

dependent.<br />

The Asthma Program includes the Pulmonary Function<br />

On-Site Testing Program, through which respiratory<br />

therapists from the Division <strong>of</strong> Pediatric Pulmonology<br />

travel to the <strong>of</strong>fices <strong>of</strong> primary care providers and to<br />

school-based health clinics in Central New York. These<br />

therapists perform pulmonary function testing for<br />

patients who have been diagnosed with or are suspected<br />

<strong>of</strong> having asthma. Interpretation <strong>of</strong> this testing is<br />

provided by a Pediatric Pulmonologist from our Division,<br />

and results are faxed or mailed to the primary care<br />

providers within a few days. This Program has helped<br />

improve the care <strong>of</strong> patients with asthma who are<br />

followed by primary care providers exclusively.<br />

In the Golidano Children’s Hospital, the Division provides<br />

state-<strong>of</strong>-the-art pulmonary function testing including,<br />

spirometry, lung volume measurements, measurement<br />

<strong>of</strong> diffusion capacity, and oscillometry. Exercise<br />

pulmonary function testing is provided in coordination<br />

with the Division <strong>of</strong> Cardiology.<br />

The Cystic Fibrosis (CF) Foundation accredited CF Care<br />

Center for pediatric patients is directed by Dr. Anbar.<br />

The Center staff includes two nurse practitioners, three<br />

respiratory therapists, three research coordinators, a<br />

social worker, and a dietician. The Center evaluates all<br />

patients referred for possible CF through the State <strong>of</strong><br />

New York Newborn Screening Program. The Division<br />

transitions its patients between the ages <strong>of</strong> 18 to 21 to<br />

an adult CF program administered through the SUNY<br />

Upstate University <strong>Department</strong> <strong>of</strong> Medicine Division <strong>of</strong><br />

Pulmonology.<br />

An active flexible bronchoscopy service is under<br />

the direction <strong>of</strong> Dr. Soultan. Patients utilizing the<br />

bronchoscopy service include those who are technology<br />

dependent, and patients with airway illnesses <strong>of</strong> unclear<br />

etiology, e.g., patients with stridor, or recurrent lower<br />

respiratory infections, including some <strong>of</strong> our patients<br />

with cystic fibrosis.<br />

The Allergy Program is under the supervision <strong>of</strong> Dr.<br />

Kurlandsky. Through this Program patients who<br />

have been referred for evaluation <strong>of</strong> asthma our<br />

Center, can undergo skin scratch testing and other<br />

allergy evaluations, as indicated. Administration <strong>of</strong><br />

immunotherapy, if necessary, is coordinated with the<br />

patients’ primary care provider.<br />

The Bronchopulmonary Dysplasia Program is under the<br />

supervision <strong>of</strong> Dr. Hingre. This Program provides followup<br />

care to all high risk newborns who are discharged<br />

from the Neonatal Intensive Care Unit, and helps<br />

coordinate their care between different sub-specialty<br />

services and their primary care providers.<br />

The High Technology Program is under the supervision<br />

<strong>of</strong> Dr. Ragosta. This Program provides long-term care<br />

and coordination <strong>of</strong> services for patients who require<br />

ventilator support, including both in the in-patient and<br />

out-patient settings.<br />

The Pediatric Sleep Program is under the supervision<br />

<strong>of</strong> Dr. Soultan. Through this program, patients who<br />

have been referred for evaluation <strong>of</strong> sleep disorders<br />

to our Center undergo a comprehensive medical and<br />

psychological evaluation. Sleep studies are performed,<br />

when indicated, in collaboration with Community<br />

General Hospital in Syracuse.<br />

The Hypnotherapy Program is under the supervision<br />

<strong>of</strong> Dr. Anbar. Common reasons for referral for<br />

hypnotherapy include patients with chest pain, habit<br />

cough, shortness <strong>of</strong> breath without a clear etiology, vocal<br />

cord dysfunction, anxiety, chronic pain, enuresis, habits,<br />

headaches, and irritable bowel syndrome.<br />

Outpatient care in Syracuse by the Division <strong>of</strong><br />

Pulmonology is provided at the Pediatric multi-specialties<br />

Center at University Hospital. The Division also supplies<br />

care at an almost weekly satellite clinic in Binghamton<br />

General Hospital and a monthly satellite clinic at Good<br />

Samaritan Hospital in Watertown.


40 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

CURRENT RESEARCH HIGHLIGHTS<br />

Members <strong>of</strong> our division are conducting studies involving<br />

asthma, cystic fibrosis, and hypnosis.<br />

Dr. Anbar is principle investigator in a number <strong>of</strong><br />

epidemiological studies involving pediatric patients<br />

with asthma, which include evaluation <strong>of</strong> drug effects,<br />

environmental pollutants, and family dynamics in these<br />

patients.<br />

Doctors Anbar, Kurlandsky, and Soultan have been<br />

involved in the 16 studies <strong>of</strong> patients with cystic fibrosis<br />

including multi-center therapeutic trials, as well as<br />

observational studies. Because <strong>of</strong> our CF Center’s high<br />

rate <strong>of</strong> enrollment in a number <strong>of</strong> multi-center trials,<br />

Dr. Anbar has been asked to be an author <strong>of</strong> publications<br />

regarding TOBI for patients with CF with early lung<br />

disease, DHA formula fortification for infants with<br />

CF, growth hormone for patients with CF, and use <strong>of</strong><br />

nebulized denufosol for patients with CF.<br />

Dr. Anbar is a national authority regarding use <strong>of</strong><br />

hypnotherapy with children, and has authored several<br />

publications regarding hypnosis. Current research<br />

includes studying the content <strong>of</strong> patient self-analysis<br />

expressed during hypnosis, as compared to when<br />

patients describe their thoughts without use <strong>of</strong> hypnosis.<br />

PUBLICATIONS<br />

Fiese B, Winter M, Anbar R, Howell K, Poltrock S. Family<br />

climate <strong>of</strong> routine asthma care: Associating perceived<br />

burden and mother-child interaction patterns to child<br />

well-being. Family Process. <strong>2008</strong>; 47:63-79.<br />

Anbar RD. Subconscious guided therapy with hypnosis.<br />

Am J Clin Hypnosis. <strong>2008</strong>; 50:323-334.<br />

Anbar RD, Zoughbi GG. Relationship <strong>of</strong> headacheassociated<br />

stressors and hypnosis therapy outcome<br />

in children: a retrospective chart review. Am J Clin<br />

Hypnosis. <strong>2008</strong>; 50:335-341.<br />

Garber E, Desai M, Zhou J, Alba L, Angst D, Cabana M,<br />

Saiman L, CF Infection Control Study Consortium.<br />

Barriers to adherence to cystic fibrosis infection control<br />

guidelines. Pediatr Pulmonary. <strong>2008</strong>; 43:900-907.<br />

Soultan ZN, Foster MM, Newman NB, Anbar RD. Sweat<br />

chloride testing in infants identified as heterozygote<br />

carriers by newborn screening. J Pediatr. <strong>2008</strong>; 153:857-<br />

859.<br />

Raz A, Raikhel E, Anbar RD. Placebos in medicine:<br />

knowledge, beliefs, and patterns <strong>of</strong> use. McGill J Med.<br />

<strong>2008</strong>; 11:206-211.<br />

Hingre RV, Souid AK, and Reiners CR. Newborn<br />

Evaluation. Essential Evidence Plus. Ebell M, Editor-in-<br />

Chief. <strong>2008</strong>. Hoboken NJ: John Wiley & Sons.<br />

Anbar RD. Pseudo-asthma revisited (letter). <strong>Pediatrics</strong>.<br />

<strong>2008</strong>; 121:221.<br />

Anbar RD. Perspectives <strong>of</strong> a physician parent. In: Center<br />

for Spiritual Care at University Hospital (ed), A Second<br />

Set <strong>of</strong> Hands. Syracuse, NY: SUNY Upstate Medical<br />

University, <strong>2008</strong>; 18-25.<br />

Anbar RD. Lung transplantation and survival in children<br />

with cystic fibrosis (letter). N Engl J Med. <strong>2008</strong>; 358:1754.<br />

Anbar RD. Treatment <strong>of</strong> psychological complications<br />

<strong>of</strong> prematurity with self-hypnosis: a case report. Clin<br />

Pediatr. <strong>2009</strong>; 48: 106-108.<br />

Henderson JF, Anbar RD. Care for Amish and Mennonite<br />

children with cystic fibrosis: a case series. BMC<br />

<strong>Pediatrics</strong>. <strong>2009</strong>; 9:4.<br />

Anbar RD. Childhood habit cough treated with<br />

consultation by telephone: a case report. Cough. <strong>2009</strong>;<br />

5:2.<br />

Irland JM, Anbar RD, Kohen DP. Hypnoanalgesia: No<br />

clamps and needles required. American Society <strong>of</strong><br />

Clinical Hypnosis Newsletter. Spring, <strong>2009</strong>; 11.<br />

Rosenbaum PF, Crawford JA, Anagnost SE, Wang CJ, Hunt<br />

A, Anbar RD, Hargrave TM, Hall EG, Liu CC, Abraham JL.<br />

Indoor airborne fungi and wheeze in the first year <strong>of</strong> life<br />

among a cohort <strong>of</strong> infants at risk for asthma. J Expo Sci<br />

Environ Epidemiol. <strong>2009</strong>; Jun 17.<br />

Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC,<br />

Bourke B, Castaldo G, Castellani C, Cipolli M, Colombo<br />

C, Colombo JL, Debray D, Fernandez A, Lacaille F,<br />

Macek M, Rowland M, Salvatore F, Taylor CJ, Wainwright<br />

C, Wilschanski M, Zemkova D, Hannah WB, Phillips<br />

MJ, Corey M, Zielenski J, Dorfman R, Wand Y, Zou F,<br />

Silverman LM, Drumm ML, Wright FA, Lange EM, Durie<br />

PR, Knowles MR; Gene Modifier Study Group. Genetic<br />

modifiers <strong>of</strong> liver disease in cystic fibrosis. JAMA. <strong>2009</strong>;<br />

302:1076-1083.<br />

Treggiari MM, Rosenfeld M, Mayer-Hamblett N, Retsch-<br />

Bogart G, Gibson RL, Williams J, Emerson J, Kronmal RA,<br />

Ramsey BW; EPIC Study Group. Early anti-pseudomonal<br />

acquisition in young patients with cystic fibrosis: rationale<br />

and design <strong>of</strong> the EPIC clinical trial and observational<br />

study. Contemp Clin Trials. <strong>2009</strong>; 30:256-268.<br />

Fiese BH, Winter MA, Wamboldt FS, Anbar RD, Wamboldt<br />

MZ. Do family mealtime interactions mediate the<br />

association between asthma symptoms and separation<br />

anxiety. J Clin Pediatr Psychology. <strong>2009</strong>; Sept 14.<br />

Anbar RD. Favorite stories, magic rocks, and a crystal<br />

ball: Personalizing metaphors in hypnotic work with<br />

children. American Society <strong>of</strong> Clinical Hypnosis<br />

Newsletter. Summer, <strong>2009</strong>; 4.<br />

Irland JM, Anbar RD, Kohen DP. A note <strong>of</strong> dissent:<br />

authors’ response. American Society <strong>of</strong> Clinical Hypnosis<br />

Newsletter. Summer, <strong>2009</strong>; 11.<br />

Soultan ZN, Anbar RD. An infant with obstructed<br />

breathing. In: Antonio Culebras (ed.), Case Studies<br />

in Sleep Medicine: Common & Uncommon Causes.<br />

Cambridge, England: Cambridge University Press, <strong>2009</strong>.<br />

Anbar RD. Adding hypnosis to the therapeutic toolbox <strong>of</strong><br />

pediatric respiratory care. Pediatr Asthma All Immunol.<br />

<strong>2009</strong>; 22.


Bi-Annual <strong>Report</strong> • 41<br />

PRESENTATIONS AT SCIENTIFIC MEETINGS<br />

Stalvey MS, Geller DE, Anbar RD, Konstan MW, Jacobs<br />

JR, Bakker B. Growth hormone (GH) therapy in<br />

prepubertal children with cystic fibrosis (CF): Glucose<br />

tolerance safety monitoring <strong>of</strong> a multicenter randomized<br />

controlled trial (RCT). Endocrine Society Annual<br />

Meeting, June, <strong>2008</strong>.<br />

Geller DE, Anbar RD, Konstan MW, Stalvey MS, Jacobs JR,<br />

and Bakker B. Growth hormone effects on pulmonary<br />

function in prepubertal children with cystic fibrosis (CF)<br />

(abstract). Pediatr Pulmonary. <strong>2008</strong>; Supplement 31, 368.<br />

Moss RB, Anbar RD, Wilmott RW, Barnes M, Schaberg<br />

AE, Durham RA, Accurso FJ. Phase 3 study <strong>of</strong> denufosol<br />

tetrasodium for the treatment <strong>of</strong> cystic fibrosis<br />

(abstract). Am J Resp Crit Care Med. May, <strong>2009</strong>.<br />

Soultan ZN, Nketiah EO, Finocchiaro SA, Trust SA, Anbar<br />

RD. Pulmonary function on-site testing helps avoid<br />

unnecessary treatment in children with exercise induced<br />

respiratory symptoms (abstract). Am J Resp Crit Care<br />

Med. May, <strong>2009</strong>.<br />

Kurlandsky LE, Anbar RD, Soultan ZN.<br />

Carboxyhemoglobin level has a positive correlation with<br />

FEV1 in patients with cystic fibrosis (abstract). Pediatr<br />

Pulmonary. <strong>2009</strong>; Supplement 32, 255.<br />

Anbar RD, Soultan Z, Kulandsky L, Sullivan M. Overnight<br />

use <strong>of</strong> high frequency chest wall oscillation: preliminary<br />

observations (abstract). Pediatr Pulmonary. <strong>2009</strong>;<br />

Supplement 32, 364.<br />

Hatch TP, Sullivan ML, Anbar RD, Soultan ZN, Kurlandsky<br />

LE, Sexton JF. Adherence <strong>of</strong> prescribed use <strong>of</strong> high<br />

frequency chest wall oscillation (abstract). Pediatr<br />

Pulmonary. <strong>2009</strong>; Supplement 32, 392.<br />

HONORS, VISITING PROFESSORSHIPS<br />

Anbar RD. Visiting pr<strong>of</strong>essor at Case Western Reserve<br />

University Rainbow Babies and Children’s Hospital.<br />

Grand Rounds on, “Hypnosis for Childhood Respiratory<br />

Disorders”, and presentation on, “Update on Newborn<br />

Screening for Cystic Fibrosis”, Cleveland, OH, February,<br />

<strong>2008</strong>.<br />

Anbar RD. Visiting pr<strong>of</strong>essor at West Virginia University<br />

Charleston Division <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong>. Grand<br />

Rounds on, “Hypnosis for Childhood Respiratory<br />

Disorders”, and presentation on, “Quality Improvement<br />

for Cystic Fibrosis Centers”, Charleston, WV, February,<br />

<strong>2008</strong>.<br />

Anbar RD. Elected Treasurer <strong>of</strong> American Society <strong>of</strong><br />

Clinical Hypnosis, <strong>2008</strong>.<br />

Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />

Presidential Award, March, <strong>2008</strong>.<br />

Anbar RD. Cystic Fibrosis Foundation Distinguished<br />

Service Award, September, <strong>2008</strong>.<br />

Ragosta KG: Visiting pr<strong>of</strong>essor at West Virginia School<br />

<strong>of</strong> Osteopathic Medicine. Topic: “Topics in Pulmonary<br />

System”, Homestead, WV, October, <strong>2008</strong>.<br />

Anbar RD. Elected Fellow, American Society <strong>of</strong> Clinical<br />

Hypnosis, March, <strong>2009</strong>.<br />

Anbar RD. University Hospital Upstate Star for<br />

“Innovation and Discovery”, May, <strong>2009</strong>.<br />

Hingre RV. Appointed adjunct faculty for Syracuse<br />

University in the Special Education department to guest<br />

lecture at undergraduate and graduate seminars on<br />

topics related to preterm infants, survival and disabilities,<br />

<strong>2009</strong>.<br />

Ragosta KG: Visiting pr<strong>of</strong>essor at West Virginia School<br />

<strong>of</strong> Osteopathic Medicine. Topic: “Topics in Pulmonary<br />

System”, Homestead, WV, October, <strong>2009</strong>.<br />

Anbar RD. Elected President <strong>of</strong> American Society <strong>of</strong><br />

Clinical Hypnosis, <strong>2009</strong>.<br />

INVITED WORKSHOPS, CME PRESENTATIONS<br />

Anbar RD. SUNY Upstate Medical University Child<br />

Psychiatry presentation on, “Hypnosis for Pediatric<br />

Psychiatric Disorders”, Syracuse, NY, <strong>2008</strong>.<br />

Anbar RD, Soultan ZN. SUNY Upstate Medical University<br />

<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong> Grand Rounds on, “The Dark<br />

Side <strong>of</strong> Newborn Screening for Cystic Fibrosis: Infants<br />

with Borderline Sweat Tests Should be Evaluated Fully”,<br />

Syracuse, NY, February, <strong>2008</strong>.<br />

Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />

Individualized Consultation Workshop, Chicago, IL, March,<br />

<strong>2008</strong>.<br />

Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />

Intermediate Workshop presentation on, “Hypnosis for<br />

Children <strong>of</strong> all Ages”, Chicago, IL, March, <strong>2008</strong>.<br />

Kurlandsky LE. SUNY Upstate Medical University<br />

<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong> Grand Rounds on, “Respiratory<br />

Effects <strong>of</strong> Gastroesophageal Reflux”, Syracuse, NY, April,<br />

<strong>2008</strong>.<br />

Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />

Introductory Workshop presentation on, “Medical<br />

Applications <strong>of</strong> Hypnosis”, Seattle, WA, April, <strong>2008</strong>.<br />

Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />

Intermediate Workshop presentation on, “Hypnosis for<br />

Children and Adolescents”, Seattle, WA, April, <strong>2008</strong>.<br />

Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />

Intermediate Workshop presentation on, “Hypnosis for<br />

Chronic Disease”, Seattle, WA, April, <strong>2008</strong>.<br />

Anbar RD. Basic Hypnosis Workshop presentation on,<br />

“Integrating Hypnosis into the Care <strong>of</strong> Children with<br />

Chronic Disease”, Syracuse, NY, May, <strong>2008</strong>.<br />

Hingre, RV. SUNY Upstate Medical University Pediatric<br />

Teaching Day presentation on, “Primary Care <strong>of</strong> Preemies<br />

for the Community Pediatrician”, Syracuse, NY, June,<br />

<strong>2008</strong>.<br />

Anbar RD. Basic American Society <strong>of</strong> Clinical Hypnosis<br />

Workshop presentation on, “Induction and Realerting<br />

Demonstrations”, Norfolk, VA, June, <strong>2008</strong>.


42 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Anbar RD. Basic American Society <strong>of</strong> Clinical Hypnosis<br />

Workshop presentation on, “Case Examples <strong>of</strong> Hypnosis<br />

with Children and Adolescents”, Norfolk, VA, June, <strong>2008</strong>.<br />

Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />

Hypnosis Workshop presentation on, “Medical<br />

Applications <strong>of</strong> Hypnosis: Video Examples and<br />

Discussion”, Norfolk, VA, June, <strong>2008</strong>.<br />

Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />

Hypnosis Workshop presentation on, “Automatic Word<br />

Processing”, Norfolk, VA, June, <strong>2008</strong>.<br />

Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />

Hypnosis Workshop presentation on, “The Psychology <strong>of</strong><br />

Symptoms”, Norfolk, VA, June, <strong>2008</strong>.<br />

Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />

Hypnosis Workshop presentation on, “Use <strong>of</strong> Hypnosis in<br />

<strong>Pediatrics</strong>”, Norfolk, VA, June, <strong>2008</strong>.<br />

Anbar RD. Syracuse University presentation to Pediatric<br />

Psychology class on “Introduction to Pediatric Hypnosis”,<br />

Syracuse, NY, June, <strong>2008</strong>.<br />

Anbar RD. Intermediate American Society <strong>of</strong> Clinical<br />

Hypnosis Workshop presentation on, “Communication<br />

with the Subconscious”, Lombard, IL, September, <strong>2008</strong>.<br />

Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />

Hypnosis Workshop presentation on, “Hypnosis in<br />

<strong>Pediatrics</strong>: An Experiential Approach”, Lombard, IL,<br />

September, <strong>2008</strong>.<br />

Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />

Hypnosis Workshop presentation on, “Communication<br />

with the Subconscious”, Lombard, IL, September, <strong>2008</strong>.<br />

Anbar RD. Basic American Society <strong>of</strong> Clinical Hypnosis<br />

Workshop presentation on, “Hypnosis Induction<br />

Techniques”, Albuquerque, NM, December, <strong>2008</strong>.<br />

Anbar RD. Basic American Society <strong>of</strong> Clinical Hypnosis<br />

Workshop presentation on, “Hypnosis with Children and<br />

Adolescents”, Albuquerque, NM, December, <strong>2008</strong>.<br />

Anbar RD. Basic American Society <strong>of</strong> Clinical Hypnosis<br />

Workshop presentation on, “Hypnosis for Chronic<br />

Disease”, Albuquerque, NM, December, <strong>2008</strong>.<br />

Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />

Hypnosis Workshop presentation on, “Hypnosis for<br />

Chronic Disease”, Albuquerque, NM, December, <strong>2008</strong>.<br />

Anbar RD. Morristown Memorial Hospital <strong>Department</strong><br />

<strong>of</strong> <strong>Pediatrics</strong> Grand Rounds on, “Hypnosis for Childhood<br />

Respiratory Disorders”, Morristown, NJ, December, <strong>2008</strong>.<br />

Anbar RD. Overlook Hospital <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Grand Rounds on, “Hypnosis for Childhood Respiratory<br />

Disorders”, Morristown, NJ, December, <strong>2008</strong>.<br />

Anbar RD. SUNY Upstate Medical University Pediatric<br />

Grand Rounds on, “Interactive Education through a Video<br />

Presentation: A 10-year-old with Shortness <strong>of</strong> Breath”,<br />

Parts I and II, Syracuse, NY, January, <strong>2009</strong>.<br />

Anbar RD. SUNY Upstate Medical University Child<br />

Psychiatry presentation on, “Hypnosis in <strong>Pediatrics</strong>”,<br />

Syracuse, NY, January, <strong>2009</strong>.<br />

Anbar RD. American Society <strong>of</strong> Clinical Hypnosis annual<br />

meeting workshop presentation on, “Teaching Hypnosis<br />

to Meet the ASCH Standards <strong>of</strong> Training”, Boston, MA,<br />

March, <strong>2009</strong>.<br />

Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />

annual meeting workshop presentation on, “Writing and<br />

Publishing your Hypnosis Articles”, Boston, MA, March,<br />

<strong>2009</strong>.<br />

Anbar RD. American Society <strong>of</strong> Clinical Hypnosis annual<br />

meeting basic workshop presentation on, “Hypnosis in<br />

<strong>Pediatrics</strong>”, Boston, MA, March, <strong>2009</strong>.<br />

Anbar RD. Onondaga Pediatric Society presentation on,<br />

“Hypnosis in <strong>Pediatrics</strong>”, Syracuse, NY, April, <strong>2009</strong>.<br />

Anbar RD. Syracuse University presentation to Pediatric<br />

Psychology class on “Introduction to Pediatric Hypnosis”,<br />

Syracuse, NY, April, <strong>2009</strong>.<br />

Anbar RD. Cystic Fibrosis Foundation Therapeutics<br />

Development Network presentation on, “Being a<br />

Successful Site”, Denver, CO, April, <strong>2009</strong>.<br />

Hingre RV. SUNY Upstate Medical University<br />

<strong>Department</strong> <strong>of</strong> Pediatric Grand Rounds presentation on,<br />

“Group B Strep in <strong>2009</strong>: More Questions than Answers”,<br />

Syracuse, NY, May, <strong>2009</strong>.<br />

Hingre RV. Central New York Nurse Practitioner Teaching<br />

Day presentation on, “Primary Care <strong>of</strong> Preemies: Special<br />

Issues and Concerns”, Syracuse, NY, May, <strong>2009</strong>.<br />

Anbar RD. Faculty member in an American Society <strong>of</strong><br />

Clinical Hypnosis Individualized Consultation workshop,<br />

Philadelphia, PA, July, <strong>2009</strong>.<br />

Anbar RD. Upstate University Health Link presentation<br />

on, “Hypnosis for medical care: myths and truths”,<br />

Syracuse, NY, August, <strong>2009</strong>.<br />

Anbar RD. CF Foundation presentation on, “Hypnosis for<br />

People with Cystic Fibrosis”, Minneapolis, MN, October,<br />

<strong>2009</strong>.<br />

Anbar RD. American Academy <strong>of</strong> <strong>Pediatrics</strong> presentation<br />

on, “Basic Pediatric Hypnosis”, Washington, DC, October,<br />

<strong>2009</strong>.<br />

Anbar RD. SUNY at Buffalo Counseling Service<br />

presentation on, “Hypnosis and the college student”,<br />

Buffalo, NY, November, <strong>2009</strong>.<br />

Hingre RV. SUNY Upstate Medical University<br />

<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong> Grand Rounds presentation<br />

on, “Universal Serologic Screening for Herpes Simplex<br />

During Pregnancy: Opening Pandora’s Box”, Syracuse, NY,<br />

December, <strong>2009</strong>.


Bi-Annual <strong>Report</strong> • 43<br />

GRANTS AND CONTRACTS<br />

Cystic Fibrosis Foundation Care Center Grant, $184,655<br />

total in <strong>2008</strong> and <strong>2009</strong><br />

Cystic Fibrosis Foundation Clinical Research Facilitation<br />

Award, $156,600 in <strong>2008</strong> and <strong>2009</strong><br />

SELECTED CLINICAL DATA<br />

Outpatient visits: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15,357<br />

Inpatient encounters: . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,059<br />

Outreach encounters: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,191<br />

Bronchoscopies:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117<br />

Hypnotherapy encounters: . . . . . . . . . . . . . . . . . . . . . . . 1,350<br />

Cystic Fibrosis Patients: . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143<br />

New York State Cystic Fibrosis Newborn Screening<br />

Program evaluations:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195<br />

Pulmonary Function On-Site Program Tests: . . . . . . . . 470<br />

Pulmonary Function Tests at University Hospital:. . . 6,216


44 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

RHEUMATOLOGY<br />

FACULTY<br />

William P. Hannan, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />

Director, Pediatric Arthritis Center<br />

Paul E. Phillips, MD, Pr<strong>of</strong>essor <strong>of</strong> Medicine and <strong>Pediatrics</strong><br />

CLINICAL OVERVIEW<br />

The Division <strong>of</strong> Pediatric Rheumatology provides<br />

comprehensive evaluation and treatment <strong>of</strong> children,<br />

adolescents and young adults with juvenile rheumatoid<br />

arthritis (JRA), systemic lupus erythematosus (SLE),<br />

juvenile dermatomyositis, and other related disorders.<br />

Other children seen in the Pediatric Arthritis Center<br />

include those referred for evaluation <strong>of</strong> acute and<br />

chronic joint pain, limp, fevers <strong>of</strong> unknown origin, and<br />

post-infectious causes <strong>of</strong> joint pain and arthritis.<br />

All patients referred to the Pediatric Arthritis Center are<br />

seen and evaluated by a pediatric rheumatologist. There<br />

is a nurse dedicated to the Pediatric Arthritis Center who<br />

is available for teaching families and children. Other<br />

ancillary services available to assist in the care <strong>of</strong> referred<br />

children include pediatric physical and occupational<br />

therapists, social workers, and child life specialists.<br />

Approximately 200 children with chronic rheumatologic<br />

disease are followed in the Pediatric Arthritis Center.<br />

EDITORIAL DUTY<br />

Phillips, P.E. Editorial Board, Clinical and Experimental<br />

Rheumatology.<br />

CLINICAL DATA<br />

Total Pediatric Arthritis Center visits, <strong>2008</strong>: . . . . . . . . 636<br />

New patient referrals, <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 161<br />

Total Pediatric Arthritis Center visits, <strong>2009</strong>: . . . . . . . . . 726<br />

New patient referrals, <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . 164


Bi-Annual <strong>Report</strong> • 45<br />

PEDIATRIC SURGICAL SPECIALTIES<br />

It is impossible to operate a tertiary pediatric program without substantial surgical support. Syracuse is fortunate to<br />

have a group <strong>of</strong> pediatric surgeons and surgical subspecialists that are technically superb and extraordinarily collegial<br />

with their pediatric medical colleagues. While these surgeons have primary appointments in a surgical department,<br />

most have joint appointments in the department <strong>of</strong> pediatrics.<br />

PEDIATIC ANESTHESIOLOGY<br />

FACULTY<br />

Full-Time:<br />

Bettina Smallman, M.D., Associate Pr<strong>of</strong>essor <strong>of</strong><br />

Anesthesiology and <strong>Pediatrics</strong>, Director <strong>of</strong> Pediatric<br />

Anesthesiology<br />

Richard Beers, M.D., Pr<strong>of</strong>essor <strong>of</strong> Anesthesiology<br />

Debnath Chatterjee, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Anesthesiology and <strong>Pediatrics</strong><br />

Elizabeth Demers-Lavelle, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Anesthesiology<br />

Mirna Abdallah, M.D., Clinical Instructor <strong>of</strong><br />

Anesthesiology<br />

Vipin Bansal, M.D., Clinical Instructor <strong>of</strong> Anesthesiology<br />

Jadwiga Bednarczyk, M.D., Clinical Instructor <strong>of</strong><br />

Anesthesiology<br />

Part-Time:<br />

Tracy Buckingham, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Anesthesiology<br />

Robert Calimlim, M.D., Associate Pr<strong>of</strong>essor <strong>of</strong><br />

Anesthesiology<br />

Dorothy Hwang, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Anesthesiology<br />

Fenghua Li, M.D., Clinical Instructor <strong>of</strong> Anesthesiology<br />

David Romano, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Anesthesiology<br />

Xiuli Zhang, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong> Anesthesiology<br />

CLINICAL OVERVIEW<br />

The Division <strong>of</strong> Pediatric Anesthesia in the <strong>Department</strong><br />

<strong>of</strong> Anesthesiology at SUNY Upstate Medical University<br />

Hospital continued to experience significant growth in<br />

<strong>2008</strong>-<strong>2009</strong>. More than 4,800 children were anesthetized<br />

each year in the Pietrafesa Center for Children’s Surgery<br />

(CCS), spanning the full spectrum <strong>of</strong> pediatric surgical<br />

specialties, as well as procedures conducted outside the<br />

operating room environment (CT, MRI, Interventional<br />

Radiology, Radiation Therapy and Nuclear Medicine).<br />

The pediatric medical specialties, such as pulmonology<br />

and gastroenterology, have increased their procedural<br />

volume, and the pediatric oncologists have continued<br />

to utilize pediatric anesthesiology services frequently<br />

for their interventional procedures. As one <strong>of</strong> the<br />

few referral centers in Central New York for children<br />

undergoing MRIs and CTs, we have been able to<br />

streamline the process, making it safe and efficient to<br />

accommodate an ever-increasing demand.<br />

Two new faculty were hired during this period. Dr. Vipin<br />

Bansal joined the faculty in <strong>2008</strong> after completing a<br />

pediatric fellowship at The Cleveland Clinic. Dr. Elizabeth<br />

Demers-Lavelle joined the faculty in <strong>2008</strong> after a<br />

pediatric fellowship at the Cleveland Clinic.<br />

The Pediatric Anesthesia Division continued to<br />

show a strong commitment to the education <strong>of</strong> our<br />

anesthesiology residents and medical students. In<br />

addition to active participation in patient care, residents<br />

rotating in pediatric anesthesiology undergo a series<br />

<strong>of</strong> didactic lectures and journal clubs. Our team also<br />

teaches basic pediatric airway skills to Pediatric and<br />

Emergency Medicine residents and fellows who rotate<br />

through the CCS.<br />

The highlight <strong>of</strong> <strong>2009</strong> was the opening <strong>of</strong> Upstate<br />

Golisano Children’s Hospital. While the philosophy <strong>of</strong><br />

care “Patients First” was a maxim for many years, the<br />

development <strong>of</strong> a Center <strong>of</strong> Excellence enabled an<br />

intensified focus on collaborative communication on<br />

patient and family centered care.<br />

PUBLICATIONS<br />

Beers RA. Office Based Anesthesia Practice: Which<br />

patients? In Twersky R, Rosenberg A, eds. Post Graduate<br />

Assembly in Anesthesiology; New York State Society <strong>of</strong><br />

Anesthesiologists. <strong>2008</strong><br />

Smallman B. Timing All When Prop<strong>of</strong>ol is Used to Limit<br />

Emergence Delirium. Anesthesiology News, October<br />

<strong>2009</strong><br />

Smallman B, Ball R. A Novel Technique <strong>of</strong> Retrograde<br />

Nasal Intubation for the Pierre-Robin Sequence Infant<br />

with a Known Difficult Airway. Pediatric Anesthesia,<br />

19(9):919-921. Sept <strong>2009</strong>.<br />

Beers RA. Patient Safety in Office Based Anesthesia.<br />

In Twersky R, Rosenberg A, eds. Post Graduate<br />

Assembly in Anesthesiology. New York State Society <strong>of</strong><br />

Anesthesiologists, <strong>2009</strong>.<br />

Beers RA. Implementing Infection Prevention Guidelines<br />

into Anesthesia Practice. In Twersky R, Rosenberg A, eds.<br />

Post Graduate Assembly in Anesthesiology. New York<br />

State Society <strong>of</strong> Anesthesiologists, <strong>2009</strong>


46 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Green ES, Beers RA, Stackhouse RA. Preventing Health<br />

Care Associated Transmission <strong>of</strong> Bloodborne Pathogens<br />

Secondary to Unsafe Injection Practices. American<br />

society <strong>of</strong> Anesthesiologists Newsletter 73:28-31, <strong>2009</strong>.<br />

Green ES, Beers RA,. Prevention <strong>of</strong> Healthcare Associated<br />

Transmission <strong>of</strong> Blood Borne Pathogens by the<br />

Application <strong>of</strong> Safe Injection Practices. American Society<br />

<strong>of</strong> Anesthesiologists Safety Module, <strong>2009</strong><br />

PRESENTATIONS<br />

Bansal V, Rosen K. Lesser Evil in Multiple Metabolic<br />

Diseases. Problem Based Learning Discussion, Society <strong>of</strong><br />

Pediatric Anesthesiology (SPA), San Diego, CA, Spring <strong>2008</strong><br />

Beers R. Office Based Anesthesia Practice: Which<br />

Patients? Presented at the Post Graduate Assembly in<br />

Anesthesiology, New York, NY, December, <strong>2008</strong><br />

Beers R. Preventing Health Care Acquired Infections:<br />

Implementing the CDC Guidelines into Anesthesiology<br />

Practice. Presentation in conjunction with the New<br />

York State <strong>Department</strong> <strong>of</strong> Health at the Post Graduate<br />

Assembly in Anesthesiology, New York, NY December,<br />

<strong>2008</strong><br />

Beers R. Anesthetic Management <strong>of</strong> Children Undergoing<br />

Scoliosis Surgery. Presented at Winthrop Hospital,<br />

Mineola, NY, May, <strong>2008</strong><br />

Beers R. Political Mindfulness for the New York State<br />

Anesthesiologist. Presented at the 2 nd Annual New York<br />

State Conference for Residents and Fellows, Syracuse,<br />

NY, May <strong>2008</strong><br />

Koshel M, Chatterjee D. Anesthetic Challenges in a Three<br />

Year Old Male with Mitochondrial Cytopathy. 2 nd Annual<br />

NYSSA Conference for Anesthesiology Residents and<br />

Fellows, Syracuse, NY, May, <strong>2008</strong><br />

Parikh J, Caswell J, Mortelliti A, Chatterjee D, Smallman<br />

B. Anesthetic Management <strong>of</strong> a Child with Junctional<br />

Epidermolysis Bullosa Presenting with Stridor. 2 nd Annual<br />

NYSSA Conference for Anesthesiology Residents and<br />

Fellows. Syracuse, NY, May 4, <strong>2008</strong><br />

Aron J, Tham SW, Caswell J, Giorgi S, Hwang D, Sills R,<br />

Prust L, Smallman B. Intrathecal Fentanyl for Combined<br />

Lumbar Puncture and Bone Marrow Aspiration in a<br />

Pediatric Patient with Mediastinal Mass. 2 nd Annual NYSSA<br />

Conference for Anesthesiology Residents and Fellows,<br />

Syracuse, NY, May 4, <strong>2008</strong><br />

Li F, Su Z, Barry WH. Effect <strong>of</strong> Endothelin-1 on [Ca2+]I In<br />

Rabbit Myocytes During Metabolic Inhibition. IARS, March<br />

<strong>2008</strong><br />

Smallman B. Regional Anesthesia in Children Focus<br />

session. Postgraduate Assembly in NYSSA, New York, NY,<br />

December <strong>2008</strong><br />

Smallman B. Pediatric Pain Management – A<br />

Pharmaceutical Approach. Focus Session. Postgraduate<br />

Assembly in NYSSA, New York, NY, December <strong>2008</strong><br />

Trusilo M, Smallman B, Puthumana N, Romano D. Spinal<br />

Anesthesia in a Two Week Old Full Term Neonate<br />

Presenting with Hypotonia and Failure to Thrive with<br />

Suspected Congenital Myopathy for Vastus Muscle<br />

Biopsy. 2 nd Annual NYSSA Conference for Anesthesiology,<br />

Syracuse, NY, May 4, <strong>2008</strong><br />

Smallman B, Puthumana N, Romano D. Spinal Anesthesia<br />

in a Two Week Old Full Term Neonate Presenting with<br />

Hyptonia and Failure to Thrive with Suspected Congenital<br />

Myopathy for Vastus Muscle Biopsy. 62 nd Annual Post<br />

Graduate Assembly, New York, NY December, <strong>2008</strong><br />

Aron J, Smallman B. Goal Oriented Preoperative Anxiety<br />

Prevention – The Balloon and Mask Technique. 2 nd Annual<br />

NYSSA Conference for Anesthesiology Residents and<br />

Fellows. Syracuse, NY, May 4, <strong>2008</strong><br />

Smallman B, Caswell J. Intrathecal Fentanyl in a Child<br />

with a Mediastinal Mass Undergoing a Spinal Tap. 2 nd<br />

Annual NYSSA Conference for Anesthesiology Residents<br />

and Fellows. Syracuse, NY, May 4, <strong>2008</strong><br />

Smallman B. Pediatric Regional Anesthesia. Post Graduate<br />

Assembly, New York, NY <strong>2008</strong><br />

Bansal V, Oliver J, Romano D. Difficult Pediatric Airway:<br />

Laceration with Glidescope. 63 rd Annual Post Graduate<br />

Assembly, New York, NY, December, <strong>2009</strong><br />

Beers R. Undiagnosed Myopathy in a Toddler: Inhalation<br />

or Intravenous Anesthesia? Problem-Based Learning<br />

Discussion presented at the Post Graduate Assembly in<br />

Anesthesiology, New York, NY, December <strong>2009</strong><br />

Beers R. Implementing Infection Prevention Guidelines<br />

in Anesthesia Practice. Focus Session Presentation at the<br />

Post Graduate Assembly in Anesthesiology, New York, NY<br />

December, <strong>2009</strong><br />

Beers R. Patient Safety in Office Based Anesthesia. Focus<br />

Session Presentation at the Post Graduate Assembly in<br />

Anesthesiology, New York, NY, December, <strong>2009</strong><br />

Smallman B, Ball R. A Novel Technique <strong>of</strong> Retrograde<br />

Nasal Intubation for the Pierre-Robin Sequence Infant<br />

with a Known Difficult Airway. Society for Pediatric<br />

Anesthesia, Jacksonville, Florida, March 19-22, <strong>2009</strong><br />

Smallman B, Yamout I, Sweeney D, Lemmens HJ. Effect<br />

<strong>of</strong> Prop<strong>of</strong>ol on Sev<strong>of</strong>lurane Induced Agitation in Young<br />

Children – A Novel Approach. Society for Pediatric<br />

Anesthesia Jacksonville, Florida, March 19-22, <strong>2009</strong>


Bi-Annual <strong>Report</strong> • 47<br />

PEDIATRIC CARDIOVASCULAR-THORACIC SURGERY<br />

FACULTY<br />

George Alfieris, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> Clinical<br />

Surgery and <strong>Pediatrics</strong><br />

Francisco Gensini, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> Clinical<br />

Surgery<br />

CLINICAL OVERVIEW<br />

For a city <strong>of</strong> its size, Syracuse is very fortunate to have<br />

a high quality, nationally known program in congenital<br />

cardiac surgery. Part <strong>of</strong> the reason this program has been<br />

successful is the innovative arrangement Dr. Alfieris has<br />

developed with the University <strong>of</strong> Rochester, by which<br />

his time is shared between both institutions. This has<br />

enabled both programs to benefit from skilled surgery<br />

and has allowed Dr. Alfieris to undertake a higher volume<br />

<strong>of</strong> cases than he would in either center alone.<br />

PEDIATRIC GENERAL SURGERY<br />

FACULTY<br />

Michael Ratner, MD, Pr<strong>of</strong>essor <strong>of</strong> Clinical Surgery and<br />

<strong>Pediatrics</strong>, Director, Division <strong>of</strong> Pediatric Surgery<br />

CLINICAL OVERVIEW<br />

Surgeons in the division provide care to children both at<br />

University Hospital and at Crouse Hospital. This includes<br />

the Neonatal Intensive Care Unit at Crouse Hospital.<br />

The group cares for the full range <strong>of</strong> surgical problems<br />

<strong>of</strong> infancy and childhood, including complex congenital<br />

anomalies. University Hospital’s busy pediatric oncology<br />

program particularly benefits from the support <strong>of</strong> the<br />

general surgery service.<br />

The full-time surgery faculty is supplemented by<br />

additional part-time contract pediatric surgeons. This<br />

year, we have concluded a joint venture in pediatric<br />

surgery services with Cincinnati Children’s Hospital, and<br />

have recently recruited two new surgeons to join us on a<br />

full-time basis in 2010.<br />

PEDIATRIC NEUROSURGERY<br />

FACULTY<br />

Zulma Tovar-Spinoza MD –Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Neurosurgery, Director <strong>of</strong> Pediatric Neurosurgery<br />

Satish Krishnamurthy MD, Mch- Associate Pr<strong>of</strong>essor <strong>of</strong><br />

Neurosurgery<br />

Walter Hall MD- Pr<strong>of</strong>essor <strong>of</strong> Neurosurgery<br />

Jim Holsapple, MD- Associate Pr<strong>of</strong>essor <strong>of</strong> Neurosurgery<br />

– No longer in our practice-<br />

Other <strong>Department</strong> Neurosurgeons, although not subspecialized<br />

in <strong>Pediatrics</strong>, have the essential training and<br />

provide supplementary care as needed.<br />

CLINICAL OVERVIEW<br />

The Pediatric Neurosurgery division provides care for<br />

children with structural disorders <strong>of</strong> the brain and spinal<br />

cord. Our patients are from the regional community, with<br />

some referrals from other states and some international<br />

referrals. We enjoy collaborating with expert pediatric<br />

neurologists, neuroradiologists, neonatologists and<br />

intensivists in the community. We participate regularly<br />

with the Upstate Epilepsy Center, Spina Bifida Program<br />

, Cranio-facial Center, the Center for Development,<br />

Behavior and Genetics and the Physical Medicine and<br />

Rehabilitation Program.<br />

During the last year the <strong>Department</strong> <strong>of</strong> Neurosurgery<br />

recruited Dr. Zulma Tovar- Spinoza to lead the Division <strong>of</strong><br />

Pediatric Neurosurgery. Dr Tovar Spinoza is a fellowship<br />

trained pediatric neurosurgeon with international<br />

expertise in the field <strong>of</strong> pediatric neurosurgery and<br />

epilepsy surgery. Under her direction, the division is<br />

consolidating services with the other disciplines <strong>of</strong><br />

pediatric care. Two new multidisciplinary services<br />

are being established: the spasticity center and the<br />

Pediatric Comprehensive Epilepsy Center. The Division<br />

has incorporated the spina bifida patients for pre-natal<br />

and post-natal care with the cooperation <strong>of</strong> the Prenatal<br />

center and the Spina bifida clinic. Preventive and


48 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

educational campaigns are being designed in conjunction<br />

with the Trauma center and pediatric department, i.e<br />

the use <strong>of</strong> helmets to avoid brain trauma. The division is<br />

strongly involved with the planning and funding for the<br />

Cancer Center. Research clinical activities are currently<br />

focused on positional plagiocephaly, decompressive<br />

craniectomies and tethered cord.<br />

Dr. Satish Krishnamurthy has recently returned to<br />

the <strong>Department</strong> <strong>of</strong> Neurosurgery. Dr. Krishnamurthy<br />

has recognized national and international expertise in<br />

pediatric and minimally invasive neurosurgery. His very<br />

well known interest in hydrocephalus and device less<br />

solutions for this condition are meritorious <strong>of</strong> several<br />

grants and publications. He is a frequent speaker in<br />

national and international conferences on this topic. His<br />

current interest is to develop a Comprehensive Program<br />

for Hydrocephalus at SUNY Upstate.<br />

Dr.Walter Hall joined our <strong>Department</strong> in 2007. He is a<br />

nationally respected expert in: infectious diseases <strong>of</strong> the<br />

nervous system and in the use <strong>of</strong> intraoperative MRI to<br />

guide the resection <strong>of</strong> childhood brain tumors. He brings<br />

his subspecialty expertise to the management <strong>of</strong> our<br />

pediatric patients.<br />

Community education regarding the services the Division<br />

provides has been an important goal. The division has<br />

been working on providing local community updates on<br />

TV and newspapers about our services and noteworthy<br />

cases. Constant feedback has been established with<br />

the pediatric services in regional hospitals at Syracuse,<br />

Rochester, Albany and Boston in order to facilitate the<br />

care to our patients.<br />

In the national and international arena, the division was<br />

recently linked to the American Association for Pediatric<br />

Neurosurgery, the International Society for Pediatric<br />

Neurosurgery. These links represent the opportunity<br />

to be involved in national and international research<br />

projects like the Chiari Consortium, the Hydrocephalus<br />

International Study and the Pediatric Craniocervical<br />

Society.<br />

Conditions Treated:<br />

• Brain and Spine tumors<br />

• Chiari malformation<br />

• Congenital and developmental malformations <strong>of</strong><br />

the nervous system<br />

• Epilepsy<br />

• Hydrocephalus<br />

• Nervous system vascular lesions<br />

• Pediatric brain trauma<br />

• Spasticity<br />

Clinical Services Provided:<br />

• Surgical treatment <strong>of</strong> congenital and developmental<br />

lesions <strong>of</strong> the nervous system [Spina bifida, Chiari<br />

Malformation, Cranio cervical spine abnormalities,<br />

tethered cord]<br />

• Surgical treatment <strong>of</strong> brain and spine tumors [Open<br />

surgery and endoscopic]<br />

• Surgical treatment <strong>of</strong> craniosynostosis [skull<br />

reconstructive surgery]<br />

• Surgical treatment <strong>of</strong> epilepsy [invasive monitoring<br />

and resection <strong>of</strong> the brain area producing epilepsy]<br />

• Surgical treatment <strong>of</strong> hydrocephalus [shunts and<br />

endoscopic third ventriculostomies -without shunt]<br />

• Surgical treatment <strong>of</strong> spasticity [Bacl<strong>of</strong>en Pumps,<br />

Dorsal Rhizotomies]<br />

• Surgical treatment <strong>of</strong> vascular lesions <strong>of</strong> the<br />

nervous system [aneurysms, arterio-venous<br />

malformations, Moyamoya disease]<br />

PUBLICATIONS<br />

Tovar-Spinoza ZS, Ochi A, Rutka JT, et al: The role <strong>of</strong><br />

magnetoencephalography in epilepsy surgery. Neurosurg<br />

Focus, 25(3):E16, <strong>2008</strong>.<br />

Yamazaki M, Chan D, Tovar-Spinoza Z, Go C, et al:<br />

Interictal epileptogenic fast oscillations on neonatal and<br />

infantile EEGs in hemimegalencephaly. Epilepsy Res, 83(2-<br />

3):198-206, <strong>2009</strong>.


Bi-Annual <strong>Report</strong> • 49<br />

PEDIATRIC OPHTHALMOLOGY<br />

FACULTY<br />

Leon-Paul Noël, MD, Pr<strong>of</strong>essor <strong>of</strong> Clinical<br />

Ophthalmology and <strong>Pediatrics</strong><br />

Walter W. Merriam, MD, Associate Pr<strong>of</strong>essor <strong>of</strong><br />

Ophthalmology<br />

Stephen W. Merriam, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Ophthalmology<br />

Marc J. Safran, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Ophthalmology<br />

CLINICAL OVERVIEW<br />

The pediatric ophthalmology service is involved in the<br />

gamut <strong>of</strong> infant and child ocular disorders, ranging from<br />

simple errors <strong>of</strong> refraction to significant anomalies.<br />

Dr. Noël also works closely with Dr. Botash and the<br />

critical care medicine division in the evaluation and<br />

documentation <strong>of</strong> ocular manifestations <strong>of</strong> child abuse.<br />

The service also has a growing experience with the use <strong>of</strong><br />

intraocular lens placement in infants.<br />

PUBLICATIONS<br />

Nagao K, Noel LP, Noel ME, Walton DS: The spontaneous<br />

resolution <strong>of</strong> primary congenital glaucoma. J Pediatr<br />

Ophthalmol Strabismus. 46(3):139-43, <strong>2009</strong>.<br />

PEDIATRIC ORTHOPEDIC SURGERY<br />

FACULTY<br />

Stephen Albanese, MD, Pr<strong>of</strong>essor <strong>of</strong> Orthopedic Surgery<br />

and <strong>Pediatrics</strong>, <strong>Department</strong> Chairman<br />

Timothy Damron, MD, Pr<strong>of</strong>essor <strong>of</strong> Orthopedic Surgery<br />

Danielle Katz, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> Orthopedic<br />

Surgery<br />

Kathryn Palomino, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> Orthopedic<br />

Surgery<br />

Brian Harley, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> Orthopedic<br />

Surgery<br />

CLINICAL OVERVIEW<br />

Upstate Medical University’s pediatric orthopedic<br />

group is one <strong>of</strong> upstate New York’s largest resources<br />

for children’s orthopedic care. In addition to the<br />

management <strong>of</strong> traumatic injuries for children in the<br />

immediate Syracuse area, the group provides advanced<br />

care for complex disorders such as scoliosis and vertebral<br />

anomalies for an extensive referral area.<br />

Several other orthopedic surgeons within the<br />

<strong>Department</strong> <strong>of</strong> Orthopedic Surgery also play a major<br />

role in the care <strong>of</strong> children. Prominent among these are<br />

Dr. Timothy Damron and Dr. Brian Harley. Dr. Damron<br />

is trained in children’s orthopedic oncology and is an<br />

expert in the management <strong>of</strong> skeletal malignancies. He<br />

works closely with the pediatric hematology oncology<br />

service. Dr. Harley completed a pediatric and congenital<br />

upper extremity fellowship. His expertise includes<br />

hand surgery as well as microsurgery and trauma<br />

reconstruction.<br />

PUBLICATIONS<br />

Damron TA, Horton JA, Pritchard MR, et al:<br />

Histomorphometric evidence <strong>of</strong> growth plate recovery<br />

potential after fractionated radiotherapy: an in vivo<br />

model. Radiat Res. 170(3):284-91, <strong>2008</strong>.<br />

Zhang M, Pritchard MR, Middleton FA, Horton JA,<br />

Damron TA: Microarray analysis <strong>of</strong> perichondral and<br />

reserve growth plate zones identifies differential gene<br />

expressions and signal pathways. Bone. 43(3):511-20, <strong>2008</strong>.<br />

Lisle JW, Choi JY, Horton JA, Allen MJ, Damron TA:<br />

Metastatic osteosarcoma gene expression differs in vitro<br />

and in vivo. Clin Orthop Relat Res. 466(9):2071-80, <strong>2008</strong>.<br />

Joyner DE, Aboulafia AJ, Damron TA, Randall RL: Fas<br />

death pathway in sarcomas correlates with epidermal<br />

growth factor transcription. Clin Orthop Relat Res.<br />

466(9):2092-8, <strong>2008</strong>.<br />

Margulies BS, Damron TA, Allen MJ: The differential<br />

effects <strong>of</strong> the radioprotectant drugs amifostine and<br />

sodium selenite treatment in combination with radiation<br />

therapy on constituent bone cells, Ewing’s sarcoma <strong>of</strong><br />

bone tumor cells, and rhabdomyosarcoma tumor cells in<br />

vitro. J Orthop Res. 26(11):1512-9, <strong>2008</strong>.<br />

Damron TA, Leerapun T, Hugate RR, et al: Does the<br />

second-generation intercalary humeral spacer improve<br />

on the first? 466(6):1309-17, <strong>2008</strong>.<br />

Mann KA, Lee J, Arrington SA, Damron TA, Allen MJ:<br />

Predicting distal femur bone strength in a murine model<br />

<strong>of</strong> tumor osteolysis. Clin Orthop Relat Res. 466(6):1271-8,<br />

<strong>2008</strong>.<br />

Evans AR, Bottros J, Grant W, Chen BY, Damron TA:<br />

Mirels’ rating for humerus lesions is both reproducible<br />

and valid. Clin Orthop Relat Res. 466(6):1279-84, <strong>2008</strong>.


50 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

Clabeaux J, Hojnowski L, Valente A, Damron TA: Case<br />

report: parachordoma <strong>of</strong> s<strong>of</strong>t tissues <strong>of</strong> the arm. Clin<br />

Orthop Relat Res. 466(5):1251-6, <strong>2008</strong>.<br />

Sherman GM, Spath C, Harley BJ, Weiner MM, Werner<br />

FW, Palmer AK: Core decompression <strong>of</strong> the distal radius<br />

for the treatment <strong>of</strong> Kienbock’s disease: a biomechanical<br />

study. J Hand Surg Am. 33(9):1478-81, <strong>2008</strong>.<br />

Wong DA, Herndon JH, Canale ST, Brooks RL, Hunt TR,<br />

Epps HR, Fountain SS, Albanese SA, et al: Medical errors<br />

in orthopaedics. Results <strong>of</strong> an AAOS member survey. J<br />

Bone Joint Surg Am. 91(3):547-57, <strong>2009</strong>.<br />

Joyner DE, Trang SH, Aboulafia AJ, Damron TA, Randall<br />

RL: FAP-associated desmoid invasiveness correlates with<br />

in vitro resistance to doxorubicin. Fam Cancer. 8(4):569-<br />

80, <strong>2009</strong>.<br />

Damron TA, Zhang M, Pritchard MR, Middleton FA, et al:<br />

Microarray cluster analysis <strong>of</strong> irradiated growth plate<br />

zones following laser microdissection. Int J Radiat Oncol<br />

Biol Phys. 74(3):949-56, <strong>2009</strong>.<br />

Damron TA, Morris C, Rougraff B, Tamurian R: Diagnosis<br />

and treatment <strong>of</strong> joint-related tumors that mimic sportsrelated<br />

injuries. Instr Course Lect. 58:833-47, <strong>2009</strong>.<br />

Joyner DE, Trang SH, Damron TA, Aboulafia AJ, et al:<br />

Desmoid cell motility is induced in vitro by rhEGF. J<br />

Orthop Res. 27(9):1258-62, <strong>2009</strong>.<br />

Sherman RA, Damron TA: Penetration <strong>of</strong> a metallic<br />

femoral head through the acetabular shell. J<br />

Arthroplasty. 24(7):1143.e7-10, <strong>2009</strong><br />

PEDIATRIC OTOLARYNGOLOGY<br />

FACULTY<br />

Anthony Mortelliti, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Otolaryngology and <strong>Pediatrics</strong><br />

Robert Shprintzen, PhD, Pr<strong>of</strong>essor <strong>of</strong> Otolaryngology and<br />

<strong>Pediatrics</strong><br />

Sherard Tatum, MD, Associate Pr<strong>of</strong>essor <strong>of</strong><br />

Otolaryngology<br />

CLINICAL OVERVIEW<br />

The <strong>Department</strong> <strong>of</strong> Otolaryngology provides state-<strong>of</strong>-the<br />

art management for children with ear, nose, and throat<br />

disorders, as well as severe crani<strong>of</strong>acial anomalies and<br />

airway problems. The department is particularly known<br />

for its work with children affected by velocardi<strong>of</strong>acial<br />

syndrome, providing a multidisciplinary approach to<br />

evaluation and treatment through the VCF Center. This<br />

program also directs a highly visible research program in<br />

this disorder.<br />

PUBLICATIONS<br />

Tatum SA, Losquadro WD: Advances in crani<strong>of</strong>acial<br />

surgery. Arch Facial Plast Surg, 10(6):376-80, <strong>2008</strong>.<br />

Gothelf D, Frisch A, Michaelovsky E, Weizman A,<br />

Shprintzen RJ: Velo-Cardio-Facial Syndrome. J Ment<br />

Health Res Intellect Disabil, 2(2):149-167, <strong>2009</strong>.<br />

Sriharan A, Abdeen Z, Bojrab D, David S, Elnasser Z,<br />

Patterson T, Shprintzen R, et al: Academic medicine as<br />

a bridge to peace: building Arab and Israeli cooperation.<br />

Acad Med, 84(11):1488-9, <strong>2009</strong>.<br />

Nelson J, Tatum S: Pediatric Rhabdomyosarcoma in<br />

an Oronasal Fistula in a Repaired Cleft Palate: A Case<br />

<strong>Report</strong>. Cleft Palate Crani<strong>of</strong>ac J, 5:1, <strong>2009</strong>.<br />

Portnoy JE, Tatum S: Retrograde nasal intubation via the<br />

cleft in Pierre-Robin Sequence neonates: a case series.<br />

Int J Pediatr Otorhinolaryngol, 73(12):1828-32, <strong>2009</strong>.<br />

Smallman B, Ball R, Tatum S: A novel technique <strong>of</strong><br />

retrograde nasal intubation for the Pierre Robin Sequence<br />

infant with a known difficult airway. Paediatr Anaesth,<br />

19(9):919-21, <strong>2009</strong>.<br />

Shprintzen RJ, Marrinan E: Velopharyngeal insufficiency:<br />

diagnosis and management. Curr Opin Otolaryngol Head<br />

Neck Surg, 17(4):302-7, <strong>2009</strong>.<br />

Losquadro WD, Tatum SA, Allen MJ, Mann KA:<br />

Polytactide-co-glycolide fiber-reinforced calcium<br />

phosphate bone cement. Arch Facial Plast Surg, 11(2):104-<br />

9, <strong>2009</strong>.


Bi-Annual <strong>Report</strong> • 51<br />

AFFILIATED FACULTY<br />

The clinical and educational missions <strong>of</strong> the <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong> are enhanced by several specialty groups in<br />

affiliated institutions or private practice. These pediatricians have academic appointments in the department and are<br />

fully integrated into our activities.<br />

PEDIATRIC CARDIOLOGY<br />

FACULTY<br />

Nader H. Atallah, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Craig J. Byrum, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong> and Medicine<br />

Daniel A. Kveselis, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Frank C. Smith, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Ellen Weinstein, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

CLINICAL OVERVIEW<br />

The Division <strong>of</strong> Pediatric Cardiology provides the full<br />

spectrum <strong>of</strong> non-invasive and interventional diagnostic<br />

and therapeutic services. This activity occurs in the<br />

neonatal intensive care unit at Crouse Hospital as well<br />

as in the inpatient and critical care units at University<br />

Hospital. A number <strong>of</strong> satellite clinics are staffed by<br />

these faculty as well.<br />

NEONATALOGY: ST. JOSEPH’S HOSPITAL<br />

FACULTY<br />

Larry Consenstein, MD, Clinical Associate Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

James Pergolizzi, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

Jonathan Chai, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

Michele Chai, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

CLINICAL OVERVIEW<br />

These physicians staff the Neonatal Intensive Care Unit at<br />

St. Joseph’s Hospital as well as providing normal newborn<br />

coverage for other hospitals and pediatric practices.<br />

One <strong>of</strong> the three one-month neonatology rotations<br />

in our pediatric residency is served at St. Joseph’s<br />

Hospital under the supervision <strong>of</strong> faculty members <strong>of</strong><br />

neonatology.<br />

NEONATOLOGY: CROUSE HOSPITAL<br />

FACULTY<br />

Steven Gross, MD, Clinical Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Ellen Bifano, MD, Clinical Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Michelle Bode, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

Boura’a Bou Aram, M.D, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

Thomas Curran, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

<strong>Pediatrics</strong><br />

Bonnie Marr, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

Beverly Roy, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />

CLINICAL OVERVIEW<br />

These neonatologists staff the 60 bed neonatal intensive<br />

care unit at Crouse Hospital. In addition to the clinical<br />

activity in this busy unit, two <strong>of</strong> the one-month<br />

neonatology rotations <strong>of</strong> our pediatric residents are<br />

spent in this NICU.


52 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />

FACULTY RECOGNITION<br />

Many department faculty have received national recognition.<br />

AMERICAN PEDIATRIC SOCIETY<br />

The following faculty are members <strong>of</strong> the American<br />

Pediatric Society, recognizing their national reputation as<br />

academic pediatricians:<br />

Ann Botash, MD<br />

Robert Kanter, MD<br />

Gregory Liptak, MD<br />

Irene Sills, MD<br />

Leonard Weiner, MD<br />

Thomas Welch, MD<br />

SOCIETY FOR PEDIATRIC RESEARCH<br />

The Society for Pediatric Research is an elective society<br />

which recognizes nationally prominent accomplishments<br />

in research by pediatricians. Upstate faculty members<br />

include:<br />

Ann Botash, MD<br />

Joseph Domachowske, MD<br />

James Listman, MD<br />

Scott Schurman, MD<br />

Thomas Welch, MD<br />

AMERICAN ACADEMY OF PEDIATRICS,<br />

SECTION ON ENDOCRINOLOGY<br />

Irene Sills, MD - Executive Committee<br />

AMERICAN BOARD OF PEDIATRICS<br />

Gregory Liptak, MD – Chair, Neurodevelopmental<br />

Disabilities Sub-Board<br />

THE HELFER SOCIETY<br />

Ann Botash, MD – President<br />

THE AMERICAN SOCIETY OF CLINICAL<br />

HYPNOSIS<br />

Ran Anbar, MD - President<br />

SIGMA XI SCIENTIFIC RESEARCH SOCIETY<br />

BEST DOCTORS IN AMERICA<br />

Best Doctors is a national program which recognizes<br />

physicians in the United States who are considered by<br />

their peers to be outstanding clinicians. Nearly a quarter<br />

<strong>of</strong> the physicians in Onondaga County recognized by<br />

Best Doctors are members <strong>of</strong> our pediatric full-time or<br />

volunteer faculty.<br />

Stephen Albanese<br />

Ran Anbar<br />

John Andrake<br />

Mirza Beg<br />

Steven Blatt<br />

Ann Botash<br />

Robert Cavanaugh<br />

Irene Cherrick<br />

Carl Crosley<br />

Timothy Damron<br />

Joseph Domachowske<br />

Wanda Fremont<br />

William Hannan<br />

Gregory Liptak<br />

Victoria Meguid<br />

Paul Phillips<br />

Michael Ratner<br />

Scott Schurman<br />

Irene Sills<br />

Richard Sills<br />

Zafer Soultan<br />

Ann Sveen<br />

Leonard Weiner<br />

Thomas Welch<br />

Denise Woodall-Ruff<br />

The following outpatient centers were also included in<br />

the Best Doctors list:<br />

Pediatric and Adolescent Center<br />

William Kerr, PhD - Member


10-0491 Rev. 5/2010

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