Department of Pediatrics Biannual Report 2008-2009
Department of Pediatrics Biannual Report 2008-2009
Department of Pediatrics Biannual Report 2008-2009
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Upstate Golisano Children’s Hospital<br />
SUNY Upstate Medical University<br />
<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Bi-Annual <strong>Report</strong><br />
January 1, <strong>2008</strong> – December 31, <strong>2009</strong>
CONTENTS<br />
INTRODUCTION FROM THE CHAIR. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1<br />
DEPARTMENT LEADERSHIP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2<br />
PEDIATRICS BY THE NUMBERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3<br />
CRITICAL CARE AND INPATIENT PEDIATRICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />
Hospital Medicine:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />
RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />
SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4<br />
EDUCATION PROGRAM IN GENERAL PEDIATRICS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />
Graduate Medical Education. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5<br />
Undergraduate Medical Education . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />
Administrative . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />
OVERVIEW. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />
RESIDENCY CURRICULUM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5<br />
PEDIATRIC CLERKSHIP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6<br />
EDUCATION OUTCOMES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6<br />
EDUCATION PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7<br />
Book Chapters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7<br />
PUBLICATIONS WITH RESIDENTS, FELLOWS, OR STUDENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7<br />
PRESENTATIONS AT NATIONAL MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8<br />
PRESENTATIONS AT NATIONAL MEETINGS WITH RESIDENTS, FELLOWS AND STUDENTS . . . . . . . . . . . 8<br />
GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9<br />
PEDIATRIC EMERGENCY MEDICINE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />
HONORS, VISITING PROFESSORSHIPS, EDITORIAL DUTY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />
Editorial Boards/Reviewer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11<br />
GRANT ACTIVITY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />
SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />
PEDIATRIC ENDOCRINOLOGY, DIABETES & METABOLISM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />
AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />
RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13<br />
INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13<br />
GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13<br />
SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13<br />
GASTROENTEROLOGY & NUTRITION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14<br />
AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14<br />
RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14<br />
SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14<br />
GENERAL PEDIATRICS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15<br />
AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15<br />
RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />
Child Sex Abuse Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />
Foster Care . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />
PRESENTATIONS AT NATIONAL MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />
HONORS, VISITING PROFESSORSHIPS, EDITORIAL DUTY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17<br />
INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18<br />
GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .19<br />
Blatt SD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19<br />
Botash AS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19<br />
SELECTED CLINICAL DATA (DIVISION TOTALS) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .19<br />
General <strong>Pediatrics</strong>, Adolescent, CARE, Enhance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19<br />
Upstate <strong>Pediatrics</strong> Outpatient. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19<br />
Inpatient encounters (General <strong>Pediatrics</strong> and Upstate <strong>Pediatrics</strong>) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19<br />
Newborn inpatient encounters (General <strong>Pediatrics</strong> and Upstate <strong>Pediatrics</strong>) . . . . . . . . . . . . . . . . . . . . . . . 19<br />
GENETICS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />
Adjunct Faculty: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />
AFFILIATED CLINICAL STAFF: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />
RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21<br />
INVITED WORKSHOPS AND CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22<br />
GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22<br />
SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22<br />
HEMATOLOGY & ONCOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />
AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />
AFFILIATED RESEARCH STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />
Children’s Oncology Group Participation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />
KNOT Center. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />
Neuro-Oncology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23<br />
Hemophilia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />
New York State Designated . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />
Hemoglobinopathy Center . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />
Autologous Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />
Educational Specialist and Neuropsychology Service. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />
Pediatric Palliative Care. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />
RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />
Dr. William Kerr . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24<br />
Dr. Jody Sima . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />
Dr. Richard Sills . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />
GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />
EDITORIAL SERVICE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />
SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25<br />
INFECTIOUS DISEASES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />
FELLOWS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />
AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />
AFFILIATED RESEARCH STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />
RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />
Clinical Trials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
HONORS, VISITING PROFESSORSHIPS, EDITORIAL DUTY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28<br />
INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28<br />
GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29<br />
Weiner LB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29<br />
Domachowske JB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30<br />
SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30<br />
NEPHROLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />
AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />
AFFILIATED RESEARCH STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />
RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />
Role <strong>of</strong> Local Complement Synthesis in the Kidney . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31<br />
Development <strong>of</strong> Novel Inhibitors <strong>of</strong> Inflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />
HONORS, VISITING PROFESSORSHIPS, EDITORIAL DUTY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />
INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />
SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32<br />
NEURODEVELOPMENTAL PEDIATRICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33<br />
AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33<br />
PROGRAMS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33<br />
RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34<br />
Original Scientific Articles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34<br />
Reviews . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34<br />
Reviews with American Academy <strong>of</strong> <strong>Pediatrics</strong> Council on Children with Disabilities (Dr. Liptak). . . . . . . . . . . 34<br />
Books and Book Chapters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34<br />
Other . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35<br />
INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36<br />
GRANTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36<br />
SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37<br />
Neurodevelopmental <strong>Pediatrics</strong> . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37<br />
Physical Disabilities (excluding spina bifida) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37<br />
Spina Bifida Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37<br />
NEUROLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />
AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />
RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38<br />
PULMONOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39<br />
AFFILIATED CLINICAL STAFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39<br />
CURRENT RESEARCH HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41<br />
HONORS, VISITING PROFESSORSHIPS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41<br />
INVITED WORKSHOPS, CME PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .41<br />
GRANTS AND CONTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43<br />
SELECTED CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43<br />
RHEUMATOLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44<br />
EDITORIAL DUTY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44<br />
CLINICAL DATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44<br />
PEDIATRIC SURGICAL SPECIALTIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />
PEDIATIC ANESTHESIOLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />
Full-Time: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />
Part-Time:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45<br />
PRESENTATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46<br />
PEDIATRIC CARDIOVASCULAR-THORACIC SURGERY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />
PEDIATRIC GENERAL SURGERY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />
PEDIATRIC NEUROSURGERY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47<br />
Conditions Treated: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48<br />
Clinical Services Provided: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48<br />
PEDIATRIC OPHTHALMOLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />
PEDIATRIC ORTHOPEDIC SURGERY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49<br />
PEDIATRIC OTOLARYNGOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />
PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />
AFFILIATED FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />
PEDIATRIC CARDIOLOGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />
NEONATALOGY: ST. JOSEPH’S HOSPITAL. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />
NEONATOLOGY: CROUSE HOSPITAL. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />
FACULTY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />
CLINICAL OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51<br />
FACULTY RECOGNITION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />
AMERICAN PEDIATRIC SOCIETY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />
SOCIETY FOR PEDIATRIC RESEARCH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />
AMERICAN ACADEMY OF PEDIATRICS, SECTION ON ENDOCRINOLOGY. . . . . . . . . . . . . . . . . . . . 52<br />
AMERICAN BOARD OF PEDIATRICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />
THE HELFER SOCIETY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />
THE AMERICAN SOCIETY OF CLINICAL HYPNOSIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />
SIGMA XI SCIENTIFIC RESEARCH SOCIETY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52<br />
BEST DOCTORS IN AMERICA. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52
INTRODUCTION FROM THE CHAIR<br />
Bi-Annual <strong>Report</strong> • 1<br />
I am happy to share with you our department report for <strong>2008</strong> and <strong>2009</strong>!<br />
This may have been the most important couple <strong>of</strong> years for our<br />
department since our first Chair, William Tomlinson Plant, published<br />
a study <strong>of</strong> childhood seizures in the inaugural edition <strong>of</strong> Archives <strong>of</strong><br />
<strong>Pediatrics</strong>, in 1884. <strong>2009</strong> was the year that we opened the Upstate<br />
Golisano Children’s Hospital, realizing a decades-long dream <strong>of</strong> the<br />
community and many <strong>of</strong> my predecessors. In the short time we have<br />
been open, the hospital has already garnered some national recognition<br />
for its architecture, and some <strong>of</strong> our patient care innovations have been<br />
the subject <strong>of</strong> presentations in national meetings.<br />
Although the hospital was only open for the last three months covered<br />
by this report, its impact can be seen in many places. Many <strong>of</strong> the new<br />
pediatricians and pediatric surgical specialists who have joined us in<br />
the past two years were attracted to Syracuse by the opportunities<br />
afforded by a state <strong>of</strong> the art facility. Our volumes <strong>of</strong> patient activity,<br />
both in the outpatient and the inpatient settings, have been increasing<br />
substantially. We have made a number <strong>of</strong> efforts to streamline our<br />
referral process, including opening new regional subspecialty satellite<br />
clinics, initiating a “one call” system for transfers and appointments<br />
(1-800-464-KIDS), improving the entirety <strong>of</strong> the family experience<br />
during the visit, and providing timely and complete reports to referring<br />
pr<strong>of</strong>essionals.<br />
One <strong>of</strong> our newest initiatives is a joint effort with the American Board<br />
<strong>of</strong> <strong>Pediatrics</strong>, which will permit us to <strong>of</strong>fer a project which will help<br />
both referring physicians and our subspecialty consultants evaluate<br />
each other’s roles in the consultation experience, insure the safety <strong>of</strong><br />
primary care/subspecialist “hand <strong>of</strong>fs”, and provide ABP Maintenance <strong>of</strong><br />
Certification (“MOC”) category 4 credit. As I am writing this letter, we<br />
are finalizing the operational details <strong>of</strong> this project, and will make these<br />
available on the Golisano Children’s Hospital website shortly.<br />
I hope that you will agree that the activity <strong>of</strong> our faculty and programs<br />
has grown in concert with our new hospital. Keep up with our<br />
programs through our newsletter (http://www.upstate.edu/gch/<br />
education/newsletters.php) or through our website (http://www.<br />
upstate.edu/gch/). Remember that you can also register to use our<br />
online clinical question system, ePED Direct, through our website.<br />
Thomas R. Welch, MD<br />
Pr<strong>of</strong>essor and Chair<br />
<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Upstate Medical University<br />
Medical Director<br />
Upstate Golisano Children’s Hospital
2 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
DEPARTMENT LEADERSHIP<br />
With the growth in department activity which has already occurred, and which is planned for the coming years, it<br />
has become critical to apportion leadership responsibilities in a meaningful way. We now have a group <strong>of</strong> vice chairs<br />
who have primary responsibilities for a variety <strong>of</strong> functions within the department. This group meets weekly, and<br />
together acts as a deliberative body to set policy and direction. Each <strong>of</strong> these individuals is also empowered to make<br />
independent decisions within his or her area <strong>of</strong> responsibility. Although I am always available to speak with referring<br />
physicians regarding hospital or department issues, these individuals may also be contacted directly in regard to<br />
matters within their respective purviews.<br />
Ann Botash, MD (botasha@upstate.edu) is Vice Chair for Educational Affairs, with ultimate responsibility for all<br />
aspects <strong>of</strong> education in the department: undergraduate, graduate, and continuing. The enormous growth in our<br />
education services is outlined in the education section <strong>of</strong> this report.<br />
Ann is a well-known figure in pediatrics nationally. She has received the Advocacy Award from the Ambulatory<br />
<strong>Pediatrics</strong> Association, and is very visible regionally and nationally in the area <strong>of</strong> child abuse.<br />
Scott Schurman, MD (schurmas@upstate.edu) continues to serve as our Vice Chair for Clinical Affairs. Scott also<br />
directs our highly-regarded and growing program in kidney diseases.<br />
In his Vice Chair role, Scott has ultimate responsibility for all inpatient and outpatient activity in the department. He<br />
has played an important role in our recent growth in faculty and programs, and is in charge <strong>of</strong> the development <strong>of</strong> our<br />
satellites.<br />
Leonard Weiner, MD (weinerl@upstate.edu) rounds out the department leadership team as Vice Chair for Academic<br />
Affairs. A former interim chair <strong>of</strong> our department, with a national reputation for clinical care and research in infectious<br />
diseases, Len is well suited for this role.<br />
In addition to responsibility for the department’s faculty promotion and tenure process, Len has overall responsibility<br />
for our research programs. We have made some steady strides in this area, as indicated by the individual division and<br />
section reports. With growth in faculty and programs, this will continue.<br />
The leadership team is supported by Leo Sawyer (sawyerl@upstate.edu), practice administrator, Cherlynn Clarry<br />
(clarryc@upstate.edu), department <strong>of</strong>fice manager, and Barbara Delaney (delaneyb@upstate.edu), assistant to the<br />
chair. In the past year, additional support positions have been created. Joy Tompkins, RN, MS, PNP has assumed the<br />
role <strong>of</strong> department research coordinator and provides invaluable support to our investigators. Bonnie Miner, MS, RN,<br />
CNS recently assumed the role <strong>of</strong> patient safety <strong>of</strong>ficer. She is leading a number <strong>of</strong> GCH safety initiatives, including<br />
our collaborative involvement with safety projects <strong>of</strong> the National Association <strong>of</strong> Children’s Hospitals and Related<br />
Institutions.
Bi-Annual <strong>Report</strong> • 3<br />
PEDIATRICS BY THE NUMBERS<br />
A few pertinent numbers provide a snapshot <strong>of</strong> our growth in child health care activity over the past two years. The<br />
Golisano Children’s Hospital did not open until September, <strong>2009</strong>, but in the remaining months <strong>of</strong> the year, our inpatient<br />
activity has accelerated significantly.<br />
Measure <strong>2008</strong> <strong>2009</strong> % change<br />
Inpatient discharges 3,713 3,884 + 4.6%<br />
Observation patients 595 671 + 12.8%<br />
Average length <strong>of</strong> stay 4.4 4.3 - 2.3%<br />
Pediatric ED visits 20,714 23,123 + 11.6%<br />
Pediatric outpatient visits 63,334 65,292 + 3%<br />
Surgical procedures 3,558 4,076 + 14.6%<br />
About 46.8% (1,477) <strong>of</strong> the pediatric inpatients in the Golisano Children’s Hospital in calendar year <strong>2009</strong> came from<br />
Onondaga County, and nearly 1.4% (43) were from outside New York State. Approximately 46% (1,460) <strong>of</strong> inpatients<br />
were under the age <strong>of</strong> five years and about half <strong>of</strong> admissions come through the Pediatric Emergency <strong>Department</strong>.<br />
Outpatient pediatric visits were drawn from an even wider geographic area throughout New York State, with nearly 30%<br />
(19,469) <strong>of</strong> children from outside Onondaga County. About 1% (529) <strong>of</strong> our outpatient visits were from outside New York State.
4 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
CRITICAL CARE AND INPATIENT PEDIATRICS<br />
FACULTY<br />
Critical Care:<br />
William P. Hannan, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Robert K. Kanter, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Division<br />
Director<br />
Kevin Ragosta, DO, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Neal A. Seidberg, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Jennifer Zuccaro, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Hospital Medicine:<br />
John Andrake, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Charles Bergstrom, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Elizabeth Jamme, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
James Listman, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
P. David Sadowitz, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Thomas Welch, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
CLINICAL OVERVIEW<br />
The Pediatric Critical Care service in the Golisano<br />
Children’s Hospital provides the only critical care for<br />
infants and children in a 15 county area <strong>of</strong> Central New<br />
York. The multidisciplinary medical and surgical Pediatric<br />
Intensive Care Unit includes 15 intensive care beds<br />
admitting 800 patients annually. The PICU serves the<br />
region’s Level 1 Trauma center. The Pediatric Interhospital<br />
Transport Service sends pediatric transport specialists to<br />
referring hospitals to provide care at the earliest possible<br />
time for critically ill infants and children throughout<br />
the region. We also coordinate the transition <strong>of</strong> care for<br />
children with special health care needs from intensive<br />
care to community based care, including formulation <strong>of</strong><br />
plans for emergency treatment <strong>of</strong> future unpreventable<br />
illnesses in this vulnerable population. Outpatient care<br />
is provided for selected technology assisted patients<br />
(Dr. Ragosta), in collaboration with the patient’s other<br />
subspecialists and primary care physicians. Finally, the<br />
Pediatric Critical Care service provides pediatric critical<br />
care education to residents in pediatrics and emergency<br />
medicine, nursing students, respiratory therapy students,<br />
and pharmacy students. In recent years many <strong>of</strong> our<br />
pediatric residents have gone on to training in critical care<br />
medicine at the finest fellowship programs after their<br />
residency in Syracuse.<br />
The inpatient (“hospitalist”) service provides<br />
comprehensive, coordinated inpatient care to children<br />
who are not on a subspecialty service or whose primary<br />
care provider does not serve inpatients. National trends<br />
in inpatient child health care over the past few years have<br />
been reflected in Syracuse as well, resulting in significant<br />
growth <strong>of</strong> this program.<br />
Outstanding care coordination, including active<br />
involvement <strong>of</strong> nurse practitioners and discharge<br />
planners, has resulted in severity adjusted length <strong>of</strong> stay<br />
for children at the Golisano Children’s Hospital being<br />
below national benchmarks.<br />
The growth in volume and complexity <strong>of</strong> this program has<br />
necessitated its planning to add additional faculty in 2010<br />
and become a separate division within the department.<br />
RESEARCH HIGHLIGHTS<br />
Dr Kanter’s health services research investigates the<br />
balance between pediatric acute care needs and existing<br />
regional hospital resources. In large public health<br />
emergencies, hospital resources would be overwhelmed<br />
if large numbers <strong>of</strong> children were involved. Quantitative<br />
modeling studies demonstrate that temporary<br />
mass critical care approaches would be essential<br />
to accommodate large surges <strong>of</strong> patients in sudden<br />
impact regional emergencies. Sustained mass critical<br />
care approaches would be necessary to accommodate<br />
pandemic surges (study in progress). A panel <strong>of</strong> experts<br />
demonstrated a method to develop pr<strong>of</strong>essional<br />
consensus regarding those hospital interventions that<br />
should be regarded as essential in mass critical care<br />
responses to a public health emergency. Evidence-based<br />
considerations for pediatric mass critical care in public<br />
health emergencies have been reviewed. A recently<br />
completed study found persistent changes in child<br />
mortality in the New Orleans region recovering from<br />
Hurricane Katrina. Persistent population displacement<br />
and post-disaster changes in demographics affect<br />
children’s needs for hospital services.<br />
SELECTED CLINICAL DATA<br />
Hospitalist service discharges <strong>2008</strong>: . . . . . . . . . . . . . . . 2,809<br />
Hospitalist service discharges <strong>2009</strong>: . . . . . . . . . . . . . . . 3,309<br />
Pediatric intensive care unit discharges <strong>2008</strong>: . . . . . . . . 209<br />
Pediatric intensive care unit discharges <strong>2009</strong>: . . . . . . . . . 266
Bi-Annual <strong>Report</strong> • 5<br />
EDUCATION PROGRAM IN GENERAL PEDIATRICS<br />
FACULTY<br />
Ann S. Botash, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Vice Chair for<br />
Educational Affairs<br />
Graduate Medical Education<br />
John Andrake, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Director <strong>of</strong> Residency Program<br />
Bradley Olson, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Associate Director <strong>of</strong> Residency<br />
Gloria Kennedy, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Associate Director <strong>of</strong> Residency<br />
Undergraduate Medical Education<br />
Charles Bergstrom, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Clerkship Director<br />
Robert Hingre, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Associate Clerkship Director<br />
Administrative<br />
James F. Peacock, MS, Education Program Administrator<br />
Patricia Mondore, MA, Residency Program Coordinator<br />
Carol Plumley, Clerkship Coordinator<br />
OVERVIEW<br />
For more than fifty years, the <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
has maintained a residency training program in<br />
general pediatrics that provides residents with a<br />
strong foundation in primary care pediatrics, acute<br />
care medicine and all subspecialties. Our collegial<br />
environment allows a “hands on” approach with a low<br />
faculty to resident ratio. Due to the large catchment<br />
area served by the department, residents directly care<br />
for patients with a vast array <strong>of</strong> medical problems,<br />
from common primary care issues to the most unique<br />
subspecialty conditions. Residents are actively involved<br />
in varied learning experiences such as resident run journal<br />
clubs, research and pathophysiology conferences, casebased<br />
ambulatory care and subspecialty conferences,<br />
daily rounds with faculty, weekly grand rounds, and<br />
regular discourse with visiting pr<strong>of</strong>essors. Our allencompassing<br />
curriculum has successfully prepared<br />
residents for fellowship training in subspecialties and<br />
careers in primary care pediatrics across the country. In<br />
<strong>2008</strong>, the residency received a full five-year accreditation<br />
from the ACGME with no citations.<br />
Our 6-week clerkship provides pediatric education to<br />
about 120 students every year. The students are exposed<br />
to extensive in-patient (3 weeks) and out-patient (3 weeks)<br />
experiences. They attend thirty core lectures given by<br />
the faculty and are required to study CLIPP (Computer<br />
Learning in Pediatric Project; www.clippcases.org) cases.<br />
A teaching attending is assigned to the students during<br />
their in-patient rotation.<br />
RESIDENCY CURRICULUM<br />
The broad-based curriculum enables residents to<br />
become competent in all areas <strong>of</strong> general pediatrics.<br />
Some <strong>of</strong> the highlights <strong>of</strong> the curriculum include:<br />
• Seminars - In 2007, the core curriculum for the<br />
residents was updated with some innovative<br />
changes. The faculty have translated the core<br />
curriculum to an on-line environment that is<br />
available to the residents anytime and anywhere.<br />
The material is contained within Blackboard and<br />
resident participation in the online curriculum is<br />
actively monitored. The first year residents have<br />
a separate case based series <strong>of</strong> seminars and the<br />
senior residents attend a more in depth seminar on<br />
the same topics later in the day. These interactive<br />
seminars reinforce and complement the on-line<br />
lectures and <strong>of</strong>fer and interactive approach to<br />
learning through cases. Residents complete quiz<br />
materials online that can be used for preparation<br />
for the board examination.<br />
• Primary care – The training in primary care takes<br />
advantage <strong>of</strong> the well-developed division <strong>of</strong> general<br />
pediatrics and takes place at the University Pediatric<br />
and Adolescent Center (UPAC). The residents<br />
participate in a continuity clinic experience one<br />
half day per week. In addition, there are six<br />
separate month-long block rotations at UPAC.<br />
This combination <strong>of</strong> experience provides residents<br />
with a greater continuity for health maintenance,<br />
chronic diseases and acute illnesses. In the second<br />
year, residents combine their UPAC experience<br />
with longitudinal training in the outpatient clinics<br />
<strong>of</strong> various subspecialties. An additional rotation in<br />
Adolescent Medicine rounds out their education<br />
in general pediatrics. Community practices are<br />
also available as sites for resident education, and<br />
nicely complement their training in the inner city,<br />
hospital-based UPAC.<br />
• Critical Care – The Golisano Children’s Hospital<br />
PICU is the setting for the training in Pediatric<br />
Critical Care Medicine. Residents provide direct<br />
patient care for the sickest children in Central<br />
New York, with a wide-range <strong>of</strong> acute conditions.<br />
Residents also provide concurrent care for<br />
patients admitted primarily for surgical conditions.<br />
Residents have exposure to Neonatal Intensive Care<br />
through two distinct NICU experiences, first at St.<br />
Joseph’s Hospital Health Center and subsequently<br />
at the tertiary care NICU at Crouse Hospital.<br />
• Emergency Medicine – Residents are the front line<br />
for children up to 18 years <strong>of</strong> age who come with<br />
medical or surgical emergencies to the area’s only<br />
Pediatric Emergency <strong>Department</strong>. More than 20,000<br />
annual visits are seen, and supervised by board<br />
certified Pediatric Emergency Medicine faculty.
6 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
• Developmental <strong>Pediatrics</strong> – This rotation takes<br />
advantage <strong>of</strong> some <strong>of</strong> the outstanding community<br />
resources in child development, as well as those<br />
at our Center for Neurodevelopmental <strong>Pediatrics</strong>.<br />
The Center is home to services for children with<br />
developmental and behavioral problems, including<br />
the autistic spectrum disorders, as well as those<br />
with complex medical conditions, such as spina<br />
bifida, cerebral palsy, and genetic disorders.<br />
• Inpatient – Dedicated hospitalists provide oversight<br />
and direct care for the inpatients at the Golisano<br />
Children’s Hospital. They also provide consultative<br />
care to other medical and surgical patients. A great<br />
deal <strong>of</strong> the education <strong>of</strong> residents and medical<br />
students is provided by these inpatient specialists.<br />
In addition, a separate attending, the Teaching<br />
Attending, provides hands-on and didactic teaching<br />
to complement the learning on the wards.<br />
• Pediatric surgery rotation – In <strong>2009</strong> our secondyear<br />
residents began taking a required onemonth<br />
rotation with the pediatric surgery team.<br />
This allows the pediatric residents to gain a<br />
better understanding <strong>of</strong> diagnosis, treatment<br />
and management <strong>of</strong> common pediatric surgical<br />
problems and allows them to teach the<br />
surgery team basic pediatric examination and<br />
communication skills.<br />
• Subspecialties – The curriculum continues to<br />
provide comprehensive training in the pediatric<br />
subspecialties. Clinical instruction is available in<br />
virtually all the major pediatric medical and surgical<br />
subspecialties. Residents have elective time that<br />
allows them to create additional experiences in<br />
focused areas <strong>of</strong> the subspecialties. In the third<br />
year, residents are able to spend a clinical rotation<br />
away from the medical center as an “away elective.”<br />
• Systems Based Care – A program <strong>of</strong> learning<br />
advocacy, established in 1995 as the Community<br />
Oriented Advocacy Training program, was one <strong>of</strong><br />
the first such advocacy training programs nationally.<br />
The curriculum now includes experiences in<br />
systems based care and educates residents on<br />
a wide range <strong>of</strong> advocacy skills and community<br />
related topics. Using a case based approach,<br />
residents identify a system issue affecting a patient<br />
and research community resources. Throughout<br />
this experience, the residents develop advocacy<br />
skills and then present their experience at an<br />
educational conference.<br />
• Teaching Skills for Housestaff – This monthly seminar<br />
series is in its 13th year and is designed to meet the<br />
needs <strong>of</strong> residents as teachers. The series addresses<br />
topics such as: delivering effective lectures, teaching<br />
at the bedside, providing feedback, evaluating<br />
students and serving as a role model.<br />
• Evidence Based Medicine – The housestaff present<br />
and participate in a series <strong>of</strong> workshops designed to<br />
analyze recent literature and demonstrate possible<br />
effects on practice. These workshops are held twice<br />
each month and utilize a curriculum in evidence<br />
based medicine.<br />
• Residents and students have the opportunity<br />
to participate in international health activities<br />
including electives in Central America such as the<br />
Rural Health, Adolescent Mentoring and Medical<br />
Spanish elective in El Salvador and the STI/HIV<br />
Education elective in Panama.<br />
• Many <strong>of</strong> our residents participate in active research<br />
with faculty. The underlined authors <strong>of</strong> the<br />
manuscripts in the sections below identify our<br />
residents or students.<br />
PEDIATRIC CLERKSHIP<br />
Medical students rotating through our pediatric clerkship<br />
are assigned for three weeks to an “outpatient program”<br />
at either on-site (general pediatrics and subspecialty<br />
clinics) or in the community. They are also assigned<br />
for three weeks to one <strong>of</strong> two inpatient services. A<br />
teaching attending is assigned to them during their<br />
in-patient rotation. Her or his role is to work closely<br />
with the students, mostly providing bed-side teaching<br />
(communicating with patients and families, taking medical<br />
histories, performing physical examinations, evaluation<br />
laboratory findings, interpreting x-rays, etc.)<br />
The students actively participate in patient care, morning<br />
report, teaching rounds, evidence based medicine<br />
conferences, adolescent conferences and on-line cases.<br />
They attend 30 core lectures given by the faculty and are<br />
required to study CLIPP (Computer Learning in Pediatric<br />
Project; www.clippcases.org) cases.<br />
EDUCATION OUTCOMES<br />
Graduates <strong>of</strong> the Residency program go on to careers in<br />
both primary care practice and in academic medicine, in<br />
the subspecialties and in general pediatrics. In the past<br />
five years, 62% <strong>of</strong> our residents have pursued academic<br />
fellowship programs. These have included: Hematology/<br />
Oncology, Endocrinology, Critical Care, Infectious<br />
Diseases, Gastroenterology, Pediatric Emergency<br />
Medicine, Neonatology, Allergy/Immunology and General<br />
Academic <strong>Pediatrics</strong>. In addition, 35% <strong>of</strong> our residents<br />
have joined primary care practices in the Syracuse area<br />
as well as various communities in New York State, North<br />
Carolina, California, Ohio, Louisiana, New Hampshire,<br />
Pennsylvania, and Washington. Another 2% have joined<br />
academic faculties directly upon completion <strong>of</strong> the<br />
residency. Nine percent have stayed on to become our<br />
chief residents. Of these, 100% entered fellowships upon<br />
completion <strong>of</strong> their chief year.<br />
In <strong>2008</strong>, 89% <strong>of</strong> our residents passed the American Board<br />
<strong>of</strong> <strong>Pediatrics</strong> Certifying Examination on the first attempt<br />
with a mean score well above the national average.<br />
On the NBME subject exam in pediatrics, our medical<br />
students’ scores for the years 2006-2007 average above<br />
the 50 th percentile nationally.
Bi-Annual <strong>Report</strong> • 7<br />
EDUCATION PUBLICATIONS<br />
Book Chapters<br />
Koszalka T, Olson B. Transforming a <strong>Pediatrics</strong> Lecture<br />
Series to Online Instruction. Handbook <strong>of</strong> research on<br />
distributed medical informatics and e-health. Hershey,<br />
PA. Medical Information Science Ref, Aug <strong>2008</strong>.<br />
PUBLICATIONS WITH RESIDENTS, FELLOWS,<br />
OR STUDENTS<br />
Anbar RD and Zoughbi GG. Relationship <strong>of</strong> headache<br />
associated stressors and hypnosis therapy outcome<br />
in children: a retrospective chart review. Am J <strong>of</strong> Clin<br />
Hypnosis. <strong>2008</strong>; 50:335-341<br />
Bennett N - E-Medicine: “HIV Disease” http://www.<br />
emedicine.com/MED/topic24.htm (Oct 22, <strong>2008</strong>)<br />
Bennett N, Domachowske D. Rocky Mountain Spotted<br />
Fever. Emedicine, 9/10/09<br />
Bennett, N – Emedicine<br />
Mononucleosis and Epstein-Barr Virus Infection (10/20/09)<br />
http://emedicine.medscape.com/article/963894-overview<br />
Nocardiosis and Gonorrhea.<br />
http://emedicine.medscape.com/article/966919-overview<br />
http://emedicine.medscape.com/article/964220-overview<br />
Bern RA, van Woensel JBM, Bos AP, Koski A, Farnand<br />
A, Domachowske JB, Rosenberg HF, Martin TR, and<br />
Matute-Bello G. Mechanical ventilation enhances lung<br />
inflammation and caspase activity in a model <strong>of</strong> mouse<br />
pneumovirus infection. AJP Lung <strong>2009</strong>; 296; L46-56.<br />
Dardas M, Abboud M, Salti I, et al. Thyroid cancer in<br />
Lebanese children and adolescents: a 15-year experience<br />
at a single institution. Pediatr Hematol Oncol. <strong>2009</strong> Sep<br />
26(6):439-47<br />
de Waal Malefyt D, Pecha M, Domachowske J. Poster,<br />
“Bacterial Meningitis in Children with Mondini Dysplasia”<br />
Poster, PAS, 5/09, Baltimore, MD<br />
Henderson JF, Anbar RD. Care for Amish and Mennonite<br />
children with cystic fibrosis: a case series. BMC <strong>Pediatrics</strong><br />
<strong>2009</strong>, 9:4.<br />
Kobayaa H, Souki RR, Trust S and Domachowske JB.<br />
Pastuerella multocida meningitis in newborns after<br />
incidental animal exposure. Pediatr Infect Dis J <strong>2009</strong>; in<br />
press<br />
Mallick D, Thapa R. An 11-year-old boy with dark skin,<br />
swallowing difficulty and absence <strong>of</strong> tears. Indian Journal<br />
<strong>of</strong> Dermatology, <strong>2009</strong>; 54(1)<br />
Mallick D, Thapa R. ‘Molar tooth’ sign in Joubert<br />
syndrome. Pediatr Radiol. 7/7/09.<br />
Maniscalco J, Dryer AL, Marks A, Yunghans M, Pierson<br />
SB, Sgarlat CM, Sveen AR, Blanch LE. Index <strong>of</strong> suspicion.<br />
Pediatr Rev. <strong>2008</strong> Sep;29(9):321-8.<br />
Moro M, Suryadevara M, Kiska D, Ridell S and Shaw<br />
J. Incidence <strong>of</strong> invasive community-onset (CO)<br />
Staphylococcus aureus infections in children in central<br />
New York - The Journal <strong>of</strong> <strong>Pediatrics</strong>. Accepted for<br />
publication. <strong>2009</strong>.<br />
Moro R, Contello K, Holz W, Weiner L, Shaw J.<br />
“Subcutaneous (SCIG) Versus Intravenous (IVIG)<br />
Immunoglobulin Replacement Therapy in a Pediatric<br />
Population with Primary Immunodeficiencies (PID)”<br />
Poster, PAS, 5/09, Baltimore, MD.<br />
Moro MR, Bonville CA, Suryadevara, M, Cummings E,<br />
Faddoul D, Kobayaa H., Branigan P, Domachowske JB.<br />
Clinical features, adenovirus types, and local production<br />
<strong>of</strong> inflammatory mediators in adenovirus infections.<br />
Pediatric Infectious Disease Journal. 28(5):376-380, May<br />
<strong>2009</strong>.<br />
Samkari A, Kiska D, Riddell et al. Dipylidium Caninum<br />
Mimicking Recurrent Enterobius Vermicularis (Pinworm)<br />
Infection. Clinical <strong>Pediatrics</strong>, In Press, <strong>2008</strong>.<br />
Samkari A, Sveen A. Pityriasis Rosea. Consultant for<br />
<strong>Pediatrics</strong>, February <strong>2008</strong><br />
Samkari A, Sveen A. Localized Schleroderma. Consult for<br />
Pediatricians, June <strong>2008</strong>:258-259.<br />
Samkari A. “Dipylidium caninum mimicking recurrent<br />
Enterobius vermicularis (pinworm) infection.” Poster<br />
presented at the Medical Society <strong>of</strong> the State New<br />
York (MSSNY) Resident and Fellow Research Poster<br />
Symposium. April 11, <strong>2008</strong>.<br />
Sgarlat C and Sveen A. Case presentation on<br />
hyperimmunoglobulin E syndrome. Pediatr in ev.<br />
<strong>2008</strong>;29:322-7<br />
Sgarlat CM, Sveen AR. Case Presentation. <strong>Pediatrics</strong> in<br />
Review. Sept <strong>2008</strong>. 324-327.<br />
Suryadevara M, Schurman S, Landas S, et al. BRIEF<br />
REPORT: Systemic Calciphylaxis. Pediatr Blood Cancer<br />
<strong>2008</strong>; 100:1-2.<br />
Tabarani CM, Bennett NJ, Kiska DL, Riddell SW, Botash AS<br />
and Domachowske JB. Empyema <strong>of</strong> pre-existing subdural<br />
hemorrhage caused by a rare Salmonella species after<br />
exposure to bearded dragons in a foster home. J Pediatr<br />
<strong>2009</strong>.<br />
Thapa R, Biswas B, Mallick D. Classic Hemorrhagic Disease<br />
<strong>of</strong> the Newborn Presenting with Bilateral Vitreous<br />
Hemorrhage. To The Editor. J <strong>of</strong> Emerg Med. <strong>2009</strong>.<br />
Thapa R, Ganguly D, Dhar S, Banerjee P. Short<br />
Communication: Pachyonychia congenital Type 1<br />
(Jadassohn-Lewandowky Type): <strong>Report</strong> <strong>of</strong> four cases.<br />
Indian Journal <strong>of</strong> Dermatology, <strong>2009</strong>; 54(2).<br />
Thapa R. Scientific Letters to the Editor: Discordance<br />
for Congenital Toxoplasmosis in Twins. Indian Journal <strong>of</strong><br />
<strong>Pediatrics</strong>, Vol 26, October, <strong>2009</strong>.Thapa R. Letter: Bilateral<br />
Subconjunctival Haemorrhage in Childhood Enteric Fever.<br />
Singapore Med J <strong>2009</strong> 50(10):1038.<br />
Thapa R, Ghosh A, Mallick D, Biswajit B. Letter: Lung<br />
Abscess Secondary to Non-Typhoidal Salmonellosis in an<br />
Immunocompetent Girl. Singapore Med J <strong>2009</strong> 50(10):1033-5.
8 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Thapa R, Ghosh A, Dhar S. Infantile giant congenital<br />
melanocytic nevus: report <strong>of</strong> three unusual cases. Int J<br />
<strong>of</strong> Derm, <strong>2009</strong>, 48, 1209-1212.<br />
Thapa R. Letter to the Editor. Moebius Syndrome with<br />
Atrial Septal Defect. Singapore Med J <strong>2009</strong>; 50(10):1.<br />
Thapa R, Mallick D, Biswas B, Ghosh A. Open and Closed<br />
Lip Schizencephaly in Seckel Syndrome: A Case <strong>Report</strong>.<br />
Journal <strong>of</strong> Child Neurology. <strong>2009</strong><br />
Thapa R, Bishwajit B, Debkrishna M et al.<br />
Childhood Plasmodium vivax Malaria With Severe<br />
Thrombocytopenia and Bleeding Manifestations. Pediatr<br />
Hematol Oncol, <strong>2009</strong>.<br />
Thapa R, Gosh A, Banerjee T. Childhood Plasmodium<br />
falciparum malaria complicated by spenic abscess.<br />
Emergency Medicine Australasia (<strong>2009</strong>) 21, 237-239.<br />
Thapa R, Ghosh A, Dhar S. Letter to Editors: Progressive<br />
hemifacial atrophy (Parry-Romberg syndrome ) with<br />
band-like alopecia. Indian Journal <strong>of</strong> <strong>Pediatrics</strong>. <strong>2009</strong>.<br />
Thapa R, Ghosh A, Mondol S et al. A 13-Year-old Boy With<br />
Extensive Bilateral Lung Infiltrates. J Pediatr Hematol<br />
Oncol. <strong>2009</strong>.<br />
Thapa R, Mallick D, Biswas B. Perinatal malaria and<br />
tuberculosis co-infection: A case report. . Int J <strong>of</strong><br />
Infectious Diseases (<strong>2009</strong>).<br />
Thapa R. Letter: Acute disseminated encephalomyelitis.<br />
Indian Journal <strong>of</strong> <strong>Pediatrics</strong>, Vol 26, Jan, <strong>2009</strong>.<br />
Thapa R, Chakrabartty S. Atyipcal Kawasaki disease with<br />
remarkable paucity <strong>of</strong> signs and symptoms. Rheumatol<br />
Int,, April <strong>2009</strong>.<br />
Thapa R, Mallick D, et al. Case <strong>Report</strong>: Childhood<br />
cutaneous polyarteritis nodosa: an unusual presentation.<br />
Rheumatol Int. June <strong>2009</strong>.<br />
Thapa R, Pal P, Mukhopadhyay M. To the Editor: Beta<br />
Thalassemia Major and Hodgkin Lymphoma. Pediatr<br />
Hematol ONcol, 31:6, June <strong>2009</strong>.<br />
Thapa R, Biswas B, et al. Pharyngeal-Cervical-Brachial<br />
Variant <strong>of</strong> Pediatric Guillain-Barre’ Syndrome With<br />
Antecedent Acute Hepatitis A Virus Infection. J <strong>of</strong> Child<br />
Neurol. July <strong>2009</strong>: 24(7).<br />
Thapa R, Mallick D, Biswas B, Chakrabartty. Transient<br />
unilateral oculomotor palsy and severe headach in<br />
childhood Kawasaki disease. Rheumatol Int, Oct 12, <strong>2009</strong>;<br />
1154-6.<br />
PRESENTATIONS AT NATIONAL MEETINGS<br />
Andrake J, Olsen BG, Peacock J, Harlan GA, Guralnick<br />
S, Blair RJ, Fahner J, Starr T, Perspectives on Curriculum<br />
Reform: Different Approaches to the Same Goal.<br />
Presented at the Annual Meeting <strong>of</strong> the Association <strong>of</strong><br />
Pediatric Program Directors,Baltimore, MDApril 28 – May<br />
2, <strong>2009</strong><br />
Andrake J, Sveen A.Building a Communication Skills<br />
Curriculum for the <strong>Pediatrics</strong> Clerkship. Presented at the<br />
Annual Meeting <strong>of</strong> COMSEP. Atlanta, GA; April 3-6, <strong>2008</strong><br />
PRESENTATIONS AT NATIONAL MEETINGS<br />
WITH RESIDENTS, FELLOWS AND STUDENTS<br />
Bennett N (et al) Poster Presentation: “The Effects <strong>of</strong><br />
Teaching a Novel Communication Skills Curriculum in<br />
<strong>Pediatrics</strong> on Medical Students’ Perceptions” at MSSNY<br />
(Medical Student Society <strong>of</strong> NY), Friday, May 1, <strong>2009</strong>.<br />
Bem RA, van Woensel JB, Bos AP, Koski A, Domachowske<br />
JB, Rosenberg HF, Martin TR, and Matute-Bello G.<br />
Mechanical ventilation enhances lung inflammation and<br />
cellular apoptosis in a model <strong>of</strong> mouse pneumovirus<br />
infection. American Thoracic Society Toronto Canada<br />
<strong>2008</strong>.<br />
Dawson E, Greenberg S, Mahar S, Olson B. Poster<br />
“The Predictive Value <strong>of</strong> Eosinophilia in Chronic<br />
Schistosomiasis and Strongyloidiasis: An Examination<br />
<strong>of</strong> the CDC Screening Guidelines for Newly Arriving<br />
Refugees”<br />
de Waal Malefyt S, Pecha M, Domachowske J. Poster,<br />
“Bacterial Meningitis in Children with Mondini Dysplasia”<br />
Poster, Baltimore, MD, PAS, 5/09<br />
El Feghaly R, McGann L, Domachowske J. et al – Poster,<br />
PAS, 5/09, Baltimore, MD. “A Decade <strong>of</strong> Pediatric<br />
Parainfluenza Virus Infections: Clinical Manifestations<br />
and Biomarkers <strong>of</strong> Disease Severity” et al – Poster, PAS,<br />
5/09, Baltimore, MD.<br />
El Feghaly R, McGann L, Domachowske J. et al – Poster,<br />
“A Decade <strong>of</strong> Pediatric Parainfluenza Virus Infections:<br />
Clinical Manifestations and Biomarkers <strong>of</strong> Disease<br />
Severity” et al – Poster, PAS, 5/09, Baltimore, MD.<br />
Moro R, Contello K, Holz W, Weiner L, Shaw J.<br />
“Subcutaneous (SCIG) Versus Intravenous (IVIG)<br />
Immunoglobulin Replacement Therapy in a Pediatric<br />
Population with Primary Immunodeficiencies (PID)”<br />
Poster, PAS, 5/09, Baltimore, MD.<br />
Pekarsky S, Botash A. Poster “Pediatric Patient Assent<br />
and Medical Provider Compliance with New York State<br />
Guidelines for HIV Post-Exposure Prophylaxis for Sexual<br />
Assault” PAS 5/09, Baltimore, MD<br />
Samkari A. “Dipylidium Caninum Mimicking Recurrent<br />
Enterobius Vermicularis (pinworm) Infection.” Poster<br />
presented at the Medical Society <strong>of</strong> the State New<br />
York (MSSNY) Resident and Fellow Research Poster<br />
Symposium. April 11, <strong>2008</strong>.
Bi-Annual <strong>Report</strong> • 9<br />
GRANTS AND CONTRACTS<br />
Botash AS: Child Abuse Medical Provider NYS Training<br />
Initiative: <strong>2008</strong>-2010 New York State <strong>Department</strong> <strong>of</strong><br />
Health, Rape Crisis Program Preventive Health and<br />
Health Services Block Grant from CDC, Rape Prevention<br />
Education. ~$160,000.<br />
Botash AS: Child Abuse Medical Provider Training and<br />
Network: <strong>2008</strong>-09, NYS Office <strong>of</strong> Children and Family<br />
Services pending legislative approval, $90,000 .<br />
Botash AS: Child Abuse Medical Provider Training and<br />
Network, Children’s Miracle Network Grant, <strong>2009</strong>.<br />
$30,000.<br />
Botash AS: Procedure Management Education (LEAPP).<br />
$8,400<br />
Botash AS: Friend In Deed Funding for Child Fatality<br />
Review Team: $2400<br />
Botash AS, Unger C, Ryan M.: Onondaga County Child<br />
Fatality Review Team: NYS OCFS <strong>2009</strong>- 2010. $ 52,000<br />
Botash AS: Assistance for Abused Children. St. Agatha<br />
Foundation. $25,000<br />
Botash AS, Bifano E: Empire Clinical Reseach Investigator<br />
Program, Post Graduate Medical Education research in<br />
Neonatology, September <strong>2008</strong> – August 2010, $120,000.<br />
Dosa NP: Parent Partners in Health Education. New York<br />
State Developmental Disabilities Planning Council: 2006-<br />
<strong>2009</strong>: $135,000
10 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
PEDIATRIC EMERGENCY MEDICINE<br />
Syracuse is fortunate to have a group <strong>of</strong> specialists in<br />
Pediatric Emergency Medicine. While these physicians<br />
have primary appointments in the <strong>Department</strong> <strong>of</strong><br />
Emergency Medicine, most have joint appointments in<br />
the <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong>.<br />
FACULTY<br />
Richard M. Cantor, MD FAAP/FACEP, Director <strong>of</strong> Pediatric<br />
Emergency Services/Medical Director, Central NY Poison<br />
Control Center, Associate Pr<strong>of</strong>essor <strong>of</strong> Emergency<br />
Medicine and <strong>Pediatrics</strong><br />
P. David Sadowitz, MD, Associate Pr<strong>of</strong>essor, Emergency<br />
Medicine and <strong>Pediatrics</strong><br />
James D’Agostino, MD, FAAP, Assistant Pr<strong>of</strong>essor,<br />
Emergency Medicine and <strong>Pediatrics</strong><br />
Jennifer E. Mackey, MD, FAAP, Assistant Pr<strong>of</strong>essor,<br />
Emergency Medicine and <strong>Pediatrics</strong><br />
Lisa Marie Keough, MD, Assistant Pr<strong>of</strong>essor, Emergency<br />
Medicine and <strong>Pediatrics</strong><br />
Alison McCrone MD, Assistant Pr<strong>of</strong>essor, Emergency<br />
Medicine and <strong>Pediatrics</strong><br />
CLINICAL OVERVIEW<br />
The Pediatric Emergency <strong>Department</strong> at University<br />
Hospital for the greater part <strong>of</strong> 25 years has provided<br />
24-hours a day, 7 days a week coverage for any and all<br />
pediatric emergencies. We service the entire Central<br />
New York region consisting <strong>of</strong> over 18 counties and over<br />
25 hospitals. We are the primary referral center for all<br />
pediatric emergencies, including major trauma, major<br />
medical emergencies, poisonings, and child abuse. All<br />
pediatric transports within our region are evaluated<br />
within our emergency department and disposition is<br />
arranged for daily. With the opening <strong>of</strong> the Golisano<br />
Children’s Hospital, the Pediatric Emergency <strong>Department</strong><br />
continues to play an expanded role in the delivery <strong>of</strong> subspecialty<br />
Pediatric Emergency Medical Services.<br />
The last few years have demonstrated a marked<br />
growth in both patient volume and diversity in our<br />
academic efforts. The faculty maintains a strong clinical<br />
relationship with all practitioners within the region,<br />
including family physicians and pediatricians alike. We<br />
maintain a strong educational presence in the region as<br />
evidenced by the annual Pediatric Emergency Medicine<br />
Teaching Day, which has been in place for the greater<br />
part <strong>of</strong> 10 years. In addition, under our directorship, PALS,<br />
APLS, and PEPP courses are <strong>of</strong>fered almost on a monthly<br />
basis. Target audiences include students, residents,<br />
paramedics, and private practitioners. Members <strong>of</strong><br />
the Pediatric Emergency Medicine faculty, specifically<br />
Drs. Cantor, Sadowitz, and D’Agostino, are nationally<br />
recognized figures in our field and are <strong>of</strong>ten invited to<br />
present to national and international audiences. This<br />
past year, our division was responsible for a reference<br />
text, “Neonatal Emergencies”, edited by Drs. Cantor and<br />
Sadowitz, and published by McGraw Hill.<br />
Within the Upstate Medical University College <strong>of</strong><br />
Medicine, the Pediatric Emergency <strong>Department</strong> <strong>of</strong>fers<br />
many educational opportunities. We are developing<br />
an educational model within the MedSTAR Simulation<br />
Center, addressing the needs <strong>of</strong> medical students and<br />
residents. In addition, we <strong>of</strong>fer a fourth year medical<br />
student elective in Pediatric Emergency Medicine.<br />
Lectures are given to residents within both the<br />
<strong>Department</strong>s <strong>of</strong> Emergency Medicine and <strong>Pediatrics</strong><br />
throughout the year. In addition, we maintain a strong<br />
affiliation with the family practice residency at St.<br />
Joseph’s Hospital, with their residents rotating through<br />
our Pediatric Emergency <strong>Department</strong> four days a week.<br />
Over the last five years, we have re-instituted our<br />
fellowship program in Pediatric Emergency Medicine,<br />
under the leadership <strong>of</strong> Dr. Richard Cantor. We accept<br />
one fellow per year, and at present will have three in<br />
place working within our division. These fellows are<br />
graduates <strong>of</strong> both pediatric residencies and emergency<br />
medicine residencies. The fellowship program in<br />
Pediatric Emergency Medicine at University Hospital is<br />
unique in the country in <strong>of</strong>fering positions to graduates <strong>of</strong><br />
emergency medicine residency programs. These are very<br />
competitive positions, and we are fortunate to have this<br />
<strong>of</strong>fering on a local basis.<br />
PUBLICATIONS<br />
Sadowitz PD, Souid A-K. Cancer and cancer related<br />
complications in children. Pediatric Emergency Medicine,<br />
<strong>2008</strong>. Ed. Baren, Brennan, Brown and Rothrock.<br />
Sadowitz PD, Souid A-K. Idiopathic thrombocytopenic<br />
purpura and other platelet disorders. Pediatric<br />
Emergency Medicine, <strong>2008</strong> Ed. Baren, Brennan, Brown and<br />
Rothrock<br />
Sadowitz PD: Neonatal Hematologic Emergencies, in<br />
Neonatal Emergency Medicine, Cantor and Sadowitz,<br />
McGraw-Hill, <strong>2009</strong><br />
Sadowitz PD: Neonatal Infectious Emergencies, in<br />
Neonatal Emergency Medicine, Cantor and Sadowitz,<br />
McGraw-Hill, <strong>2009</strong><br />
Cantor RM: Neonatal Emergencies, in Pediatric<br />
Emergency Medicine, Baren J. Elsevier, <strong>2008</strong>.<br />
Cantor RM: Aspirin and APAP Poisoning, in Pediatric<br />
Emergency Medicine, Baren J. Elsevier, <strong>2008</strong>.<br />
Cantor RM: Classic Pediatric Poisonings, in Pediatric<br />
Emergency Medicine, Baren J. Elsevier, <strong>2008</strong>.<br />
Cantor RM: Respiratory Distress in The Clinical Practice<br />
<strong>of</strong> Emergency Medicine, Wolfson A, Lippincott, Williams<br />
and Wilkins <strong>2009</strong><br />
Cantor RM: Upper Airway Emergencies, in Pediatric<br />
Emergency Medicine, 3rd Ed, McGraw-Hill <strong>2009</strong>
Bi-Annual <strong>Report</strong> • 11<br />
Cantor RM: Neonatal Abdominal Emergencies, in<br />
Neonatal Emergency Medicine, Cantor and Sadowitz,<br />
McGraw-Hill, <strong>2009</strong><br />
Cantor RM: Neonatal Neurological Emergencies, in<br />
Neonatal Emergency Medicine, Cantor and Sadowitz,<br />
McGraw-Hill, <strong>2009</strong><br />
D’Agostino J. Malrotation and Midgut Volvulus. In:<br />
Baren JM, et al., eds. Pediatric Emergency Medicine.<br />
Philadelphia, Saunders; <strong>2008</strong>, pp 630-633.<br />
Mackey JE Neonatal Respiratory Emergencies. in<br />
Neonatal Emergency Medicine, Cantor and Sadowitz,<br />
McGraw-Hill <strong>2009</strong><br />
PRESENTATIONS AT SCIENTIFIC MEETINGS<br />
Cantor RM. Pediatric Emergency Medicine Literature<br />
Review; Mistakes You Don’t Want to Make in Pediatric<br />
Patients. Presented at the American College <strong>of</strong><br />
Emergency Physicians Scientific Assembly, Chicago,<br />
Illinois. <strong>2008</strong><br />
Cantor RM. Pediatric Emergency Medicine Literature<br />
Review; Chief Complaints in Inafants Less Than 28<br />
Days <strong>of</strong> Age; Mistakes You Don’t Want to Make in<br />
Pediatric Patients. Presented at the American College<br />
<strong>of</strong> Emergency Physicians Scientific Assembly, Boston,<br />
Massachusetts. <strong>2009</strong><br />
Cantor RM. Emergency Medicine Grand Rounds.<br />
Presented at NYU Bellevue Medical Center <strong>Department</strong><br />
<strong>of</strong> Emergency Medicine, June, <strong>2008</strong><br />
Cantor RM. Keynote Speaker, St. Barnabus NJ Hospital<br />
Annual Emergency Medicine Teaching Day, <strong>2008</strong>, <strong>2009</strong>:<br />
Mistakes You Don’t Want To Make in Pediatric Emergency<br />
Patients, Short Hills, NJ<br />
Cantor RM. Keynote Speaker, Methodist Hospital Annual<br />
Pediatric Medicine Teaching Day, <strong>2008</strong>, <strong>2009</strong>: Lit Review,<br />
Toxicology, Mistakes, Miami, Florida<br />
Cantor RM. Speaker, NJ ACEP Annual Emergency<br />
Medicine Teaching Conference, <strong>2008</strong>, <strong>2009</strong>: Lit Review,<br />
Toxicology, Mistakes, Atlantic City, NJ<br />
Cantor RM. Invited Speaker, Stanford University Annual<br />
Emergency Medicine Teaching C<strong>of</strong>erence, <strong>2009</strong>: Lit<br />
Review, Toxicology, Mistakes, Maui, Hawaii<br />
Cantor RM. Visiting Pr<strong>of</strong>essor, <strong>Department</strong> <strong>of</strong> Emergency<br />
Medicine, University <strong>of</strong> Maryland, August, <strong>2009</strong>.<br />
Cantor RM. Visiting Pr<strong>of</strong>essor, <strong>Department</strong> <strong>of</strong> Emergency<br />
Medicine, University <strong>of</strong> Texas Southwestern, November,<br />
<strong>2009</strong>.<br />
HONORS, VISITING PROFESSORSHIPS,<br />
EDITORIAL DUTY<br />
Editorial Boards/Reviewer<br />
Cantor, R. Annals <strong>of</strong> Emergency Medicine. Pediatric<br />
Emergency Care, American Journal <strong>of</strong> Emergency<br />
Medicine, Micromedex Poisondex, Pediatric Emergency<br />
Medicine Abstracts, PRETx (Pediatric Research in<br />
Emergency Therapeutics).<br />
GRANT ACTIVITY<br />
Cantor RM. Development <strong>of</strong> a Child Life Specialist in the<br />
Pediatric Emergency <strong>Department</strong> (2005-8), Children’s<br />
Miracle Network, $40,000/year<br />
Sadowitz, PD. An Epidemiologic Study to Evaluate the<br />
Seasonality <strong>of</strong> Respiratory Syncytial Virus Associated<br />
Lower Respiratory Tract Infections or Apnea in Infants in<br />
the Emergency <strong>Department</strong>. $45,000 received to date<br />
9/1/06 – May 1, <strong>2008</strong><br />
SELECTED CLINICAL DATA<br />
Pediatric Emergency <strong>Department</strong> Visits, <strong>2008</strong>: . . . . . . 21,242<br />
Pediatric Emergency <strong>Department</strong> Visits, <strong>2009</strong>:. . . . . 21,338<br />
Percentage <strong>of</strong> patients admitted: . . . . . . . . . . . . . . . . . . . 10%<br />
Ambulances received per day: . . . . . . . . . . . . . . . . . . . . . 6-10<br />
Private patient referrals per day: . . . . . . . . . . . . . . . . . . . 10-15
12 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
PEDIATRIC ENDOCRINOLOGY, DIABETES & METABOLISM<br />
FACULTY<br />
Roberto Izquierdo, MD, Pr<strong>of</strong>essor <strong>of</strong> Medicine and<br />
<strong>Pediatrics</strong>; Section Head; Associate Medical Director,<br />
Joslin Diabetes Center Affiliate; Medical Director, Thyroid<br />
Cancer Center<br />
Lauren Lipeski, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Irene N. Sills, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>; Director,<br />
New York State Newborn Screening Program; Director,<br />
Pediatric Endocrine and Diabetes Fellowship<br />
Susan E. Stred, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>;<br />
Associate Medical Director, KNOT Program<br />
AFFILIATED CLINICAL STAFF<br />
Kathleen Bratt, PNP, CDE<br />
Sheri Hill, RN, Diabetes Educator<br />
Lynn Horowitch, PNP<br />
Joanne Kearns, RD, CDE<br />
Khuyet Le, PA<br />
Barbara Lindenmayer, PNP<br />
Andrea Gross, RN, Diabetes Educator<br />
CLINICAL OVERVIEW<br />
The Section <strong>of</strong> Pediatric Endocrinology, Diabetes and<br />
Metabolism provides care for children and adolescents<br />
with the full spectrum <strong>of</strong> disorders <strong>of</strong> the endocrine<br />
system. Staff endocrinologists and nurse practitioners<br />
evaluate and treat children with diabetes mellitus,<br />
short stature, thyroid disease, Turner syndrome,<br />
hypopituitarism, disorders <strong>of</strong> puberty, congenital<br />
adrenal hyperplasia, metabolic bone disorders, and<br />
other hormonal disorders. Our Center is one <strong>of</strong> the<br />
original referral sites for New York State’s Newborn<br />
Screening Program for congenital hypothyroidism<br />
and 21-hydroxylase congenital adrenal hyperplasia.<br />
We were recognized as an Endocrine Specialty Center<br />
for Congenital Hypothyroidism, Congenital Adrenal<br />
Hyperplasia, and Diabetes by the New York State<br />
<strong>Department</strong> <strong>of</strong> Health in 2004.<br />
Diabetes mellitus is treated by a comprehensive group<br />
<strong>of</strong> pr<strong>of</strong>essionals using the team model, under the<br />
direction <strong>of</strong> Dr. Izquierdo at the Joslin Diabetes Center<br />
at SUNY Upstate Medical University. The team includes<br />
nurse practitioners with a special interest in diabetes<br />
care, diabetes educators, including diabetes pump<br />
educators, dieticians, and an exercise physiologist. This<br />
multidisciplinary team provides care to children with<br />
type 1 and type 2 diabetes mellitus. On a consultative<br />
basis, we have support from adult and pediatric<br />
psychologists.<br />
Dr. Izquierdo and Kathleen Bratt direct the School<br />
Telemedicine Project, supported by a New York State<br />
Diabetes Center <strong>of</strong> Excellence Grant. This program<br />
provides diabetes care via telemedicine to students with<br />
diabetes in schools in our northern regions <strong>of</strong> New York.<br />
We are able provide pediatric DXA scanning and<br />
consultations on patients at risk for osteoporosis. In <strong>2008</strong>,<br />
Dr. Sills attained certification as a clinical Densitometrist<br />
by the International Society for Clinical Densitometry.<br />
Dr. Irene Sills is a member <strong>of</strong> the Harry Benjamin<br />
International Gender Dysphoria Association, Inc. and<br />
directs our program to treat children with gender<br />
dysphoria and adolescents with transsexualism.<br />
Dr. Stred supervises the endocrine portion <strong>of</strong> the KNOT<br />
(Kids Now Off Therapy) Program, the latter providing<br />
comprehensive care to cancer survivors. Although more<br />
than 70% <strong>of</strong> all children diagnosed with a malignancy<br />
during childhood now survive, 40-50% <strong>of</strong> those<br />
experience significant endocrine dysfunction as a result<br />
<strong>of</strong> their treatment.<br />
RESEARCH HIGHLIGHTS<br />
Dr. Izquierdo’s research interests lie in type 1 and 2<br />
diabetes mellitus, and thyroid nodular disease and<br />
cancer. He is the principal investigator for the Protégé<br />
Study, which is a multi-centered study that uses a<br />
monoclonal antibody to preserve beta-cell function in<br />
children and adolescents with type 1 diabetes mellitus.<br />
This improves glycemic control and prolongs the<br />
“honeymoon” phase <strong>of</strong> type 1 diabetes. He is also involve<br />
in the Diamyd clinical trial in which a GAD vaccine is<br />
administer to children early in the diagnoses <strong>of</strong> diabetes<br />
to preserve beta-cell function. Dr. Izquierdo continues as<br />
co-investigator <strong>of</strong> the TODAY study, a multicenter NIHsponsored<br />
trial to determine the best treatment options<br />
in children and adolescents with type 2 diabetes mellitus.<br />
Dr. Sills is interested in the natural history <strong>of</strong> type 1<br />
diabetes. She is our Center’s principal investigator for<br />
TrialNet, which aims at identifying individuals at high<br />
risk for development <strong>of</strong> type 1 diabetes. Identified high<br />
risk individuals are then eligible to participate in trials<br />
designed to delay or prevent the development <strong>of</strong> type 1<br />
diabetes mellitus.<br />
PUBLICATIONS<br />
Trief P.M., J. Sandberg, R.I. Izquierdo, P.C. Morin, S.<br />
Shea, R. Brittain, E.B. Feldhousen, R.S. Weinstock.<br />
Diabetes management assisted by telemedicine: patient<br />
perspectives. Telemedicine and e-Health 14(7):647-655,<br />
<strong>2008</strong>.<br />
Izquierdo R, Shankar R, Kort K, Khurana K. Ultrasound-<br />
Guided Fine-Needle Aspiration in the Management <strong>of</strong><br />
Thyroid Nodules in Children and Adolescents. Thyroid 19<br />
(7): 703-705, <strong>2009</strong><br />
Shea, S., R.S. Weinstock, J.A. Teresi, W. Palmas, J. Starren,<br />
J.J. Cimino, A.M. Lai, L. Field, P.C. Morin, R. Goland,
Bi-Annual <strong>Report</strong> • 13<br />
R.E. Izquierdo, S. Ebner, S. Silver, E. Petkova, J. Kong, J.P.<br />
Eimicke for the IDEATel Consortium. A randomized trial<br />
comparing telemedicine case management with usual<br />
care in older, ethnically diverse, medically underserved<br />
patients with diabetes mellitus: 5 year results <strong>of</strong> the<br />
IDEATel study. J Am Med Inform Assoc, 16: 446-456, <strong>2009</strong>.<br />
Sandberg J, Trief PM, Izquierdo R, Goland R, Morin PC,<br />
Palmas W, Larson CD, Shea S, Weinstock RS. A qualitative<br />
study <strong>of</strong> the experiences and satisfaction <strong>of</strong> direct<br />
telemedicine providers in diabetes case management.<br />
Telemedicine and e-Health <strong>2009</strong>: 15: 742-750.<br />
Izquierdo R, Morin PC, Bratt K, Moreau Z, Meyer S, Ploutz-<br />
Snyder R, Wade M, Weinstock RS. School Centered<br />
Telemedicine for Children with Type 1 Diabetes Mellitus. J<br />
Pediatr <strong>2009</strong>; 155:374-9.<br />
Shah SS, Faquin WC, Izquierdo R, Khurana KK. FNA<br />
<strong>of</strong> misclassified primary malignant neoplasms <strong>of</strong> the<br />
thyroid: Impact on clinical management. CytoJournal<br />
<strong>2009</strong>; vol 6, issue 1.<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS<br />
Izquierdo R, Weinstock RS, Morin P, Meyer S, Bratt<br />
K, Moreau Z, Ploutz-Snyder R. School Centered<br />
Telemedicine Study for Children with Diabetes. 68 th<br />
American Diabetes Association Scientific Sessions, June<br />
6-10, <strong>2008</strong>, San Francisco, CA.<br />
Izquierdo R, Barham K, Kort K, Khurana K, Hsu J, Numann<br />
P, Cico L. Intraoperative Use <strong>of</strong> Nck Sonography in the<br />
Management <strong>of</strong> Recurrent Thyroid Cancer. Endocrine<br />
Society’s 90 th Annual Meeting, June 16, <strong>2008</strong>, San<br />
Francisco, CA.<br />
INVITED WORKSHOPS, CME PRESENTATIONS<br />
Izquierdo, R. “Multiple Small Feedings <strong>of</strong> the Mind: New<br />
Directions in the Management <strong>of</strong> the Patient with Type<br />
1 Diabetes.” American College <strong>of</strong> Physicians NYACP<br />
Meeting. June 9, <strong>2009</strong>.<br />
Izquierdo, R. “Studies in Thyroid Cancer”. Endocrinology,<br />
Diabetes & Metabolism Journal Club. February 1, <strong>2008</strong>.<br />
Izquierdo, R. “Making Sense <strong>of</strong> Sensors”. School Nurse<br />
Teaching Day. September 13, <strong>2008</strong>.<br />
Izquierdo, R. “New Directions in the Management <strong>of</strong> the<br />
Patient with Type 1 Diabetes”. Medicine Grand Rounds,<br />
SUNY Upstate Medical University. February 19, <strong>2009</strong>.<br />
Izquierdo, R. “New Directions in the Management <strong>of</strong> the<br />
Patient with Type 1 Diabetes”. Pediatric Grand Rounds,<br />
SUNY Upstate Medical University. April 29, <strong>2009</strong>.<br />
Izquierdo, R. School Nurse Diabetes Teaching Day:<br />
“Insulin Pump Therapy”. Upstate Golisano Children’s<br />
Hospital at Upstate University Hospital. October 24,<br />
<strong>2009</strong>.<br />
Izquierdo, R. “Impact <strong>of</strong> Telemedicine on Medical<br />
Education”. Faculty Development Seminar. October 27,<br />
<strong>2009</strong>.<br />
Lipeski, L. Vitamin D Deficiency. Onondaga Pediatric<br />
Society Meeting. February 24, <strong>2009</strong>.<br />
Lipeski, L. Pediatric Obesity. Pediatric Grand Rounds.<br />
April 15, <strong>2009</strong>.<br />
Lipeski, L. Thyroid function testing. Endocrine<br />
Conference. October 8, <strong>2009</strong>.<br />
Sills, I. “Pediatric Endocrine Update” Annual Meeting <strong>of</strong><br />
New York State Nurse Practitioners, <strong>2008</strong>.<br />
Sills, I. “Gender Dysphoric Children and Transsexual<br />
Adolescents” Grand Rounds, Plattsburgh Hospital, <strong>2008</strong>.<br />
Sills, I. “Gender Dysphoric Children and Transsexual<br />
Adolescents”. American Academy <strong>of</strong> <strong>Pediatrics</strong> Meeting<br />
<strong>2009</strong>.<br />
Sills, I. “Transsexuality”. Psychiatry Grand Rounds <strong>2009</strong><br />
GRANTS AND CONTRACTS<br />
Sills, I. NIDDK: Diabetes TrialNet: Natural History<br />
Study <strong>of</strong> the Development <strong>of</strong> Type 1 Diabetes (Principal<br />
Investigator for our center). Funding accrual based.<br />
Izquierdo R. NIDDK: Trial for the Treatment <strong>of</strong> Type 2<br />
Diabetes in Children and Adolescents (co-investigator)<br />
Izquierdo R. A Phase 2/3, Randomized, Double-Blind,<br />
Multicenter, Multinational, 4-Arm, Controlled, Dose-<br />
Ranging Study to Evaluate Efficacy and Safety <strong>of</strong><br />
Teplizumab (MGA031), a Humanized, FcR Non-Binding,<br />
Anti-CD3 Monoclonal Antibody, in Children and Adults<br />
with Recent-Onset Type 1 Diabetes Mellitus. (Dr.<br />
Izquierdo, principal investigator for our center). Industrysponsored<br />
Trial (funding accrual based)<br />
Izquierdo R. NYS <strong>Department</strong> <strong>of</strong> Health School Centered<br />
Telemedicine Program for Children with Type 1 Diabetes<br />
Mellitus (Co-Investigator).<br />
Izquierdo R. Diamyd: A Phase III, 3- Arm, Randomized,<br />
Double-Blind, Placebo-Controlled, Multicenter Study<br />
to Investigate the Impact <strong>of</strong> Diamyd on the Progression<br />
<strong>of</strong> Diabetes in Newly Diagnosed with Type 1 Diabetes<br />
Mellitus. Industry-sponsored Trial (funding accrual<br />
based)<br />
SELECTED CLINICAL DATA<br />
Children in the diabetes mellitus program: .. . . . . . . . . 1000<br />
Children with new onset diabetes seen in <strong>2009</strong>: . . . . . . 100<br />
Children followed with congenital hypothyroidism: . . 100<br />
Children with diagnosed with congenital<br />
hypothyroidism in <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12<br />
Children with congenital adrenal hyperplasia<br />
who are actively followed:. . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />
Children with septo-optic dysplasia<br />
who are actively followed:. . . . . . . . . . . . . . . . . . . . . . . . . . 30<br />
Endocrine component <strong>of</strong> KNOT Clinic: . . . . . . . . . . . . . . 80
14 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
GASTROENTEROLOGY & NUTRITION<br />
FACULTY<br />
Manoochehr Karjoo, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Section<br />
Chief<br />
Mirza Beg, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Christopher Justinich, MD, Clinical Associate Pr<strong>of</strong>essor<br />
AFFILIATED CLINICAL STAFF<br />
Shannon Kesselring, MSN, FNP<br />
CLINICAL OVERVIEW<br />
The Section <strong>of</strong> Pediatric Gastroenterology and Nutrition<br />
provides care for patients from birth to 21 years <strong>of</strong> age<br />
with all types <strong>of</strong> gastroenterological disorders. This<br />
includes neonates and infants with hyperbilirubinemia,<br />
and liver disease such as biliary atresia and all forms <strong>of</strong><br />
hepatitis. We <strong>of</strong>fer multi-modal therapy for children<br />
with a variety <strong>of</strong> functional intestinal disorders ranging<br />
from cyclic vomiting and chronic abdominal pain to<br />
constipation.<br />
Our division has a particular interest in the management<br />
<strong>of</strong> children with inflammatory bowel disease and<br />
the gastrointestinal manifestations <strong>of</strong> food allergy.<br />
Gastroesophageal reflux disease is an increasingly<br />
recognized entity in children from infancy through young<br />
adulthood. We <strong>of</strong>fer a broad range <strong>of</strong> diagnostic and<br />
therapeutic approaches for such disorders.<br />
The section works closely and collaboratively with a<br />
number <strong>of</strong> other programs, including pediatric surgery,<br />
ENT, general pediatrics, pulmonary, and endocrinology.<br />
We are particularly expert in the gastroenterological<br />
issues impacting children with developmental delays. We<br />
coordinate procedures with our pediatric surgeons, such<br />
as gastrostomy tube placement, esophageal dilatation<br />
and endoscopies.<br />
The gastroenterologists undertake a full array <strong>of</strong><br />
procedures including pH probe tests, Bravo pH<br />
monitoring, esophago-gastro-duodenoscopy with<br />
biopsy, esophageal dilatation, esophageal sclerotherapy<br />
and banding procedures for varices, rectal biopsy for<br />
evaluation <strong>of</strong> Hirshsprung’s disease, colonoscopy with<br />
biopsy and polypectomy, liver biopsy, breath hydrogen<br />
test for lactase and sucrase deficiency, esophageal<br />
and colon motility and esophageal impedance studies.<br />
Most procedures are done in the Pietrafesa Center for<br />
Children’s Surgery, while others are done in our clinic.<br />
Outpatient care is provided in the newly remodeled and<br />
expanded <strong>of</strong>fice located in the 725 Irving Avenue, Suite<br />
805, in Syracuse. For the past few years, a satellite clinic<br />
in Watertown, NY has been staffed by one <strong>of</strong> our parttime<br />
faculty, Dr. Justinich. With the recruitment <strong>of</strong> two<br />
new full-time gastroenterologists in 2010, our plan is to<br />
continue that service and add a satellite clinic in Utica, NY.<br />
The section continues to be very active in medical<br />
student and resident education. Many <strong>of</strong> our<br />
residency graduates have gone on to train in pediatric<br />
gastroenterology.<br />
RESEARCH HIGHLIGHTS<br />
The section currently is participating in a multi-center<br />
trial <strong>of</strong> treatment <strong>of</strong> eosinophilic esophagitis using an<br />
antagonist <strong>of</strong> IL5.<br />
We are also preparing to join a Phase 3, multi-center,<br />
double-blind randomized placebo controlled, parallelgroup,<br />
withdrawal study to evaluate the safety and<br />
efficacy <strong>of</strong> delayed release Rabeprazole in 1 to 11 month<br />
old pediatric subjects with symptomatic erosive<br />
gastroesophageal reflux disease.<br />
SELECTED CLINICAL DATA<br />
Outpatients seen in <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 5,243<br />
Outpatients seen in <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 5,300<br />
Endoscopies in <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 494<br />
Endoscopies in <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 544<br />
Colonoscopies in <strong>2008</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . . 249<br />
Colonoscopies in <strong>2009</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 276<br />
Ph probe studies in <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . 280<br />
Ph probe studies in <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . .240<br />
Bravo Ph Analysis in <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . 26<br />
Bravo pH analysis in <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Bi-Annual <strong>Report</strong> • 15<br />
GENERAL PEDIATRICS<br />
FACULTY<br />
John Andrake, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Director, Pediatric Residency<br />
Joseph Bearman, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
Charles Bergstrom, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Director, Undergraduate Medical Education<br />
Steven Blatt, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Director, General <strong>Pediatrics</strong>, Associate Pr<strong>of</strong>essor Syracuse<br />
University College <strong>of</strong> Law (courtesy appointment)<br />
Ann Botash, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Vice Chair,<br />
Educational Affairs<br />
Robert Cavanaugh, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Section<br />
Head, Adolescent Medicine<br />
Katherine Chang, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
John Friedman, MD, Clinical Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong> and<br />
Psychiatry<br />
Paul Fuller, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Robert Hingre, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Elizabeth Jamme, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Toby Kressel, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
Ellen McHugh, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
Victoria Meguid, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Bradley Olson, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Associate Director, Pediatric Residency<br />
Alicia Pekarsky, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Ronald Saletsky, PhD, Associate Pr<strong>of</strong>essor <strong>of</strong> Psychiatry<br />
Ellen Schurman, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
Anne Sveen, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Howard Weinberger, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
AFFILIATED CLINICAL STAFF<br />
Wendy Broton, RN, FNP, Nurse Practitioner<br />
Karen Dygert MS, RN, PNP, PMHNP, Nurse Practitioner<br />
Susan Mahar, RN, PNP-BC Nurse Practitioner<br />
Nancy Mitchell, RN, PNP, Nurse Practitioner<br />
Terri Morse, RN-BC, FNP, Nurse Practitioner<br />
CLINICAL OVERVIEW<br />
The component programs <strong>of</strong> the Division <strong>of</strong> General<br />
<strong>Pediatrics</strong> encompass all <strong>of</strong> the inpatient and ambulatory<br />
clinical activities providing general pediatric and specialty<br />
program care to children and adolescents in a universitybased<br />
urban practice serving a diverse population. The<br />
Division has significant responsibilities for ambulatory<br />
and inpatient teaching <strong>of</strong> medical students and training <strong>of</strong><br />
pediatric residents.<br />
Clinical activity occurs in the term newborn nursery<br />
at Crouse Hospital, the inpatient pediatric units <strong>of</strong><br />
Golisano Children’s Hospital, and at University Pediatric<br />
and Adolescent Center located in University Health<br />
Care Center. A free-standing ambulatory care site <strong>of</strong><br />
Upstate Medical University, Upstate <strong>Pediatrics</strong>, a busy<br />
three-pediatrician practice, participates in departmental<br />
teaching and research activities. Medical students rotate<br />
through the <strong>of</strong>fice during their clerkship and residents<br />
can choose the <strong>of</strong>fice as an elective rotation. The <strong>of</strong>fice is<br />
also a study site for vaccine research.<br />
The Division provides a wide array <strong>of</strong> services to children,<br />
adolescents and families, including well child and<br />
adolescent care, acute episodic and chronic disease<br />
care, specialized care <strong>of</strong> abused and foster children,<br />
and a growing refugee population from Eastern Europe,<br />
Russia and Africa. An adolescent consultation practice is<br />
an active program in the Division. Academic generalists<br />
<strong>of</strong>ten consult and provide second opinions to family<br />
physicians in the central New York region. Faculty<br />
and resident physicians have established practices at<br />
University Pediatric and Adolescent Center with the<br />
goal <strong>of</strong> providing a stable medical home and continuity<br />
for children and adolescents with 24-hour availability.<br />
Inpatient care is provided under the supervision <strong>of</strong> the<br />
academic generalist faculty.<br />
Faculty have clinical expertise and research interests<br />
in child abuse, foster care, refugee health, substance<br />
abuse, childhood obesity and nutrition, lead poisoning,<br />
adolescent eating disorders and reproductive health,<br />
dermatology and medical education. The Medical Legal<br />
Partnership provides a unique opportunity for patients,<br />
families, and the medical staff to easily access legal<br />
services within our <strong>of</strong>fices.<br />
The Adolescent Medicine Program <strong>of</strong>fers primary and<br />
specialty care to patients 11 to 21 years <strong>of</strong> age. This is a<br />
state-<strong>of</strong>-the-art program in which the psychosocial as<br />
well as the physical needs <strong>of</strong> the adolescent patient are<br />
uniquely addressed. Our physicians have been at the<br />
forefront <strong>of</strong> adolescent preventive services for many<br />
years. They are particularly well qualified to screen<br />
adolescents in order to identify high-risk activities and<br />
behaviors and to <strong>of</strong>fer appropriate counseling. They are<br />
supported by a highly skilled “teen-friendly” nursing staff.<br />
The program welcomes referrals for second opinions or<br />
for consultations. Findings are promptly communicated
16 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
to referring physicians when applicable. A dietician who<br />
specializes in adolescent nutrition is available on site for<br />
consultation at the time <strong>of</strong> the visit.<br />
There is also a very close relationship with physicians<br />
in the <strong>Department</strong> <strong>of</strong> Psychiatry and a large referral<br />
network <strong>of</strong> other specialists at University Hospital and<br />
SUNY Upstate Medical University.<br />
Services include:<br />
• Behavioral evaluation and counseling<br />
• Comprehensive physicals and preventive exams<br />
• Contraceptive counseling<br />
• Gynecologic exams<br />
• Immunizations<br />
• Pregnancy testing and counseling<br />
• Risk-reduction assessment and counseling<br />
• Sports physicals as part <strong>of</strong> a comprehensive<br />
examination<br />
• Substance abuse evaluation and referral<br />
The CARE (Child Abuse Referral and Evaluation) team<br />
<strong>of</strong> pr<strong>of</strong>essionals includes a pediatrician, pediatric<br />
nurse practitioner, nurse and social worker who work<br />
together to provide child abuse medical evaluations.<br />
Team members include Ann Botash, MD, Alicia Pekarsky,<br />
MD, Nancy Mitchell, RN, CPNP, Anne Galloway, RN, and<br />
Elizabeth Kinsey, CSW.<br />
With over 10 years <strong>of</strong> experience, the program <strong>of</strong>fers<br />
comprehensive history and physical examinations,<br />
forensic evidence collection, photodocumentation and<br />
court-ready record documentation. Legal testimony<br />
and non-patient care case reviews are also available.<br />
Examinations are performed utilizing state-<strong>of</strong>–the-art<br />
colposcopic documentation <strong>of</strong> physical findings, and a<br />
variety <strong>of</strong> advanced patient coping techniques.<br />
Over 250 referrals per year come from several counties in<br />
Central and Upstate New York. Referral sources include<br />
child protective services, law enforcement agencies, rape<br />
crisis centers, teachers, parents and other physicians.<br />
These children are evaluated at 90 Presidential Plaza,<br />
University Pediatric and Adolescent Center as well as at a<br />
community <strong>of</strong>f-site location, 509 West Onondaga Street,<br />
the McMahon/Ryan Child Advocacy Site.<br />
The McMahon/Ryan Child Advocacy Site’s main goals are<br />
to provide a safe, child and family friendly environment<br />
for child abuse victims and their non-<strong>of</strong>fending family<br />
members and to reduce the trauma that abused children<br />
face during the investigative and treatment processes.<br />
The site’s focus is to support and enhance existing<br />
community agencies that work with child abuse. The<br />
staff at the McMahon/Ryan Child Advocacy Site is funded<br />
through a SUNY Research Foundation grant provided<br />
through CARE and other funding through a non-pr<strong>of</strong>it<br />
501-c donations. Children evaluated there have improved<br />
access to counseling services (Rape Crisis Center), law<br />
enforcement, and child protective investigators. (http://<br />
www.mcmahonryan.org)<br />
The CARE team <strong>of</strong>fers regular Child Abuse Licensing<br />
courses for physicians or other pr<strong>of</strong>essionals needing<br />
certification for licensing in New York State. Further<br />
information can be found at: http://www.upstate.edu/<br />
cme/licensing.shtml<br />
ENHANCE Services for Children in Foster Care has<br />
provided primary and comprehensive health care<br />
services to children in DSS custody since 1991. Consistent<br />
with the recommendations outlined in Fostering<br />
Health: Health Care for Children and Adolescents in<br />
Foster Care <strong>of</strong> the AAP Task Force on Health Care for<br />
Children in Foster Care, ENHANCE provides primary<br />
and comprehensive health care services, developmental<br />
testing and mental health services to the 500 children<br />
in DSS foster care. Medical care is provided by two<br />
pediatricians, Dr. Steven Blatt, Director and Dr. Victoria<br />
Meguid, Associate Director, two pediatric nurse<br />
practitioners, and two registered nurses. A nurse<br />
practitioner also performs developmental testing on<br />
young children in their home or day care setting. A child<br />
psychologist meets with older children and their foster<br />
parents to assess their need for mental health services.<br />
Annually, the 500 children in foster care are seen in more<br />
than 2400 ENHANCE visits.<br />
ENHANCE staff have also been active in policy issues.<br />
There are regular meetings with DSS administration,<br />
focusing on local policy and procedures. ENHANCE<br />
representatives participates on the New York State<br />
Permanent Judicial Commission on Justice for Children<br />
and the New York State, District II AAP Task Force on<br />
Health Care for Children in Foster Care. ENHANCE staff<br />
also meet with New York State foster care <strong>of</strong>ficials and<br />
have testified to legislative bodies.<br />
The Syracuse Medical-Legal Partnership (SMLP) is a<br />
Medical-Legal Partnership between the University<br />
Pediatric and Adolescent Center (UPAC) <strong>of</strong> University<br />
Hospital <strong>of</strong> SUNY Upstate Medical University and<br />
the Children’s Rights and Family Law Clinic (CRC) and<br />
Family Law and Social Policy Center (FLSPC) <strong>of</strong> Syracuse<br />
University College <strong>of</strong> Law. Through a triad approach,<br />
SMLP seeks to engage the disciplines <strong>of</strong> law and medicine<br />
to provide comprehensive advocacy to improve the<br />
overall health <strong>of</strong> low-income children and their families.<br />
SMLP helps improve health outcomes for low-income<br />
children and their families through collaborative<br />
advocacy and legal intervention. Cases handled through<br />
SMLP have included custody, adoption and child support;<br />
housing issues including landlord disputes, handicap<br />
access and utility disputes; education law including<br />
special education and unlawful exclusion from public<br />
schools; and other legal issues directly affecting child<br />
health. SMLP provides students, faculty and staff from<br />
both the <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong> and the College<br />
or Law with opportunities to learn about <strong>Pediatrics</strong><br />
and Legal Advocacy from experts in both disciplines.<br />
SMLP has been instrumental in educating state and<br />
national legislators about this new and growing national<br />
movement.<br />
The Pediatric International Health Clinic was started in
Bi-Annual <strong>Report</strong> • 17<br />
July 2005 in order to provide more specialized care to<br />
the more than 500 new immigrants arriving annually in<br />
Central New York. The care <strong>of</strong> such patients has become<br />
increasingly complex, requiring a degree <strong>of</strong> sophistication<br />
not allowed in a typical outpatient pediatric setting.<br />
Although they originate from all over the globe, this<br />
diverse refugee population most recently has come from<br />
the African continent. In addition to providing a much<br />
needed service to this medically diverse and fascinating<br />
population, this new service, directed by Dr. Bradley<br />
Olson, is a rich environment for housestaff education.<br />
RESEARCH HIGHLIGHTS<br />
Vaccines<br />
Faculty and staff at University Pediatric and Adolescent<br />
Center collaborate with the Division <strong>of</strong> Pediatric<br />
Infectious Disease on an ongoing basis with funded<br />
vaccine studies. Recent studies involve vaccines against<br />
meningococcus, pneumococcus, and influenzae.<br />
Child Sex Abuse Evaluation<br />
Dr. Ann Botash was one <strong>of</strong> the founders <strong>of</strong> the McMahon/<br />
Ryan Child Advocacy Center in 2002 and serves as<br />
medical director to the board <strong>of</strong> this non-pr<strong>of</strong>it<br />
organization. Dr. Botash is the primary investigator for a<br />
grant through the New York State Office <strong>of</strong> Children and<br />
Family Services, to fund the Advocacy site and is primary<br />
investigator <strong>of</strong> the New York State <strong>Department</strong> <strong>of</strong> Health<br />
grant to support the Child Abuse Medical Provider<br />
Program. This program began as a model network <strong>of</strong> child<br />
abuse medical providers with the creation <strong>of</strong> a training<br />
manual and now provides continuing education to child<br />
abuse medical pr<strong>of</strong>essionals throughout New York State.<br />
It is a resource for child abuse pr<strong>of</strong>essionals nationally as<br />
well as statewide.<br />
Foster Care<br />
Drs. Steven Blatt and Victoria Meguid have collaborated<br />
with researchers from Cornell University on the<br />
relationships between prenatal drug and alcohol use and<br />
subsequent involvement in the child protection system.<br />
The same faculty are also working with colleagues at the<br />
University <strong>of</strong> Rochester to examine the effectiveness<br />
<strong>of</strong> foster care clinics at both institutions in meeting the<br />
needs <strong>of</strong> children in foster care.<br />
PUBLICATIONS<br />
Cavanaugh RM. Managing the Transitions <strong>of</strong> Early<br />
Adolescence. Adolescent Health Update, American<br />
Academy <strong>of</strong> <strong>Pediatrics</strong> <strong>2008</strong>; 20(3): 1-8.<br />
Cavanaugh RM. Screening for Genitourinary<br />
Abnormalities in Adolescent Males. <strong>Pediatrics</strong> in Review<br />
<strong>2009</strong> 30: 431-438.<br />
Koszalka T, Olson B. Transforming a <strong>Pediatrics</strong> Lecture<br />
Series to Online Instruction. Handbook <strong>of</strong> research on<br />
distributed medical informatics and e-health. Hershey,<br />
PA. Medical Information Science Ref, Aug <strong>2008</strong>.<br />
PRESENTATIONS AT NATIONAL MEETINGS<br />
Blatt SD. Enhancing Services: Legal Aspects <strong>of</strong> Infant<br />
Attachment. CASA Conference: Healthy Beginnings:<br />
Creating Positive Attachments in Children. Painted Post,<br />
NY, April 3, <strong>2008</strong>.<br />
Blatt SD. Healthy Children in Foster Care: An Attainable<br />
Goal. Children in Foster Care: Development, Health and<br />
Well-Being. Westchester, NY, April 11, <strong>2008</strong>.<br />
Blatt SD. The Wonder Years: Children in Foster Care<br />
in the Courtroom. New York State Judicial Institute.<br />
Rye Brook, NY, (Presented at three different Judicial<br />
Institutes) June 24, July 8, August 26, <strong>2008</strong>.<br />
Blatt SD. Plenary: Opportunities and Challenges<br />
in Interdisciplinary Collaborative Education.<br />
Interdisciplinary Collaborative Education, Partnerships<br />
Between Law Schools and Health Pr<strong>of</strong>essions. Atlanta,<br />
GA. September 24, <strong>2009</strong>.<br />
Dawson E, Greenberg S, Olson B. The Predictive<br />
Value <strong>of</strong> Eosinophilia in Chronic Schistosomiasis and<br />
Strongyloidiasis: An Examination <strong>of</strong> the CDC Screening<br />
Guidelines for Newly Arriving Refugees. <strong>2009</strong> Pediatric<br />
Academic Society. Baltimore, MD. April 28-May 2, <strong>2009</strong>.<br />
Pekarsky AR, Cohen N, Singhi V and Botash, AS. Pediatric<br />
Patient Assent and Medical Provider Compliance with<br />
New York State Guidelines for HIV Post-exposure<br />
Prophylaxis for Sexual Assault. Poster presented at<br />
the Pediatric Academic Societies Meeting: May 3, <strong>2009</strong>:<br />
Baltimore, Maryland.<br />
HONORS, VISITING PROFESSORSHIPS,<br />
EDITORIAL DUTY<br />
Blatt SD: Member, New York State Permanent Judicial<br />
Committee on Justice for Children<br />
Blatt SD: New York State Children’s Cabinet Advisory<br />
Board Member (Appointed by the Governor)<br />
Blatt SD: National Center for Medical-Legal Partnership,<br />
Assistant National Medical Director<br />
Blatt SD: National Center for Medical-Legal Partnership,<br />
Medical Advisory Board Member<br />
Blatt SD: Peace Action <strong>of</strong> Central New York: Peace Award<br />
November 16, <strong>2008</strong><br />
Botash AS: Ray E. Helfer Society Vice President, 2007-<strong>2009</strong><br />
Botash AS: Ray E. Helfer Society President, <strong>2009</strong>-2010<br />
Cavanaugh RM: Executive Committee, American<br />
Academy <strong>of</strong> <strong>Pediatrics</strong> Section on Adolescent Health<br />
Cavanaugh RM: Program Chair, American Academy <strong>of</strong><br />
<strong>Pediatrics</strong>, Section on Adolescent Health<br />
Cavanaugh RM: Editorial Board, American Academy <strong>of</strong><br />
<strong>Pediatrics</strong> Adolescent Health Update<br />
Friedman J: Island Peer Review Organization, Vice<br />
President<br />
Meguid V: National Committee-AAMC Group on Women<br />
in Medicine and Science.
18 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
INVITED WORKSHOPS, CME PRESENTATIONS<br />
Andrake JS, Olson B, Peacock J, et al. Perspectives on<br />
Curriculum Reform: Different Approaches to the Same<br />
Goal. Presented at the Annual Meeting <strong>of</strong> the Association<br />
<strong>of</strong> Pediatric Program Directors. Baltimore, MD, April 28-<br />
May 2, <strong>2009</strong>.<br />
Andrake SJ, Sveen A. Building a Communication Skills<br />
Curriculum for the <strong>Pediatrics</strong> Clerkship. Presented at the<br />
Annual Meeting <strong>of</strong> COMSEP. Atlanta, GA. April 3-6, <strong>2008</strong><br />
Blatt SD, Galowitz P, Retkin R, Tames P. Hot Topics in<br />
Medical-Legal Partnerships. American Bar Association<br />
& National Legal Aid Defender Association Equal Justice<br />
Conference. Orlando, FL, May 14, <strong>2009</strong>.<br />
Blatt SD, Lawry K, Leon J, Ryan A. Do MLP’s Need<br />
Institutional Review Board Approval? What? Why? How?<br />
Medical-Legal Partnership National Summit, Cleveland,<br />
OH, March 27, <strong>2009</strong>.<br />
Blatt SD, Norwood M, Cumbie Reckess S, White<br />
McCormick H, Melendez S. Fostering the Next<br />
Generation <strong>of</strong> Pr<strong>of</strong>essionals: Engaging Educational<br />
Institutions as Partners. Medical-Legal Partnerships.<br />
Medical-Legal Partnership National Summit, Cleveland,<br />
OH, March 26, <strong>2009</strong>.<br />
Blatt SD, Melendez SM, Ramsey SH, Broton W, Krishna<br />
S, Gresens L. Unmet Legal Needs in a Clinic Population.<br />
Medical-Legal Partnership National Summit. Kansas City,<br />
Mo, March 12, <strong>2008</strong>.<br />
Blatt SD, Morton S, Tichner J. Ethics at 40,000 Feet: Big<br />
Picture Ethical Dimensions <strong>of</strong> MLP Practice. Medical-Legal<br />
Partnership National Summit, Cleveland, OH, March 27,<br />
<strong>2009</strong>.<br />
Blatt SD, Seagriff P, Heer T, Gambino J. Meeting the<br />
Medical and Dental Needs <strong>of</strong> Children in Foster Care.<br />
Children in Foster Care: Development, Health and Well-<br />
Being. Westchester, NY, April 11, <strong>2008</strong>.<br />
Blatt SD, Tames P, Zolezzi-Wyndham V. Training and<br />
Education Working Group. Medical-Legal Partnership<br />
National Summit, Cleveland, OH, March 27, <strong>2009</strong>.<br />
Blatt SD, Tichner J, Morton S. “It’s None <strong>of</strong> Your<br />
Business!” Doctors, Lawyers and Confidentiality.<br />
Medical-Legal Partnership National Summit. Kansas City,<br />
Mo, March 12, <strong>2008</strong>.<br />
Botash AS. Sexually Transmitted Infections in Sexual<br />
abuse and Assault: A Bug’s Life in Perspective. PREP:<br />
CAP: An Intensive Review and Update in Child Abuse<br />
<strong>Pediatrics</strong>, Portland, Oregon, July 22-25 <strong>2009</strong>.<br />
Botash AS. Head to Toe and Other Body Parts: The Male<br />
Genital Examination. PREP: CAP: An Intensive Review and<br />
Update in Child Abuse <strong>Pediatrics</strong>, Portland, Oregon, July<br />
22-25 <strong>2009</strong>.<br />
Botash AS, DeJong A. Sexually Transmitted Infections<br />
in Children and Adolescents. PREP: CAP: An Intensive<br />
Review and Update in Child Abuse <strong>Pediatrics</strong>, Portland,<br />
Oregon, July 22-25 <strong>2009</strong>.<br />
Botash AS, Kaplan R, Levit C. Basic Medical Training<br />
Academy in Child Abuse (on the topics <strong>of</strong> Fractures, STI’s,<br />
and Child Sexual Abuse), National Children’s Alliance<br />
Funded Conference. Burlington, VT. October 20. <strong>2008</strong><br />
Brandfield J, Melendez S, Blatt SD. Training and<br />
Education: Tips on how to Develop and Present<br />
Educational Programs to Pr<strong>of</strong>essionals in other<br />
Disciplines. Medical-Legal Partnerships: NY<br />
Pr<strong>of</strong>essionals Working Together to Improve Health Care.<br />
Syracuse, NY. June 5, <strong>2009</strong>.<br />
Retkin R, Blatt SD, White McCormick H, Palumbo CM,<br />
Aerni JM, Branchfield J. Bringing the Law Office into the<br />
Healthcare Setting: Creating a Medical-Legal Partnership.<br />
New York State Bar Association <strong>2008</strong> Partnership<br />
Conference. Albany, NY, September 24, <strong>2008</strong>.<br />
Roswig BB, Tobin Tyler L, Tames P, Blatt SD. Lighting<br />
the Way: How Medical and Legal Pr<strong>of</strong>essionals Use<br />
Community Projects to Bring Services to Clients<br />
and Greater Communication to Their Pr<strong>of</strong>essional<br />
Partnerships. American Bar Association & National Legal<br />
Aid Defender Association Equal Justice Conference.<br />
Orlando, FL. May 15, <strong>2009</strong>.<br />
Tames P, Blatt SD, Riseberg R. Training & Evaluation.<br />
Medical-Legal Partnership National Summit. Kansas City,<br />
Mo, March 12, <strong>2008</strong>.
Bi-Annual <strong>Report</strong> • 19<br />
GRANTS AND CONTRACTS<br />
Blatt SD<br />
Syracuse Medical Legal Partnership for Children, The<br />
John Ben Snow Foundation, 7/09: $10,000<br />
Regional Lead Poisoning Resource Center, NY State<br />
Health <strong>Department</strong> in the amount <strong>of</strong> $200,000 per year<br />
for five years.<br />
Botash AS<br />
Rape Crisis Program (CHAMP), <strong>2009</strong>, NYS DOH: $36,000<br />
Rape Crisis Program for CHAMP, <strong>2008</strong>, NYS DOH: $75,000<br />
PI: <strong>2009</strong>-2010, NYS Office <strong>of</strong> Children and Family Services<br />
CHAMP Initiative, through a grant from Senator Valesky’s<br />
<strong>of</strong>fice ($65,0000) and from Sen. Aubertine’s Office<br />
($30,000)<br />
PI: 2007- <strong>2008</strong>, NYS Office <strong>of</strong> Children and Family Services<br />
Child Abuse Medical Provider Initiative: $500,000<br />
PI: Child Fatality Review Team, NYS OCFS, 2010-<strong>2009</strong>:<br />
$52,000<br />
PI: Child Fatality Review Team, NYS OCFS, <strong>2009</strong>-2010:<br />
$52,000<br />
PI, with grant assistance from Catherine Unger and<br />
Martha Ryan for Child Fatality Review Team, 2007-<strong>2009</strong>,<br />
NYS OCFS: $ 88,224<br />
<strong>2009</strong>: Friend in Deed Foundation for Child Fatality Review<br />
Team: $2,400<br />
<strong>2009</strong>: St. Agatha’s Foundation for CARE program: $25,000<br />
<strong>2009</strong>: CHAMP medical education grant: $30,000<br />
<strong>2009</strong>: Golisano Children’s Hospital education grant for<br />
Procedure Management (LEAPP) project: $8400<br />
SELECTED CLINICAL DATA (DIVISION TOTALS)<br />
General <strong>Pediatrics</strong>, Adolescent, CARE, Enhance<br />
<strong>2008</strong>: . . . . . . . . . 23,632<br />
<strong>2009</strong>: . . . . . . . . . 23,766<br />
Upstate <strong>Pediatrics</strong> Outpatient<br />
<strong>2008</strong>: . . . . . . . . . 13,611<br />
<strong>2009</strong>: . . . . . . . . . 13,336<br />
Inpatient encounters (General <strong>Pediatrics</strong> and<br />
Upstate <strong>Pediatrics</strong>)<br />
<strong>2008</strong>: . . . . . . . . . 1,043<br />
<strong>2009</strong>: . . . . . . . . . 833<br />
Newborn inpatient encounters (General<br />
<strong>Pediatrics</strong> and Upstate <strong>Pediatrics</strong>)<br />
<strong>2009</strong>: . . . . . . . . . 1,172<br />
<strong>2009</strong>: . . . . . . . . . 1,397
20 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
GENETICS<br />
FACULTY<br />
Robert Roger Lebel, MD, FACMG, Chief, Section Medical<br />
Genetics, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Internal Medicine, Ob/<br />
Gyn & Pathology, Lecturer in Bioethics & Humanities<br />
Joan Pellegrino, MD, FAAP, FACMG, Associate Pr<strong>of</strong>essor<br />
<strong>of</strong> <strong>Pediatrics</strong><br />
Adjunct Faculty:<br />
Constance Stein, PhD, Director Cytogenetics Laboratory;<br />
Pr<strong>of</strong>essor, Pathology<br />
Antony Shrimpton, PhD, Director, Molecular Diagnostic<br />
Laboratory; Associate Pr<strong>of</strong>essor, Pathology<br />
AFFILIATED CLINICAL STAFF:<br />
Bonnie R. Braddock, MPH, CGC, Senior Certified Genetic<br />
Counselor<br />
Ryan T. Miller, MS, CGC, Certified Genetic Counselor<br />
CLINICAL OVERVIEW<br />
The section <strong>of</strong> Medical Genetics provides high quality<br />
and comprehensive clinical genetics services, including<br />
screening, diagnosis, treatment, counseling and<br />
preventive services to the 11 counties defined as Health<br />
Services Area 3 (HSA3) and to several other surrounding<br />
counties. Medical Genetics provides genetic evaluation<br />
and genetic counseling services for a wide range <strong>of</strong><br />
neonatal, pediatric and adult onset indications. The<br />
Medical Genetics staff <strong>of</strong> clinical geneticists and genetic<br />
counselors work in a team approach to providing<br />
services. The program includes general genetic<br />
evaluation clinics, Inherited Metabolic Disease Specialty<br />
Center (IMD), inpatient genetic evaluation consultations,<br />
cancer and general genetic counseling, and genetic<br />
counseling within various specialty clinics at Upstate,<br />
including in conjunction with the Multidisciplinary Breast<br />
Cancer Program, the cystic fibrosis newborn screening<br />
program and crani<strong>of</strong>acial clinic. Medical Genetics also<br />
provides outreach genetic evaluation services at satellite<br />
clinics in Watertown and Binghamton.<br />
Medical Genetics is staffed by clinical geneticists, Robert<br />
Roger Lebel, MD, FACMG, and Joan Pellegrino, MD,<br />
FAAP, FACMG, and two full time board certified genetic<br />
counselors, Bonnie R. Braddock, MPH, CGC, and Ryan<br />
T. Miller, MS, CGC. Dr. Lebel arrived as new section<br />
chief in July <strong>2008</strong>, and has interacted extensively with<br />
the extended <strong>Pediatrics</strong> department as well as other<br />
sectors <strong>of</strong> the medical university. As such, he supervises<br />
the activities <strong>of</strong> the genetic counselors and administers<br />
the section. He has seen over 700 new patients since<br />
arriving, and has had the opportunity to make diagnoses<br />
<strong>of</strong> a number <strong>of</strong> very rare syndromes, and also to lead<br />
the group in proposing a syndrome “new” to the medical<br />
literature. The lengthy waiting list which had grown<br />
during the interim has been reduced to manageable<br />
length and the satellite clinics in Watertown and<br />
Binghamton were re-established after Dr. Lebel arrived.<br />
Dr. Joan Pellegrino manages the Inherited Metabolic<br />
Diseases Specialty Center (IMD), which has continued<br />
to grow. The center is staffed by a dedicated nurse<br />
practitioner, registered nurse, dietician, social worker,<br />
genetic counselor and geneticist. The IMD evaluates<br />
infants with abnormal newborn screens or suspected<br />
metabolic disorders and manages those individuals<br />
with a known inborn error <strong>of</strong> metabolism. In <strong>2008</strong>, 144<br />
patients were seen and, in <strong>2009</strong>, 179 patients have been<br />
seen. The Center has also had an increase in the number<br />
<strong>of</strong> abnormal newborn screening patients sent in for<br />
evaluation. In the year <strong>2009</strong> alone, 9 newborns with PKU<br />
were identified and treated. The IMD is actively involved<br />
with the other Metabolic centers in the state.<br />
Ryan T. Miller, MS, CGC, works closely with Dr. Pellegrino<br />
in the IMD. He also works closely with the Crani<strong>of</strong>acial<br />
Clinic and the Pediatric Pulmonary section providing<br />
genetic counseling input at their locations.<br />
Bonnie R. Braddock, MPH, CGC, provides genetic<br />
counseling for the inherited cancer risk services, which<br />
has continued to grow over the last several years. In <strong>2008</strong><br />
and <strong>2009</strong>, a total <strong>of</strong> 386 patients were seen for cancer<br />
genetic counseling.<br />
Medical Genetics coordinates the monthly Genetics<br />
Pr<strong>of</strong>essional Review Group meeting at Upstate.<br />
Attendees include a range <strong>of</strong> clinical- and research-based<br />
genetics pr<strong>of</strong>essionals and students throughout various<br />
departments at Upstate. The goals <strong>of</strong> the meetings are to<br />
foster collaboration <strong>of</strong> cases and research opportunities<br />
and to provide in-house educational opportunities.<br />
RESEARCH HIGHLIGHTS<br />
The IMD participates with the Lysosomal Storage<br />
Registry sponsored by Genzyme and has IRB approval to<br />
participate in studies on Gaucher, Fabry, Pompe and MPS1<br />
diseases. Patients are enrolled into long term follow-up<br />
studies after being identified on newborn screen to have<br />
an increased risk for Krabbe disease.<br />
Dr. Lebel’s research interests include syndrome<br />
identification and ethical issues in genetics. Dr. Stein’s<br />
research interests include investigation <strong>of</strong> chromosomal<br />
fragile sites, cytogenetic and molecular characterization<br />
<strong>of</strong> malignant tumors, chromosome imprinting. Dr.<br />
Shrimpton has research interest in sequencing<br />
Neuroserpin in patients with autism.
Bi-Annual <strong>Report</strong> • 21<br />
PUBLICATIONS<br />
Vajpayee N, Stein CK, Poiesz B, Hutchison R. Case <strong>of</strong><br />
the Quarter - February <strong>2008</strong>: Extramedullary Blast<br />
Transformation <strong>of</strong> CML at Initial Presentation. www.<br />
socforheme.org/case-feb-08.htm. <strong>2008</strong>.<br />
Narendra S, Tull J, Muscolino D, Stein CK, Zhang<br />
S. Detection <strong>of</strong> DDIT3(CHOP) Gene Break-Apart by<br />
Fluorescence in Situ Hybridization (FISH) in Formalin Fixed<br />
Paraffin Embedded Myxoid/Round Cell Liposarcoma.<br />
Abstract, presented at a meeting, <strong>2008</strong>.<br />
Riccardi GF, Stein CK, de la Roza G, Damron TA. Newly<br />
described translocation, t(18;19)(q23;q13.3) in abdominal<br />
wall s<strong>of</strong>t tissue tumor resembling Ewing sarcoma/<br />
Peripheral Neuroectodermal Tumor. (accepted pending<br />
modification by Cancer Genetics and Cytogenetics).<br />
Lebel RR, Spranger JW. Chance favors the prepared<br />
mind: A brief moral biography <strong>of</strong> Gregor Johann Mendel<br />
(7/22/1822-1/6/1884). Proc Greenwood Genet Center 27:3-<br />
5, <strong>2008</strong>.<br />
Lebel RR, Logrieco GP. First report <strong>of</strong> Majewski-type<br />
short limbed polydactyly. Proc Greenwood Genet<br />
Center 27:6-7, <strong>2008</strong>.<br />
Stallworth LJ, Avery J, DuPont BR, Lebel RR. Partial<br />
trisomy 2p and partial monosomy 9p in a fetus with<br />
anencephaly, polydactyly, and other abnormalities. Proc<br />
Greenwood Genet Center 27:18-21, <strong>2008</strong>.<br />
Lebel RR, Collins JS, Avery JM, Logrieco GP, Broome PJ.<br />
Perinatal autopsy: prenatal growth in trisomy 21. Proc<br />
Greenwood Genet Center 27:22-24, <strong>2008</strong>.<br />
Lebel RR, Jones JR, Pridgen C, Gregg AR, Avery JM,<br />
Broome PJ, Friez MJ. Monosomy X proven (confirming<br />
clinical suspicion) in a fetus from which cells failed to<br />
grow in tissue culture: novel application <strong>of</strong> “multiplex<br />
ligation-dependent probe amplification” (MLPA), Proc<br />
Greenwood Genet Center 27:42-44, <strong>2008</strong>.<br />
Lebel RR, Avery JM, Broome PJ, Gregg AR, Alan C,<br />
Mostafa M. Fetal peritonitis due to appendiceal rupture:<br />
a rare complication <strong>of</strong> hydrops. Fetal Pediatr Pathol<br />
27(3):121-125, <strong>2008</strong>.<br />
Lebel RR. The Language <strong>of</strong> God (Collins). Proc<br />
Greenwood Genet Center 27:45-47, <strong>2008</strong>.<br />
Gopaluni S, Perzova R, Abbott L, Farah R, Shrimpton<br />
A, Hutchison R, Poiesz BJ. CD8+ Cutaneous T-cell<br />
lymphoma successfully treated with Bexarotene: a case<br />
report and review <strong>of</strong> the literature. American Journal <strong>of</strong><br />
Hematology. 83(9):744-6, <strong>2008</strong>.<br />
Mehra A, Tull J, Shrimpton AE, dela Rosa G, Valente A,<br />
Zhang S. Detection <strong>of</strong> FKHR (FOX01) gene break-apart<br />
by Fluorescence in situ hybridization (FISH) in formalin<br />
fixed paraffin embedded Alveolar Rhabdomyosarcomas.<br />
Diagnostic Molecular Pathology, 17(1): 14-20, <strong>2008</strong>.<br />
Shrimpton AE, Levinsohn EM. HOXD10 and congenital<br />
vertical talus. Chapter 71 “Inborn errors <strong>of</strong> development”<br />
Second Edition. Ed Epstein CJ, Erickson RP, Wynshaw-<br />
Boris A. Oxford University Press NY, <strong>2008</strong>, pp 682-688.<br />
Lebel RR, Avery JM, Broome PJ, Collins JS. Prenatal<br />
diagnostic accuracy in South Carolina, demonstrated by<br />
autopsy. Fetal Pediatr Pathol 28(6):253-261, <strong>2009</strong>.<br />
Barker SD, Bale S, Buller A, Das S, Friedman K, Godwin AK,<br />
Grody W, Highsmith E, Kant J, Lyon E, Mao R, Monaghan<br />
KG, Payne DA, Pratt VM, Roa B, Schrijver I, Shrimpton AE*,<br />
Hoopes RR*, Knohl SJ, Hueber P, Scheinman SJ. OCRL1<br />
Mutations in Dent 2 Patients Suggest a Mechanism for<br />
Phenotypic Variability. Nephron Physiology 112:27-36, <strong>2009</strong>.<br />
Shrimpton A, Kessler J, Bassuk AG. Variability <strong>of</strong> Epilepsy,<br />
Autism, Brachydactyly, and Other Clinical Features in<br />
Familial and Sporadic 2q37.3 Deletion. J Ped Neurol. 7:1-5,<br />
<strong>2009</strong>.<br />
Shrimpton AE, Spector E, Telatar M, Weck K, Zehnbauer<br />
B, Booker J, Kalmanet LV, al. Development and<br />
characterization <strong>of</strong> reference materials for MTHFR,<br />
SERPINA1, RET, BRCA1, and BRCA2 genetic testing<br />
Accepted The Journal <strong>of</strong> Molecular Diagnostics. #JMD09-<br />
0078 accepted.<br />
Duffner PK, Caggana M, Orsini JJ, Wegner DA, Patterson<br />
MC, Crosley CJ, Kurtzberg J, Arnold, GL, Escolar ML,<br />
Adams DJ, Andriola MR, Aron AM, Ciafaloni E, Djukie A,<br />
Erbe RW, Galvin-Parton P, Helton LE, Kolodny EH, Kos<strong>of</strong>sky<br />
BE, Kronn DF, Kwon JM, Levy PA, Miller-Horn J, Naidich TP,<br />
Pellegrino JE, Provenzale JM, Rothman SJ, Wasserstein MP,<br />
Newborn Screening <strong>of</strong> Krabbe Disease: the New York State<br />
Model. Pediatr Neurol 40:245-252, <strong>2009</strong>.<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS<br />
Lebel R, Seaver L, Gregg A, Edwards J, Salley M, Avery<br />
J, Broome P, Stevenson R. Prenatal phenotypic variation<br />
in Ellis-van Creveld syndrome. Am J Hum Genet<br />
83:(Suppl):161, Abstract #692, <strong>2008</strong>.<br />
Miller RT, Barkan HI, Lebel RR. MECP2 duplication found<br />
by microarray study in a man with developmental<br />
regression. Genet Med 11 (Suppl.):151, Abstract #216, <strong>2009</strong>.<br />
Lebel RR, Miller, RT, Havernick NJ, Dosa NP, Braddock<br />
BR, Smith FC, Shprintzen RJ. Cardio-renal-epilepsydigital-oculo<br />
(CREDO) syndrome: a “new” syndrome <strong>of</strong><br />
developmental-delays and multiple-malformations. Am<br />
J Hum Genet 85(Suppl):206, Abstract #2600, <strong>2009</strong>.<br />
Arnold GL, Galvin-Parton PA, Erbe R, DeVincentis E,<br />
Kronn D, M<strong>of</strong>idi S, Wasserstein M, Pellegrino JE, Levy PA,<br />
Adams DJ, Saavedra-Matiz CA, Nichols TJ. Genotype-<br />
Metabolite Correlations and Outcome in MCAD<br />
Deficiency Diagnosed by Newborn Screening in New<br />
York State. Abstract 137, Platform presentation, Society<br />
<strong>of</strong> Inherited Metabolis Diseases meeting, San Diego, CA,<br />
September <strong>2009</strong>
22 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
INVITED WORKSHOPS AND CME<br />
PRESENTATIONS<br />
Braddock B. Invited Lecture, “Hereditary Risk for Colon<br />
Cancer”, Healthlink Program, March, <strong>2008</strong>.<br />
Braddock B. Invited Lecture, “Genetic Counseling”,<br />
Genetics, Disability and the Law, March 23, <strong>2008</strong>.<br />
Braddock B. Invited Lecture, “Genetic Counseling and<br />
Testing for Inherited Colon Cancer Syndromes”, VA<br />
Hospital Gastroenterology Dept, September, <strong>2009</strong>.<br />
Braddock B. Invited Lecture, “Genetic Testing for<br />
Hereditary Risk to Cancer”, Hematology Oncology<br />
Associates <strong>of</strong> Central New York, October, <strong>2008</strong>.<br />
Lebel R. Invited Lecture, Grand Rounds, Dept <strong>Pediatrics</strong>,<br />
SUNY Upstate Med Univ (9/17/08, 3/18/09, 11/18/09).<br />
Lebel R. Invited Lecture, Grand Rounds, Dept Int Med,<br />
SUNY Upstate Med Univ (8/28/08, 4/30/09)<br />
Lebel R. Invited Lecture, Grand Rounds, Dept Obstet/<br />
Gynecol, SUNY Upstate Med Univ (10/10/08, 2/6/09, 11/13/09)<br />
Lebel R. Invited Lecture, Grand Rounds, Dept Pathology,<br />
SUNY Upstate Med Univ (11/19/08)<br />
Lebel R. Invited Lecture, Grand Rounds, Dept Bioethics &<br />
Humanities, SUNY Upstate Med Univ (12/12/08)<br />
Lebel R. Invited Lecture, Onondaga County <strong>Pediatrics</strong><br />
Society (11/18/08)<br />
Lebel R. Invited Lecture, Central New York Medical<br />
Academy (2/12/09)<br />
Lebel R. Invited Lecture, St. Olaf College, Northfield, MN,<br />
Scientific Day (5/1/09)<br />
Lebel R. Invited Lecture, Central New York<br />
Cytogeneticists’ Seminar (9/12/09)<br />
Lebel R. Invited Lecture, Regional seminar for Lutheran<br />
Pastors (10/7/09, 12/2/09)<br />
Lebel R. Invited Lecture, Onondaga Community College<br />
Special Education Class (11/9/09)<br />
Lebel R. Invited Lecture, Cato-Meridian High School<br />
Biology Classes (11/30/09)<br />
Miller R. Invited Lecture, Grand Rounds, <strong>Pediatrics</strong>,<br />
Chromosomal Microarray: New Diagnostic Frontier<br />
(5/27/09)<br />
Pellegrino J. Invited Lecture, Annual Pediatric Teaching<br />
Day, Newborn Screening: It’s not just PKU anymore,<br />
OnCenter Syracuse NY 6/4/08.<br />
Pellegrino J. Invited Lecture, Brighton Hills Pediatric<br />
Group, Update on Newborn Screening. Syracuse NY<br />
10/9/09<br />
Pellegrino J. Invited Lecture, Children at Risk Nursing<br />
Conference, Update on Newborn Screening, Syracuse NY<br />
11/19/08<br />
GRANTS AND CONTRACTS<br />
New York State <strong>Department</strong> <strong>of</strong> Health Genetic Services<br />
Program grant, in the amount <strong>of</strong> $140,858 annually from<br />
January 1, <strong>2009</strong> through December 31, 2013.<br />
CNY Children’s Miracle Network Patient Supplies for<br />
Metabolic Clinic, $4660, awarded in 2006.<br />
SELECTED CLINICAL DATA<br />
<strong>2008</strong> total number <strong>of</strong> patients<br />
seen by Medical Genetics: . . . . . . . . . . . . . . . . . . . . . . . . . 865<br />
<strong>2009</strong> total number <strong>of</strong> patients<br />
seen by Medical Genetics: . . . . . . . . . . . . . . . . . . . . . . . . . 1,019
Bi-Annual <strong>Report</strong> • 23<br />
HEMATOLOGY & ONCOLOGY<br />
FACULTY<br />
Richard H. Sills, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Division<br />
Director<br />
Irene Cherrick, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Gloria Kennedy, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Trisha Tavares, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Jody Sima, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Karol Kerr, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
William Kerr, Ph.D., Murphy Family Pr<strong>of</strong>essor <strong>of</strong><br />
Children’s Oncology Research<br />
AFFILIATED CLINICAL STAFF<br />
Diane Groth, R.N., C.P.N.P., Pediatric Nurse Practitioner<br />
Susan Shaw, M.S.N, P.N.P., A.N.P., Pediatric and Adult<br />
Nurse Practitioner<br />
Karen Leshko, L.M.S.W., Licensed Medical Social Worker<br />
Brittany Metcalf, C.C.L.S., Certified Childlife Specialist<br />
Ruth McKay, M.A., L.M.F.T., Licensed Family Medical<br />
Therapist<br />
Kristi Scully, M.S. Ed., Education Specialist<br />
AFFILIATED RESEARCH STAFF<br />
Michelle Cavallerano, C.C.R.P., Clinical Research<br />
Associate<br />
Gayle Froio, M.T., Clinical Research Associate<br />
CLINICAL OVERVIEW<br />
The Division <strong>of</strong> Hematology/Oncology cares for infants,<br />
children and adolescents with the full spectrum <strong>of</strong><br />
hematologic and malignant disorders. The clinical<br />
activity <strong>of</strong> the section is based in the Waters Center for<br />
Children’s Cancer and Blood Disorders (CCCBD). Serving<br />
a 21 country area in New York and Northern Pennsylvania,<br />
we are the sole regional provider for the specialty. The<br />
division also provides the primary source <strong>of</strong> patients for<br />
the 11G Pediatric Hematology/ Oncology Inpatient unit in<br />
the new Golisano Children’s Hospital.<br />
The Center employs five full-time and one part-time<br />
physician. We currently have two nurse practitioners;<br />
Diane Groth provides a primary role in caring for children<br />
with bleeding disorders, as well as, children with<br />
malignancies. Susan Shaw provides care part-time to<br />
children and young adults who were previously treated<br />
for a malignancy but are now considered long-term<br />
survivors. William Kerr, Ph.D., provides the basic science<br />
research component to the division.<br />
At the present time, the division has 5.7 registered nurses,<br />
3.5 <strong>of</strong>fice personnel, a social worker, family therapist,<br />
educational specialist, two clinical research associates, a<br />
research technician and a post doctoral student.<br />
The division cares for over 50 newly diagnosed children<br />
with cancer annually and more than 70 children on active<br />
chemotherapy programs. The division also provides care<br />
to children with a wide variety <strong>of</strong> hematologic disorders<br />
on an ongoing basis as well as providing consultative<br />
services for regional primary care providers who need<br />
assistance caring for children with potential hematologic<br />
or oncologic diagnoses.<br />
Children’s Oncology Group Participation<br />
The division continues to function as a full member <strong>of</strong><br />
the Children’s Oncology Group under the leadership <strong>of</strong><br />
Dr. Irene Cherrick. All <strong>of</strong> COG’s research protocols are<br />
available to our patients and we have been very effective<br />
at entering the great majority <strong>of</strong> newly diagnosed patients<br />
onto research protocols.<br />
KNOT Center<br />
This is our program <strong>of</strong> long-term follow up for late<br />
effects which was one <strong>of</strong> the first <strong>of</strong> its kind in the nation.<br />
The program follows more than 500 patients. Susan<br />
Shaw, RN, PNP provides the primary clinical services<br />
under the supervision <strong>of</strong> Dr. Jody Sima. Dr. Sima’s prime<br />
research interest has been late effects, providing a<br />
research component to this clinical service. Dr. Sima has<br />
begun to better organize our databases on late effects<br />
and has been able to publish her initial studies looking<br />
at primary care providers and their understanding<br />
(or relative lack <strong>of</strong> understanding) <strong>of</strong> readily available<br />
resources concerning late effects <strong>of</strong> the malignancies and<br />
their treatment.<br />
Ms. Shaw has a national reputation for her work and is a<br />
frequently invited speaker. She is on the COG late effects<br />
committee. Patients usually enter the KNOT program<br />
when they are five years from diagnosis and at low risk<br />
for relapse. Specific protocols are followed to assure that<br />
the longer term effects <strong>of</strong> chemotherapy, radiation and<br />
surgery are recognized and managed appropriately.<br />
Neuro-Oncology<br />
This multidisciplinary neuro-oncology program is now<br />
directed by Dr. Gloria Kennedy with the assistance <strong>of</strong><br />
Dr. Trisha Tavares. The program is held in the CCCBD on<br />
a monthly basis and is regularly attended by pediatric<br />
neurology, radiation oncology and an educational<br />
specialist. The visits focus not only on the medical care<br />
and management <strong>of</strong> long term complications but also<br />
focus on the psychosocial and educational needs <strong>of</strong> these<br />
children. It is a true multi-disciplinary program which<br />
makes it much simpler for patients and their families;<br />
they are able to see all their neuron-oncology providers<br />
at a single visit.
24 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Hemophilia<br />
Diane Groth, RN, PNP and Dr. Kennedy coordinate the<br />
federally funded hemophilia program. More than fifty<br />
patients with hemophilia and more than 220 with other<br />
coagulopathies receive consistent, comprehensive care<br />
through this program. Camp High Hopes, co-founded and<br />
operated by Ms. Groth, provides a wonderful week-long<br />
camp experience for boys with hemophilia. It is open to<br />
boys from the entire upstate region and is unique for this<br />
area.<br />
New York State Designated<br />
Hemoglobinopathy Center<br />
This program is directed by Dr. Richard Sills. Its primary<br />
role is to provide the focus <strong>of</strong> care for children with<br />
hemoglobinopathies; most <strong>of</strong> these children are<br />
identified by the New York State Newborn Screening<br />
Program and referred to us directly as the regional<br />
center. Smaller numbers <strong>of</strong> children are referred<br />
when they move into the area. We currently care for<br />
approximately 100 children with sickle cell disease.<br />
We also provide service to children with other<br />
hemoglobinopathies such as thalassemia and hemoglobin<br />
C or E disorders. In addition we provide genetic<br />
counseling to families identified as having infants with<br />
hemoglobinopathy traits identified by newborn screening<br />
or referred by outside physicians.<br />
Autologous Stem Cell Transplantation<br />
The pediatric stem cell transplant program continues to<br />
develop and serve the needs <strong>of</strong> patients with a variety <strong>of</strong><br />
solid tumors, particularly those with neuroblastoma and<br />
brain tumors. We are an approved autologous transplant<br />
center for COG studies.<br />
Educational Specialist and Neuropsychology<br />
Service<br />
This is an area <strong>of</strong> innovation in our division. Kristi Scully<br />
has taken over the role since Nan Songer’s death. This<br />
was a difficult time for the division, but Ms. Scully is<br />
doing a remarkable job. Ms. Scully’s role is to coordinate<br />
tutoring, school re-entry, assessing and guaranteeing<br />
adaptation <strong>of</strong> the educational system to the unique needs<br />
<strong>of</strong> our children, the monitoring <strong>of</strong> school performance<br />
and active participation in the educational planning for<br />
children with neurocognitive deficits. Close collaboration<br />
with the regional school districts and the use <strong>of</strong> school<br />
visits is integral to the success <strong>of</strong> this program. She also<br />
coordinates our “When Cancer Enters the Classroom”<br />
program for school nurses and teachers in our region to<br />
learn more about working with our children. Brian Rieger,<br />
PhD, a neuropsychologist in the <strong>Department</strong> <strong>of</strong> Physical<br />
Medicine and Rehabilitation, is a close collaborator with<br />
the service and supervises all <strong>of</strong> the neuropsychological<br />
testing. Participation <strong>of</strong> PhD students from the School<br />
<strong>of</strong> Education at Syracuse University has been funded by<br />
the CCCBD and has been an integral part <strong>of</strong> an innovative<br />
research program.<br />
Pediatric Palliative Care<br />
Dr. Irene Cherrick has very successfully expanded the<br />
palliative care program which is becoming a separate<br />
program as much <strong>of</strong> its activity has moved beyond<br />
pediatric hematology and oncology. It has been very<br />
successful. It fills a tremendous void by organizing and<br />
providing support for children who are still receiving<br />
some therapy to improve their quality <strong>of</strong> survival in<br />
spite <strong>of</strong> an inability to cure their disease. The traditional<br />
hospice program manages patients only after therapies,<br />
such as chemotherapy, are no longer being used. Dr.<br />
Cherrick’s program has expanded beyond the population<br />
<strong>of</strong> children with hematologic and oncologic diagnoses<br />
and now includes all children in our region whose<br />
insurance qualifies them for this support.<br />
RESEARCH HIGHLIGHTS<br />
Dr. William Kerr<br />
An important area <strong>of</strong> investigation for Dr. Kerr’s lab is the<br />
role that SHIP plays in stem cell biology, both pluripotent<br />
stem (PS) cells and hematopoietic stem cells (HSC). In<br />
2001 we identified a stem cell specific is<strong>of</strong>orm <strong>of</strong> SHIP,<br />
s-SHIP, that is expressed by PS cells and HSC. s-SHIP<br />
associates with Grb2 and is constitutively recruited<br />
to the plasma membrane to receptor components<br />
like gp130. Thus, we propose that s-SHIP sets signaling<br />
thresholds for PS cell populations. We also found that<br />
SHIP expression is required to sustain their multi-lineage<br />
repopulating capacity. We have recently demonstrated<br />
that SHIP is required for the normal function <strong>of</strong> the BM<br />
niche that supports HSC. Future studies will define the<br />
cell types and signaling pathways that SHIP influences<br />
which are required for niche function. We have recently<br />
developed SHIP1 inhibitors that our research suggests<br />
might be used to mobilize HSC for transplant purposes<br />
and to improve blood cell recovery in myelosuppressed<br />
patients. Applications <strong>of</strong> SHIP1 inhibition that we will be<br />
examining in the near future.<br />
We find that SHIP is critical to maintaining a diverse<br />
repertoire <strong>of</strong> activating and inhibitory receptors in<br />
mature Natural Killer (NK) cells. The NK repertoire<br />
disruption that occurs in<br />
SHIP -/- mice has pr<strong>of</strong>ound functional consequences<br />
and disables rejection <strong>of</strong> allogeneic bone marrow<br />
(BM) grafts. Surprisingly, SHIP-deficiency also appears<br />
to abrogate graft-versus-host-disease (GVHD) - the<br />
major cause <strong>of</strong> treatment-related mortality in human<br />
allogeneic BM transplantation. This appears to be due<br />
to a dramatic expansion <strong>of</strong> a myeloid and T lymphoid<br />
immunoregulatory cells in SHIP -/- hosts that suppress<br />
allogeneic T cell responses that mediate GvHD or organ<br />
graft rejection. We have recently developed chemicals<br />
inhibitors <strong>of</strong> SHIP1 that might be used to increase both the<br />
efficacy and utility <strong>of</strong> allogeneic BM transplantation in<br />
cancer and genetic diseases. SHIP1/2 inhibitors might also<br />
find utility in prevention <strong>of</strong> solid organ rejection and in<br />
the treatment <strong>of</strong> malignancy - two possibilities we will be<br />
examining in the future.
Bi-Annual <strong>Report</strong> • 25<br />
Dr. Jody Sima<br />
Dr. Sima has effectively examined the current<br />
understanding <strong>of</strong> late effects <strong>of</strong> childhood cancer by<br />
primary care providers. As these children age out <strong>of</strong><br />
pediatrics and begin to <strong>of</strong>ten be followed by primary<br />
care providers, it is essential to improve the ability <strong>of</strong><br />
these providers to understand and recognize potential<br />
complications.<br />
Dr. Richard Sills<br />
Dr. Sills is trying to re-establish the planned regional<br />
consortium involving Rochester, Buffalo and Syracuse for<br />
a research basis into children with sickle cell disease.<br />
PUBLICATIONS<br />
Collazo, M.C., Wood, D., Paraiso, K.H.T., Lund, E.,<br />
Engelman, R.W., Le, C.T., Stauch, D., Kotsch, K. and Kerr,<br />
W.G. SHIP limits immunoregulatory capacity in the T cell<br />
compartment. Blood 113: 2934-44 (<strong>2009</strong>). [featured on<br />
cover]<br />
Hazen, A.L, Smith, M.J., Desponts, C., Winter, O., Moser,<br />
K., and Kerr, W.G. SHIP is required for a functional<br />
hematopoietic stem cell niche. Blood 113: 2924-33 (<strong>2009</strong>).<br />
HYD1-induced increase in reactive oxygen species leads to<br />
autophagy and necrotic cell death in multiple myeloma<br />
cells. Nair R.R., Emmons M.F., Cress A.E., Argilagos R.F.,<br />
Lam K., Kerr W.G., Wang H.G., Dalton W.S., Hazlehurst L.A.<br />
Mol. Cancer Ther. 8:2441-51 (<strong>2009</strong>).<br />
Kanwar VS, Sills RH. Hereditary disorders <strong>of</strong> red cell<br />
permeability. Emedicine <strong>2008</strong>. Available from URL: http://<br />
emedicine.medscape.com/article/955921-overview<br />
Sills RH, Meck M. Hereditary elliptocytosis and related<br />
disorders. Emedicine <strong>2008</strong>. Available from URL: http://<br />
emedicine.medscape.com/article/955827-overview<br />
Cerone JB, Kanwar VS, Sills RH. Consumption<br />
coagulopathy. Emedicine <strong>2009</strong>. Available from URL: http://<br />
emedicine.medscape.com/article/955059-overview<br />
Kanwar VS, Sills RH. Lymphadenopathy. Emedicine, <strong>2009</strong>.<br />
Available from URL: http://emedicine.medscape.com/<br />
article/956340-overview<br />
Kanwar VS, Sills RH. Splenomegaly. Emedicine, <strong>2009</strong>.<br />
Available from URL: http://emedicine.medscape.com/<br />
article/958739-overview<br />
Shaw S.(<strong>2009</strong>). Endocrine Late Effects in Survivors <strong>of</strong><br />
Pediatric Brain Tumors. Journal <strong>of</strong> Pediatric Oncology<br />
Nursing 26(5):295-302.<br />
Landier, W., Kinahan, K., Shaw, S., Bhatia, S.(<strong>2009</strong>).<br />
Screening for Late Effects in Brain Tumor Survivors. In S.<br />
Goldman and C. Turner (Eds.), Late Effects <strong>of</strong> Treatment<br />
for Brain Tumors (Chapter 26, pp.389-409). New York:<br />
Springer.<br />
GRANTS AND CONTRACTS<br />
COG – Irene Cherrick, PI<br />
Novartis Exjade Study – Richard Sills, PI<br />
NIH – William Kerr<br />
2002-2011 RO1 HL72523: Role <strong>of</strong> SHIP in NK Cell Biology (PI)<br />
<strong>2008</strong>-2012 R01HL085580: SHIP and Immunoregulatory Cell<br />
Function (PI)<br />
2007-2010 R21CA118632: Defining the Multiple Myeloma<br />
Kinome (PI)<br />
2007-2010 R21CA25398: The Kinomes <strong>of</strong> Non-Hodgkin<br />
Lymphoma (PI)<br />
EDITORIAL SERVICE<br />
Dr. Sills serves as a consulting editor <strong>of</strong> PREP 2001-present<br />
and continues to be a question writer for PREP.<br />
SELECTED CLINICAL DATA<br />
Outpatient visits: <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . 4,608<br />
<strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 5,261<br />
Inpatient Visits: <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 2,718<br />
<strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 3,291
26 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
INFECTIOUS DISEASES<br />
FACULTY<br />
Leonard B. Weiner, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Pathology<br />
and Family Medicine, Director, Division <strong>of</strong> Infectious<br />
Disease and Immunology<br />
Joseph B. Domachowske, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Microbiology and Immunology<br />
Jana Shaw, MD, MPH, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Jeffrey D. Snedeker, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
John A. Bradshaw, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
FELLOWS<br />
Nicholas Bennett MD, PhD, MB/BChir<br />
Manika Suryadevara, MD<br />
AFFILIATED CLINICAL STAFF<br />
Kathie Contello, RN, MS, CPNP<br />
M. Christine Crandall, RN, MS, PNP<br />
Wendy Holz, RN, MS, PNP<br />
AFFILIATED RESEARCH STAFF<br />
Cynthia Bonville, MS, Senior Research Support<br />
Technologist<br />
Lisa Susko RN, Study Coordinator<br />
Christy Tabarani, MD, Research Assistant<br />
Joy M. Tompkins, RN, MS, PNP, Administrator<br />
CLINICAL OVERVIEW<br />
The Division <strong>of</strong> Infectious Diseases provides care for<br />
infants, children and adolescents with severe or unusual<br />
infections and immune deficiency syndromes, including<br />
HIV. Infectious disease specialists evaluate and treat<br />
children with recurrent infections, persistent or periodic<br />
fever syndromes, unusual or severe bacterial, viral,<br />
fungal and parasitic diseases, and innate or acquired<br />
immune deficiency syndromes. As a designated New York<br />
State <strong>Department</strong> <strong>of</strong> Health Pediatric AIDS Center <strong>of</strong><br />
Excellence, we provide medical care for pediatric patients<br />
infected with, or exposed to human immunodeficiency<br />
virus. Our outpatient care is provided in the Pediatric<br />
and Adolescent Infectious Disease and Immunology<br />
Center in the pediatric subspecialty outpatient setting<br />
located in the Golisano Children’s Hospital. Patients<br />
referred by their primary care physicians for infectious<br />
disease immunologic diagnostic evaluations or who need<br />
intravenous antibiotics and immunoglobulin infusions<br />
are administered in this Center. Follow-up evaluations<br />
on recently hospitalized patients also take place in this<br />
setting.<br />
Hospitalized patients are evaluated upon the request<br />
<strong>of</strong> their primary care physician at University, Crouse<br />
and Saint Joseph’s Hospitals. Our infectious disease<br />
specialists work closely with the primary care<br />
pediatricians and family physicians, surgical specialist,<br />
intensivists, hospitalists, and neonatologists to direct the<br />
diagnostic and therapeutic evaluations <strong>of</strong> patients with<br />
infectious disease and/or immunologic problems.<br />
The activities <strong>of</strong> the Division <strong>of</strong> Infectious Disease include<br />
the only Pediatric Designated AIDS Center in the region.<br />
This program has also received a Center <strong>of</strong> Excellence<br />
designation and grant from the New York State<br />
<strong>Department</strong> <strong>of</strong> Health.<br />
The Pediatric Infectious Disease Division has an<br />
accredited fellowship program that accommodates one<br />
post graduate resident a year. The focus <strong>of</strong> this specialty<br />
education is on clinical care and research.<br />
RESEARCH HIGHLIGHTS<br />
Clinical Trials<br />
A major effort <strong>of</strong> the infectious disease physicians is the<br />
participation in multi-center, national and international<br />
clinical trials to evaluate the safety and efficacy <strong>of</strong> new<br />
pharmacologic agents and vaccines related to the care<br />
<strong>of</strong> children and adolescents. Specifically, Dr. Weiner<br />
currently supervises protocols to evaluate novel antiviral<br />
therapies and multiple clinical vaccine trials.<br />
Studies involving newer meningococcal, pneumococcal,<br />
influenza, DTAP/Hib/IPV and MMRV vaccines are currently<br />
underway. Vaccine trials usually take place at University<br />
Pediatric and Adolescent Center or Upstate <strong>Pediatrics</strong>.<br />
Dr. Domachowske’s clinical research interests focus on<br />
the epidemiology and clinical manifestations <strong>of</strong> lower<br />
respiratory tract viral infections. He has paralleled these<br />
interests with an extensive laboratory program involving<br />
the study <strong>of</strong> severe respiratory virus infection utilizing<br />
animal models. Severe viral bronchiolitis and pneumonia<br />
depend on both active viral replication, and on the<br />
host cell immune responses to that infection. Studies<br />
to elucidate these host responses and to determine<br />
the clinical effects <strong>of</strong> inhibiting these responses have<br />
revealed that combination therapy with antiviral<br />
compounds and specific immunomodulatory agents <strong>of</strong>fer<br />
dramatic clinical benefits. Dr. Domachowske’s clinical<br />
and epidemiologic trials include four RSV-prevention<br />
protocols, two RSV/parainfluenza vaccine trials, and a<br />
large scale pediatric influenza vaccine trial.<br />
Dr. Shaw’s clinical research interests focus on<br />
epidemiology and severity <strong>of</strong> S. aureus infection<br />
among healthy children. Current research focuses on<br />
establishing the role <strong>of</strong> S. aureus virulence factors among<br />
seriously ill children and the importance <strong>of</strong> S. aureus<br />
colonization among children with cystic fibrosis.
Bi-Annual <strong>Report</strong> • 27<br />
Dr. Shaw has also been interested in a quality <strong>of</strong> life and<br />
clinical outcomes among immuncompromised patients<br />
receiving immunoglobulin replacement therapy. She has<br />
been mentoring and supervising medical students and<br />
fellows engaged in her research.<br />
PUBLICATIONS<br />
Samkari A, Kiska DL, Riddell SW, Wilson K, Weiner LB,<br />
and Domachowske JB. Dipylidium Caninum Mimicking<br />
Recurrent Enterobius Vermicularis (Pinworm) Infection.<br />
Clin Pediatr, <strong>2008</strong>;47:397-99.<br />
Krilov, LR, Weiner LB, Yogev R, Fergie J, Katz<br />
BZ, Henrickson KJ, Welliver RC, The <strong>2009</strong> COID<br />
Recommendations for RSV Prophylaxis: Issues <strong>of</strong><br />
Efficacy, Cost and Evidence-Based Medicine. <strong>Pediatrics</strong>,<br />
<strong>2009</strong>;124:1682-1684.<br />
Rosenberg HF and Domachowske JB. Respiratory viruses<br />
and eosinophils: exploring the connections Antiviral Res<br />
<strong>2009</strong>; 83:1-9.<br />
Tabarani C and Domachowske JB. Influenza vaccine in<br />
health care workers. Pediatr Annals <strong>2009</strong>; 38:661-6.<br />
Arguedas A, Cespedes J, Botet FA, Blumer J, Yogev R,<br />
Gesser R, Wang J, West J, Snyder T, Wimmer W; Protocol<br />
036 Study Group. Safety and tolerability <strong>of</strong> ertapenem<br />
versus ceftriaxone in a double-blind study performed<br />
in children with complicated urinary tract infection,<br />
community-acquired pneumonia or skin and s<strong>of</strong>ttissue<br />
infection. Int J Antimicrob Agents. <strong>2009</strong>;33:163-7.<br />
(Domachowske)<br />
Percopo CM, Phipps S, Foster PS, Domachowske JB, and<br />
Rosenberg HF. Pulmonary eosinophils and their role in<br />
immunopathologic responses to formalin-inactivated<br />
pneumonia virus <strong>of</strong> mice. J Immunol <strong>2009</strong>; 183:604-12.<br />
Kobayaa H, Souki RR, Trust S and Domachowske JB.<br />
Pastuerella multocida meningitis in newborns<br />
after incidental animal exposure. Pediatr Infect Dis J<br />
<strong>2009</strong>; 28:928-9.<br />
Bonville CA, Percopo CM, Dyer KD, Gao JL, Prussin<br />
C, Foster B, Rosenberg HF and Domachowske JB.<br />
Interferon-gamma coordinates CCL3-mediated<br />
neutrophil recruitment in vivo. BMC Immunology<br />
<strong>2009</strong>;10:14.<br />
Moro MR, Bonville CA, Suryadevara, M, Cummings<br />
E, Faddoul D, Branigan P, Domachowske JB. Clinical<br />
features, adenovirus types, and local production <strong>of</strong><br />
inflammatory mediators in adenovirus infections. Pediatr<br />
Infect Dis J <strong>2009</strong>; 28:376-80.<br />
Rosenberg HF, Dyer KD, and Domachowske JB.<br />
Eosinophils and their interactions with respiratory virus<br />
pathogens. Immunologic Res. <strong>2009</strong>; 43:128-37.<br />
Bern RA, van Woensel JBM, Bos AP, Koski A, Farnand<br />
A, Domachowske JB, Rosenberg HF, Martin TR, and<br />
Matute-Bello G. Mechanical ventilation enhances lung<br />
inflammation and caspase activity in a model <strong>of</strong> mouse<br />
pneumovirus infection. AJP Lung <strong>2009</strong>;296;L46-56.<br />
Rosenberg HF and Domachowske JB. Pneumonia virus <strong>of</strong><br />
mice: Severe respiratory virus infection in a natural host.<br />
Immunol Lett. <strong>2008</strong>; 118:6-12.<br />
Samkari A, Kiska DL, Riddell SW, Wilson KW, and<br />
Domachowske JB. Dipylidium canium infestation<br />
masquerading as treatment-resistant pinworms. Clin<br />
Pediatr. <strong>2008</strong>;47:397-99.<br />
Eick A, Karron R, Shaw J, Thumar B, Reid R, Santosham<br />
M, O’Brien KL. The role <strong>of</strong> neutralizing antibodies in<br />
protection <strong>of</strong> American Indian infants against respiratory<br />
syncytial virus disease.Pediatr Infect Dis J. <strong>2008</strong><br />
Mar;27(3):207-12.<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS<br />
Moro MR, Contello K, Holz W, Weiner LB, Shaw<br />
J. Subcutaneous (SCIG) versus Intravenous (IVIG)<br />
Immunoglobulin Replacement Therapy in a Pediatric<br />
Population with Primary Immunodeficiencies (PID).<br />
Pediatric Academic Societies, Baltimore MD, May <strong>2009</strong>.<br />
El Feghaly RE, McGann L, Bonville CA, Rosenberg HF, and<br />
Domachowske JB.<br />
A Decade <strong>of</strong> Pediatric Parainfluenza Virus Infections:<br />
Clinical Manifestations and Biomarkers <strong>of</strong> Disease<br />
Severity. Pediatric Academic Societies Baltimore MD May<br />
<strong>2009</strong>.<br />
deWaal Malefyt SK, Pecha MM, and Domachowske JB.<br />
Bacterial meningitis in children with Mondini dysplasia.<br />
Pediatric Academic Societies Baltimore MD May <strong>2009</strong>.<br />
Gilroy SA, Martin D, Stahl R, Domachowske JB, Weiner<br />
LB, Johnson H, Costello K, Dadey J, Gross S, Bode M,<br />
Fuller P, Agnew M, Smith F, Susman R, Barrington K, and<br />
Johnson L. RSV Infection in a neonatal ICU: <strong>Report</strong> <strong>of</strong><br />
prevention strategies to control an outbreak. Society for<br />
Healthcare Epidemiology <strong>of</strong> America. San Diego CA <strong>2009</strong><br />
Gilroy SA, Martin D, Stahl R, Domachowske JB, Allen R,<br />
Johnson H, Costello K, Bode, M, Treatmen S, Sikora R,<br />
Hall E, Fuller P, LeRoy S, Steinman R Kosinsky M, Agnew M,<br />
Shaw J, Smith F, Susman R, Barrington K, Cook B, Johnson<br />
L, Watkins J, Richey D, Morrow C. Mumps exposure in<br />
a neonatal intensive care unit: <strong>Report</strong> <strong>of</strong> prevention<br />
strategies implemented to control an outbreak. Society<br />
for Healthcare Epidemiology <strong>of</strong> America. San Diego CA<br />
<strong>2009</strong><br />
Bonville CA, Rosenberg HF, and Domachowske JB.<br />
Newborn inflammatory responses to severe viral<br />
bronchiolitis. Infectious Disease Society <strong>of</strong> America.<br />
Washington, DC October, <strong>2008</strong><br />
Bonville CA, Moro RM, and Domachowske JB. A decade<br />
<strong>of</strong> pediatric adenovirus infection in Upstate New York:<br />
Clinical features and adenovirus types. Infectious Disease<br />
Society <strong>of</strong> America. Washington, DC October, <strong>2008</strong><br />
Cummings E, Suryadevara M, Bonville CA, Bartholoma<br />
N, Riddell S, Kiska D, and Domachowske JB. Viral coinfection<br />
is common in RSV-infected hospitalized<br />
children. Infectious Disease Society <strong>of</strong> America.<br />
Washington, DC October, <strong>2008</strong>
28 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Moro RM and Domachowske JB. Tracking curbside<br />
questions posed to a pediatric infectious disease service<br />
2007 compared to 1990. Pediatric Academic Societies,<br />
Honolulu HI, May <strong>2008</strong>.<br />
Moro MR, Bonville CA, Suryadevara M, Cummings E,<br />
Faddoul D, Kobayaa H, Branigan PJ and Domachowske<br />
JB. Adenovirus Infection Induces a Series <strong>of</strong> Pro-<br />
Inflammatory Mediators, but only Interleukin-1a and<br />
Interleukin-8 Correlate with Illness Severity. Pediatric<br />
Academic Societies, Honolulu HI, May <strong>2008</strong>.<br />
Bem RA, van Woensel JB, Bos AP, Koski A, Domachowske<br />
JB, Rosenberg HF, Martin TR, and Matute-Bello G.<br />
Mechanical ventilation enhances lung inflammation and<br />
cellular apoptosis in a model <strong>of</strong> mouse pneumovirus<br />
infection. American Thoracic Society Toronto Canada<br />
<strong>2008</strong>.<br />
Moro MR, Contello K, Holz W, Weiner LB, Shaw<br />
J. Subcutaneous (SCIG) versus Intravenous (IVIG)<br />
Immunoglobulin Replacement Therapy in a Pediatric<br />
Population with Primary Immunodeficiencies (PID).<br />
Pediatric Academic Societies, Baltimore MD, May <strong>2009</strong>.<br />
Gilroy SA, Martin D, Stahl R, Domachowske JB, Allen R,<br />
Johnson H, Costello K, Bode, M, Treatmen S, Sikora R,<br />
Hall E, Fuller P, LeRoy S, Steinman R Kosinsky M, Agnew<br />
M, Shaw J, et al. Mumps exposure in a neonatal intensive<br />
care unit: <strong>Report</strong> <strong>of</strong> prevention strategies implemented<br />
to control an outbreak. Society for Healthcare<br />
Epidemiology <strong>of</strong> America. San Diego CA <strong>2009</strong><br />
Suryadevara M, Moro MR, Rosenbaum P, Kiska D, Ridell<br />
S, Shaw J. Invasive community-acquired methicillinresistant<br />
Staphylococcus aureus infections in children in<br />
upstate New York. Pediatric Academic Societies, Honolulu<br />
HI, May <strong>2008</strong>.<br />
HONORS, VISITING PROFESSORSHIPS,<br />
EDITORIAL DUTY<br />
Joseph Domachowske, MD<br />
Leonard Tow Humanism in Medicine Award<br />
<strong>2009</strong><br />
Editor, Clinical Microbiology Reviews<br />
2002-2007, 2007-2012<br />
Managing Editor, <strong>Pediatrics</strong> e-medicine<br />
Infectious Diseases Section www.emedicine.com<br />
1999-present<br />
INVITED WORKSHOPS, CME PRESENTATIONS<br />
Domachowske JB: Immunization Advocacy. American<br />
Academy <strong>of</strong> <strong>Pediatrics</strong> Vaccine Summitt. Canandaguia NY<br />
May <strong>2009</strong><br />
Domachowske JB: Global health: the Central America<br />
perspective. High school advocacy group, Young Life Feb<br />
10, <strong>2009</strong>.<br />
Domachowske JB: Mucosal delivery <strong>of</strong> vaccines for<br />
respiratory tract infections. Albany Pediatric Society. Jan<br />
13, <strong>2009</strong>.<br />
Domachowske JB: Vaccines: The accused. Pediatric<br />
Grand Rounds Syracuse, NY Jan 7, <strong>2009</strong><br />
Domachowske JB: Measles and mumps in <strong>2008</strong>. Children<br />
at Risk Conference. Liverpool NY Nov 19 , <strong>2008</strong>.<br />
Domachowske JB: Invasive fungal infections in children.<br />
Diagnosis and treatment. Resident education seminar.<br />
Syracuse, NY Nov 13, <strong>2008</strong><br />
Domachowske JB: Maintaining public confidence in<br />
vaccines. American Academy <strong>of</strong> <strong>Pediatrics</strong> Vaccine<br />
Summitt. New Palz NY Nov 8, <strong>2008</strong><br />
Domachowske JB: Immune deficiencies and<br />
immunoglobulin replacement. Family advocacy group.<br />
Nov 5 th <strong>2008</strong> Syracuse NY<br />
Domachowske JB: The quest for an RSV vaccine. Pediatric<br />
Grand Rounds Duke University November 4, <strong>2009</strong><br />
Domachowske JB: <strong>2008</strong> Pr<strong>of</strong>essional Immunization<br />
Seminar: The Future is Now. Erie County <strong>Department</strong> <strong>of</strong><br />
Health, Erie PA. September <strong>2008</strong><br />
Domachowske JB: <strong>2008</strong> Immunization Update. Nursing<br />
conference. Canastota, NY March <strong>2008</strong>.<br />
Domachowske JB: Adolescent Immunization: A new<br />
focus on the next generation. Satellite symposium during<br />
the National Immunization Conference. Atlanta, GA<br />
March <strong>2008</strong>.<br />
Domachowske JB: How protected are we? Outbreaks <strong>of</strong><br />
vaccine preventable infections. Why? How? APIC Chapter<br />
Heart <strong>of</strong> New York’s Don’t gamble with infection control.<br />
Oneida, NY. March <strong>2008</strong>.<br />
Domachowske JB: Travel advice for college students:<br />
vaccines, food, water, and malaria. Syracuse University<br />
Teaching Day, Syracuse, NY January <strong>2008</strong><br />
Weiner LB: Invited Speaker – Albany County Medical<br />
Society, Albany, NY, “Influenza Vaccine Update <strong>2008</strong>”, May<br />
14, <strong>2008</strong>.<br />
Weiner LB: Invited Participant – New York City,<br />
Meningococcal Vaccine Advisory Committee, August 6,<br />
<strong>2008</strong>.<br />
Weiner LB: Invited Speaker – Monroe County Medical<br />
Society, Rochester, NY, “New Approaches to Pertussis<br />
Prevention”, August 14, <strong>2008</strong>.<br />
Weiner LB: Invited Speaker – New York State <strong>Department</strong><br />
<strong>of</strong> Health, Immunization Conference, Syracuse, NY,<br />
September 12, <strong>2008</strong>.<br />
Weiner LB: Pediatric Grand Rounds, “Influenza<br />
Immunization – Today and in the Future”, SUNY Upstate<br />
Medical University, Syracuse, NY, December 10, <strong>2008</strong>.<br />
Weiner LB: Invited Speaker – Sullivan County Medical<br />
Society, NYSDOH/MSSNY, “Immunization Update for<br />
Health Care Pr<strong>of</strong>essionals-<strong>2009</strong>”, Rock Hill, NY, December<br />
17, <strong>2008</strong>.<br />
Weiner LB: Invited Speaker – “Pediatric Respiratory Viral<br />
Infections”, Saratoga Springs, NY, February 4, <strong>2009</strong>.<br />
Weiner LB: Invited Speaker – Ulster County Medical
Bi-Annual <strong>Report</strong> • 29<br />
Society, NYSDOH/MSSNY, “Immunization Update for<br />
Health Care Pr<strong>of</strong>essionals-<strong>2009</strong>”, Woodstock, NY, April 7,<br />
<strong>2009</strong>.<br />
Weiner LB: Invited Speaker – Medical Grand Rounds, Our<br />
Lady <strong>of</strong> Lourdes Memorial Hospital, “New Considerations<br />
for Adult Immunization”, Binghamton, NY, April 23, <strong>2009</strong>.<br />
Weiner LB: Invited Speaker - Orange County Medical<br />
Society, NYSDOH/MSSNY, “Immunization Update for<br />
Health Care Pr<strong>of</strong>essionals-<strong>2009</strong>”, Newburgh, NY, May 12,<br />
<strong>2009</strong>.<br />
Weiner LB: Invited Speaker – Pediatric Associates,<br />
“Update – Rotavirus Vaccines”, Camillus, NY, May 20, <strong>2009</strong>.<br />
Weiner LB: Invited Speaker – Immunization Summit<br />
<strong>2009</strong>, “Immunization Safety & Breaking Communication<br />
Barriers”, Albany, NY, June 30, <strong>2009</strong>.<br />
Weiner LB: Invited Speaker – Northeast <strong>Pediatrics</strong> ,<br />
“Update on Prevention <strong>of</strong> Rotavirus Disease”, Ithaca, NY,<br />
September 30, <strong>2009</strong>.<br />
Weiner LB: Participant – Scientific Advisory Board<br />
Meeting, “Epidemiology <strong>of</strong> RSV Disease”, Washington, DC,<br />
October 1-2, <strong>2009</strong>.<br />
Weiner LB: Invited Speaker – Broome County Pediatric<br />
Society, “Update on RSV & Influenza”, Binghamton, NY,<br />
October 21, <strong>2009</strong>.<br />
Weiner LB: Invited Speaker – Arnot Ogden Hospital,<br />
NYSDOH/MSSNY, “A 2010 Clinician’s Guide to Influenza<br />
and Vaccination Protocols”, Ogdensburg, NY, October 27,<br />
<strong>2009</strong>.<br />
Weiner LB: Invited Speaker – American Academy <strong>of</strong><br />
<strong>Pediatrics</strong>/NYSDOH Vaccine Summit, “Emerging Vaccines<br />
in the Research Pipeline”, Mohonk, NY, November 6-8,<br />
<strong>2009</strong>.<br />
Weiner LB: Invited Speaker – SUNY Upstate Medical<br />
University, <strong>Department</strong> <strong>of</strong> Medicine, NYSDOH/MSSNY,<br />
“A 2010 Clinician’s Guide to Influenza and Vaccination<br />
Protocols”, Syracuse, NY, November 23, <strong>2009</strong>.<br />
GRANTS AND CONTRACTS<br />
Weiner LB<br />
2005-<strong>2009</strong> Comparative Immunogenicity <strong>of</strong><br />
Different Multivalent Component<br />
Pertussis Vaccine Formulations Based<br />
on a 5-component Acellular Pertussis in<br />
Infants and Toddlers, M5A10: Principal<br />
Investigator<br />
2006-<strong>2008</strong> Phase III Study for the Immunogenicity<br />
and Consistency Evaluation <strong>of</strong> 3 Hib-<br />
MenCY-TT Vaccine Lots and Evaluation<br />
<strong>of</strong> Safety and Immunogenicity <strong>of</strong> GSK<br />
Biologicals’ Haemophilus Influenzae Type<br />
B and Neisseria Meningitidis Serogroups<br />
C & Y-tetanus T, Hib 009/010: Principal<br />
Investigator<br />
2006-<strong>2008</strong> A phase III, single-blind, Randomized,<br />
Controlled, Multinational Study for the<br />
Evaluation <strong>of</strong> Safety <strong>of</strong> GSK Biologicals’<br />
Haemophilus Influenzae Type B and<br />
Neisseria Meningitidis Serogroups<br />
C and Y-Tetanus Toxoid Conjugate<br />
Vaccine Combined, Hib 011/012: Principal<br />
Investigator<br />
2007-<strong>2008</strong> Wyeth Pharmaceuticals: Trial<br />
Evaluating the Safety, Tolerability,<br />
and Immunogenicity <strong>of</strong> Three Lots <strong>of</strong><br />
13-valent Pneumococcal Conjugate<br />
Vaccine in Healthy Infants, 6096A1-3005:<br />
Principal Investigator<br />
2007-<strong>2009</strong> GlaxoSmithKline: A Phase II Randomized,<br />
Observer Blind, Multicenter Study <strong>of</strong><br />
GlaxoSmithKline Biologicals’ Combined<br />
Measles-Mumps-Rubella-Varicella<br />
Vaccine (MMRV) Versus ProQuad,<br />
According to a One Dose Schedule,<br />
both Administered Subcutaneously<br />
at 12-14 months, MMRV-054: Principal<br />
Investigator<br />
<strong>2009</strong>-2010 Merck and Company: Safety, Tolerability<br />
and Immunogenicity <strong>of</strong> VARIVAX<br />
(2007 Commercial VZV Bulk Process)<br />
Administered Concomitantly with MMRII<br />
in Healthy Children 12-23 Months <strong>of</strong> Age,<br />
V210-057: Principal Investigator<br />
<strong>2008</strong>-2010 Novartis: A Phase I, Open Label,<br />
Randomized Multi-Center Study to<br />
Evaluate the Safety and Immunogenicity<br />
<strong>of</strong> ProQuad Vaccine When Administered<br />
Concomitantly with Novartis<br />
Meningococcal ACWY Conjugate Vaccine<br />
to Healthy Toddlers, Protocol # V59P21:<br />
Principal Investigator<br />
<strong>2008</strong>-2010 Novartis: A Phase 3b, Open-Label,<br />
Randomized, Parallel-Group,<br />
MultiCenter Study to Evaluate the Safety<br />
<strong>of</strong> Novartis MenACWY Conjugate Vaccine<br />
when Administered with Routine Infant<br />
Vaccinations to Healthy Infants, V59P23:<br />
Principal Investigator<br />
<strong>2008</strong>-<strong>2009</strong> Tibotec: A Phase II, Open-Label Trial<br />
to Evaluate the Safety, Tolerability<br />
and Antiviral Activity <strong>of</strong> TMC125 in<br />
Antiretroviral Experienced HIV-1 Infected<br />
Children and Adolescents, TMC125-<br />
TiDP35-C213: Principal Investigator<br />
2006-<strong>2009</strong> San<strong>of</strong>i Pasteur: An Immunogenicity,<br />
Safety, and Non-Interference Evaluation<br />
<strong>of</strong> Pediatric Vaccines Administered<br />
Concomitantly with Menactra ®<br />
(Meningococcal [Groups A, C, Y and<br />
W-135] Polysaccharide Diphtheria Toxoid<br />
Conjugate Vaccine) to Healthy Toddlers:<br />
MTA37: Principal Investigator
30 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
2006-<strong>2008</strong> An Immunogenicity and Safety<br />
Evaluation <strong>of</strong> Two Doses <strong>of</strong> Menactra®<br />
(Meningococcal [Groups A,C,Y and<br />
W-135] Polysaccharide Diphtheria Toxoid<br />
Conjugate Vaccine) Given to Healthy<br />
Subjects at 9 and 12 Months <strong>of</strong> Age<br />
(MTA44): Principal Investigator<br />
2006-<strong>2008</strong> Immunogenicity and Safety <strong>of</strong><br />
Meningococcal (Serogroups A,C,Y, and<br />
W-135) Polysaccharide Diphtheria Toxoid<br />
Conjugate Vaccine (Menactra) in Children<br />
Aged 4 to 6 Years in the US when<br />
Administered Concomitantly with a Fifth<br />
Dose Diphtheria and Tetanus Toxoids and<br />
Acellular Pertussis Vaccine Adsorbed,<br />
MTA 43: Principal Investigator<br />
2004-2010 New York State, <strong>Department</strong> <strong>of</strong> Health,<br />
AIDS Institute – Center <strong>of</strong> Excellence,<br />
Pediatric HIV Care.<br />
A Double Blind, Placebo-Controlled,<br />
Virologic Efficacy Trial <strong>of</strong> Pleconaril<br />
(VP63843) in the Treatment <strong>of</strong> Neonates<br />
with Enteroviral Sepsis Syndrome, NIH/<br />
NIAID/CASG 106<br />
A Phase III, Randomized, Placebo-<br />
Controlled, Blinded Investigation<br />
<strong>of</strong> Six Weeks Vs. Six Months Of Oral<br />
Valganciclovir Therapy In Infants<br />
With Symptomatic Congenital<br />
Cytomegalovirus Infection (NIH/NIAID/<br />
CASG 112) Protocol Number: 06-0046:<br />
Principal Investigator<br />
<strong>2008</strong>- A Phamacokinetic/Pharmacodynamic and<br />
Safety Evaluation <strong>of</strong> Oseltamivir (Tamiflu)<br />
for the Treatment <strong>of</strong> Children less<br />
than 24 Months <strong>of</strong> Age with Confirmed<br />
Influenza Infection (NIH/NIAID/CASG 114,<br />
Protocol# 06-0059): Principal Investigator<br />
<strong>2009</strong>- A Pharmacokinetic/Pharmacodynamic<br />
And Safety Evaluation Of Investigational<br />
Intravenous Peramivir In Children With<br />
Influenza Disease NIH/NIAID/CASG 117:<br />
Principal Investigator<br />
Domachowske JB<br />
<strong>2009</strong> GlaxoSmithKline<br />
Phase 3, observer-blind, randomized<br />
study to evaluate the immunogenicity<br />
and safety <strong>of</strong> FluLaval TF (GSK<br />
Biologicals) compared with Fluzone<br />
(San<strong>of</strong>i –Pasteur,Inc) administered<br />
intramuscularly in children 3 to 17 years<br />
<strong>of</strong> age in the US. Role: PI<br />
<strong>2009</strong>-2011 National Institutes <strong>of</strong> Health, NIAID. The<br />
Innate Immune Shield: Lactobacillus<br />
species promote resistance to the lethal<br />
sequelae <strong>of</strong> respiratory virus infection.<br />
Role: Collaborator<br />
<strong>2009</strong>- Medimmune Research Grant<br />
Respiratory events among premature<br />
infants (32-36 week GA): Outcomes and<br />
risk tracking study Role: PI<br />
<strong>2009</strong>- Medimmune Research Grant<br />
A Phase 1/2a, Randomized, Double-Blind,<br />
Placebo-Controlled Study to Evaluate<br />
the Safety, Tolerability, Immunogenicity,<br />
and Viral Shedding <strong>of</strong> MEDI-559, a Live<br />
Attenuated Intranasal Vaccine Against<br />
Respiratory Syncytial Virus in Healthy 1 to<br />
Bi-Annual <strong>Report</strong> • 31<br />
NEPHROLOGY<br />
FACULTY<br />
James Listman, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Scott Schurman, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Section Head<br />
Thomas Welch, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, Chairman,<br />
<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
AFFILIATED CLINICAL STAFF<br />
Susan Sheffield, PNP, Nurse Practitioner and Coordinator<br />
Voiding Improvement Program<br />
Vickie Keeler, RN, BSN, MA<br />
AFFILIATED RESEARCH STAFF<br />
Lisa W. Blystone, MS, Instructional Support Specialist<br />
JoAnne E. Race, MS, Instructional Support Specialist<br />
CLINICAL OVERVIEW<br />
The Section <strong>of</strong> Nephrology provides inpatient<br />
consultation and acute dialysis care, including peritoneal<br />
dialysis, hemodialysis, and hem<strong>of</strong>iltration at the Upstate<br />
Golisano Children’s Hospital. Outpatient dialysis care,<br />
both peritoneal dialysis and hemodialysis, is provided<br />
at the University Dialysis Center in Syracuse. Other<br />
outpatient services are provided at our primary site in<br />
Syracuse, 725 Irving Ave., Suite 401, and satellite facilities<br />
in Watertown (Dr. Listman), Utica (Dr. Schurman), and<br />
Binghamton (Dr. Welch).<br />
The section evaluates and treats infants, children, and<br />
adolescents with the full spectrum <strong>of</strong> disorders <strong>of</strong> the<br />
urinary tract. This activity includes bread and butter<br />
nephrology, disorders such as nephrotic syndrome,<br />
glomerulonephritis, and all stages <strong>of</strong> chronic renal<br />
insufficiency. However, the section’s activity has few<br />
limits. We have an established expertise in the diagnosis<br />
and treatment <strong>of</strong> children with hypertension, including<br />
24 hour ambulatory blood pressure monitoring. We<br />
care for patients with mineral metabolism disorders<br />
and metabolic bone disease, including inherited and<br />
acquired forms <strong>of</strong> rickets, osteogenesis imperfecta, and<br />
osteoporosis. Metabolic evaluations <strong>of</strong> children with<br />
urolithiasis are performed, stressing dietary measures<br />
that can minimize risk <strong>of</strong> recurrence.<br />
The section provides coordinated care to infants and<br />
children with simple and complex urologic abnormalities,<br />
including prenatal visits. Patients with congenital or<br />
other hydronephrosis and vesicoureteral reflux are<br />
evaluated and followed. When necessary, urologic<br />
intervention is accessed.<br />
In addition, the section has attempted to address the<br />
growing number <strong>of</strong> children with voiding dysfunction,<br />
particularly children with associated daytime urinary<br />
urgency/incontinence and recurrent urinary tract<br />
infections. This effort, the “Voiding Improvement<br />
Program” (VIP) is coordinated by our pediatric nurse<br />
practitioner and nephrology nurse specialist, Susan<br />
Sheffield and Vickie Keeler. A multimodal approach to<br />
treatment is employed, including dietary, behavioral<br />
modification, and medication therapy.<br />
RESEARCH HIGHLIGHTS<br />
Role <strong>of</strong> Local Complement Synthesis in the<br />
Kidney<br />
Dr. Welch’s laboratory has continued its study <strong>of</strong><br />
novel roles for the human complement system in<br />
progressive renal disease. The role <strong>of</strong> activation and<br />
deposition <strong>of</strong> serum complement in the glomerulus<br />
as a major mediator <strong>of</strong> glomerulonephritis has long<br />
been established. We were the first laboratory to<br />
demonstrate that the human kidney itself could be a<br />
source <strong>of</strong> a number <strong>of</strong> complement components and<br />
that activation <strong>of</strong> these components in the peritubular<br />
interstitium was a major mediator <strong>of</strong> progressive renal<br />
damage.<br />
Over the past few years, we have developed a murine<br />
model <strong>of</strong> chronic immune complex glomerulonephritis<br />
and have used animals lacking various complement<br />
components as a mechanism for dissecting the specific<br />
role <strong>of</strong> complement in this process. We have further<br />
demonstrated that expression <strong>of</strong> the third component<br />
<strong>of</strong> complement, C3, is differentially regulated in the<br />
kidney and the liver. This has opened the possibility<br />
<strong>of</strong> specifically targeting renal complement expression<br />
without interfering with the important role <strong>of</strong> the<br />
complement cascade in the systemic immune response.<br />
We are now using the technique <strong>of</strong> gene expression<br />
analysis through microarray in order to examine<br />
differences in gene expression pr<strong>of</strong>iles between wild<br />
type animals and those lacking specific complement<br />
components. This is permitting us to understand<br />
the downstream molecular mechanisms by which<br />
peritubular complement activation induces renal<br />
damage.<br />
Finally, we have very recently been investigating ways in<br />
which progressive interstitial scarring can be attenuated.<br />
We have now shown in our murine model that<br />
angiotensin converting enzymes (ACE) inhibitors have a<br />
very important effect in attenuating interstitial injury in<br />
this model. Examining this effect in various complement<br />
deficient animals suggests preliminarily that this effect is<br />
mediated by a non-complement-dependent mechanism.<br />
Further examination <strong>of</strong> microarray data will allow us to<br />
explore more deeply the interplay between the many<br />
inflammatory cascades participating in renal damage.<br />
The ultimate goal <strong>of</strong> this would be to identify important<br />
pathways to target pharmacologically.
32 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Development <strong>of</strong> Novel Inhibitors <strong>of</strong><br />
Inflammation<br />
The major goal <strong>of</strong> Dr. Listman’s laboratory is to define<br />
small molecules that will specifically inhibit transcritpion<br />
<strong>of</strong> the IL-1b gene. IL-1b is a potent cytokine with diverse<br />
roles in inflammation including induction <strong>of</strong> the acute<br />
phase response, activation <strong>of</strong> the cellular components<br />
<strong>of</strong> acquired immunity, and promotion <strong>of</strong> chronic<br />
inflammation. Thus, inhibiting IL-1b expression (and<br />
other similarly regulated cytokines like TNFa) has major<br />
therapeutic potential for the treatment <strong>of</strong> a variety <strong>of</strong><br />
disease states including sepsis, arthritis, autoimmune<br />
diseases and transplant rejection among others.<br />
To accomplish our goal, the laboratory is investigating the<br />
structural/functional interactions <strong>of</strong> several transcription<br />
factors that regulate the IL-1b gene. These include Spi-1<br />
and C/EBPb, which are endogenous regulators <strong>of</strong> the<br />
IL-1b promoter, and the exogenous regulator Immediate-<br />
Early 2 (IE2) protein <strong>of</strong> Cytomegalovirus (CMV). The IE2<br />
protein provides a powerful tool for our task because<br />
it is a potent regulator <strong>of</strong> numerous host genes besides<br />
IL-1b, including TNFa, IL-8 and IL-2. Our laboratory<br />
is investigating the structural interactions that allow<br />
IE2 to participate with Spi-1 and C/EBPb to induce IL-1b<br />
expression. By narrowing down the peptide or, better<br />
yet, amino acid interactions between these molecules<br />
we hope to devise mimetic peptides would lack the<br />
major functional components <strong>of</strong> the parent molecule,<br />
but retain ability to bind to ligand, thus, interfering<br />
with the normal productive interactions that permit<br />
gene transcription. This goal is achieved by utilizing a<br />
combination <strong>of</strong> functional and biochemical techniques<br />
including recombinant DNA technology, gene reporter<br />
assays, and NMR spectroscopy, among others.<br />
Thus far, we identified a 14-residue fragment <strong>of</strong> the IE2<br />
molecule can function in a dominant negative manner to<br />
inhibit IL-1b promoter activity in heterologous systems.<br />
We are currently performing confirmatory analyses in<br />
CMV infected monocytic cell lines and in LPS activated<br />
monocytes to determine the effectiveness <strong>of</strong> this<br />
technology.<br />
PUBLICATIONS<br />
Listman JA, Race JE, Walker-Kopp N, Unlu S, Auron PE.<br />
Molecular Immunology 45(9), 2667, <strong>2008</strong>.<br />
Listman JA, Schurman SJ. Vasculitis. In: Kiessling,<br />
S. G., Goebel, J., and Somers, M. J. G. (eds). Pediatric<br />
Nephrology in the ICU, Springer, <strong>2008</strong>.<br />
Welch TR, Blystone LW. Immune complex<br />
glomerulonephritis following bone marrow<br />
transplantation in C3 deficient mice. PLoS ONE, Oct<br />
6;3(10):e3334, <strong>2008</strong>.<br />
Schurman SJ, Welch TR. Treatment <strong>of</strong> severe<br />
gentamicin overdose in a child with hemodialysis.<br />
Pediatr Nephrol, 26:211-213, <strong>2009</strong>.<br />
Welch TR, Berman D, Clement K. Wilderness first aid: Is<br />
there an industry standard? Wilderness Environ Med,<br />
20:113-117, <strong>2009</strong>.<br />
Welch TR, Blystone, LW. Renal disease associated with<br />
inherited disorders <strong>of</strong> the complement system. Pediatr<br />
Nephrol, 24:1439-1444, <strong>2009</strong>.<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS<br />
Welch TR, Miner B, Page N, Nimeh J. Implementation<br />
<strong>of</strong> ‘Patient Safety Rounds’ in Pediatric Inpatient Units,<br />
Pediatric Academic Socieities Annual Meeting, Baltimore,<br />
MD, <strong>2009</strong>.<br />
Welch TR, Blystone L, Gentile K, Middleton F. ACE<br />
Inhibition Attenuates Interstitial Injury in a Murine Model<br />
<strong>of</strong> Chronic Immune Complex Glomerulonephritis.<br />
Pediatric Academic Socieities Annual Meeting, Baltimore,<br />
MD, <strong>2009</strong>.<br />
HONORS, VISITING PROFESSORSHIPS,<br />
EDITORIAL DUTY<br />
Welch TR: Associate editor, the Journal <strong>of</strong> <strong>Pediatrics</strong><br />
Welch TR: Visiting Pr<strong>of</strong>essor, Columbia University,<br />
<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong>, New York, NY, September,<br />
<strong>2008</strong>.<br />
INVITED WORKSHOPS, CME PRESENTATIONS<br />
Welch TR. Manuscript Preparation for Peer Reviewed<br />
Publication workshop, Southern Society for Pediatric<br />
Research Annual Meeting, Atlanta, GA, February, <strong>2008</strong>.<br />
Welch TR. Manuscript Preparation for Peer Reviewed<br />
Publication workshop, Southern Society for Pediatric<br />
Research Annual Meeting, New Orleans, LA, February,<br />
<strong>2009</strong>.<br />
Welch TR. Ethical Issues in Manuscript Preparation<br />
and Publishing – A Round-Table Discussion. Pediatric<br />
Academic Socieities Annual Meeting, Baltimore, MD, <strong>2009</strong>.<br />
Welch TR. What are These Mysterious Things Called<br />
RVU’s? Pediatric Academic Socieities Annual Meeting,<br />
Baltimore, MD, <strong>2009</strong>.<br />
SELECTED CLINICAL DATA<br />
Outpatient visits, <strong>2008</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . 2,704<br />
Outpatient visits, <strong>2009</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . 2,653<br />
Inpatient visits, <strong>2008</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 648<br />
Inpatient visits, <strong>2009</strong>:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 564<br />
Inpatient dialysis procedures, <strong>2008</strong>:. . . . . . . . . . . . . . . . . . 128<br />
Inpatient dialysis procedures, <strong>2009</strong>:. . . . . . . . . . . . . . . . . . . 79<br />
Kidney transplants, <strong>2008</strong>-<strong>2009</strong>:. . . . . . . . . . . . . . . . . . . . . . . . 9
Bi-Annual <strong>Report</strong> • 33<br />
NEURODEVELOPMENTAL PEDIATRICS<br />
FACULTY<br />
Nienke Dosa, MD, MPH, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Gregory Liptak, MD, MPH, Upstate Foundation Pr<strong>of</strong>essor<br />
<strong>of</strong> Development, Division Director<br />
Louis Pellegrino, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Carol Grant, PhD, Clinical Assistant Pr<strong>of</strong>essor<br />
Henry Roane, PhD, Associate Pr<strong>of</strong>essor, Psychiatry and<br />
Behavioral Sciences, <strong>Pediatrics</strong><br />
Terry Hargrave, MD, MPH, Assistant Pr<strong>of</strong>essor, Psychiatry<br />
and Behavioral Sciences, <strong>Pediatrics</strong><br />
AFFILIATED CLINICAL STAFF<br />
Susan Delaney, FNP<br />
Mary MacBlane, RNC, PNP<br />
CLINICAL OVERVIEW<br />
The Center for Development, Behavior and Genetics<br />
provides evaluation, treatment, and management services<br />
for children and adolescents with developmental delays<br />
and disabilities. Outpatient clinical services are located<br />
in the Physician Office Building, Suite 112. These include<br />
interdisciplinary programs in Autism Spectrum Disorders,<br />
Child Development, Clinical Genetics, Inherited<br />
Metabolic Diseases (accredited by New York State),<br />
Physical Disabilities, and Spina Bifida. Dr. Nienke Dosa<br />
focuses on the care <strong>of</strong> children with physical disabilities,<br />
Dr. Louis Pellegrino focuses on children with cognitive<br />
challenges, while Dr. Liptak provides care for children<br />
with cognitive disorders and physical disabilities. Genetic<br />
services are also provided under the umbrella <strong>of</strong> this<br />
program, and are described separately in the “Genetics”<br />
section.<br />
Dr. Dosa directs the Physical Disabilities Program for<br />
children with cerebral palsy and those who other<br />
physical disabilities. She also directs the Spina Bifida<br />
Clinic. Dr. Pellegrino directs the Autism Spectrum<br />
Program and the Child Development Program, which<br />
includes children with developmental delays from other<br />
causes.<br />
In addition, the Center is staffed by two nurse<br />
practitioners, Mary MacBlane, RNC, PNP, and Susan<br />
Delaney, FNP; they provides care for patients with<br />
metabolic disorders (MM) and developmental disabilities<br />
(both). The Center also has pr<strong>of</strong>essionals in pediatric<br />
nursing, nutrition, occupational therapy, and social<br />
work. Pediatric specialists in orthopaedics, psychiatry,<br />
neurosurgery, and urology provide on-site consultation.<br />
Most recently, the team has been joined by Drs.<br />
Henry Roane and Terry Hargrave, faculty with joint<br />
appointments in <strong>Pediatrics</strong> and Psychiatry.<br />
PROGRAMS<br />
The Child Development Program <strong>of</strong>fers diagnostic,<br />
management and counseling services to the families<br />
<strong>of</strong> children with a variety <strong>of</strong> neurodevelopmental<br />
concerns, including the autistic spectrum disorders,<br />
cognitive and learning disabilities, speech and language<br />
disorders, attention deficit hyperactivity disorder, motor<br />
coordination disorders, and Down syndrome. Children<br />
from birth through the teenage years are served through<br />
the program. Diagnostic evaluations are provided<br />
by Drs. Liptak and Lou Pellegrino, both <strong>of</strong> whom are<br />
certified in general pediatrics and neurodevelopmental<br />
pediatrics. Special, standardized testing is employed in<br />
the assessment <strong>of</strong> children on the autistic spectrum. The<br />
physicians, with the support <strong>of</strong> Mary MacBlane and Susan<br />
Delaney, also provide ongoing support and management<br />
<strong>of</strong> children with a variety <strong>of</strong> neurodevelopmental<br />
disorders, including targeted medication management<br />
when appropriate. Amy Beale, a social worker at Upstate<br />
Medical University’s Psychiatry <strong>Department</strong>, provide<br />
behavioral assessment, counseling services and support<br />
for the development <strong>of</strong> social-adaptive skills, targeting<br />
children less than 6 years <strong>of</strong> age.<br />
The Physical Disability Program provides specialty care to<br />
children who are multiply disabled by conditions such as<br />
cerebral palsy, vision impairment/blindness, and genetic<br />
disorders. The focus is on habilitation. Some children<br />
may be referred for a single visit, such as spasticity<br />
evaluation and management, including injections with<br />
botulinum toxin (Botox), while other children may<br />
receive ongoing care for complex medical problems.<br />
The program <strong>of</strong>fers a multidisciplinary approach and<br />
addresses both medical and behavioral/developmental<br />
issues. It helps to establish a diagnosis and to develop<br />
a care plan. The Physical Disability Program <strong>of</strong>fers an<br />
interdisciplinary approach and collaboration with other<br />
pediatric specialists and surgeons. The program is staffed<br />
by Dr. Dosa who is board-certified in pediatrics and in<br />
neurodevelopmental disabilities, and pr<strong>of</strong>essionals in<br />
occupational therapy, physical therapy, nutrition, and<br />
specialty nursing.<br />
The Spina Bifida Center <strong>of</strong> Central New York provides<br />
comprehensive specialty care to children and<br />
adolescents with spina bifida. The center is staffed by<br />
Dr. Dosa who is board-certified in pediatrics and in<br />
neurodevelopmental disabilities, and pr<strong>of</strong>essionals in<br />
physiatry, occupational therapy, physical therapy, social<br />
work, nutrition, and specialty nursing. Our focus is on<br />
wellness and the prevention <strong>of</strong> secondary conditions.<br />
The Spina Bifida program schedules screening studies<br />
as needed and coordinate care with surgical subspecialists<br />
in neurosurgery, orthopaedics and urology.<br />
It also collaborates with specialists in wound care and<br />
facilitates the ordering <strong>of</strong> adaptive equipment. It <strong>of</strong>fers a<br />
multidisciplinary approach and address both medical and<br />
behavioral/developmental issues. In collaboration with
34 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
faculty from SUNY Cortland, Dr. Dosa has developed a<br />
Group Visit Model for individuals with spina bifida.<br />
In collaboration with faculty in adapted physical<br />
education from SUNY Cortland, Dr. Dosa has developed<br />
a Group Visit Model for individuals with spina bifida,<br />
cerebral palsy, and other motor disabilities. Group<br />
Visits focus on adapted sports and physical activity for<br />
the entire family. Group Visits take place at a state-<strong>of</strong>the-art<br />
gym and pool facility at the Institute for Human<br />
Performance on the SUNY Upstate campus.<br />
RESEARCH HIGHLIGHTS<br />
Dr. Dosa’s work is focused on improving communitybased<br />
health services for children and adolescents with<br />
disabilities and complex medical conditions, especially<br />
as they transition from adolescence to adulthood. She<br />
heads the New York State Institute for Health Transition<br />
Training (www.HealthyTransitionsNY.org) and coordinates<br />
the Parent Partners in Health Education home visit<br />
program for residents in pediatrics, psychiatry and<br />
family medicine. She is collaborating with the Family<br />
Medicine <strong>Department</strong> on a funded grant entitled, “Center<br />
for Excellence in Primary Care,” whose purpose is to<br />
increase the knowledge <strong>of</strong> primary care providers in<br />
areas <strong>of</strong> developmental pediatrics. She is part <strong>of</strong> a multiinstitutional<br />
study, funded by the NIH, to evaluate the<br />
safety and efficacy <strong>of</strong> oral Bacl<strong>of</strong>en in children who have<br />
cerebral palsy.<br />
Dr. Liptak is interested in researching the health services<br />
received by children who have special needs. He<br />
completed a project that examined the use <strong>of</strong> group<br />
visits in children with vision impairments to evaluate its<br />
feasibility as a model <strong>of</strong> care. He currently is analyzing<br />
data from the National Longitudinal Transition Study-2<br />
to evaluate the transitions <strong>of</strong> adolescents who have<br />
spina bifida as well as those who have autism. He is<br />
working on the clinical trial <strong>of</strong> Bacl<strong>of</strong>en with Dr. Dosa, and<br />
serves as an epidemiological consultant to NASPGHAN<br />
(North American Society for Pediatric Gastroenterology<br />
Hepatology and Nutrition).<br />
PUBLICATIONS<br />
Original Scientific Articles<br />
Liptak GS, Benzoni LB, Mruzek DW, Nolan KW, Thingvoll<br />
MA, Wade CM, Fryer GE. Disparities in diagnosis and<br />
utilization <strong>of</strong> health services for children with autism:<br />
Data from the National Survey <strong>of</strong> Children’s Health.<br />
Journal <strong>of</strong> Developmental and Behavioral <strong>Pediatrics</strong>. <strong>2008</strong><br />
Jun;29(3):152-60.<br />
Dosa NP, Foley JT, Eckrich M, Woodall-Ruff D, Liptak GS.<br />
Obesity across the lifespan among persons with spina<br />
bifida. Disabil Rehabil. <strong>2008</strong> Nov 26:1-7.<br />
Reviews<br />
Liptak GS. Health and well being <strong>of</strong> adults with cerebral<br />
palsy. Current Opinion in Neurology. <strong>2008</strong>;21:136–142.<br />
Pierce K, Glatt SJ, Liptak GS, McIntyre LL. The power<br />
and promise <strong>of</strong> identifying autism early: insights from<br />
the search for clinical and biological markers. Ann Clin<br />
Psychiatry. <strong>2009</strong> Jul-Sep;21(3):132-47.<br />
Vandenplas Y, Rudolph CD, Di Lorenzo C, Hassall<br />
E, Liptak GS, Mazur M, Sondheimer J, Staiano A,<br />
Thomson M, Veereman-Wauters G, Wenzl TG. Pediatric<br />
Gastroesophageal Reflux Clinical Practice Guidelines:<br />
Joint Recommendations <strong>of</strong> the North American Society<br />
for Pediatric Gastroenterology, Hepatology, and Nutrition<br />
(NASPGHAN) and the European Society for Pediatric<br />
Gastroenterology, Hepatology, and Nutrition (ESPGHAN).<br />
Journal <strong>of</strong> Pediatric Gastroenterology and Nutrition,<br />
<strong>2009</strong>;49:498–547.<br />
Dosa NP, Mukherjee S, Tovar-Spinoza Z. Spina Bifida and<br />
Neural Tube Defects. BMJ Point <strong>of</strong> Care, November <strong>2009</strong>.<br />
Reviews with American Academy <strong>of</strong> <strong>Pediatrics</strong><br />
Council on Children with Disabilities (Dr. Liptak)<br />
Murphy NA, Carbone PS; American Academy <strong>of</strong> <strong>Pediatrics</strong><br />
Council on Children With Disabilities. Promoting the<br />
participation <strong>of</strong> children with disabilities in sports,<br />
recreation, and physical activities. <strong>Pediatrics</strong>. <strong>2008</strong><br />
May;121(5):1057-61.<br />
Desch LW, Gaebler-Spira D; Council on Children With<br />
Disabilities. Prescribing assistive-technology systems:<br />
focus on children with impaired communication.<br />
<strong>Pediatrics</strong>. <strong>2008</strong> Jun;121(6):1271-80.<br />
Council on Children With Disabilities. From the American<br />
Academy <strong>of</strong> <strong>Pediatrics</strong>: Policy statements--Supplemental<br />
Security Income (SSI) for children and youth with<br />
disabilities. <strong>Pediatrics</strong>. <strong>2009</strong> Dec;124(6):1702-8.<br />
Books and Book Chapters<br />
Dosa NP, Liptak GS. School Related Issues for Children<br />
with Special Needs. In: McInerny TK, Adam HM, Campbell<br />
D, Kamat DK, Kelleher KJ, Eds. American Academy <strong>of</strong><br />
<strong>Pediatrics</strong> Textbook <strong>of</strong> Pediatric Care. Elk Grove Village,<br />
IL. American Academy <strong>of</strong> <strong>Pediatrics</strong>; <strong>2009</strong>, pp. 588-592 .<br />
Liptak GS. Diaper rash. In: McInerny TK, Adam HM,<br />
Campbell D, Kamat DK, Kelleher KJ, Eds. American<br />
Academy <strong>of</strong> <strong>Pediatrics</strong> Textbook <strong>of</strong> Pediatric Care. Elk<br />
Grove Village, IL. American Academy <strong>of</strong> <strong>Pediatrics</strong>; <strong>2009</strong>,<br />
pp. 2010-2016.<br />
Liptak GS. Spina bifida. In: McInerny TK, Adam HM,<br />
Campbell D, Kamat DK, Kelleher KJ, Eds. American<br />
Academy <strong>of</strong> <strong>Pediatrics</strong> Textbook <strong>of</strong> Pediatric Care . Elk<br />
Grove Village, IL. American Academy <strong>of</strong> <strong>Pediatrics</strong>; <strong>2009</strong>,<br />
pp2537-2545.<br />
Liptak GS. Cerebral palsy. In: McInerny TK, Adam HM,<br />
Campbell D, Kamat DK, Kelleher KJ, Eds. American<br />
Academy <strong>of</strong> <strong>Pediatrics</strong> Textbook <strong>of</strong> Pediatric Care . Elk<br />
Grove Village, IL. American Academy <strong>of</strong> <strong>Pediatrics</strong>; <strong>2009</strong>,<br />
pp 1903-1910.<br />
Liptak GS. Chromosomal abnormalities. In Beers MH.<br />
Ed. The Merck Manual <strong>of</strong> Medical Information: Second<br />
Home Edition. Whitehouse Station, NJ: Merck Research
Bi-Annual <strong>Report</strong> • 35<br />
Laboratories, <strong>2009</strong>, http://www.merck.com/mmpe/sec19/<br />
ch294/ch294a.html.<br />
Osterlund CA, Dosa NP, Arnott-Smith CA. Mother knows<br />
best: What role do patients with chronic conditions<br />
and parents play in the management <strong>of</strong> their medical<br />
information? In The Informatics <strong>of</strong> Diabetes: A Research<br />
Agenda for the Socially and Institutionally Sensitive<br />
Use <strong>of</strong> Information Technology to Improve Healthcare,<br />
Barbara M. Hayes and William Aspray, editors. MIT Press,<br />
<strong>2009</strong>.<br />
Other<br />
Educational DVDs<br />
Dosa NP, Judd-Litera K, Nellis J, LaMacchia S, LaValley<br />
R. Special Needs Advocacy Partners: (a) Preparing Your<br />
Child For Surgery (b) What We Can Do To Make Your<br />
Hospital Stay Better. Instructional DVD, published<br />
August <strong>2009</strong> in collaboration with Child Life Service at<br />
Golisano Childrens Hospital at SUNY Upstate Medical<br />
University with grant support from the New York State<br />
Developmental Disabilities Planning Council.<br />
Cleary D and Dosa NP. Collaboration for Orientation and<br />
Mobility at the Elementary School Level. Instructional<br />
DVD, published May <strong>2009</strong> in collaboration with Syracuse<br />
City School District and Syracuse University School <strong>of</strong><br />
Education. Distributed state-wide to teachers for visually<br />
impaired children with grant support from the New York<br />
State Developmental Disabilities Planning Council.<br />
Cleary D, Dosa NP, Foley JT, Lieberman L. Liptak GS,<br />
MacBlane M, Welch T. (A SUNY Upstate-SUNY Cortland-<br />
SUNY Brockport collaboration) Sport Opportunities<br />
and Activities for Children with Visual Impairments.<br />
Instructional DVD, published October <strong>2008</strong> and on the<br />
internet at http://www.campabilitiesbrockport.org/Camp-<br />
Video.html. DVD distributed state-wide to adaptive<br />
physical education instructors with grant support from<br />
Children’s Miracle Network.<br />
Liptak GS. Medical home optimizes care for children with<br />
cerebral palsy. AAP News <strong>2009</strong>(September):15.<br />
Liptak GS. Reviewer and Contributor to Shelov SP. Ed.<br />
Caring for Your Baby And Young Child: Birth To Age 5.<br />
American Academy <strong>of</strong> <strong>Pediatrics</strong>, Bantam Books. <strong>2009</strong>.<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS<br />
Liptak GS, Foley JT, Dosa NP, Cleary D, Welch TR,<br />
Columna L. A group visit model program for children<br />
who are blind/visually impaired. Poster presented at the<br />
Association for Education and Rehabilitation <strong>of</strong> the Blind<br />
and Visually Impaired (AER) International Meeting July 22-<br />
27, <strong>2008</strong>, Chicago.<br />
Liptak GS, Worley G. The year’s top ten articles on<br />
developmental disabilities. Instructional Course<br />
presented at the American Academy <strong>of</strong> Cerebral Palsy<br />
and Developmental Medicine annual meeting, Atlanta,<br />
GA, September 19, <strong>2008</strong>.<br />
Liptak GS. Complications <strong>of</strong> botulinum toxin. Invited<br />
Presidential Guest Speaker. Presented at the American<br />
Academy <strong>of</strong> Cerebral Palsy and Developmental Medicine<br />
annual meeting, Atlanta, GA, September 20, <strong>2008</strong>.<br />
Liptak GS, Murphy N. Controversies and Challenges<br />
for Children and Youth with Disabilities: The Ashley<br />
Treatment: A Cry for Help. Presented at the American<br />
Academy <strong>of</strong> <strong>Pediatrics</strong> National Conference and<br />
Exposition. Boston, MA, October 11, <strong>2008</strong>.<br />
Liptak GS, Foley JT, Dosa NP, Cleary D, Welch TR,<br />
Columna L. Group Visits Model: A Collaborative<br />
Perspective in Adapted Physical Education. Research<br />
Consortium presentation at the <strong>2009</strong> AAHPERD National<br />
Convention in Tampa, Florida; April 1, <strong>2009</strong>.<br />
Dosa NP, Osterlund C, Tamburo J, Morley C, Beatty P,<br />
Epling J, Liptak GS. Curriculum and Interactive Tools<br />
to Facilitate Health Care Transition <strong>of</strong> Youth with<br />
Developmental Disabilities. Poster presented at the Spina<br />
Bifida World Congress, Orlando, Florida, March 16-19,<br />
<strong>2009</strong>.<br />
MacBlane ME, Garver K, Hodge J, Mahunik A, Davis T,<br />
Columna L, Foley J, Dosa NP, Liptak GS. A Group Visit<br />
Model Program for Children with Spina Bifida. Poster<br />
presented at the Spina Bifida World Congress, Orlando,<br />
Florida, March 16-19, <strong>2009</strong>.<br />
Liptak GS, Kennedy JA, Dosa NP. Youth with Spina Bifida<br />
and Transitions: Using the WHO ICF Model in a Nationally<br />
Representative Sample. Poster presented at the Spina<br />
Bifida World Congress, Orlando, Florida, March 16-19,<br />
<strong>2009</strong>. Platform presentation at the American Academy<br />
<strong>of</strong> Cerebral Palsy and Developmental Medicine annual<br />
meeting, Scottsdale, Arizona, September 24, <strong>2009</strong>.<br />
Liptak GS. Disease Management and 10 Simple Rules for<br />
the 21st Century Health Care System. Presented at the<br />
Spina Bifida World Congress, Orlando, Florida, March 16,<br />
<strong>2009</strong>.<br />
Liptak GS. Health care and spina bifida: the canary in the<br />
coal mine. Keynote address. Presented at the Spina Bifida<br />
World Congress, Orlando, Florida, March 18, <strong>2009</strong>.<br />
Liptak GS, Kennedy JA, Dosa NP. Youth with Autism and<br />
Transitions: Using the WHO ICF Model in a Nationally<br />
Representative Sample. Platform presentation at the<br />
American Academy <strong>of</strong> Cerebral Palsy and Developmental<br />
Medicine annual meeting, Scottsdale, Arizona, September<br />
24, <strong>2009</strong>.<br />
Liptak GS, Worley G. The year’s top ten articles on<br />
developmental disabilities. Instructional Course<br />
presented at the American Academy <strong>of</strong> Cerebral Palsy<br />
and Developmental Medicine annual meeting, Scottsdale,<br />
AZ, September 24, <strong>2009</strong>.<br />
Liptak GS, O’Donnell M. To screen or not to screen for<br />
autism. Plenary presentation at the American Academy<br />
<strong>of</strong> Cerebral Palsy and Developmental Medicine annual<br />
meeting, Scottsdale, AZ, September 25, <strong>2009</strong>.<br />
Liptak GS, Myers SM. Beyond Developmental Screening:<br />
Office Management <strong>of</strong> the Child with a Developmental<br />
Disability in the Primary Care Medical Home. Presented<br />
at the National Conference and Exhibition, American
36 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Academy <strong>of</strong> <strong>Pediatrics</strong>, Washington, DC, October 17 and<br />
18, <strong>2009</strong>.<br />
Dosa NP, Slaski P, James L. HealthyTransitionsNY.org<br />
curriculum and toolkit, Instructional Course, American<br />
Academy <strong>of</strong> Cerebral Palsy and Developmental Medicine,<br />
Phoenix Arizona, September 24, <strong>2009</strong>.<br />
Dosa NP, Webb T, Walters C,Worley G, Nolan K,<br />
Armstrong J, Boerger P, Hulse C, Dias M, Olson A, Liptak<br />
GS. Assessment <strong>of</strong> Spina Bifida Care for Adolescents:<br />
A Quality Improvement Tool for Spina Bifida Centers.<br />
Spina Bifida World Congress, abstracts with programs,<br />
Orlando, Florida, March 16-19, <strong>2009</strong>.<br />
Dosa NP, Transition and Adult Health Care, plenary panel,<br />
Spina Bifida World Congress, Orlando, Florida, March 17,<br />
<strong>2009</strong>.<br />
Morley C, Dosa NP, Jain S, Kelly B, Jurczyck I, Reiss J,<br />
Winslow M, Boyd D, Tamburo J, Transition Planning<br />
and Management Continuity <strong>of</strong> Care for Youth with<br />
Developmental Disabilities. Panel discussion, 35th<br />
Annual Predoctoral Education Conference, Society <strong>of</strong><br />
Teachers <strong>of</strong> Family Medicine, Savannah, Ga, January 23,<br />
<strong>2009</strong>.<br />
INVITED WORKSHOPS, CME PRESENTATIONS<br />
Pellegrino L. Sensory Integration Dysfunction. <strong>2009</strong><br />
Menichello Teaching Day, Wilson Hospital, Johnson City,<br />
New York (Regional Conference), May <strong>2009</strong><br />
Dosa NP and Columna L. Promoting Physical Activity for<br />
Children with Vision Impairment/Blindness. Onondaga-<br />
Cortland-Madison BOCES annual conference for<br />
Teachers for the Visually Impaired. Syracuse, NY. April 2,<br />
<strong>2008</strong>.<br />
Pellegrino L, Liptak GS, McIntyre LL, Magyar CI.<br />
Understanding Individuals With Asperger’s Syndrome<br />
or High Functioning Autism in New York. Syracuse, NY,<br />
December 10, <strong>2008</strong>. Sponsored by Lorman Education<br />
Services.<br />
Dosa NP and Columna L. Promoting Physical Activity for<br />
Children with Vision Impairment/Blindness. Onondaga-<br />
Cortland-Madison BOCES annual conference for<br />
Teachers for the Visually Impaired. Syracuse, NY. April 2,<br />
<strong>2008</strong>.<br />
Dosa NP and Epling J. Making Health Transitions Caring<br />
for Young Adults with Disabilities. 37th Annual Family<br />
Medicine Refresher Course. SUNY Upstate <strong>Department</strong><br />
<strong>of</strong> Family Medicine, Syracuse, NY, March 29, <strong>2008</strong>.<br />
Pellegrino L. Autism Spectrum Disorders: What We Think<br />
We Know. <strong>2008</strong> Menichello Teaching Day, Wilson Hospital,<br />
Johnson City, New York (Regional Conference), May <strong>2008</strong><br />
GRANTS<br />
NICHD/NIH Contract No. HHSN267200603421C. (Janice<br />
Brunstrum, MD, PI [St. Louis University]) 9/1/<strong>2009</strong> -<br />
8/31/2010. Bacl<strong>of</strong>en for spasticity [Clinical trial]. ($36,000<br />
plus enrollment).<br />
Competency in Transition for Physicians in Training, New<br />
York-Mid Atlantic Consortium for Genetic and Newborn<br />
Screening Services Grant. Robert Ostrander MD, Kim<br />
Garver MSW, Nienke Dosa MD, MPH 32,000 (2010).<br />
Fit Families Group Visits: Physical Activity and Medical<br />
Services for Hispanic and Caucasian Children with<br />
Spina Bifida and their Families, Christopher and Dana<br />
Reeve Foundation Quality <strong>of</strong> Life Award, Co-Principal<br />
Investigator with Luis Columna, PhD <strong>Department</strong> <strong>of</strong><br />
Adapted Physical Education, SUNY Cortland, $6000<br />
(<strong>2009</strong>).<br />
Center for Excellence in Primary Care (HRSA AAU Grant<br />
Award Number 2 D54HP05462-04-00). September<br />
<strong>2008</strong>-August 2011. ($858,000) 0.10 FTE.<br />
Parent Partners in Health Education. (Principal<br />
Investigator, 0.1 FTE) New York State Developmental<br />
Disabilities Planning Council: 2006-<strong>2009</strong>: $135,000.<br />
New York State Institute for Health Transition Training<br />
for Youth with developmental Disabilities, (Principal<br />
Investigator, 0.2 FTE) New York State Developmental<br />
Disabilities Planning Council: 2006-2010: $580,000.<br />
Group Visits for Children with Spina Bifida. American<br />
Legion Auxiliary (in collaboration with SUNY Cortland<br />
Adapted Physical Education <strong>Department</strong>), <strong>2008</strong>: $2,500.<br />
Usability Testing <strong>of</strong> Healthy Transitions Network<br />
s<strong>of</strong>tware via Model High School Transition Programs.<br />
Maternal Child Health Bureau/New York State<br />
<strong>Department</strong> <strong>of</strong> Health: Integrated Community Systems<br />
Grant (Principal Investigator). June <strong>2008</strong>-April <strong>2009</strong>.<br />
$15,700.<br />
State-wide distribution <strong>of</strong> instructional DVD to adaptive<br />
physical education teachers: “Sport Opportunities and<br />
Activities for Children with Visual Impairments.” Central<br />
New York Golisano/Children’s Miracle Network Project<br />
Grant (Dosa NP, in collaboration with John Foley PhD,<br />
Deborah Cleary TVI, Lauren Lieberman PhD, Terry Welch<br />
PhD, Mary MacBlane PNP, and Gregory Liptak MD, MPH):<br />
February <strong>2008</strong> $4,000<br />
Trajectory <strong>of</strong> Transition for Adolescents and Young<br />
Adults with Spina Bifida, a multi-center longitudinal study<br />
<strong>of</strong> medical and social outcomes among youths with spina<br />
bifida. (In collaboration with Kimberlee Garver CSW,<br />
Mary MacBlane PNP, and Judy Hodge RN), Spina Bifida<br />
Association <strong>of</strong> America, local co- investigator, 2007-2010<br />
($1,500).<br />
A Six-Month, Multi-Center, Open-Label Study to Assess<br />
the Safety and Efficacy <strong>of</strong> Oral Glycopyrrolate Liquid for<br />
the Treatment <strong>of</strong> Pathologic (Chronic Moderate to Severe)<br />
Drooling in Pediatric Patients 3 to 16 Years <strong>of</strong> Age with<br />
Cerebral Palsy or other Neurologic Conditions, Protocol<br />
No. Sc-06-01: IND #61,716, Sciele Pharmaceuticals.
Bi-Annual <strong>Report</strong> • 37<br />
(Principal Investigator, SUNY Upstate Medical University)<br />
June 2007-February <strong>2008</strong>. (per enrollment).<br />
New York State <strong>Department</strong> <strong>of</strong> Health Youth Advisory<br />
Council Collaboration: Usability Testing for Healthy<br />
Transitions Network s<strong>of</strong>tware. Maternal Child Health<br />
Bureau/New York State <strong>Department</strong> <strong>of</strong> Health: Integrated<br />
Community Systems Grant (Principal Investigator).<br />
August 2007-April <strong>2008</strong>. $9,600.<br />
NICHD/NIH Contract No. HHSN267200603421C. (Janice<br />
Brunstrum, MD, PI [St. Louis University]) 9/1/<strong>2009</strong> -<br />
8/31/2010. Bacl<strong>of</strong>en for spasticity [Clinical trial]. ($36,000<br />
plus enrollment).<br />
SELECTED CLINICAL DATA<br />
Neurodevelopmental <strong>Pediatrics</strong><br />
Outpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,356<br />
Outpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,474<br />
Inpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16<br />
Inpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6<br />
Physical Disabilities (excluding spina bifida)<br />
Outpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210<br />
Outpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263<br />
Inpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35<br />
Inpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15<br />
Spina Bifida Program<br />
Outpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . 254<br />
Outpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243<br />
Inpatient Visits <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11<br />
Inpatient Visits <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15
38 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
NEUROLOGY<br />
Child neurology services are provided through the<br />
Section <strong>of</strong> Child Neurology <strong>of</strong> the <strong>Department</strong> <strong>of</strong><br />
Neurology. These faculty have joint appointments in the<br />
<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong>.<br />
FACULTY<br />
Carl J. Crosley, MD, Pr<strong>of</strong>essor <strong>of</strong> Neurology and<br />
<strong>Pediatrics</strong>, Director<br />
Nancy Havernick, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Neurology and Psychiatry<br />
Melissa Ko, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> Neurology<br />
Malavalli Seetharam, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Neurology<br />
AFFILIATED CLINICAL STAFF<br />
Leigh B. Wilson, MSN, PNP, Pediatric Nurse Practitioner<br />
Mary MacBlane, MS, RN, PNP<br />
CLINICAL OVERVIEW<br />
The Section <strong>of</strong> Child Neurology provides diagnosis,<br />
treatment, and management for children and<br />
adolescents with neurodevelopmental and neurologic<br />
disorders. The outpatient <strong>of</strong>fices are located in the<br />
University Health Care Center, 90 Presidential Plaza,<br />
Syracuse, NY 13202. Extensive services are in particular<br />
available for children with epilepsy, headaches, cerebral<br />
palsy, muscular dystrophy, neur<strong>of</strong>ibromatosis. The<br />
neurodevelopmental conditions <strong>of</strong> developmental delay,<br />
attention deficit disorder and autism also receive full<br />
attention.<br />
Children with epilepsy are reviewed as appropriate with<br />
the additional input and services <strong>of</strong> the epilepsy team <strong>of</strong><br />
the <strong>Department</strong> <strong>of</strong> Neurology and have the full services<br />
<strong>of</strong> the <strong>Department</strong> <strong>of</strong> Clinical Neurophysiology available<br />
to them including, electroencephalography, long-term<br />
video electroencephalographic monitoring, ambulatory<br />
electroencephalograms, and epilepsy surgery.<br />
Children with muscular dystrophies are eligible for<br />
care under the auspices <strong>of</strong> the Muscular Dystrophy<br />
Association weekly clinic centrally located in Syracuse<br />
with continuing care available in Utica and Watertown<br />
New York.<br />
In collaboration with Dr. Gloria Kennedy children with<br />
brain tumors and other tumors <strong>of</strong> the central nervous<br />
system are cared for at the monthly Pediatric Brain<br />
Tumor Clinic at University Hospital.<br />
Dr. Crosley is Medical Director at Enable in Syracuse<br />
where children with developmental disabilities<br />
including cerebral palsy and pervasive developmental<br />
disorders are provided the locally unique mix <strong>of</strong><br />
ongoing multidisciplinary therapies including physical<br />
occupational and speech therapy as well as on site<br />
aquatherapy, and individual and group behavioral<br />
therapies.<br />
RESEARCH HIGHLIGHTS<br />
The section is currently participating in sponsored<br />
clinical trials investigating the efficacy and safety <strong>of</strong><br />
two anti-epileptic drugs in infants and toddlers and in a<br />
sponsored clinical trial studying the efficacy and safety <strong>of</strong><br />
a particular triptan in adolescents with migraine.<br />
PUBLICATIONS<br />
Ko MW, Tamhankar MA, Volpe NJ, Porter D, McGrath C,<br />
Galetta SL: Acute promyelocytic leukemic involvement<br />
<strong>of</strong> the optic nerves following mitoxantrone treatment for<br />
multiple sclerosis. J Neurol Sci, 273(1-2):144-7, <strong>2008</strong>.<br />
Ko MW, Dalmau J, Galetta SL: Neuro-ophthalmologic<br />
manifestations <strong>of</strong> paraneoplastic syndromes. J<br />
Neuroophthalmol, 28(1):58-68, <strong>2008</strong>.<br />
Duffner PK, Caggana M, Orsini JJ, Wenger DA, Patterson<br />
MC, Crosley CJ, et al: Newborn screening for Krabbe<br />
disease: the New York State model. Pediatr Neurol<br />
40(4):245-52, <strong>2009</strong>.<br />
Ko MW, Turkeltaub PE, Lee EB, Gonatas NK, Volpe NJ,<br />
Moster ML, Galetta SL: Primary diffuse leptomeningeal<br />
gliomatosis mimicking a chronic inflammatory meningitis.<br />
J Neurol Sci, 278(1-2):127-31, <strong>2009</strong>.
Bi-Annual <strong>Report</strong> • 39<br />
PULMONOLOGY<br />
FACULTY<br />
Ran D. Anbar, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong> and Medicine,<br />
Division Director<br />
Robert V. Hingre, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Lawrence E. Kurlandsky, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
Kevin G. Ragosta, DO, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Zafer N. Soultan, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
AFFILIATED CLINICAL STAFF<br />
Susan Delaney, NP, Nurse Practitioner, High Technology<br />
Program<br />
Mary Foster, NP, Nurse Practitioner, Cystic Fibrosis<br />
Center Coordinator<br />
Margaret O’Shea, NP, Nurse Practitioner, Hypnosis<br />
Program<br />
CLINICAL OVERVIEW<br />
The Division <strong>of</strong> Pulmonology provides care for children<br />
and adolescents with lung and airway diseases. Major<br />
clinical activities <strong>of</strong> the Division include care <strong>of</strong> patients<br />
with asthma, allergies, cystic fibrosis, bronchopulmonary<br />
dysplasia, sleep disorders, and children who require<br />
assistance from technology, such as patients with<br />
tracheostomies, some <strong>of</strong> whom are ventilator<br />
dependent.<br />
The Asthma Program includes the Pulmonary Function<br />
On-Site Testing Program, through which respiratory<br />
therapists from the Division <strong>of</strong> Pediatric Pulmonology<br />
travel to the <strong>of</strong>fices <strong>of</strong> primary care providers and to<br />
school-based health clinics in Central New York. These<br />
therapists perform pulmonary function testing for<br />
patients who have been diagnosed with or are suspected<br />
<strong>of</strong> having asthma. Interpretation <strong>of</strong> this testing is<br />
provided by a Pediatric Pulmonologist from our Division,<br />
and results are faxed or mailed to the primary care<br />
providers within a few days. This Program has helped<br />
improve the care <strong>of</strong> patients with asthma who are<br />
followed by primary care providers exclusively.<br />
In the Golidano Children’s Hospital, the Division provides<br />
state-<strong>of</strong>-the-art pulmonary function testing including,<br />
spirometry, lung volume measurements, measurement<br />
<strong>of</strong> diffusion capacity, and oscillometry. Exercise<br />
pulmonary function testing is provided in coordination<br />
with the Division <strong>of</strong> Cardiology.<br />
The Cystic Fibrosis (CF) Foundation accredited CF Care<br />
Center for pediatric patients is directed by Dr. Anbar.<br />
The Center staff includes two nurse practitioners, three<br />
respiratory therapists, three research coordinators, a<br />
social worker, and a dietician. The Center evaluates all<br />
patients referred for possible CF through the State <strong>of</strong><br />
New York Newborn Screening Program. The Division<br />
transitions its patients between the ages <strong>of</strong> 18 to 21 to<br />
an adult CF program administered through the SUNY<br />
Upstate University <strong>Department</strong> <strong>of</strong> Medicine Division <strong>of</strong><br />
Pulmonology.<br />
An active flexible bronchoscopy service is under<br />
the direction <strong>of</strong> Dr. Soultan. Patients utilizing the<br />
bronchoscopy service include those who are technology<br />
dependent, and patients with airway illnesses <strong>of</strong> unclear<br />
etiology, e.g., patients with stridor, or recurrent lower<br />
respiratory infections, including some <strong>of</strong> our patients<br />
with cystic fibrosis.<br />
The Allergy Program is under the supervision <strong>of</strong> Dr.<br />
Kurlandsky. Through this Program patients who<br />
have been referred for evaluation <strong>of</strong> asthma our<br />
Center, can undergo skin scratch testing and other<br />
allergy evaluations, as indicated. Administration <strong>of</strong><br />
immunotherapy, if necessary, is coordinated with the<br />
patients’ primary care provider.<br />
The Bronchopulmonary Dysplasia Program is under the<br />
supervision <strong>of</strong> Dr. Hingre. This Program provides followup<br />
care to all high risk newborns who are discharged<br />
from the Neonatal Intensive Care Unit, and helps<br />
coordinate their care between different sub-specialty<br />
services and their primary care providers.<br />
The High Technology Program is under the supervision<br />
<strong>of</strong> Dr. Ragosta. This Program provides long-term care<br />
and coordination <strong>of</strong> services for patients who require<br />
ventilator support, including both in the in-patient and<br />
out-patient settings.<br />
The Pediatric Sleep Program is under the supervision<br />
<strong>of</strong> Dr. Soultan. Through this program, patients who<br />
have been referred for evaluation <strong>of</strong> sleep disorders<br />
to our Center undergo a comprehensive medical and<br />
psychological evaluation. Sleep studies are performed,<br />
when indicated, in collaboration with Community<br />
General Hospital in Syracuse.<br />
The Hypnotherapy Program is under the supervision<br />
<strong>of</strong> Dr. Anbar. Common reasons for referral for<br />
hypnotherapy include patients with chest pain, habit<br />
cough, shortness <strong>of</strong> breath without a clear etiology, vocal<br />
cord dysfunction, anxiety, chronic pain, enuresis, habits,<br />
headaches, and irritable bowel syndrome.<br />
Outpatient care in Syracuse by the Division <strong>of</strong><br />
Pulmonology is provided at the Pediatric multi-specialties<br />
Center at University Hospital. The Division also supplies<br />
care at an almost weekly satellite clinic in Binghamton<br />
General Hospital and a monthly satellite clinic at Good<br />
Samaritan Hospital in Watertown.
40 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
CURRENT RESEARCH HIGHLIGHTS<br />
Members <strong>of</strong> our division are conducting studies involving<br />
asthma, cystic fibrosis, and hypnosis.<br />
Dr. Anbar is principle investigator in a number <strong>of</strong><br />
epidemiological studies involving pediatric patients<br />
with asthma, which include evaluation <strong>of</strong> drug effects,<br />
environmental pollutants, and family dynamics in these<br />
patients.<br />
Doctors Anbar, Kurlandsky, and Soultan have been<br />
involved in the 16 studies <strong>of</strong> patients with cystic fibrosis<br />
including multi-center therapeutic trials, as well as<br />
observational studies. Because <strong>of</strong> our CF Center’s high<br />
rate <strong>of</strong> enrollment in a number <strong>of</strong> multi-center trials,<br />
Dr. Anbar has been asked to be an author <strong>of</strong> publications<br />
regarding TOBI for patients with CF with early lung<br />
disease, DHA formula fortification for infants with<br />
CF, growth hormone for patients with CF, and use <strong>of</strong><br />
nebulized denufosol for patients with CF.<br />
Dr. Anbar is a national authority regarding use <strong>of</strong><br />
hypnotherapy with children, and has authored several<br />
publications regarding hypnosis. Current research<br />
includes studying the content <strong>of</strong> patient self-analysis<br />
expressed during hypnosis, as compared to when<br />
patients describe their thoughts without use <strong>of</strong> hypnosis.<br />
PUBLICATIONS<br />
Fiese B, Winter M, Anbar R, Howell K, Poltrock S. Family<br />
climate <strong>of</strong> routine asthma care: Associating perceived<br />
burden and mother-child interaction patterns to child<br />
well-being. Family Process. <strong>2008</strong>; 47:63-79.<br />
Anbar RD. Subconscious guided therapy with hypnosis.<br />
Am J Clin Hypnosis. <strong>2008</strong>; 50:323-334.<br />
Anbar RD, Zoughbi GG. Relationship <strong>of</strong> headacheassociated<br />
stressors and hypnosis therapy outcome<br />
in children: a retrospective chart review. Am J Clin<br />
Hypnosis. <strong>2008</strong>; 50:335-341.<br />
Garber E, Desai M, Zhou J, Alba L, Angst D, Cabana M,<br />
Saiman L, CF Infection Control Study Consortium.<br />
Barriers to adherence to cystic fibrosis infection control<br />
guidelines. Pediatr Pulmonary. <strong>2008</strong>; 43:900-907.<br />
Soultan ZN, Foster MM, Newman NB, Anbar RD. Sweat<br />
chloride testing in infants identified as heterozygote<br />
carriers by newborn screening. J Pediatr. <strong>2008</strong>; 153:857-<br />
859.<br />
Raz A, Raikhel E, Anbar RD. Placebos in medicine:<br />
knowledge, beliefs, and patterns <strong>of</strong> use. McGill J Med.<br />
<strong>2008</strong>; 11:206-211.<br />
Hingre RV, Souid AK, and Reiners CR. Newborn<br />
Evaluation. Essential Evidence Plus. Ebell M, Editor-in-<br />
Chief. <strong>2008</strong>. Hoboken NJ: John Wiley & Sons.<br />
Anbar RD. Pseudo-asthma revisited (letter). <strong>Pediatrics</strong>.<br />
<strong>2008</strong>; 121:221.<br />
Anbar RD. Perspectives <strong>of</strong> a physician parent. In: Center<br />
for Spiritual Care at University Hospital (ed), A Second<br />
Set <strong>of</strong> Hands. Syracuse, NY: SUNY Upstate Medical<br />
University, <strong>2008</strong>; 18-25.<br />
Anbar RD. Lung transplantation and survival in children<br />
with cystic fibrosis (letter). N Engl J Med. <strong>2008</strong>; 358:1754.<br />
Anbar RD. Treatment <strong>of</strong> psychological complications<br />
<strong>of</strong> prematurity with self-hypnosis: a case report. Clin<br />
Pediatr. <strong>2009</strong>; 48: 106-108.<br />
Henderson JF, Anbar RD. Care for Amish and Mennonite<br />
children with cystic fibrosis: a case series. BMC<br />
<strong>Pediatrics</strong>. <strong>2009</strong>; 9:4.<br />
Anbar RD. Childhood habit cough treated with<br />
consultation by telephone: a case report. Cough. <strong>2009</strong>;<br />
5:2.<br />
Irland JM, Anbar RD, Kohen DP. Hypnoanalgesia: No<br />
clamps and needles required. American Society <strong>of</strong><br />
Clinical Hypnosis Newsletter. Spring, <strong>2009</strong>; 11.<br />
Rosenbaum PF, Crawford JA, Anagnost SE, Wang CJ, Hunt<br />
A, Anbar RD, Hargrave TM, Hall EG, Liu CC, Abraham JL.<br />
Indoor airborne fungi and wheeze in the first year <strong>of</strong> life<br />
among a cohort <strong>of</strong> infants at risk for asthma. J Expo Sci<br />
Environ Epidemiol. <strong>2009</strong>; Jun 17.<br />
Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC,<br />
Bourke B, Castaldo G, Castellani C, Cipolli M, Colombo<br />
C, Colombo JL, Debray D, Fernandez A, Lacaille F,<br />
Macek M, Rowland M, Salvatore F, Taylor CJ, Wainwright<br />
C, Wilschanski M, Zemkova D, Hannah WB, Phillips<br />
MJ, Corey M, Zielenski J, Dorfman R, Wand Y, Zou F,<br />
Silverman LM, Drumm ML, Wright FA, Lange EM, Durie<br />
PR, Knowles MR; Gene Modifier Study Group. Genetic<br />
modifiers <strong>of</strong> liver disease in cystic fibrosis. JAMA. <strong>2009</strong>;<br />
302:1076-1083.<br />
Treggiari MM, Rosenfeld M, Mayer-Hamblett N, Retsch-<br />
Bogart G, Gibson RL, Williams J, Emerson J, Kronmal RA,<br />
Ramsey BW; EPIC Study Group. Early anti-pseudomonal<br />
acquisition in young patients with cystic fibrosis: rationale<br />
and design <strong>of</strong> the EPIC clinical trial and observational<br />
study. Contemp Clin Trials. <strong>2009</strong>; 30:256-268.<br />
Fiese BH, Winter MA, Wamboldt FS, Anbar RD, Wamboldt<br />
MZ. Do family mealtime interactions mediate the<br />
association between asthma symptoms and separation<br />
anxiety. J Clin Pediatr Psychology. <strong>2009</strong>; Sept 14.<br />
Anbar RD. Favorite stories, magic rocks, and a crystal<br />
ball: Personalizing metaphors in hypnotic work with<br />
children. American Society <strong>of</strong> Clinical Hypnosis<br />
Newsletter. Summer, <strong>2009</strong>; 4.<br />
Irland JM, Anbar RD, Kohen DP. A note <strong>of</strong> dissent:<br />
authors’ response. American Society <strong>of</strong> Clinical Hypnosis<br />
Newsletter. Summer, <strong>2009</strong>; 11.<br />
Soultan ZN, Anbar RD. An infant with obstructed<br />
breathing. In: Antonio Culebras (ed.), Case Studies<br />
in Sleep Medicine: Common & Uncommon Causes.<br />
Cambridge, England: Cambridge University Press, <strong>2009</strong>.<br />
Anbar RD. Adding hypnosis to the therapeutic toolbox <strong>of</strong><br />
pediatric respiratory care. Pediatr Asthma All Immunol.<br />
<strong>2009</strong>; 22.
Bi-Annual <strong>Report</strong> • 41<br />
PRESENTATIONS AT SCIENTIFIC MEETINGS<br />
Stalvey MS, Geller DE, Anbar RD, Konstan MW, Jacobs<br />
JR, Bakker B. Growth hormone (GH) therapy in<br />
prepubertal children with cystic fibrosis (CF): Glucose<br />
tolerance safety monitoring <strong>of</strong> a multicenter randomized<br />
controlled trial (RCT). Endocrine Society Annual<br />
Meeting, June, <strong>2008</strong>.<br />
Geller DE, Anbar RD, Konstan MW, Stalvey MS, Jacobs JR,<br />
and Bakker B. Growth hormone effects on pulmonary<br />
function in prepubertal children with cystic fibrosis (CF)<br />
(abstract). Pediatr Pulmonary. <strong>2008</strong>; Supplement 31, 368.<br />
Moss RB, Anbar RD, Wilmott RW, Barnes M, Schaberg<br />
AE, Durham RA, Accurso FJ. Phase 3 study <strong>of</strong> denufosol<br />
tetrasodium for the treatment <strong>of</strong> cystic fibrosis<br />
(abstract). Am J Resp Crit Care Med. May, <strong>2009</strong>.<br />
Soultan ZN, Nketiah EO, Finocchiaro SA, Trust SA, Anbar<br />
RD. Pulmonary function on-site testing helps avoid<br />
unnecessary treatment in children with exercise induced<br />
respiratory symptoms (abstract). Am J Resp Crit Care<br />
Med. May, <strong>2009</strong>.<br />
Kurlandsky LE, Anbar RD, Soultan ZN.<br />
Carboxyhemoglobin level has a positive correlation with<br />
FEV1 in patients with cystic fibrosis (abstract). Pediatr<br />
Pulmonary. <strong>2009</strong>; Supplement 32, 255.<br />
Anbar RD, Soultan Z, Kulandsky L, Sullivan M. Overnight<br />
use <strong>of</strong> high frequency chest wall oscillation: preliminary<br />
observations (abstract). Pediatr Pulmonary. <strong>2009</strong>;<br />
Supplement 32, 364.<br />
Hatch TP, Sullivan ML, Anbar RD, Soultan ZN, Kurlandsky<br />
LE, Sexton JF. Adherence <strong>of</strong> prescribed use <strong>of</strong> high<br />
frequency chest wall oscillation (abstract). Pediatr<br />
Pulmonary. <strong>2009</strong>; Supplement 32, 392.<br />
HONORS, VISITING PROFESSORSHIPS<br />
Anbar RD. Visiting pr<strong>of</strong>essor at Case Western Reserve<br />
University Rainbow Babies and Children’s Hospital.<br />
Grand Rounds on, “Hypnosis for Childhood Respiratory<br />
Disorders”, and presentation on, “Update on Newborn<br />
Screening for Cystic Fibrosis”, Cleveland, OH, February,<br />
<strong>2008</strong>.<br />
Anbar RD. Visiting pr<strong>of</strong>essor at West Virginia University<br />
Charleston Division <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong>. Grand<br />
Rounds on, “Hypnosis for Childhood Respiratory<br />
Disorders”, and presentation on, “Quality Improvement<br />
for Cystic Fibrosis Centers”, Charleston, WV, February,<br />
<strong>2008</strong>.<br />
Anbar RD. Elected Treasurer <strong>of</strong> American Society <strong>of</strong><br />
Clinical Hypnosis, <strong>2008</strong>.<br />
Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />
Presidential Award, March, <strong>2008</strong>.<br />
Anbar RD. Cystic Fibrosis Foundation Distinguished<br />
Service Award, September, <strong>2008</strong>.<br />
Ragosta KG: Visiting pr<strong>of</strong>essor at West Virginia School<br />
<strong>of</strong> Osteopathic Medicine. Topic: “Topics in Pulmonary<br />
System”, Homestead, WV, October, <strong>2008</strong>.<br />
Anbar RD. Elected Fellow, American Society <strong>of</strong> Clinical<br />
Hypnosis, March, <strong>2009</strong>.<br />
Anbar RD. University Hospital Upstate Star for<br />
“Innovation and Discovery”, May, <strong>2009</strong>.<br />
Hingre RV. Appointed adjunct faculty for Syracuse<br />
University in the Special Education department to guest<br />
lecture at undergraduate and graduate seminars on<br />
topics related to preterm infants, survival and disabilities,<br />
<strong>2009</strong>.<br />
Ragosta KG: Visiting pr<strong>of</strong>essor at West Virginia School<br />
<strong>of</strong> Osteopathic Medicine. Topic: “Topics in Pulmonary<br />
System”, Homestead, WV, October, <strong>2009</strong>.<br />
Anbar RD. Elected President <strong>of</strong> American Society <strong>of</strong><br />
Clinical Hypnosis, <strong>2009</strong>.<br />
INVITED WORKSHOPS, CME PRESENTATIONS<br />
Anbar RD. SUNY Upstate Medical University Child<br />
Psychiatry presentation on, “Hypnosis for Pediatric<br />
Psychiatric Disorders”, Syracuse, NY, <strong>2008</strong>.<br />
Anbar RD, Soultan ZN. SUNY Upstate Medical University<br />
<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong> Grand Rounds on, “The Dark<br />
Side <strong>of</strong> Newborn Screening for Cystic Fibrosis: Infants<br />
with Borderline Sweat Tests Should be Evaluated Fully”,<br />
Syracuse, NY, February, <strong>2008</strong>.<br />
Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />
Individualized Consultation Workshop, Chicago, IL, March,<br />
<strong>2008</strong>.<br />
Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />
Intermediate Workshop presentation on, “Hypnosis for<br />
Children <strong>of</strong> all Ages”, Chicago, IL, March, <strong>2008</strong>.<br />
Kurlandsky LE. SUNY Upstate Medical University<br />
<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong> Grand Rounds on, “Respiratory<br />
Effects <strong>of</strong> Gastroesophageal Reflux”, Syracuse, NY, April,<br />
<strong>2008</strong>.<br />
Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />
Introductory Workshop presentation on, “Medical<br />
Applications <strong>of</strong> Hypnosis”, Seattle, WA, April, <strong>2008</strong>.<br />
Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />
Intermediate Workshop presentation on, “Hypnosis for<br />
Children and Adolescents”, Seattle, WA, April, <strong>2008</strong>.<br />
Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />
Intermediate Workshop presentation on, “Hypnosis for<br />
Chronic Disease”, Seattle, WA, April, <strong>2008</strong>.<br />
Anbar RD. Basic Hypnosis Workshop presentation on,<br />
“Integrating Hypnosis into the Care <strong>of</strong> Children with<br />
Chronic Disease”, Syracuse, NY, May, <strong>2008</strong>.<br />
Hingre, RV. SUNY Upstate Medical University Pediatric<br />
Teaching Day presentation on, “Primary Care <strong>of</strong> Preemies<br />
for the Community Pediatrician”, Syracuse, NY, June,<br />
<strong>2008</strong>.<br />
Anbar RD. Basic American Society <strong>of</strong> Clinical Hypnosis<br />
Workshop presentation on, “Induction and Realerting<br />
Demonstrations”, Norfolk, VA, June, <strong>2008</strong>.
42 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Anbar RD. Basic American Society <strong>of</strong> Clinical Hypnosis<br />
Workshop presentation on, “Case Examples <strong>of</strong> Hypnosis<br />
with Children and Adolescents”, Norfolk, VA, June, <strong>2008</strong>.<br />
Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />
Hypnosis Workshop presentation on, “Medical<br />
Applications <strong>of</strong> Hypnosis: Video Examples and<br />
Discussion”, Norfolk, VA, June, <strong>2008</strong>.<br />
Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />
Hypnosis Workshop presentation on, “Automatic Word<br />
Processing”, Norfolk, VA, June, <strong>2008</strong>.<br />
Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />
Hypnosis Workshop presentation on, “The Psychology <strong>of</strong><br />
Symptoms”, Norfolk, VA, June, <strong>2008</strong>.<br />
Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />
Hypnosis Workshop presentation on, “Use <strong>of</strong> Hypnosis in<br />
<strong>Pediatrics</strong>”, Norfolk, VA, June, <strong>2008</strong>.<br />
Anbar RD. Syracuse University presentation to Pediatric<br />
Psychology class on “Introduction to Pediatric Hypnosis”,<br />
Syracuse, NY, June, <strong>2008</strong>.<br />
Anbar RD. Intermediate American Society <strong>of</strong> Clinical<br />
Hypnosis Workshop presentation on, “Communication<br />
with the Subconscious”, Lombard, IL, September, <strong>2008</strong>.<br />
Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />
Hypnosis Workshop presentation on, “Hypnosis in<br />
<strong>Pediatrics</strong>: An Experiential Approach”, Lombard, IL,<br />
September, <strong>2008</strong>.<br />
Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />
Hypnosis Workshop presentation on, “Communication<br />
with the Subconscious”, Lombard, IL, September, <strong>2008</strong>.<br />
Anbar RD. Basic American Society <strong>of</strong> Clinical Hypnosis<br />
Workshop presentation on, “Hypnosis Induction<br />
Techniques”, Albuquerque, NM, December, <strong>2008</strong>.<br />
Anbar RD. Basic American Society <strong>of</strong> Clinical Hypnosis<br />
Workshop presentation on, “Hypnosis with Children and<br />
Adolescents”, Albuquerque, NM, December, <strong>2008</strong>.<br />
Anbar RD. Basic American Society <strong>of</strong> Clinical Hypnosis<br />
Workshop presentation on, “Hypnosis for Chronic<br />
Disease”, Albuquerque, NM, December, <strong>2008</strong>.<br />
Anbar RD. Advanced American Society <strong>of</strong> Clinical<br />
Hypnosis Workshop presentation on, “Hypnosis for<br />
Chronic Disease”, Albuquerque, NM, December, <strong>2008</strong>.<br />
Anbar RD. Morristown Memorial Hospital <strong>Department</strong><br />
<strong>of</strong> <strong>Pediatrics</strong> Grand Rounds on, “Hypnosis for Childhood<br />
Respiratory Disorders”, Morristown, NJ, December, <strong>2008</strong>.<br />
Anbar RD. Overlook Hospital <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Grand Rounds on, “Hypnosis for Childhood Respiratory<br />
Disorders”, Morristown, NJ, December, <strong>2008</strong>.<br />
Anbar RD. SUNY Upstate Medical University Pediatric<br />
Grand Rounds on, “Interactive Education through a Video<br />
Presentation: A 10-year-old with Shortness <strong>of</strong> Breath”,<br />
Parts I and II, Syracuse, NY, January, <strong>2009</strong>.<br />
Anbar RD. SUNY Upstate Medical University Child<br />
Psychiatry presentation on, “Hypnosis in <strong>Pediatrics</strong>”,<br />
Syracuse, NY, January, <strong>2009</strong>.<br />
Anbar RD. American Society <strong>of</strong> Clinical Hypnosis annual<br />
meeting workshop presentation on, “Teaching Hypnosis<br />
to Meet the ASCH Standards <strong>of</strong> Training”, Boston, MA,<br />
March, <strong>2009</strong>.<br />
Anbar RD. American Society <strong>of</strong> Clinical Hypnosis<br />
annual meeting workshop presentation on, “Writing and<br />
Publishing your Hypnosis Articles”, Boston, MA, March,<br />
<strong>2009</strong>.<br />
Anbar RD. American Society <strong>of</strong> Clinical Hypnosis annual<br />
meeting basic workshop presentation on, “Hypnosis in<br />
<strong>Pediatrics</strong>”, Boston, MA, March, <strong>2009</strong>.<br />
Anbar RD. Onondaga Pediatric Society presentation on,<br />
“Hypnosis in <strong>Pediatrics</strong>”, Syracuse, NY, April, <strong>2009</strong>.<br />
Anbar RD. Syracuse University presentation to Pediatric<br />
Psychology class on “Introduction to Pediatric Hypnosis”,<br />
Syracuse, NY, April, <strong>2009</strong>.<br />
Anbar RD. Cystic Fibrosis Foundation Therapeutics<br />
Development Network presentation on, “Being a<br />
Successful Site”, Denver, CO, April, <strong>2009</strong>.<br />
Hingre RV. SUNY Upstate Medical University<br />
<strong>Department</strong> <strong>of</strong> Pediatric Grand Rounds presentation on,<br />
“Group B Strep in <strong>2009</strong>: More Questions than Answers”,<br />
Syracuse, NY, May, <strong>2009</strong>.<br />
Hingre RV. Central New York Nurse Practitioner Teaching<br />
Day presentation on, “Primary Care <strong>of</strong> Preemies: Special<br />
Issues and Concerns”, Syracuse, NY, May, <strong>2009</strong>.<br />
Anbar RD. Faculty member in an American Society <strong>of</strong><br />
Clinical Hypnosis Individualized Consultation workshop,<br />
Philadelphia, PA, July, <strong>2009</strong>.<br />
Anbar RD. Upstate University Health Link presentation<br />
on, “Hypnosis for medical care: myths and truths”,<br />
Syracuse, NY, August, <strong>2009</strong>.<br />
Anbar RD. CF Foundation presentation on, “Hypnosis for<br />
People with Cystic Fibrosis”, Minneapolis, MN, October,<br />
<strong>2009</strong>.<br />
Anbar RD. American Academy <strong>of</strong> <strong>Pediatrics</strong> presentation<br />
on, “Basic Pediatric Hypnosis”, Washington, DC, October,<br />
<strong>2009</strong>.<br />
Anbar RD. SUNY at Buffalo Counseling Service<br />
presentation on, “Hypnosis and the college student”,<br />
Buffalo, NY, November, <strong>2009</strong>.<br />
Hingre RV. SUNY Upstate Medical University<br />
<strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong> Grand Rounds presentation<br />
on, “Universal Serologic Screening for Herpes Simplex<br />
During Pregnancy: Opening Pandora’s Box”, Syracuse, NY,<br />
December, <strong>2009</strong>.
Bi-Annual <strong>Report</strong> • 43<br />
GRANTS AND CONTRACTS<br />
Cystic Fibrosis Foundation Care Center Grant, $184,655<br />
total in <strong>2008</strong> and <strong>2009</strong><br />
Cystic Fibrosis Foundation Clinical Research Facilitation<br />
Award, $156,600 in <strong>2008</strong> and <strong>2009</strong><br />
SELECTED CLINICAL DATA<br />
Outpatient visits: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15,357<br />
Inpatient encounters: . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,059<br />
Outreach encounters: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,191<br />
Bronchoscopies:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117<br />
Hypnotherapy encounters: . . . . . . . . . . . . . . . . . . . . . . . 1,350<br />
Cystic Fibrosis Patients: . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143<br />
New York State Cystic Fibrosis Newborn Screening<br />
Program evaluations:. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195<br />
Pulmonary Function On-Site Program Tests: . . . . . . . . 470<br />
Pulmonary Function Tests at University Hospital:. . . 6,216
44 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
RHEUMATOLOGY<br />
FACULTY<br />
William P. Hannan, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>,<br />
Director, Pediatric Arthritis Center<br />
Paul E. Phillips, MD, Pr<strong>of</strong>essor <strong>of</strong> Medicine and <strong>Pediatrics</strong><br />
CLINICAL OVERVIEW<br />
The Division <strong>of</strong> Pediatric Rheumatology provides<br />
comprehensive evaluation and treatment <strong>of</strong> children,<br />
adolescents and young adults with juvenile rheumatoid<br />
arthritis (JRA), systemic lupus erythematosus (SLE),<br />
juvenile dermatomyositis, and other related disorders.<br />
Other children seen in the Pediatric Arthritis Center<br />
include those referred for evaluation <strong>of</strong> acute and<br />
chronic joint pain, limp, fevers <strong>of</strong> unknown origin, and<br />
post-infectious causes <strong>of</strong> joint pain and arthritis.<br />
All patients referred to the Pediatric Arthritis Center are<br />
seen and evaluated by a pediatric rheumatologist. There<br />
is a nurse dedicated to the Pediatric Arthritis Center who<br />
is available for teaching families and children. Other<br />
ancillary services available to assist in the care <strong>of</strong> referred<br />
children include pediatric physical and occupational<br />
therapists, social workers, and child life specialists.<br />
Approximately 200 children with chronic rheumatologic<br />
disease are followed in the Pediatric Arthritis Center.<br />
EDITORIAL DUTY<br />
Phillips, P.E. Editorial Board, Clinical and Experimental<br />
Rheumatology.<br />
CLINICAL DATA<br />
Total Pediatric Arthritis Center visits, <strong>2008</strong>: . . . . . . . . 636<br />
New patient referrals, <strong>2008</strong>: . . . . . . . . . . . . . . . . . . . . . . . . 161<br />
Total Pediatric Arthritis Center visits, <strong>2009</strong>: . . . . . . . . . 726<br />
New patient referrals, <strong>2009</strong>: . . . . . . . . . . . . . . . . . . . . . . . 164
Bi-Annual <strong>Report</strong> • 45<br />
PEDIATRIC SURGICAL SPECIALTIES<br />
It is impossible to operate a tertiary pediatric program without substantial surgical support. Syracuse is fortunate to<br />
have a group <strong>of</strong> pediatric surgeons and surgical subspecialists that are technically superb and extraordinarily collegial<br />
with their pediatric medical colleagues. While these surgeons have primary appointments in a surgical department,<br />
most have joint appointments in the department <strong>of</strong> pediatrics.<br />
PEDIATIC ANESTHESIOLOGY<br />
FACULTY<br />
Full-Time:<br />
Bettina Smallman, M.D., Associate Pr<strong>of</strong>essor <strong>of</strong><br />
Anesthesiology and <strong>Pediatrics</strong>, Director <strong>of</strong> Pediatric<br />
Anesthesiology<br />
Richard Beers, M.D., Pr<strong>of</strong>essor <strong>of</strong> Anesthesiology<br />
Debnath Chatterjee, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Anesthesiology and <strong>Pediatrics</strong><br />
Elizabeth Demers-Lavelle, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Anesthesiology<br />
Mirna Abdallah, M.D., Clinical Instructor <strong>of</strong><br />
Anesthesiology<br />
Vipin Bansal, M.D., Clinical Instructor <strong>of</strong> Anesthesiology<br />
Jadwiga Bednarczyk, M.D., Clinical Instructor <strong>of</strong><br />
Anesthesiology<br />
Part-Time:<br />
Tracy Buckingham, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Anesthesiology<br />
Robert Calimlim, M.D., Associate Pr<strong>of</strong>essor <strong>of</strong><br />
Anesthesiology<br />
Dorothy Hwang, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Anesthesiology<br />
Fenghua Li, M.D., Clinical Instructor <strong>of</strong> Anesthesiology<br />
David Romano, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Anesthesiology<br />
Xiuli Zhang, M.D., Assistant Pr<strong>of</strong>essor <strong>of</strong> Anesthesiology<br />
CLINICAL OVERVIEW<br />
The Division <strong>of</strong> Pediatric Anesthesia in the <strong>Department</strong><br />
<strong>of</strong> Anesthesiology at SUNY Upstate Medical University<br />
Hospital continued to experience significant growth in<br />
<strong>2008</strong>-<strong>2009</strong>. More than 4,800 children were anesthetized<br />
each year in the Pietrafesa Center for Children’s Surgery<br />
(CCS), spanning the full spectrum <strong>of</strong> pediatric surgical<br />
specialties, as well as procedures conducted outside the<br />
operating room environment (CT, MRI, Interventional<br />
Radiology, Radiation Therapy and Nuclear Medicine).<br />
The pediatric medical specialties, such as pulmonology<br />
and gastroenterology, have increased their procedural<br />
volume, and the pediatric oncologists have continued<br />
to utilize pediatric anesthesiology services frequently<br />
for their interventional procedures. As one <strong>of</strong> the<br />
few referral centers in Central New York for children<br />
undergoing MRIs and CTs, we have been able to<br />
streamline the process, making it safe and efficient to<br />
accommodate an ever-increasing demand.<br />
Two new faculty were hired during this period. Dr. Vipin<br />
Bansal joined the faculty in <strong>2008</strong> after completing a<br />
pediatric fellowship at The Cleveland Clinic. Dr. Elizabeth<br />
Demers-Lavelle joined the faculty in <strong>2008</strong> after a<br />
pediatric fellowship at the Cleveland Clinic.<br />
The Pediatric Anesthesia Division continued to<br />
show a strong commitment to the education <strong>of</strong> our<br />
anesthesiology residents and medical students. In<br />
addition to active participation in patient care, residents<br />
rotating in pediatric anesthesiology undergo a series<br />
<strong>of</strong> didactic lectures and journal clubs. Our team also<br />
teaches basic pediatric airway skills to Pediatric and<br />
Emergency Medicine residents and fellows who rotate<br />
through the CCS.<br />
The highlight <strong>of</strong> <strong>2009</strong> was the opening <strong>of</strong> Upstate<br />
Golisano Children’s Hospital. While the philosophy <strong>of</strong><br />
care “Patients First” was a maxim for many years, the<br />
development <strong>of</strong> a Center <strong>of</strong> Excellence enabled an<br />
intensified focus on collaborative communication on<br />
patient and family centered care.<br />
PUBLICATIONS<br />
Beers RA. Office Based Anesthesia Practice: Which<br />
patients? In Twersky R, Rosenberg A, eds. Post Graduate<br />
Assembly in Anesthesiology; New York State Society <strong>of</strong><br />
Anesthesiologists. <strong>2008</strong><br />
Smallman B. Timing All When Prop<strong>of</strong>ol is Used to Limit<br />
Emergence Delirium. Anesthesiology News, October<br />
<strong>2009</strong><br />
Smallman B, Ball R. A Novel Technique <strong>of</strong> Retrograde<br />
Nasal Intubation for the Pierre-Robin Sequence Infant<br />
with a Known Difficult Airway. Pediatric Anesthesia,<br />
19(9):919-921. Sept <strong>2009</strong>.<br />
Beers RA. Patient Safety in Office Based Anesthesia.<br />
In Twersky R, Rosenberg A, eds. Post Graduate<br />
Assembly in Anesthesiology. New York State Society <strong>of</strong><br />
Anesthesiologists, <strong>2009</strong>.<br />
Beers RA. Implementing Infection Prevention Guidelines<br />
into Anesthesia Practice. In Twersky R, Rosenberg A, eds.<br />
Post Graduate Assembly in Anesthesiology. New York<br />
State Society <strong>of</strong> Anesthesiologists, <strong>2009</strong>
46 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Green ES, Beers RA, Stackhouse RA. Preventing Health<br />
Care Associated Transmission <strong>of</strong> Bloodborne Pathogens<br />
Secondary to Unsafe Injection Practices. American<br />
society <strong>of</strong> Anesthesiologists Newsletter 73:28-31, <strong>2009</strong>.<br />
Green ES, Beers RA,. Prevention <strong>of</strong> Healthcare Associated<br />
Transmission <strong>of</strong> Blood Borne Pathogens by the<br />
Application <strong>of</strong> Safe Injection Practices. American Society<br />
<strong>of</strong> Anesthesiologists Safety Module, <strong>2009</strong><br />
PRESENTATIONS<br />
Bansal V, Rosen K. Lesser Evil in Multiple Metabolic<br />
Diseases. Problem Based Learning Discussion, Society <strong>of</strong><br />
Pediatric Anesthesiology (SPA), San Diego, CA, Spring <strong>2008</strong><br />
Beers R. Office Based Anesthesia Practice: Which<br />
Patients? Presented at the Post Graduate Assembly in<br />
Anesthesiology, New York, NY, December, <strong>2008</strong><br />
Beers R. Preventing Health Care Acquired Infections:<br />
Implementing the CDC Guidelines into Anesthesiology<br />
Practice. Presentation in conjunction with the New<br />
York State <strong>Department</strong> <strong>of</strong> Health at the Post Graduate<br />
Assembly in Anesthesiology, New York, NY December,<br />
<strong>2008</strong><br />
Beers R. Anesthetic Management <strong>of</strong> Children Undergoing<br />
Scoliosis Surgery. Presented at Winthrop Hospital,<br />
Mineola, NY, May, <strong>2008</strong><br />
Beers R. Political Mindfulness for the New York State<br />
Anesthesiologist. Presented at the 2 nd Annual New York<br />
State Conference for Residents and Fellows, Syracuse,<br />
NY, May <strong>2008</strong><br />
Koshel M, Chatterjee D. Anesthetic Challenges in a Three<br />
Year Old Male with Mitochondrial Cytopathy. 2 nd Annual<br />
NYSSA Conference for Anesthesiology Residents and<br />
Fellows, Syracuse, NY, May, <strong>2008</strong><br />
Parikh J, Caswell J, Mortelliti A, Chatterjee D, Smallman<br />
B. Anesthetic Management <strong>of</strong> a Child with Junctional<br />
Epidermolysis Bullosa Presenting with Stridor. 2 nd Annual<br />
NYSSA Conference for Anesthesiology Residents and<br />
Fellows. Syracuse, NY, May 4, <strong>2008</strong><br />
Aron J, Tham SW, Caswell J, Giorgi S, Hwang D, Sills R,<br />
Prust L, Smallman B. Intrathecal Fentanyl for Combined<br />
Lumbar Puncture and Bone Marrow Aspiration in a<br />
Pediatric Patient with Mediastinal Mass. 2 nd Annual NYSSA<br />
Conference for Anesthesiology Residents and Fellows,<br />
Syracuse, NY, May 4, <strong>2008</strong><br />
Li F, Su Z, Barry WH. Effect <strong>of</strong> Endothelin-1 on [Ca2+]I In<br />
Rabbit Myocytes During Metabolic Inhibition. IARS, March<br />
<strong>2008</strong><br />
Smallman B. Regional Anesthesia in Children Focus<br />
session. Postgraduate Assembly in NYSSA, New York, NY,<br />
December <strong>2008</strong><br />
Smallman B. Pediatric Pain Management – A<br />
Pharmaceutical Approach. Focus Session. Postgraduate<br />
Assembly in NYSSA, New York, NY, December <strong>2008</strong><br />
Trusilo M, Smallman B, Puthumana N, Romano D. Spinal<br />
Anesthesia in a Two Week Old Full Term Neonate<br />
Presenting with Hypotonia and Failure to Thrive with<br />
Suspected Congenital Myopathy for Vastus Muscle<br />
Biopsy. 2 nd Annual NYSSA Conference for Anesthesiology,<br />
Syracuse, NY, May 4, <strong>2008</strong><br />
Smallman B, Puthumana N, Romano D. Spinal Anesthesia<br />
in a Two Week Old Full Term Neonate Presenting with<br />
Hyptonia and Failure to Thrive with Suspected Congenital<br />
Myopathy for Vastus Muscle Biopsy. 62 nd Annual Post<br />
Graduate Assembly, New York, NY December, <strong>2008</strong><br />
Aron J, Smallman B. Goal Oriented Preoperative Anxiety<br />
Prevention – The Balloon and Mask Technique. 2 nd Annual<br />
NYSSA Conference for Anesthesiology Residents and<br />
Fellows. Syracuse, NY, May 4, <strong>2008</strong><br />
Smallman B, Caswell J. Intrathecal Fentanyl in a Child<br />
with a Mediastinal Mass Undergoing a Spinal Tap. 2 nd<br />
Annual NYSSA Conference for Anesthesiology Residents<br />
and Fellows. Syracuse, NY, May 4, <strong>2008</strong><br />
Smallman B. Pediatric Regional Anesthesia. Post Graduate<br />
Assembly, New York, NY <strong>2008</strong><br />
Bansal V, Oliver J, Romano D. Difficult Pediatric Airway:<br />
Laceration with Glidescope. 63 rd Annual Post Graduate<br />
Assembly, New York, NY, December, <strong>2009</strong><br />
Beers R. Undiagnosed Myopathy in a Toddler: Inhalation<br />
or Intravenous Anesthesia? Problem-Based Learning<br />
Discussion presented at the Post Graduate Assembly in<br />
Anesthesiology, New York, NY, December <strong>2009</strong><br />
Beers R. Implementing Infection Prevention Guidelines<br />
in Anesthesia Practice. Focus Session Presentation at the<br />
Post Graduate Assembly in Anesthesiology, New York, NY<br />
December, <strong>2009</strong><br />
Beers R. Patient Safety in Office Based Anesthesia. Focus<br />
Session Presentation at the Post Graduate Assembly in<br />
Anesthesiology, New York, NY, December, <strong>2009</strong><br />
Smallman B, Ball R. A Novel Technique <strong>of</strong> Retrograde<br />
Nasal Intubation for the Pierre-Robin Sequence Infant<br />
with a Known Difficult Airway. Society for Pediatric<br />
Anesthesia, Jacksonville, Florida, March 19-22, <strong>2009</strong><br />
Smallman B, Yamout I, Sweeney D, Lemmens HJ. Effect<br />
<strong>of</strong> Prop<strong>of</strong>ol on Sev<strong>of</strong>lurane Induced Agitation in Young<br />
Children – A Novel Approach. Society for Pediatric<br />
Anesthesia Jacksonville, Florida, March 19-22, <strong>2009</strong>
Bi-Annual <strong>Report</strong> • 47<br />
PEDIATRIC CARDIOVASCULAR-THORACIC SURGERY<br />
FACULTY<br />
George Alfieris, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> Clinical<br />
Surgery and <strong>Pediatrics</strong><br />
Francisco Gensini, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> Clinical<br />
Surgery<br />
CLINICAL OVERVIEW<br />
For a city <strong>of</strong> its size, Syracuse is very fortunate to have<br />
a high quality, nationally known program in congenital<br />
cardiac surgery. Part <strong>of</strong> the reason this program has been<br />
successful is the innovative arrangement Dr. Alfieris has<br />
developed with the University <strong>of</strong> Rochester, by which<br />
his time is shared between both institutions. This has<br />
enabled both programs to benefit from skilled surgery<br />
and has allowed Dr. Alfieris to undertake a higher volume<br />
<strong>of</strong> cases than he would in either center alone.<br />
PEDIATRIC GENERAL SURGERY<br />
FACULTY<br />
Michael Ratner, MD, Pr<strong>of</strong>essor <strong>of</strong> Clinical Surgery and<br />
<strong>Pediatrics</strong>, Director, Division <strong>of</strong> Pediatric Surgery<br />
CLINICAL OVERVIEW<br />
Surgeons in the division provide care to children both at<br />
University Hospital and at Crouse Hospital. This includes<br />
the Neonatal Intensive Care Unit at Crouse Hospital.<br />
The group cares for the full range <strong>of</strong> surgical problems<br />
<strong>of</strong> infancy and childhood, including complex congenital<br />
anomalies. University Hospital’s busy pediatric oncology<br />
program particularly benefits from the support <strong>of</strong> the<br />
general surgery service.<br />
The full-time surgery faculty is supplemented by<br />
additional part-time contract pediatric surgeons. This<br />
year, we have concluded a joint venture in pediatric<br />
surgery services with Cincinnati Children’s Hospital, and<br />
have recently recruited two new surgeons to join us on a<br />
full-time basis in 2010.<br />
PEDIATRIC NEUROSURGERY<br />
FACULTY<br />
Zulma Tovar-Spinoza MD –Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Neurosurgery, Director <strong>of</strong> Pediatric Neurosurgery<br />
Satish Krishnamurthy MD, Mch- Associate Pr<strong>of</strong>essor <strong>of</strong><br />
Neurosurgery<br />
Walter Hall MD- Pr<strong>of</strong>essor <strong>of</strong> Neurosurgery<br />
Jim Holsapple, MD- Associate Pr<strong>of</strong>essor <strong>of</strong> Neurosurgery<br />
– No longer in our practice-<br />
Other <strong>Department</strong> Neurosurgeons, although not subspecialized<br />
in <strong>Pediatrics</strong>, have the essential training and<br />
provide supplementary care as needed.<br />
CLINICAL OVERVIEW<br />
The Pediatric Neurosurgery division provides care for<br />
children with structural disorders <strong>of</strong> the brain and spinal<br />
cord. Our patients are from the regional community, with<br />
some referrals from other states and some international<br />
referrals. We enjoy collaborating with expert pediatric<br />
neurologists, neuroradiologists, neonatologists and<br />
intensivists in the community. We participate regularly<br />
with the Upstate Epilepsy Center, Spina Bifida Program<br />
, Cranio-facial Center, the Center for Development,<br />
Behavior and Genetics and the Physical Medicine and<br />
Rehabilitation Program.<br />
During the last year the <strong>Department</strong> <strong>of</strong> Neurosurgery<br />
recruited Dr. Zulma Tovar- Spinoza to lead the Division <strong>of</strong><br />
Pediatric Neurosurgery. Dr Tovar Spinoza is a fellowship<br />
trained pediatric neurosurgeon with international<br />
expertise in the field <strong>of</strong> pediatric neurosurgery and<br />
epilepsy surgery. Under her direction, the division is<br />
consolidating services with the other disciplines <strong>of</strong><br />
pediatric care. Two new multidisciplinary services<br />
are being established: the spasticity center and the<br />
Pediatric Comprehensive Epilepsy Center. The Division<br />
has incorporated the spina bifida patients for pre-natal<br />
and post-natal care with the cooperation <strong>of</strong> the Prenatal<br />
center and the Spina bifida clinic. Preventive and
48 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
educational campaigns are being designed in conjunction<br />
with the Trauma center and pediatric department, i.e<br />
the use <strong>of</strong> helmets to avoid brain trauma. The division is<br />
strongly involved with the planning and funding for the<br />
Cancer Center. Research clinical activities are currently<br />
focused on positional plagiocephaly, decompressive<br />
craniectomies and tethered cord.<br />
Dr. Satish Krishnamurthy has recently returned to<br />
the <strong>Department</strong> <strong>of</strong> Neurosurgery. Dr. Krishnamurthy<br />
has recognized national and international expertise in<br />
pediatric and minimally invasive neurosurgery. His very<br />
well known interest in hydrocephalus and device less<br />
solutions for this condition are meritorious <strong>of</strong> several<br />
grants and publications. He is a frequent speaker in<br />
national and international conferences on this topic. His<br />
current interest is to develop a Comprehensive Program<br />
for Hydrocephalus at SUNY Upstate.<br />
Dr.Walter Hall joined our <strong>Department</strong> in 2007. He is a<br />
nationally respected expert in: infectious diseases <strong>of</strong> the<br />
nervous system and in the use <strong>of</strong> intraoperative MRI to<br />
guide the resection <strong>of</strong> childhood brain tumors. He brings<br />
his subspecialty expertise to the management <strong>of</strong> our<br />
pediatric patients.<br />
Community education regarding the services the Division<br />
provides has been an important goal. The division has<br />
been working on providing local community updates on<br />
TV and newspapers about our services and noteworthy<br />
cases. Constant feedback has been established with<br />
the pediatric services in regional hospitals at Syracuse,<br />
Rochester, Albany and Boston in order to facilitate the<br />
care to our patients.<br />
In the national and international arena, the division was<br />
recently linked to the American Association for Pediatric<br />
Neurosurgery, the International Society for Pediatric<br />
Neurosurgery. These links represent the opportunity<br />
to be involved in national and international research<br />
projects like the Chiari Consortium, the Hydrocephalus<br />
International Study and the Pediatric Craniocervical<br />
Society.<br />
Conditions Treated:<br />
• Brain and Spine tumors<br />
• Chiari malformation<br />
• Congenital and developmental malformations <strong>of</strong><br />
the nervous system<br />
• Epilepsy<br />
• Hydrocephalus<br />
• Nervous system vascular lesions<br />
• Pediatric brain trauma<br />
• Spasticity<br />
Clinical Services Provided:<br />
• Surgical treatment <strong>of</strong> congenital and developmental<br />
lesions <strong>of</strong> the nervous system [Spina bifida, Chiari<br />
Malformation, Cranio cervical spine abnormalities,<br />
tethered cord]<br />
• Surgical treatment <strong>of</strong> brain and spine tumors [Open<br />
surgery and endoscopic]<br />
• Surgical treatment <strong>of</strong> craniosynostosis [skull<br />
reconstructive surgery]<br />
• Surgical treatment <strong>of</strong> epilepsy [invasive monitoring<br />
and resection <strong>of</strong> the brain area producing epilepsy]<br />
• Surgical treatment <strong>of</strong> hydrocephalus [shunts and<br />
endoscopic third ventriculostomies -without shunt]<br />
• Surgical treatment <strong>of</strong> spasticity [Bacl<strong>of</strong>en Pumps,<br />
Dorsal Rhizotomies]<br />
• Surgical treatment <strong>of</strong> vascular lesions <strong>of</strong> the<br />
nervous system [aneurysms, arterio-venous<br />
malformations, Moyamoya disease]<br />
PUBLICATIONS<br />
Tovar-Spinoza ZS, Ochi A, Rutka JT, et al: The role <strong>of</strong><br />
magnetoencephalography in epilepsy surgery. Neurosurg<br />
Focus, 25(3):E16, <strong>2008</strong>.<br />
Yamazaki M, Chan D, Tovar-Spinoza Z, Go C, et al:<br />
Interictal epileptogenic fast oscillations on neonatal and<br />
infantile EEGs in hemimegalencephaly. Epilepsy Res, 83(2-<br />
3):198-206, <strong>2009</strong>.
Bi-Annual <strong>Report</strong> • 49<br />
PEDIATRIC OPHTHALMOLOGY<br />
FACULTY<br />
Leon-Paul Noël, MD, Pr<strong>of</strong>essor <strong>of</strong> Clinical<br />
Ophthalmology and <strong>Pediatrics</strong><br />
Walter W. Merriam, MD, Associate Pr<strong>of</strong>essor <strong>of</strong><br />
Ophthalmology<br />
Stephen W. Merriam, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Ophthalmology<br />
Marc J. Safran, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Ophthalmology<br />
CLINICAL OVERVIEW<br />
The pediatric ophthalmology service is involved in the<br />
gamut <strong>of</strong> infant and child ocular disorders, ranging from<br />
simple errors <strong>of</strong> refraction to significant anomalies.<br />
Dr. Noël also works closely with Dr. Botash and the<br />
critical care medicine division in the evaluation and<br />
documentation <strong>of</strong> ocular manifestations <strong>of</strong> child abuse.<br />
The service also has a growing experience with the use <strong>of</strong><br />
intraocular lens placement in infants.<br />
PUBLICATIONS<br />
Nagao K, Noel LP, Noel ME, Walton DS: The spontaneous<br />
resolution <strong>of</strong> primary congenital glaucoma. J Pediatr<br />
Ophthalmol Strabismus. 46(3):139-43, <strong>2009</strong>.<br />
PEDIATRIC ORTHOPEDIC SURGERY<br />
FACULTY<br />
Stephen Albanese, MD, Pr<strong>of</strong>essor <strong>of</strong> Orthopedic Surgery<br />
and <strong>Pediatrics</strong>, <strong>Department</strong> Chairman<br />
Timothy Damron, MD, Pr<strong>of</strong>essor <strong>of</strong> Orthopedic Surgery<br />
Danielle Katz, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> Orthopedic<br />
Surgery<br />
Kathryn Palomino, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> Orthopedic<br />
Surgery<br />
Brian Harley, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> Orthopedic<br />
Surgery<br />
CLINICAL OVERVIEW<br />
Upstate Medical University’s pediatric orthopedic<br />
group is one <strong>of</strong> upstate New York’s largest resources<br />
for children’s orthopedic care. In addition to the<br />
management <strong>of</strong> traumatic injuries for children in the<br />
immediate Syracuse area, the group provides advanced<br />
care for complex disorders such as scoliosis and vertebral<br />
anomalies for an extensive referral area.<br />
Several other orthopedic surgeons within the<br />
<strong>Department</strong> <strong>of</strong> Orthopedic Surgery also play a major<br />
role in the care <strong>of</strong> children. Prominent among these are<br />
Dr. Timothy Damron and Dr. Brian Harley. Dr. Damron<br />
is trained in children’s orthopedic oncology and is an<br />
expert in the management <strong>of</strong> skeletal malignancies. He<br />
works closely with the pediatric hematology oncology<br />
service. Dr. Harley completed a pediatric and congenital<br />
upper extremity fellowship. His expertise includes<br />
hand surgery as well as microsurgery and trauma<br />
reconstruction.<br />
PUBLICATIONS<br />
Damron TA, Horton JA, Pritchard MR, et al:<br />
Histomorphometric evidence <strong>of</strong> growth plate recovery<br />
potential after fractionated radiotherapy: an in vivo<br />
model. Radiat Res. 170(3):284-91, <strong>2008</strong>.<br />
Zhang M, Pritchard MR, Middleton FA, Horton JA,<br />
Damron TA: Microarray analysis <strong>of</strong> perichondral and<br />
reserve growth plate zones identifies differential gene<br />
expressions and signal pathways. Bone. 43(3):511-20, <strong>2008</strong>.<br />
Lisle JW, Choi JY, Horton JA, Allen MJ, Damron TA:<br />
Metastatic osteosarcoma gene expression differs in vitro<br />
and in vivo. Clin Orthop Relat Res. 466(9):2071-80, <strong>2008</strong>.<br />
Joyner DE, Aboulafia AJ, Damron TA, Randall RL: Fas<br />
death pathway in sarcomas correlates with epidermal<br />
growth factor transcription. Clin Orthop Relat Res.<br />
466(9):2092-8, <strong>2008</strong>.<br />
Margulies BS, Damron TA, Allen MJ: The differential<br />
effects <strong>of</strong> the radioprotectant drugs amifostine and<br />
sodium selenite treatment in combination with radiation<br />
therapy on constituent bone cells, Ewing’s sarcoma <strong>of</strong><br />
bone tumor cells, and rhabdomyosarcoma tumor cells in<br />
vitro. J Orthop Res. 26(11):1512-9, <strong>2008</strong>.<br />
Damron TA, Leerapun T, Hugate RR, et al: Does the<br />
second-generation intercalary humeral spacer improve<br />
on the first? 466(6):1309-17, <strong>2008</strong>.<br />
Mann KA, Lee J, Arrington SA, Damron TA, Allen MJ:<br />
Predicting distal femur bone strength in a murine model<br />
<strong>of</strong> tumor osteolysis. Clin Orthop Relat Res. 466(6):1271-8,<br />
<strong>2008</strong>.<br />
Evans AR, Bottros J, Grant W, Chen BY, Damron TA:<br />
Mirels’ rating for humerus lesions is both reproducible<br />
and valid. Clin Orthop Relat Res. 466(6):1279-84, <strong>2008</strong>.
50 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
Clabeaux J, Hojnowski L, Valente A, Damron TA: Case<br />
report: parachordoma <strong>of</strong> s<strong>of</strong>t tissues <strong>of</strong> the arm. Clin<br />
Orthop Relat Res. 466(5):1251-6, <strong>2008</strong>.<br />
Sherman GM, Spath C, Harley BJ, Weiner MM, Werner<br />
FW, Palmer AK: Core decompression <strong>of</strong> the distal radius<br />
for the treatment <strong>of</strong> Kienbock’s disease: a biomechanical<br />
study. J Hand Surg Am. 33(9):1478-81, <strong>2008</strong>.<br />
Wong DA, Herndon JH, Canale ST, Brooks RL, Hunt TR,<br />
Epps HR, Fountain SS, Albanese SA, et al: Medical errors<br />
in orthopaedics. Results <strong>of</strong> an AAOS member survey. J<br />
Bone Joint Surg Am. 91(3):547-57, <strong>2009</strong>.<br />
Joyner DE, Trang SH, Aboulafia AJ, Damron TA, Randall<br />
RL: FAP-associated desmoid invasiveness correlates with<br />
in vitro resistance to doxorubicin. Fam Cancer. 8(4):569-<br />
80, <strong>2009</strong>.<br />
Damron TA, Zhang M, Pritchard MR, Middleton FA, et al:<br />
Microarray cluster analysis <strong>of</strong> irradiated growth plate<br />
zones following laser microdissection. Int J Radiat Oncol<br />
Biol Phys. 74(3):949-56, <strong>2009</strong>.<br />
Damron TA, Morris C, Rougraff B, Tamurian R: Diagnosis<br />
and treatment <strong>of</strong> joint-related tumors that mimic sportsrelated<br />
injuries. Instr Course Lect. 58:833-47, <strong>2009</strong>.<br />
Joyner DE, Trang SH, Damron TA, Aboulafia AJ, et al:<br />
Desmoid cell motility is induced in vitro by rhEGF. J<br />
Orthop Res. 27(9):1258-62, <strong>2009</strong>.<br />
Sherman RA, Damron TA: Penetration <strong>of</strong> a metallic<br />
femoral head through the acetabular shell. J<br />
Arthroplasty. 24(7):1143.e7-10, <strong>2009</strong><br />
PEDIATRIC OTOLARYNGOLOGY<br />
FACULTY<br />
Anthony Mortelliti, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
Otolaryngology and <strong>Pediatrics</strong><br />
Robert Shprintzen, PhD, Pr<strong>of</strong>essor <strong>of</strong> Otolaryngology and<br />
<strong>Pediatrics</strong><br />
Sherard Tatum, MD, Associate Pr<strong>of</strong>essor <strong>of</strong><br />
Otolaryngology<br />
CLINICAL OVERVIEW<br />
The <strong>Department</strong> <strong>of</strong> Otolaryngology provides state-<strong>of</strong>-the<br />
art management for children with ear, nose, and throat<br />
disorders, as well as severe crani<strong>of</strong>acial anomalies and<br />
airway problems. The department is particularly known<br />
for its work with children affected by velocardi<strong>of</strong>acial<br />
syndrome, providing a multidisciplinary approach to<br />
evaluation and treatment through the VCF Center. This<br />
program also directs a highly visible research program in<br />
this disorder.<br />
PUBLICATIONS<br />
Tatum SA, Losquadro WD: Advances in crani<strong>of</strong>acial<br />
surgery. Arch Facial Plast Surg, 10(6):376-80, <strong>2008</strong>.<br />
Gothelf D, Frisch A, Michaelovsky E, Weizman A,<br />
Shprintzen RJ: Velo-Cardio-Facial Syndrome. J Ment<br />
Health Res Intellect Disabil, 2(2):149-167, <strong>2009</strong>.<br />
Sriharan A, Abdeen Z, Bojrab D, David S, Elnasser Z,<br />
Patterson T, Shprintzen R, et al: Academic medicine as<br />
a bridge to peace: building Arab and Israeli cooperation.<br />
Acad Med, 84(11):1488-9, <strong>2009</strong>.<br />
Nelson J, Tatum S: Pediatric Rhabdomyosarcoma in<br />
an Oronasal Fistula in a Repaired Cleft Palate: A Case<br />
<strong>Report</strong>. Cleft Palate Crani<strong>of</strong>ac J, 5:1, <strong>2009</strong>.<br />
Portnoy JE, Tatum S: Retrograde nasal intubation via the<br />
cleft in Pierre-Robin Sequence neonates: a case series.<br />
Int J Pediatr Otorhinolaryngol, 73(12):1828-32, <strong>2009</strong>.<br />
Smallman B, Ball R, Tatum S: A novel technique <strong>of</strong><br />
retrograde nasal intubation for the Pierre Robin Sequence<br />
infant with a known difficult airway. Paediatr Anaesth,<br />
19(9):919-21, <strong>2009</strong>.<br />
Shprintzen RJ, Marrinan E: Velopharyngeal insufficiency:<br />
diagnosis and management. Curr Opin Otolaryngol Head<br />
Neck Surg, 17(4):302-7, <strong>2009</strong>.<br />
Losquadro WD, Tatum SA, Allen MJ, Mann KA:<br />
Polytactide-co-glycolide fiber-reinforced calcium<br />
phosphate bone cement. Arch Facial Plast Surg, 11(2):104-<br />
9, <strong>2009</strong>.
Bi-Annual <strong>Report</strong> • 51<br />
AFFILIATED FACULTY<br />
The clinical and educational missions <strong>of</strong> the <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong> are enhanced by several specialty groups in<br />
affiliated institutions or private practice. These pediatricians have academic appointments in the department and are<br />
fully integrated into our activities.<br />
PEDIATRIC CARDIOLOGY<br />
FACULTY<br />
Nader H. Atallah, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Craig J. Byrum, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong> and Medicine<br />
Daniel A. Kveselis, MD, Associate Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Frank C. Smith, MD, Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Ellen Weinstein, MD, Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
CLINICAL OVERVIEW<br />
The Division <strong>of</strong> Pediatric Cardiology provides the full<br />
spectrum <strong>of</strong> non-invasive and interventional diagnostic<br />
and therapeutic services. This activity occurs in the<br />
neonatal intensive care unit at Crouse Hospital as well<br />
as in the inpatient and critical care units at University<br />
Hospital. A number <strong>of</strong> satellite clinics are staffed by<br />
these faculty as well.<br />
NEONATALOGY: ST. JOSEPH’S HOSPITAL<br />
FACULTY<br />
Larry Consenstein, MD, Clinical Associate Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
James Pergolizzi, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
Jonathan Chai, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
Michele Chai, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
CLINICAL OVERVIEW<br />
These physicians staff the Neonatal Intensive Care Unit at<br />
St. Joseph’s Hospital as well as providing normal newborn<br />
coverage for other hospitals and pediatric practices.<br />
One <strong>of</strong> the three one-month neonatology rotations<br />
in our pediatric residency is served at St. Joseph’s<br />
Hospital under the supervision <strong>of</strong> faculty members <strong>of</strong><br />
neonatology.<br />
NEONATOLOGY: CROUSE HOSPITAL<br />
FACULTY<br />
Steven Gross, MD, Clinical Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Ellen Bifano, MD, Clinical Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Michelle Bode, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
Boura’a Bou Aram, M.D, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
Thomas Curran, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pediatrics</strong><br />
Bonnie Marr, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
Beverly Roy, MD, Clinical Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong><br />
CLINICAL OVERVIEW<br />
These neonatologists staff the 60 bed neonatal intensive<br />
care unit at Crouse Hospital. In addition to the clinical<br />
activity in this busy unit, two <strong>of</strong> the one-month<br />
neonatology rotations <strong>of</strong> our pediatric residents are<br />
spent in this NICU.
52 • <strong>Department</strong> <strong>of</strong> <strong>Pediatrics</strong><br />
FACULTY RECOGNITION<br />
Many department faculty have received national recognition.<br />
AMERICAN PEDIATRIC SOCIETY<br />
The following faculty are members <strong>of</strong> the American<br />
Pediatric Society, recognizing their national reputation as<br />
academic pediatricians:<br />
Ann Botash, MD<br />
Robert Kanter, MD<br />
Gregory Liptak, MD<br />
Irene Sills, MD<br />
Leonard Weiner, MD<br />
Thomas Welch, MD<br />
SOCIETY FOR PEDIATRIC RESEARCH<br />
The Society for Pediatric Research is an elective society<br />
which recognizes nationally prominent accomplishments<br />
in research by pediatricians. Upstate faculty members<br />
include:<br />
Ann Botash, MD<br />
Joseph Domachowske, MD<br />
James Listman, MD<br />
Scott Schurman, MD<br />
Thomas Welch, MD<br />
AMERICAN ACADEMY OF PEDIATRICS,<br />
SECTION ON ENDOCRINOLOGY<br />
Irene Sills, MD - Executive Committee<br />
AMERICAN BOARD OF PEDIATRICS<br />
Gregory Liptak, MD – Chair, Neurodevelopmental<br />
Disabilities Sub-Board<br />
THE HELFER SOCIETY<br />
Ann Botash, MD – President<br />
THE AMERICAN SOCIETY OF CLINICAL<br />
HYPNOSIS<br />
Ran Anbar, MD - President<br />
SIGMA XI SCIENTIFIC RESEARCH SOCIETY<br />
BEST DOCTORS IN AMERICA<br />
Best Doctors is a national program which recognizes<br />
physicians in the United States who are considered by<br />
their peers to be outstanding clinicians. Nearly a quarter<br />
<strong>of</strong> the physicians in Onondaga County recognized by<br />
Best Doctors are members <strong>of</strong> our pediatric full-time or<br />
volunteer faculty.<br />
Stephen Albanese<br />
Ran Anbar<br />
John Andrake<br />
Mirza Beg<br />
Steven Blatt<br />
Ann Botash<br />
Robert Cavanaugh<br />
Irene Cherrick<br />
Carl Crosley<br />
Timothy Damron<br />
Joseph Domachowske<br />
Wanda Fremont<br />
William Hannan<br />
Gregory Liptak<br />
Victoria Meguid<br />
Paul Phillips<br />
Michael Ratner<br />
Scott Schurman<br />
Irene Sills<br />
Richard Sills<br />
Zafer Soultan<br />
Ann Sveen<br />
Leonard Weiner<br />
Thomas Welch<br />
Denise Woodall-Ruff<br />
The following outpatient centers were also included in<br />
the Best Doctors list:<br />
Pediatric and Adolescent Center<br />
William Kerr, PhD - Member
10-0491 Rev. 5/2010