Annual report 2009/10 - Human Fertilisation and Embryology Authority

Section 3
Issues identified in the 2009/10
horizon scanning process
27
IVF and ICSI
Use of aim Description Reference
Improving success
of ICSI
The effect of egg
electroactivation after ICSI
on the fertilisation rate
in cases of severe
oligoasthenoteratospermia
and nonobstructive
azoospermia.
Mansour R et al. (2009) Electrical activation of oocytes after
intracytoplasmic sperm injection: a controlled randomized
study. Fertility and Sterility 91(1):133-139.
Montag M et al. (2009) ART, laboratory: ICSI, MESA, TESE.
Hum Rep 24 suppl 1:i70.
Predicting likelihood of
pregnancy
Analysis of gene expression in
women before undergoing IVF
as a method of determining
the likelihood of pregnancy.
Allen et al. (2009) Gene expression profiles during in vitro
fertilization treatment describe the functional transcriptome of
the peri-conceptual period. Hum Rep 24 suppl 1: i108-109.
Mild-stimulation in IVF
treatment cycles
Mild-stimulation protocols use
smaller doses or alternative
hormones to those used in
standard IVF to stimulate a
lower rate of follicle
development. They may
reduce the incidence of
OHSS, treatment cost and
drop-out rate, potentially
provide a better rate of good
quality embryos for transfer
and help reduce multiple
births.
Clinical trials using mildstimulation
protocols study
the potential benefit to
patients and effect on
pregnancy rate per cycle.
Altmae S et al. (2009) Aromatase gene (CYP19A1) variants,
female infertility and ovarian stimulation outcome: a preliminary
report RBMO 18(5):651-657.
Brodin T et al. (2009) High basal LH levels in combination with
low basal FSH levels are associated with high success rates at
assisted reproduction. Hum rep 24(11):2755-2759.
Collins J (2009) Mild stimulation of IVF: making progress
downward. Hum Rep Update 15(1):1-3.
Dickey R (2009) Strategies to reduce multiple pregnancies due
to ovulation stimulation. Fertility and sterility 91(1):1-17.
Feliciani E et al. (2009) IVF light versus conventional ART:
cumulative ongoing pregnancy rate over a given period of
time. Hum Rep 24 suppl 1:i65.
Givens C et al. (2009) Outcomes of natural cycles versus
programmed cycles for 1677 frozen thawed embryo transfers.
RBMO 19(3):380-384.
Muasher S et al. (2009) Fewer medications for in vitro
fertilisation can be better: thinking outside the box.
Fertility and Sterility 92(4):1187-1189.
Schimberni M et al. (2009) Natural-cycle in vitro fertilisation in
poor responder patients: a survey of 500 consecutive cycles.
Fertility and Sterility 92(4):1297-130.
Verberg MF et al. (2009) Mild ovarian stimulation for IVF.
Hum Rep Update 15(1):13-29.
Weghofer A et al. (2009) The impact of LH-containing
gonadotrophin stimulation on euploidy rates in preimplantation
embryos: antagonist cycles. Fertility and Sterility 92(3):937-942.
Weissmann A et al. (2009) Timing natural cycle frozen/thawed
embryo transfer by HCG triggering: a randomised prospective
trial. Fertility and Sterility 92(3) suppl:S24.
Human Fertilisation & Embryology Authority
Scientific Horizon Scanning at the HFEA