Annual report 2009/10 - Human Fertilisation and Embryology Authority

36
Section 3
Issues identified in the 2009/10
horizon scanning process
Reproductive immunology
Use of aim Description Reference
Reproductive
immunology tests and
treatments, which aim
to improve ART
outcome
Reports of new types of
reproductive immunology
treatments.
British Fertility Society review
of evidence for use of medical
adjuncts in IVF.
A study of the effects of
Natural Killer cell level (or the
chemicals they release) in the
peripheral blood and the
uterus and establishment of
pregnancy.
Faridi R et al. (2009) Influence of activating and inhibitory killer
immunoglobulin-like receptors on predisposition to recurrent
miscarriages. Hum Rep 24(7):1758-1764.
Guerin L et al. (2009) Regulatory T-cells and immune tolerance
in pregnancy: a new target for infertility treatment?
Hum Rep Update 15(5):517-535.
King K et al. (2010) Detailed analysis of peripheral blood
natural killer (NK) cells in women with recurrent miscarriage.
Hum Rep 25(1):52-58.
Nardo L et al. (2009) Medical adjuncts in IVF: evidence for
clinical practice. Human Fertility 12(1):1-13.
Quenby S et al. (2009) Uterine natural killer cells and
angiogenesis in recurrent reproductive failure.
Hum Rep 24(1):45-54.
Scarpellini F and Sbracia M (2009) Use of granulocyte colonystimulating
factor for the treatment of unexplained recurrent
miscarriage: a randomised controlled trial.
Hum Rep 24(11):2703-2708.
Wang W et al. (2009) Improvement of fertility with adoptive
CD25+ natural killer cell transfer in subfertile non-obese
diabetic mice. RBMO 18(1):95-103.
Zammiti et al. (2009) Tumour necrosis factor and lymphotoxin
haplotypes in idiopathic recurrent pregnancy loss.
Fertility and Sterility 91(5):1903-1908.
Human Fertilisation & Embryology Authority
Scientific Horizon Scanning at the HFEA