Peptide Synthesis and Protein Engineering - Almac
Peptide Synthesis and Protein Engineering - Almac
Peptide Synthesis and Protein Engineering - Almac
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<strong>Peptide</strong> <strong>Synthesis</strong> <strong>and</strong><br />
<strong>Protein</strong> <strong>Engineering</strong><br />
Making peptide science work for you<br />
> GMP Manufacturing for Clinical Supply<br />
><br />
complete first in man package<br />
> Chemokine Catalogue<br />
><br />
Fluorescence Lifetime Assays<br />
> Proprietary best in class technologies<br />
for site specific protein modification<br />
> Preformulation Services, design <strong>and</strong><br />
development capability for biologics<br />
API Services &<br />
Chemical Development<br />
www.almacgroup.com
Biomarker Discovery & Development API Services & Chemical Development Pharmaceutical Development Analytical Services Clinical Trial Supply Clinical Technologies Commercial Services<br />
<strong>Peptide</strong> <strong>and</strong> <strong>Protein</strong> Precision <strong>Engineering</strong><br />
GMP Manufacturing for Clinical Supply<br />
> Expertise in chemical synthesis of long<br />
complex peptides<br />
> cGMP manufacturing 2 - 200 amino<br />
acids, mg to kg scale<br />
> >150 man years experience<br />
> MHRA inspected <strong>and</strong> certified facility<br />
> High throughput non-GMP custom<br />
synthesis supply<br />
> Customised products:<br />
• Labelled or unlabelled<br />
(Biotin, AlexaFluor, Fluophores)<br />
• PEGylated <strong>Peptide</strong>s<br />
• Conjugated <strong>Peptide</strong>s<br />
Complete first in man package<br />
> Chemical <strong>and</strong> analytical development<br />
> Material supply for Tox <strong>and</strong> clinical trials<br />
> Oversight <strong>and</strong> management of<br />
formulation <strong>and</strong> sterile fill<br />
> Oversight <strong>and</strong> management of tox trials<br />
> Rabiolabelling<br />
> Authorship of regulatory documentation<br />
> <strong>Almac</strong> project management through to<br />
full IND package<br />
Chemokine Catalogue<br />
> Large range of catalogue chemokine<br />
products<br />
> Labelled <strong>and</strong> unlabelled<br />
(Biotin AlexaFluor)<br />
> Site specific labelling capability<br />
FLEXYTE:<br />
Fluorescence lifetime assays<br />
> Novel assay technology realizing the<br />
benefits of fluorescence lifetime for drug<br />
discovery applications<br />
> Reagents available in bulk <strong>and</strong> kit forms<br />
for Proteases <strong>and</strong> Ser/Thr Kinases<br />
> Custom assay development available for<br />
Tyr Kinases, Phosphatases, Lipid Kinases,<br />
Epigenetic targets<br />
Proprietary best in class technologies<br />
for site specific protein modification<br />
> Site specific C-terminal PEGylation of<br />
recombinant proteins for enhanced<br />
therapeutics.<br />
> Chemical synthesis <strong>and</strong> site directed, site<br />
specific labelling of folded proteins up<br />
to 200 amino acids<br />
Preformulation Services, design <strong>and</strong><br />
development capability for biologics<br />
> <strong>Peptide</strong> structural characterisation<br />
> <strong>Peptide</strong> chemical stability determination<br />
> Formulation development studies<br />
> Compatibility & stability studies
www.almacgroup.com<br />
Biomarker Discovery & Development API Services & Chemical Development Pharmaceutical Development Analytical Services Clinical Trial Supply Clinical Technologies Commercial Services<br />
Case Studies<br />
> Chemical process design <strong>and</strong> development in-house<br />
> Natural <strong>and</strong> unnatural amino acids, biotinylated API<br />
> Complex folded chemokine, >70 amino acids in length<br />
> Analytical methods developed in-house<br />
> cGMP production of API<br />
> API Stability study<br />
> Chemical process design <strong>and</strong> development<br />
in-house<br />
> Analytical methods developed in-house<br />
> cGMP production of API<br />
> API <strong>and</strong> DP Stability study<br />
> Management of sterile vial filling of Drug<br />
Product<br />
For European Enquiries:<br />
<strong>Almac</strong><br />
Sciences<br />
<strong>Almac</strong> House<br />
20 Seagoe Industrial Estate,<br />
Craigavon, BT63 5QD,<br />
United Kingdom.<br />
T: +44 (0) 28 3833 2200<br />
E: sciences@almacgroup.com<br />
www.almacgroup.com<br />
For American Enquiries:<br />
<strong>Almac</strong> Group Incorporated<br />
25 Fretz Road<br />
Souderton, PA 18964<br />
United States of America<br />
T +1 (215) 660 8500<br />
E: sciences@almacgroup.com<br />
Case Study 1<br />
Our client required a synthetic chemokine,<br />
modified with unnatural amino acids <strong>and</strong><br />
biotin labelled for clinical trial use.<br />
Case Study 2<br />
Our client required synthetic h-MDC,<br />
presented as a sterile filtered, lyophilised<br />
Drug Product in vials, for clinical trial use.
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