Thorough QT Study: Design Features for Consideration - IIR
Thorough QT Study: Design Features for Consideration - IIR
Thorough QT Study: Design Features for Consideration - IIR
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Number of Replicate ECGs Signal Averaged to Yield an Average<br />
<strong>QT</strong> Value<br />
Slide 13<br />
•Beat-to-beat variability under optimal recording conditions is<br />
substantial<br />
‣ True variability<br />
‣ Measurement error<br />
• Signal average to strengthen the signal<br />
• How many replicates<br />
‣ 3 is common<br />
‣ Probably some slight increase in reduction of variability with 6-7<br />
‣ The more the better within a time frame where factors influencing <strong>QT</strong> are not<br />
changing but the increase in reduction of variability will be very small beyond 6-7
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