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iMBE CHARACTERISTICS OF FUNCTIONAL BIOLOGICAL SCAFFOLDS • Provide a biologically and immunologically compatible environment for tissue repair - attract and support tissue regeneration, through patients own cells, An acellular therapy • Provide low cost regenerative solutions by recruiting patients own cells • Replicate tissue specific multi-scale structure and architecture and multiscale biomechanical function and biocompatibility • Convert macro-scale forces and stresses to appropriate micro cell level strains, that stimulate appropriate cell differentiation pathways and tissue regeneration
Force/Width (N/m) iMBE MULTI SCALE TISSUE SPECIFIC BIOMECHANICAL BIOCOMPATIBILITY Micro-scale scaffold structure & architecture determines cell strain and function- Macro forces and biomechanics Scaffold architecture and structure determines Micro scale -local cell - strain field Drives scaffold - cell strain / interactions Model anisotropic scaffold 160 120 80 40 Fixed Aortic Fixed Pulmonary Fresh Aortic 0 0 5 10 15 20 25 30 35 40 Strain (%) Each tissue has its own unique scaffold architecture Micro-scale strain drives cell differentiation
Page 1 and 2: Institute of Medical & Biological E
Page 3 and 4: iMBE THREE ELEMENTS OF TISSUE REGEN
Page 5: iMBE FUNCTIONAL BIOLOGICAL SCAFFOLD
Page 9 and 10: iMBE BIO- PROCESS RESEARCH CAPABILI
Page 11 and 12: iMBE BIOLOGICAL SCAFFOLDS; Heart va
Page 13 and 14: iMBE CARDIAC VALVES: CLINICAL STUDI
Page 15 and 16: iMBE VASCULAR PATCH IN SHEEP MODEL
Page 17 and 18: iMBE CLINICAL TRANSLATION VASCULAR
Page 19 and 20: iMBE BIOLOGICAL SCAFFOLDS FOR MSK D
Page 21 and 22: iMBE BIOLOGICAL SCAFFOLD FOR LIGAME
Page 23 and 24: iMBE REGENERATIVE BIOLOGICAL SCAFFO

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